I-Cryoglobulinemia

I-Cryoglobulinemia ubukhona bamaprotheni angajwayelekile egazini. Lawa maprotheni ayajiya emazingeni okushisa abandayo.

Ama-Cryoglobulins angama-antibodies. Akukaziwa okwamanje ukuthi kungani ziqina noma zifana nejeli emazingeni okushisa aphansi elabhoratri. Emzimbeni, la ma-antibodies angakha izakhiwo zomzimba ezingadala ukuvuvukala futhi zivimbele imithambo yegazi. Lokhu kubizwa ngokuthi yi-cryoglobulinemic vasculitis. Lokhu kungaholela ezinkingeni ezisukela ekuqubukeni kwesikhumba kuye ekuhlulekeni kwezinso.

ICryoglobulinemia iyingxenye yeqembu lezifo ezidala ukulimala nokuvuvukala kwemithambo yegazi emzimbeni wonke (i-vasculitis). Kunezinhlobo ezintathu eziyinhloko zalesi simo. Ahlukaniswe ngokususelwa ohlotsheni lwe-antibody olukhiqizwayo:

• Thayipha I
• Uhlobo II
• Uhlobo III

Izinhlobo II no-III nazo zibizwa nge-cryoglobulinemia exubile.

Uhlobo I cryoglobulinemia luvame ukuhlobene nomdlavuza wegazi noma amasosha omzimba.

Izinhlobo II no-III zivame ukutholakala kubantu abanesifo esihlala isikhathi eside (esingapheli) sokuvuvukala, njengesifo sokuzilimaza noma i-hepatitis C. Abantu abaningi abanohlobo lwe-II lwe-cryoglobulinemia banokutheleleka okungapheli kwesifo sohlobo C.

Ezinye izimo ezingahlobene ne-cryoglobulinemia zifaka:

• Umdlavuza wegazi
• I-myeloma eminingi
• I-macroglobulinemia eyinhloko
• Isifo samathambo
• Uhlelo lupus erythematosus

Izimpawu zizohluka, kuya ngohlobo lokuphazamiseka onakho kanye nezitho ezithintekayo. Izimpawu zingafaka:

• Izinkinga zokuphefumula
• Ukukhathala
• I-Glomerulonephritis
• Ubuhlungu obuhlangene
• Ubuhlungu bemisipha
• I-Purpura
• Umkhuba kaRaynaud
• Ukufa kwesikhumba
• Izilonda zesikhumba

Umhlinzeki wezokunakekelwa kwempilo uzokwenza ukuhlolwa komzimba. Uzohlolelwa izimpawu zesibindi nokuvuvukala kobende.

Ukuhlolwa kwe-cryoglobulinemia kufaka:

• Qedela ukubalwa kwegazi (CBC).
• Gcwalisa i-assay - izinombolo zizobe ziphansi.
• Ukuhlolwa kwe-Cryoglobulin - kungakhombisa ukuba khona kwama-cryoglobulin. (Le inqubo eyinkimbinkimbi yelabhorethri ebandakanya izinyathelo eziningi. Kubalulekile ukuthi ilebhu elenza isivivinyo ijwayele inqubo.)
• Ukuhlolwa kokusebenza kwesibindi - kungaba phezulu uma kukhona i-hepatitis C.
• Isici se-rheumatoid - esihle ngezinhlobo II no-III.
• Skin biopsy - ingakhombisa ukuvuvukala emithanjeni yegazi, i-vasculitis.
• Amaprotheni electrophoresis - igazi - angakhombisa iphrotheni elingajwayelekile le-antibody.
• I-Urinalysis - ingakhombisa igazi emchameni uma izinso zithintekile.

Ezinye izivivinyo zingafaka:

• I-Angiogram
• I-x-ray yesifuba
• ESR
• Ukuhlolwa kwe-Hepatitis C
• Ukuhlolwa kokuqhutshwa kwemizwa, uma umuntu enobuthakathaka ezingalweni noma emilenzeni

I-CRYOGLOBULINEMIA EHLANGANISIWE (IZINHLOBO II NO-III)

Izinhlobo ezincane noma ezilinganiselayo ze-cryoglobulinemia zingaphathwa ngokuthatha izinyathelo zokubhekana nembangela eyimbangela.

