I-nephritis yangaphakathi

I-interstitial nephritis ukuphazamiseka kwezinso lapho izikhala eziphakathi kwamathambo ezinso zivuvukala (zivuvuke). Lokhu kungadala izinkinga ngendlela izinso zakho ezisebenza ngayo.

I-nephritis yangaphakathi ingaba yesikhashana (acute), noma ingahlala isikhathi eside (engapheli) futhi ibe yimbi ngokuhamba kwesikhathi.

Ifomu elibi le-nephritis eliphakathi nendawo livame ukubangelwa imiphumela emibi yezidakamizwa ezithile.

Okulandelayo kungadala i-nephritis yangaphakathi:

• Ukungezwani komzimba nomuthi (i-acute interstitial allergic nephritis).
• Ukuphazamiseka okuzenzakalelayo, njenge-antitubular basement membrane disease, isifo seKawasaki, iSjögren syndrome, i-systemic lupus erythematosus, noma i-granulomatosis ene-polyangiitis
• Izifo.
• Ukusetshenziswa kwesikhathi eside kwemithi efana ne-acetaminophen (Tylenol), i-aspirin, kanye nezidakamizwa ezingezona ukuvuvukala (ama-NSAID). Lokhu kubizwa nge-analgesic nephropathy.
• Imiphumela emibi yama-antibiotic athile njenge-penicillin, i-ampicillin, i-methicillin, nemithi ye-sulfonamide.
• Imiphumela emibi yeminye imithi efana ne-furosemide, i-thiazide diuretics, i-omeprazole, i-triamterene, ne-allopurinol.
• I-potassium encane kakhulu egazini lakho.
• I-calcium eningi noma i-uric acid egazini lakho.

I-nephritis yangaphakathi ingadala izinkinga zezinso eziphansi kakhulu, kufaka phakathi ukwehluleka okukhulu kwezinso. Cishe uhhafu wamacala, abantu bazobe banciphisile ukukhishwa komchamo kanye nezinye izimpawu zokwehluleka okukhulu kwezinso.

Izimpawu zalesi simo zingafaka:

• Igazi emchameni
• Imfiva
• Ukunyuka noma ukwehla kokukhishwa komchamo
• Izinguquko zesimo sengqondo (ukozela, ukudideka, ikhoma)
• Isicanucanu, ukuhlanza
• I-Rash
• Ukuvuvukala kwanoma iyiphi indawo yomzimba
• Ukuzuza kwesisindo (ngokugcina uketshezi)

Umhlinzeki wezokunakekelwa kwempilo uzokwenza ukuhlolwa komzimba. Lokhu kungaveza:

• Amaphaphu angajwayelekile noma inhliziyo izwakala
• Umfutho wegazi ophezulu
• Uketshezi emaphashini (i-edema yamaphaphu)

Ukuhlolwa okuvamile kufaka:

• Imithambo yegazi yegazi
• Amakhemikhali egazi
• BUN namazinga we-creatinine wegazi
• Qedela ukubalwa kwegazi
• Ukucubungula izinso
• Izinso ultrasound
• Ukuhlolwa komchamo

Ukwelashwa kuya ngesizathu senkinga. Ukugwema imithi eholela kulesi simo kungasusa izimpawu ngokushesha.

Ukunciphisa usawoti kanye noketshezi ekudleni kungathuthukisa ukuvuvukala nomfutho wegazi ophezulu. Ukukhawulela amaprotheni ekudleni kungasiza ekulawuleni inqwaba yemikhiqizo emfucumfucu esegazini (i-azotemia), engaholela ezimpawu zokuhluleka okukhulu kwezinso.

Uma i-dialysis iyadingeka, imvamisa iyadingeka isikhathi esifushane kuphela.

I-Corticosteroids noma imishanguzo elwa nokuvuvukala enamandla njenge-cyclophosphamide kwesinye isikhathi ingasiza.

Ngokuvamile, i-nephritis yangaphakathi iyisifo sesikhashana. Ezimweni ezingavamile, kungadala ukulimala okungapheli, kufaka phakathi ukwehluleka kwezinso zesikhathi eside (okungapheli).

I-nephritis enamandla kakhulu ingahle ibe nzima kakhulu futhi ibe namathuba amaningi okuholela ekulimaleni kwezinso isikhathi eside noma unomphela kubantu asebekhulile.

I-Metabolic acidosis ingenzeka ngoba izinso azikwazi ukususa i-asidi eyanele. Lesi sifo singaholela ekuhlulekeni kwezinso ezinzima noma ezingamahlalakhona noma isifo sezinso sokugcina.

Shayela umhlinzeki wakho uma unezimpawu ze-interstitial nephritis.

Uma une-nephritis yangaphakathi, shayela umhlinzeki wakho uma uthola izimpawu ezintsha, ikakhulukazi uma ungaqaphile kangako noma unokwehla kokukhishwa komchamo.

Ngokuvamile, lesi sifo asikwazi ukuvinjelwa. Ukugwema noma ukunciphisa ukusebenzisa kwakho imithi engadala lesi simo kungasiza ekunciphiseni ubungozi bakho. Uma kudingeka, umhlinzeki wakho uzokutshela ukuthi imiphi imishanguzo okufanele ayeke noma ayinciphise.

Nephritis Tubulointerstitial; I-Nephritis - ukuhlangana; I-nephritis enamandla kakhulu (i-allergen)

• Ukwakheka kwezinso

UNeilson EG. I-Tubulointerstitial nephritis. Ku: IGoldman L, iSchafer AI, ama-eds. Imithi yeGoldman-Cecil. Umhla ka-25. IPhiladelphia, PA: Elsevier Saunders; 2016: isahluko 122.

UPerazella MA, uRosner MH. Izifo ze-tubulointerstitial. Ku: Yu ASL, Chertow GM, Luyckx VA, Marsden PA, Skorecki K, Taal MW, ama-eds. IBrenner neRector's The Kidney. Umhlaka 10. IPhiladelphia, PA: Elsevier; 2020: isahluko 35.

UTanaka T, Nangaku M. Nephritis engapheli yesikhashana. Ku: Feehally J, Floege J, Tonelli M, Johnson RJ, abahleli. I-Nephrology Yomtholampilo Ephelele. Umhlaka 6. IPhiladelphia, PA: Elsevier; 2019: isahluko 62.