Umdlavuza wegilo - medullary carcinoma

IMedullary carcinoma yegilo ngumdlavuza wendlala yegilo eqala kumaseli akhipha i-hormone ebizwa nge-calcitonin. Lawa maseli abizwa ngokuthi "C" amaseli. Indlala yegilo itholakala ngaphakathi ngaphambili kwentamo yakho engezansi.

Imbangela ye-medullary carcinoma yegilo (MTC) ayaziwa. I-MTC ayivamile kakhulu. Kungenzeka ezinganeni nakubantu abadala.

Ngokungafani nezinye izinhlobo zomdlavuza we-thyroid, i-MTC mancane amathuba okuthi ibangelwe yimisebe yokwelapha ngemisebe entanyeni enikezwe ukwelapha eminye imidlavuza ngesikhathi sobuntwana.

Kunezinhlobo ezimbili ze-MTC:

• I-Sporadic MTC, engasebenzi emindenini. Ama-MTC amaningi awavamile. Leli fomu lithinta kakhulu abantu abadala asebekhulile.
• IHereditary MTC, esebenza emindenini.

Unengozi eyengeziwe yalolu hlobo lomdlavuza uma une:

• Umlando womndeni we-MTC
• Umlando womndeni we-endocrine neoplasia eminingi (MEN)
• Umlando wangaphambilini we-pheochromocytoma, mucosal neuromas, hyperparathyroidism noma pancreatic endocrine tumors

Ezinye izinhlobo zomdlavuza wegilo zifaka:

• I-Anaplastic carcinoma yegilo
• Isimila esilandelayo se-thyroid
• I-papillary carcinoma yegilo
• Indlala lymphoma

I-MTC ivame ukuqala njengesigaxa esincane endlebeni yegilo. Kukhona futhi ukuvuvukala kwe-lymph node entanyeni. Ngenxa yalokho, izimpawu zingafaka:

• Ukuvuvukala kwentamo
• Ukungahambi kahle
• Izinkinga zokuphefumula ngenxa yokuncipha kwemigwaqo yomoya
• Khwehlela
• Khwehlela ngegazi
• Uhudo ngenxa yezinga eliphakeme le-calcitonin

Umhlinzeki wakho wokunakekelwa kwezempilo uzokwenza isivivinyo somzimba abuze ngezimpawu zakho nomlando wezokwelapha.

Ukuhlolwa okungasetshenziselwa ukuxilonga i-MTC kufaka:

• Ukuhlolwa kwegazi kweCalcitonin
• Ukuhlolwa kwegazi le-CEA
• Ukuhlolwa kofuzo
• I-biopsy yegilo
• I-Ultrasound yegilo kanye nezindlala zamanzi entanyeni
• Ukuskena kwe-PET

Abantu abane-MTC kufanele bahlolwe ezinye izicubu ezithile, ikakhulukazi i-pheochromocytoma ne-parathyroid tumors kanye ne-parathyroid tumors.

Ukwelashwa kuhilela ukuhlinzwa ukuze kususwe indlala yegilo kanye nama-lymph node azungezile. Ngoba lokhu kuyisigaxa esingajwayelekile, ukuhlinzwa kufanele kwenziwe ngudokotela ohlinzayo owazi kahle lolu hlobo lomdlavuza futhi onolwazi ngokuhlinzwa okudingekayo.

Ukwelashwa okuqhubekayo kuzoya ngamazinga akho e-calcitonin. Ukukhuphuka kwamazinga e-calcitonin futhi kungakhombisa ukukhula okusha komdlavuza.

• I-Chemotherapy ne-radiation akusebenzi kahle kakhulu kulolu hlobo lomdlavuza.
• Imisebe isetshenziswa kwabanye abantu ngemuva kokuhlinzwa.
• Izindlela zokwelashwa ezihlosiwe ezintsha zinganciphisa ukukhula kwesimila futhi. Umhlinzeki wakho angakutshela okuningi mayelana nalokhu, uma kudingeka.

Izihlobo eziseduze zabantu abatholakala benamafomu we-MTC asengozini enkulu yalo mdlavuza futhi kufanele baxoxe nabahlinzeki babo.

Unganciphisa ukucindezela kokugula ngokujoyina iqembu lokusekela umdlavuza. Ukwabelana nabanye abanokuhlangenwe nakho okuvamile nezinkinga kungakusiza ungazizwa uwedwa.

Abantu abaningi abane-MTC baphila okungenani iminyaka emihlanu ngemuva kokuxilongwa, kuya ngesigaba somdlavuza. Izinga lokusinda leminyaka eli-10 lingu-65%.

Izinkinga zingafaka:

• Umdlavuza usakazekela nakwezinye izindawo zomzimba
• Izindlala zeParathyroid zisuswa ngengozi ngesikhathi sokuhlinzwa

Shayela umhlinzeki wakho uma unezimpawu ze-MTC.

Ukuvimbela kungenzeka kungenzeki. Kepha, ukwazi izinto zakho ezinobungozi, ikakhulukazi umlando wakho womndeni, kungavumela ukuxilongwa nokwelashwa kusenesikhathi. Kubantu abanomlando oqinile womndeni we-MTC, inketho yokususa indlala yegilo inganconywa. Kufanele uxoxe ngokucophelela ngale nketho nodokotela ojwayelene kakhulu nalesi sifo.

Indlala yegilo - medullary carcinoma; Umdlavuza - i-thyroid (i-medullary carcinoma); I-MTC; Indlala yegilo - medullary

• Umdlavuza wegilo - CT scan
• Indlala yegilo

UJonklass J, Cooper DS. Indlala yegilo. Ku: IGoldman L, iSchafer AI, ama-eds. Imithi yeGoldman-Cecil. Umhla ka-26. IPhiladelphia, PA: Elsevier; 2020: isahluko 213.

Iwebhusayithi yeNational Cancer Institute. Ukwelashwa komdlavuza we-thyroid (umuntu omdala) (PDQ) - inguqulo yezempilo. www.cancer.gov/types/thyroid/hp/thyroid-treatment-pdq. Kubuyekezwe ngoJanuwari 30, 2020. Kufinyelelwe ngoMashi 6, 2020.

USmith PW, uHanks LR, uSalomone LJ, uHanks JB. Indlala yegilo. Ku: Townsend CM Jr, Beauchamp RD, Evers BM, Mattox KL, eds. ISabiston Incwadi Yokuhlinzwa. Umhla ka-20. IPhiladelphia, PA: Elsevier Saunders; 2017: isahluko 36.

UViola D, u-Elisei R. Ukuphathwa komdlavuza we-thyroid we-medullary. I-Endocrinol Metab Clin eNyakatho Am. 2019; 48 (1): 285-301. I-PMID: 30717909 pubmed.ncbi.nlm.nih.gov/30717909/.

I-Wells SA Jr, i-Asa SL, i-Dralle H. Revised American Thyroid Association imihlahlandlela yokuphathwa kwe-medullary thyroid carcinoma. Indlala yegilo. 2015; 25 (6): 567-610. I-PMID: 25810047 pubmed.ncbi.nlm.nih.gov/25810047/.