Ukuhlolwa kofuzo kwe-TP53

-Delile

• Luyini uvivinyo lofuzo lwe-TP53?
• Kusetshenziselwa ini?
• Kungani ngidinga ukuhlolwa kofuzo kwe-TP53?
• Kwenzekani ngesikhathi sokuhlolwa kofuzo kwe-TP53?
• Ngabe kukhona engizodinga ukukwenza ukulungiselela isivivinyo?
• Ingabe zikhona izingozi esivivinyweni?
• Isho ukuthini imiphumela?
• Ngabe kukhona okunye engidinga ukukwazi mayelana nokuhlolwa kwe-TP53?
• Izinkomba

Luyini uvivinyo lofuzo lwe-TP53?

Ukuhlolwa kwezakhi zofuzo i-TP53 kubheka ushintsho, olwaziwa njengokuguquka kwezakhi zofuzo, kufuzo olubizwa nge-TP53 (tumor protein 53). Izakhi zofuzo yizingxenye eziyisisekelo zofuzo ezedluliswa zivela kumama nobaba wakho.

I-TP53 yisakhi sofuzo esisiza ukumisa ukukhula kwezimila. Kuyaziwa njengesicindezeli se-tumor. Isakhi sofuzo sokucindezela isimila sisebenza njengamabhuleki emotweni. Ibeka "amabhuleki" kumaseli, ukuze angahlukani ngokushesha okukhulu. Uma unokuguquka kwe-TP53, isakhi sofuzo kungenzeka singakwazi ukulawula ukukhula kwamaseli akho. Ukukhula kwamaseli okungalawulwa kungaholela kumdlavuza.

Ukuguqulwa kwe-TP53 kungazuzwa njengefa kubazali bakho, noma kungatholwa kamuva empilweni kusuka emvelweni noma ngephutha elenzeka emzimbeni wakho ngesikhathi sokuhlukaniswa kwamaseli.

• Ukuguqulwa okuzuzwe njengefa kwe-TP53 kwaziwa njenge-Li-Fraumeni syndrome.
• I-Li-Fraumeni syndrome yisimo sezakhi zofuzo esingavamile esingakhuphula ubungozi bezinhlobo ezithile zomdlavuza.
• Le mikhamo ihlanganisa umdlavuza webele, umdlavuza wethambo, i-leukemia, nomdlavuza wezicubu ezithambile, obizwa nangokuthi ama-sarcomas.

Kutholakale (okwaziwa nangokuthi yi-somatic) ukuguqulwa kwe-TP53 kuvame kakhulu. Lezi zinguquko zitholakale cishe engxenyeni yazo zonke izimo zomdlavuza, nasezinhlotsheni eziningi zomdlavuza.

Amanye amagama: Ukuhlaziywa kokuguqulwa kwezinguquko kwe-TP53, ukuhlaziywa kwe-TP53 okugcwele kofuzo, ukuguqulwa kwesimo se-TP53 somatic

Kusetshenziselwa ini?

Isivivinyo sisetshenziselwa ukubheka ukuguqulwa kwe-TP53. Akusona isivivinyo esijwayelekile.Imvamisa inikezwa abantu ngokuya ngomlando womndeni, izimpawu, noma ukuxilongwa komdlavuza kwangaphambilini.

Kungani ngidinga ukuhlolwa kofuzo kwe-TP53?

Ungadinga ukuhlolwa kwe-TP53 uma:

• Kutholwe ukuthi unomdlavuza wamathambo noma wezicubu ezithambile ngaphambi kweminyaka engama-45
• Utholwe ukuthi unomdlavuza webele, wangaphambi kokuya esikhathini, isimila sobuchopho, i-leukemia, noma umdlavuza wamaphaphu ngaphambi kweminyaka engama-46
• Ube nesimila esisodwa noma eziningi ngaphambi kweminyaka engama-46
• Ilungu elilodwa noma amaningi omndeni wakho atholakale ene-Li-Fraumeni syndrome futhi / noma abe nomdlavuza ngaphambi kweminyaka engama-45

Lezi yizimpawu ongazithola uguqukile njengefa lohlobo lwe-TP53.

Uma utholwe unomdlavuza futhi ungenawo umlando womndeni waleso sifo, umhlinzeki wakho wezokunakekelwa kwempilo anga-oda lokhu kuhlolwa ukuze ubone ukuthi ngabe ukuguqulwa kwe-TP53 kungadala umdlavuza wakho yini. Ukwazi ukuthi unokuguquka yini kungasiza umhlinzeki wakho ukuhlela ukwelashwa nokubikezela umphumela wesifo sakho.

Kwenzekani ngesikhathi sokuhlolwa kofuzo kwe-TP53?

Ukuhlolwa kwe-TP53 kuvame ukwenziwa egazini noma emnkantsheni wethambo.

