Iyini i-MS Progressive MS?

-Delile

• Ezinye izinhlobo ze-MS
• Siyini isibikezelo se-PPMS?
• I-PPMS vs. SPMS
• I-PPMS vs. RRMS
• Ziyini izimpawu ze-PPMS?
• Yini ebangela i-PPMS?
• I-PPMS itholakala kanjani?
• Iphathwa kanjani i-PPMS?
• Yiziphi izinguquko zendlela yokuphila ezisiza nge-PPMS?
• Izinguquko ze-PPMS
• Ukusekela
• Umbono
• Ukudla okudlela endlini

I-Multiple sclerosis (MS) yisifo esingalapheki sokuhlasela kwamasosha omzimba esithinta izinzwa ze-optic, umgogodla nobuchopho.

Abantu abatholakala ukuthi bane-MS bavame ukuba nokuhlangenwe nakho okuhluke kakhulu. Lokhu kuyiqiniso ikakhulukazi kulabo abatholakala ukuthi bane-multiple sclerosis eqhubekayo eqhubekayo (PPMS), enye yezinhlobo ze-MS ezingavamile.

I-PPMS uhlobo olwehlukile lwe-MS. Akubandakanyi ukuvuvukala okuningi njengezindlela ze-MS ezibuyela emuva.

Izimpawu eziyinhloko ze-PPMS zibangelwa ukulimala kwezinzwa. Lezi zimpawu zenzeka ngoba izinzwa azikwazi ukuthumela nokwamukela imiyalezo komunye nomunye ngendlela efanele.

Uma une-PPMS, kunezimo eziningi zokukhubazeka kokuhamba kunezinye izimpawu, uma kuqhathaniswa nabantu abanezinye izinhlobo ze-MS.

I-PPMS ayijwayelekile kakhulu. Ithinta cishe amaphesenti ayishumi kuya kwangu-15 alabo abatholakala bene-MS. I-PPMS iqhubeka kusukela ngesikhathi obona ngaso izimpawu zakho zokuqala (zokuqala).

Ezinye izinhlobo ze-MS zinezikhathi zokubuyela emuva okunamandla nokuxolelwa. Kepha izimpawu ze-PPMS zibonakala kancane kancane kepha ngokuqinile ngokuhamba kwesikhathi. Abantu abane-PPMS nabo bangabuyela emuva.

I-PPMS ibuye ibangele ukuthi umsebenzi wezinzwa wehle ngokushesha okukhulu kunezinye izinhlobo ze-MS. Kepha ubunzima be-PPMS nokuthi ikhula ngokushesha kangakanani kuncike ecaleni ngalinye.

Abanye abantu kungenzeka baqhubekile ne-PPMS eba nzima kakhulu. Abanye bangaba nezikhathi eziqinile ngaphandle kokuvela kwezimpawu, noma ngisho nezikhathi zokuthuthuka okuncane.

Abantu abake batholakala ukuthi bane-MS (PRMS) eqhubekayo babuye babhekwe njengabahamba phambili ngokuyinhloko.

Ezinye izinhlobo ze-MS

Ezinye izinhlobo ze-MS yilezi:

• isifo esihlukaniswe ngokwasemtholampilo (i-CIS)
• i-MS ebuyisa kabusha (RRMS)
• i-MS yesibili eqhubekayo (SPMS)

Lezi zinhlobo, ezibizwa nangokuthi izifundo, zichazwa ngokuthi ziwuthinta kanjani umzimba wakho.

Uhlobo ngalunye lunezindlela ezahlukahlukene zokwelashwa ezinokwelapha okuningi okugqagqene. Ubukhulu bezimpawu zabo nokubukwa kwesikhathi eside nakho kuzohluka.

I-CIS uhlobo olusanda kuchazwa lwe-MS. I-CIS yenzeka lapho unesikhathi esisodwa sezimpawu ze-neurologic ezihlala okungenani amahora angama-24.

Siyini isibikezelo se-PPMS?

Ukubikezelwa kwe-PPM kwehlukile kuwo wonke umuntu futhi akulindelekile.

