ICholestasis

I-Cholestasis yinoma isiphi isimo lapho ukugeleza kwenyongo kusuka esibindini kwehliswa noma kuvinjelwe.

Kunezimbangela eziningi ze-cholestasis.

I-Extrahepatic cholestasis ivela ngaphandle kwesibindi. Kungabangelwa:

• Izicubu zemifudlana ebilisiwe
• Ama-cysts
• Ukuncipha komgudu wenyongo
• Amatshe emgodini ovamile we-bile
• I-Pancreatitis
• Isimila sepancreatic noma i-pseudocyst
• Ukucindezela emathangeni e-bile ngenxa yesisindo esiseduze noma isimila
• I-primary sclerosing cholangitis

I-Intrahepatic cholestasis yenzeka ngaphakathi kwesibindi. Kungabangelwa:

• Isifo sesibindi esidakayo
• I-Amyloidosis
• Ithumba lamagciwane esibindini
• Ukondliwa kuphela ngomthambo (IV)
• I-Lymphoma
• Ukukhulelwa
• Isifo sokuqina kwesibindi esiyinhloko
• Umdlavuza wesibindi oyinhloko noma we-metastatic
• I-primary sclerosing cholangitis
• I-Sarcoidosis
• Ukutheleleka okungathi sína okusakazeke egazini (sepsis)
• Isifo sofuba
• I-hepatitis yegciwane

Imithi ethile ingadala ne-cholestasis, kufaka phakathi:

• Ama-antibiotic, njenge-ampicillin namanye ama-penicillin
• Ama-Anabolic steroids
• Amaphilisi okuvimbela inzalo
• I-chlorpromazine
• I-Cimetidine
• I-Estradiol
• Imipramine
• I-Prochlorperazine
• I-Terbinafine
• I-Tolbutamide

Izimpawu zingafaka:

• Izitulo ezinombala wobumba noma ezimhlophe
• Umchamo omnyama
• Ukwehluleka ukugaya ukudla okuthile
• Ukulunywa
• Isicanucanu noma ukuhlanza
• Ubuhlungu engxenyeni engenhla yesisu
• Isikhumba esiphuzi noma amehlo

Ukuhlolwa kwegazi kungakhombisa ukuthi uphakamise i-bilirubin ne-alkaline phosphatase.

Ukuhlolwa kokufanekisa kusetshenziselwa ukuxilonga lesi simo. Izivivinyo zifaka:

• I-CT scan yesisu
• I-MRI yesisu
• I-Endoscopic retrograde cholangiopancreatography (ERCP), nayo ingathola imbangela
• I-Ultrasound yesisu

Imbangela eyinhloko ye-cholestasis kufanele yelashwe.

Ukuthi umuntu wenza kahle kangakanani kuya ngesifo esidala isimo. Amatshe asemgodini ovamile we-bile angasuswa kaningi. Lokhu kungelapha i-cholestasis.

Ama-stents angabekwa ukuvula izindawo zomgudu ovamile we-bile owancishisiwe noma ovinjwe ngumdlavuza.

Uma isimo sidalwa ukusetshenziswa komuthi othize, uvame ukuphela lapho uyeka ukuthatha lowo muthi.

Izinkinga zingafaka:

• Uhudo
• Ukwehluleka komzimba kungenzeka uma i-sepsis iqala
• Ukumuncwa kabi kwamavithamini ancibilikayo anamafutha
• Ukulunywa okukhulu
• Amathambo abuthakathaka (i-osteomalacia) ngenxa yokuba ne-cholestasis isikhathi eside kakhulu

Shayela umhlinzeki wakho wezokunakekelwa kwezempilo uma une:

• Ukulunywa okungapheli
• Isikhumba esiphuzi noma amehlo
• Ezinye izimpawu zecholestasis

Gomela i-hepatitis A no-B uma usengozini. Ungasebenzisi imithambo efakwa emithanjeni futhi wabelane ngezinaliti.

Cholestasis Intrahepatic; I-cholestasis eyengeziwe

• Amatshe amatshe amade
• I-gallbladder
• I-gallbladder

I-Eaton JE, uLindor KD. I-primary biliary cholangitis. Ku: Feldman M, Friedman LS, Brandt LJ, ama-eds. Si-leisenger ne-Fordtran's Gastrointestinal and Liver Disease. Umhla ka-11. IPhiladelphia, PA: Elsevier; 2021: isahluko 91.

UFogel EL, uSherman S. Izifo ze-gallbladder ne-bile ducts. Ku: IGoldman L, iSchafer AI, ama-eds. Imithi yeGoldman-Cecil. Umhla ka-26. IPhiladelphia, PA: Elsevier; 2020: isahluko 146.

ILidofsky SD. I-jaundice. Ku: Feldman M, Friedman LS, Brandt LJ, ama-eds. Sleisenger kanye neFordtran's Gastrointestinal and Liver Disease. Umhla ka-11. IPhiladelphia, PA: Elsevier; 2021: isahluko 21.