Uma uthola ukuhlolwa kwegazi, uchwepheshe wezokunakekelwa kwempilo uzothatha isampuli yegazi emthanjeni osengalweni yakho, esebenzisa inaliti encane. Ngemuva kokuthi kufakwe inaliti, kuzoqoqwa inani elincane legazi kufakwe ithubhu yokuhlola noma isitsha. Ungase uzizwe uluma kancane lapho inaliti ingena noma iphuma. Lokhu ngokuvamile kuthatha imizuzu engaphansi kwemihlanu.

Uma uthola ukuhlolwa komnkantsha, inqubo yakho ingafaka lezi zinyathelo ezilandelayo:

• Uzolala ngohlangothi noma esiswini sakho, kuya ngokuthi yiliphi ithambo elizosetshenziselwa ukuhlolwa. Iningi lokuhlolwa komnkantsha wamathambo lithathwa ethangeni lesinqe.
• Umzimba wakho uzombozwa ngendwangu, ukuze kubonakale kuphela indawo ezungeze indawo yokuhlola.
• Isiza sizohlanzwa ngesibulali magciwane.
• Uzothola umjovo wesixazululo esikindayo. Kungaluma.
• Lapho indawo isikindiki, umhlinzeki wezempilo uzothatha isampula. Uzodinga ukuqamba amanga unganyakazi ngesikhathi sokuhlolwa.
• Umhlinzeki wezokunakekelwa kwempilo uzosebenzisa ithuluzi elikhethekile elizisontela emathanjeni ukukhipha isampula lezicubu zomnkantsha. Ungazizwa unengcindezi ethile kusayithi ngenkathi kuthathwa isampula.
• Ngemuva kokuhlolwa, umhlinzeki wezokunakekelwa kwempilo uzomboza isiza ngebhandishi.
• Hlela ukuthi othile akuhambise ekhaya, ngoba unganikezwa umuthi wokuthambisa ngaphambi kokuhlolwa, okungakwenza ukozele.

Ngabe kukhona engizodinga ukukwenza ukulungiselela isivivinyo?

Imvamisa awudingi amalungiselelo akhethekile wokuhlolwa kwegazi noma umnkantsha.

Ingabe zikhona izingozi esivivinyweni?

Kunengozi encane kakhulu yokuhlolwa kwegazi. Ungaba nobuhlungu obuncane noma ukulimaza lapho kufakwe khona inaliti, kepha izimpawu eziningi ziyaphela ngokushesha.

Ngemuva kokuhlolwa komnkantsha wamathambo, ungazizwa uqine noma ubuhlungu endaweni okujojelwa kuyo. Lokhu kuvame ukuphela ezinsukwini ezimbalwa. Umhlinzeki wakho wezokunakekelwa kwempilo angancoma noma anikeze umuthi wokuqeda izinhlungu ukusiza.

Isho ukuthini imiphumela?

Uma utholwe une-Li-Fraumeni syndrome, it akunjalo kusho ukuthi unomdlavuza, kodwa ingozi yakho iphakeme kunabantu abaningi. Kepha uma unokuguquka, ungathatha izinyathelo zokunciphisa ubungozi bakho, njenge:

• Ukuhlolwa kaningi komdlavuza. Umdlavuza uyelapheka uma utholakala kusaqalwa.
• Ukwenza izinguquko endleleni yokuphila, njengokuvivinya umzimba nokudla ukudla okunempilo
• I-Chemoprevention, ukuphuza imithi ethile, amavithamini, noma ezinye izinto ukunciphisa ubungozi noma ukubambezela ukukhula komdlavuza.
• Ukususa izicubu "ezisengozini"

Lezi zinyathelo zizohluka ngokuya ngomlando wakho wezempilo kanye nemvelaphi yomndeni.

Uma unomdlavuza futhi imiphumela yakho ikhombisa ukuguqulwa okutholakele kwe-TP53 (ushintsho lwatholakala, kepha awunawo umlando womdlavuza noma i-Li-Fraumeni syndrome), umhlinzeki wakho angasebenzisa imininingwane ukusiza ukubikezela ukuthi isifo sakho sizokhula kanjani futhi sikuqondise ukwelashwa.

Funda kabanzi mayelana nokuhlolwa kwelabhorethri, ububanzi bezinkomba, nemiphumela yokuqonda.

Ngabe kukhona okunye engidinga ukukwazi mayelana nokuhlolwa kwe-TP53?

Uma utholakale unesifo noma usola ukuthi une-Li-Fraumeni syndrome, kungasiza ukukhuluma nomeluleki wezofuzo. Umeluleki wezofuzo uchwepheshe oqeqeshwe ngokukhethekile kwezofuzo nasekuhloleni izakhi zofuzo. Uma ungakahlolwa, umeluleki angakusiza uqonde ubungozi nezinzuzo zokuhlolwa. Uma uhloliwe, umeluleki angakusiza uqonde imiphumela futhi akuqondise ekusekeleni izinsizakalo nezinye izinsiza.

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Imininingwane ekulesi siza akufanele isetshenziswe esikhundleni sezokunakekelwa kwezokwelapha noma iseluleko. Xhumana nomhlinzeki wezempilo uma unemibuzo ngempilo yakho.