Izimpawu zingabonakala kakhulu ngokuhamba kwesikhathi, ikakhulukazi njengoba ukhula futhi uqala ukulahlekelwa yimisebenzi ethile ezithweni ezifana nesinye, amathumbu nezitho zakho zangasese ngenxa yeminyaka ne-PPMS.

I-PPMS vs. SPMS

Nayi umehluko omkhulu phakathi kwe-PPMS ne-SPMS:

• I-SPMS ivame ukuqala njengokuxilongwa kwe-RRMS okugcina kuba nzima kakhulu ngokuhamba kwesikhathi ngaphandle kokuxolelwa noma ukwenziwa ngcono kwezimpawu.
• I-SPMS ngaso sonke isikhathi yisigaba sesibili sokuxilongwa kwe-MS, kuyilapho i-RRMS ingukuxilongwa kokuqala yodwa.

I-PPMS vs. RRMS

Nayi umehluko omkhulu phakathi kwe-PPMS ne-RRMS:

• I-RRMS uhlobo oluvame kakhulu lwe-MS (cishe amaphesenti angama-85 okuxilongwa), kuyilapho i-PPMS ingenye ye-rarest.
• I-RRMS iphindwe kabili kuya kathathu njengokujwayelekile kwabesifazane njengakwabesilisa.
• Iziqephu zezimpawu ezintsha zivame kakhulu ku-RRMS kune-PPMS.
• Ngesikhathi sokuxolelwa ku-RRMS, ungahle ungaboni zimpawu nhlobo, noma ungahle ube nezimpawu ezimbalwa ezingekho kangako.
• Imvamisa, kuvela izilonda zobuchopho kuma-MRIs obuchopho ane-RRMS kune-PPMS uma ingalashwa.
• I-RRMS ijwayele ukutholakala ngaphambi kwesikhathi empilweni kune-PPMS, cishe ngama-20s nama-30s, ngokungafani nama-40s nama-50s ane-PPMS.

Ziyini izimpawu ze-PPMS?

I-PPMS ithinta wonke umuntu ngokuhlukile.

Izimpawu zokuqala ezijwayelekile ze-PPMS zifaka ubuthakathaka emilenzeni yakho nokuba nenkinga yokuhamba. Lezi zimpawu zivame ukubonakala kakhulu esikhathini seminyaka emi-2.

Ezinye izimpawu ezijwayelekile zalesi simo zifaka:

• ukuqina emilenzeni
• izinkinga ngebhalansi
• ubuhlungu
• ubuthakathaka nokukhathala
• inkathazo ngombono
• ukungasebenzi kahle kwesinye noma kwamathumbu
• ukudana
• ukukhathala
• ukuba ndikindiki kanye / noma ukuncinza ezingxenyeni ezihlukene zomzimba

Yini ebangela i-PPMS?

Imbangela ngqo ye-PPMS, ne-MS ngokuvamile, ayaziwa.

Umbono ovame kakhulu ukuthi i-MS iqala lapho amasosha akho omzimba eqala ukuhlasela isistimu yakho yezinzwa ephakathi. Lokhu kubangela ukulahleka kwe-myelin, isembozo esivikelayo esizungeze izinzwa ohlelweni lwakho lwemizwa oluphakathi.

Ngenkathi odokotela bengakholelwa ukuthi i-PPMS ingazuzwa njengefa, ingaba nengxenye yezakhi zofuzo. Abanye bakholelwa ukuthi ingabangelwa igciwane noma ubuthi obusemvelweni okuthi lapho buhlanganiswa nokuthambekela kofuzo kungandisa ubungozi bokusungulwa yi-MS.

I-PPMS itholakala kanjani?

Sebenza eduze nodokotela wakho ukusiza ukuxilonga ukuthi yiziphi izinhlobo ezine ze-MS ongaba nazo.

Uhlobo ngalunye lwe-MS lunombono ohlukile kanye nezidingo zokwelashwa ezihlukile. Alukho uvivinyo oluthile olunikeza ukuxilongwa kwe-PPMS.

Odokotela bavame ukuba nobunzima bokuthola i-PPMS uma kuqhathaniswa nezinye izinhlobo ze-MS nezinye izimo eziqhubekayo.