Imithi yamanje esebenza ngqo ye-hepatitis C iqeda igciwane cishe kubo bonke abantu. Njengoba i-hepatitis C ihamba, ama-cryoglobulin azonyamalala cishe engxenyeni yabo bonke abantu ezinyangeni eziyi-12 ezizayo. Umhlinzeki wakho uzoqhubeka nokuqapha ama-cryoglobulins ngemuva kokwelashwa.

I-cryoglobulinemia vasculitis enamandla ifaka izitho ezibalulekile noma izindawo ezinkulu zesikhumba. Iphathwa ngama-corticosteroids kanye neminye imithi ecindezela amasosha omzimba.

• I-Rituximab iyisidakamizwa esisebenzayo futhi inezingozi ezimbalwa kuneminye imithi.
• I-Cyclophosphamide isetshenziswa ezimeni ezisongela impilo lapho i-rituximab ingasebenzi noma ingatholakali. Lo muthi wawusetshenziswa kaningi esikhathini esedlule.
• Umuthi obizwa nge- plasmapheresis nawo uyasetshenziswa. Kule nqubo, i-plasma yegazi ikhishwa ekujikelezeni kwegazi futhi kususwe amaprotheni we-cryoglobulin antibody angajwayelekile. I-plasma ithathelwa indawo uketshezi, amaprotheni noma i-plasma enikelwe.

TYPE I CRYOGLOBULINEMIA

Lesi sifo senziwa umdlavuza wegazi noma amasosha omzimba afana ne-myeloma eminingi. Ukwelashwa kubhekiswe kumaseli omdlavuza angajwayelekile akhiqiza i-cryoglobulin.

Isikhathi esiningi, i-cryoglobulinemia exubile ayiholeli ekufeni. I-Outlook ingaba mpofu uma izinso zithintekile.

Izinkinga zifaka:

• Ukopha endaweni yokugaya ukudla (akuvamile)
• Isifo senhliziyo (kuyaqabukela)
• Ukutheleleka kwezilonda
• Ukuhluleka kwezinso
• Ukuhluleka kwesibindi
• Ukufa kwesikhumba
• Ukufa

Shayela umhlinzeki wakho uma:

• Uba nezimpawu ze-cryoglobulinemia.
• Unesifo sokusha kwesibindi kohlobo C futhi uthuthukisa izimpawu ze-cryoglobulinemia.
• Une-cryoglobulinemia futhi uthuthukisa izimpawu ezintsha noma eziya ziba zimbi.

Akukho ukuvimbela okwaziwayo kwalesi simo.

• Ukuhlala kude namazinga okushisa abandayo kungavimbela ezinye izimpawu.
• Ukuhlolwa nokwelashwa kokutheleleka kwe-hepatitis C kuzonciphisa ubungozi bakho.

• I-Cryoglobulinemia yeminwe
• I-Cryoglobulinemia - iminwe
• Amaseli egazi

IPatterson ER, iWinters JL. IHemapheresis. Ku: McPherson RA, Pincus MR, abahleli. UHenry’s Clinical Diagnosis and Management by Laboratory Methods. Umhla ka-23. ISt Louis, MO: Elsevier; 2017: isahluko 37.

URoccatello D, uSaadoun D, ​​uRamos-Casals M, et al. I-Cryoglobulinaemia. Nat Rev Dis Primers. 2018; 4 (1): 11. I-PMID: 30072738 pubmed.ncbi.nlm.nih.gov/30072738/.

Itshe uJH. I-vasculitis yemikhumbi emincane eyinkimbinkimbi yomzimba. Ku: Firestein GS, Budd RC, Gabriel SE, McInnes IB, O'Dell JR, abahleli. Incwadi kaKelley noFirestein yeRheumatology. Umhlaka 10. IPhiladelphia, PA: Elsevier; 2017: isahluko 91.