Lokhu kungenxa yokuthi inkinga yezinzwa idinga ukuthi yathuthuka iminyaka eyi-1 noma emi-2 ukuze othile athole ukuxilongwa okuqinile kwe-PPMS.

Ezinye izimo ezinezimpawu ezifana ne-PPMS zifaka:

• isimo esizuzwe njengefa esidala imilenze eqinile, ebuthakathaka
• ukushoda kukavithamini B-12 okubangela izimpawu ezifanayo
• Isifo seLyme
• ukutheleleka ngegciwane, njenge-human T-cell leukemia virus type 1 (HTLV-1)
• izinhlobo zesifo samathambo, njenge-arthritis yomgogodla
• isimila eduze komgogodla

Ukuthola i-PPMS, udokotela wakho anga:

• hlola izimpawu zakho
• buyekeza umlando wakho wezinzwa
• yenza ukuhlolwa komzimba okugxile emisipheni yakho nasemisipheni yakho
• yenza ukuskena kwe-MRI kobuchopho bakho kanye nentambo yomgogodla
• yenza i-lumbar puncture ukubheka izimpawu ze-MS kuketshezi lomgogodla
• yenza izivivinyo ezinamandla (EP) okukhomba uhlobo oluthile lwe-MS; Ukuhlolwa kwe-EP kuvuselela izindlela zezinzwa zokuthola umsebenzi kagesi wobuchopho

Iphathwa kanjani i-PPMS?

I-Ocrelizumab (Ocrevus) ukuphela kwesidakamizwa esivunyelwe yi-Food and Drug Administration (FDA) ukwelapha i-PPMS. Kuyasiza ukukhawulela ukonakala kwemizwa.

Eminye imithi ilapha izimpawu ezithile ze-PPMS, njenge:

• ukuqina kwemisipha
• ubuhlungu
• ukukhathala
• Izinkinga zesisu namathumbu.

Kunezinhlobo eziningi zokwelapha eziguqula izifo (i-DMTs) kanye ne-steroids evunyelwe yi-FDA yezindlela zokubuyela emuva ze-MS.

Lawa ma-DMTs awaphathi ngqo i-PPMS.

Izindlela zokwelashwa eziningana zenzelwe i-PPMS ukusiza ukunciphisa ukuvuvukala okuhlasela ngqo izinzwa zakho.

Ezinye zazo zisiza futhi ukubhekana nezinqubo zomonakalo nezokulungisa ezithinta izinzwa zakho. Lezi zindlela zokwelashwa zingakwazi ukusiza ukubuyisela i-myelin ezungeze izinzwa zakho ezilinyazwe yi-PPMS.

Ukwelashwa okukodwa, ibudilast, sekusetshenziswe eJapan iminyaka engaphezu kwengu-20 ukwelapha isifuba somoya futhi kungenzeka kube namandla athile okwelapha ukuvuvukala ku-PPMS.

Olunye ukwelashwa olubizwa nge-masitinib selusetshenziselwe ukungezwani komzimba nokukhomba amangqamuzana amangqamuzana abandakanyeka ekuphenduleni okweqile futhi abonisa isithembiso njengokwelashwa kwe-PPMS, futhi.

Kubalulekile ukuqaphela ukuthi lezi zindlela zokwelapha ezimbili zisesekuqaleni kakhulu ekuthuthukisweni nasekucwaningeni.

Yiziphi izinguquko zendlela yokuphila ezisiza nge-PPMS?

Abantu abane-PPMS bangakhulula izimpawu ngokuzivocavoca umzimba futhi belulekele ku:

• uhlale njengoba mobile ngangokunokwenzeka
• nciphisa ukuthi uzuza isisindo esingakanani
• ukwandisa amazinga wamandla

Nazi ezinye izenzo ongazithatha ukuphatha izimpawu zakho ze-PPMS nokugcina ikhwalithi yakho yokuphila:

• Yidla ukudla okunempilo nokunomsoco.
• Hlala esimisweni sokulala njalo.
• Iya ekwelashweni ngokomzimba noma emsebenzini, okungakufundisa amasu okwandisa ukuhamba nokuphatha izimpawu.

Izinguquko ze-PPMS

Ama-modifiers amane asetshenziselwa ukufanisa i-PPMS ngokuhamba kwesikhathi:

• Iyasebenza ngokuqhubeka: I-PPMS enezimpawu eziya ziba zimbi futhi ibuye ibuye noma ngomsebenzi omusha we-MRI; ukwanda kokukhubazeka nakho kuzokwenzeka
• Iyasebenza ngaphandle kokuqhubeka: I-PPMS ngokubuyela emuva noma umsebenzi we-MRI, kepha akukho ukukhubazeka okwandayo
• Ayisebenzi ngokuqhubeka: I-PPMS ngaphandle kokubuyela emuva noma umsebenzi we-MRI, kepha ngokukhubazeka okwandayo
• Akusebenzi ngaphandle kokuqhubeka: I-PPMS ngaphandle kokubuyela emuva, umsebenzi we-MRI, noma ukukhubazeka okwandayo

Isici esiyinhloko se-PPMS ukungabi khona kokuxolelwa.

Ngisho noma umuntu one-PPMS ebona ukuthi izimpawu zakhe ziyanqamuka - okusho ukuthi akatholi umsebenzi wezifo eziwohlokayo noma ukwanda kokukhubazeka - izimpawu zabo azithuthuki empeleni. Ngaleli fomu le-MS, abantu ababuyisi imisebenzi okungenzeka ukuthi balahlekile.

Ukusekela

Uma uhlala ne-PPMS, kubalulekile ukuthola imithombo yokusekelwa. Kunezinketho zokufuna ukwesekwa ngawodwana noma emphakathini obanzi we-MS.

Ukuphila nokugula okungalapheki kungalimaza ngokomzwelo. Uma uhlangabezana nemizwa eqhubekayo yokudabuka, intukuthelo, usizi, noma eminye imizwa enzima, yazisa udokotela wakho. Bangakudlulisela kuchwepheshe wezempilo yengqondo ongasiza.

Futhi ungabheka uchwepheshe wezempilo yengqondo uwedwa. Isibonelo, i-American Psychological Association inikeza ithuluzi lokusesha lokuthola izazi zokusebenza kwengqondo kulo lonke elase-United States. IMentalHealth.gov futhi inikezela ngocingo losizo lokudlulisela ukwelashwa.

Ungakuthola kukusiza ukukhuluma nabanye abantu abaphila ne-MS. Cabanga ukubheka kumaqembu okusekela, kungaba ku-inthanethi noma ngaphakathi.

I-National Multiple Sclerosis Society inikela ngenkonzo ukukusiza ekutholeni amaqembu osizo endawo yangakini. Futhi banehlelo lokuxhuma lontanga oluqhutshwa ngamavolontiya aqeqeshiwe ahlala ne-MS.

Umbono

Ngena nodokotela wakho njalo uma une-PPMS, noma ngabe awukaze ube nazimpawu okwesikhashana futhi ikakhulukazi uma unokuphazamiseka okubonakalayo empilweni yakho ngesiqephu sezimpawu.

Kungenzeka ube nekhwalithi ephezulu yempilo ne-PPMS inqobo nje uma usebenza nodokotela wakho ukuthola izindlela zokwelashwa ezihamba phambili kanye nezinguquko zokuphila nezindlela zokudla ezikusebenzelayo.

Ukudla okudlela endlini

Alikho ikhambi le-PPMS, kepha ukwelashwa kwenza umehluko. Yize isimo siqhubeka, abantu bangathola izikhathi lapho izimpawu zingabi zimbi kakhulu.

Uma uhlala ne-PPMS, udokotela wakho uzoncoma uhlelo lokwelashwa ngokuya ngezimpawu zakho nempilo ejwayelekile.

Ukuthuthukisa imikhuba yokuphila enempilo nokuhlala uxhumekile emithonjeni yokusekelwa nakho kungakusiza ugcine ikhwalithi yakho yempilo nenhlalakahle jikelele.