Ukuntuleka kwe-antithrombin III yokuzalwa

Ukushoda kwe-antithrombin III yokuzalwa kuyisifo sofuzo esidala ukuthi igazi livale ngaphezu kokujwayelekile.

I-Antithrombin III yiprotheni esegazini evimba amahlule egazi angajwayelekile ekwakhekeni. Kuyasiza umzimba ukugcina ibhalansi enempilo phakathi kokopha nokuqina. Ukuntuleka kwe-antithrombin III yokuzalwa yisifo esizuzwe njengefa. Kwenzeka lapho umuntu ethola ikhophi elilodwa elingajwayelekile lohlobo lwe-antithrombin III kumzali onesifo.

Uhlobo olungajwayelekile luholela ezingeni eliphansi le-antithrombin III protein. Leli zinga eliphansi le-antithrombin III lingadala amahlule egazi angajwayelekile (i-thrombi) angavimba ukuhamba kwegazi futhi alimaze izitho zomzimba.

Abantu abanalesi simo bavame ukuba nehlule legazi besebancane. Kungenzeka futhi ukuthi babe namalungu omndeni abenenkinga yokuvala igazi.

Abantu bavame ukuba nezimpawu zegazi. Amahlule egazi ezandleni noma emilenzeni ngokuvamile abangela ukuvuvukala, ubomvu, nobuhlungu. Lapho iqabunga legazi liphuka lapho lakhiwa khona futhi lihambela kwenye ingxenye yomzimba, libizwa ngokuthi i-thromboembolism. Izimpawu zincike lapho ihlule legazi lihambela khona. Indawo ejwayelekile yiphaphu, lapho ihlwili lingadala ukukhwehlela, ukuphefumula kancane, ubuhlungu ngenkathi uphefumula kakhulu, ubuhlungu besifuba, ngisho nokufa. Amahlule egazi aya ebuchosheni angadala isifo sohlangothi.

Ukuhlolwa ngokomzimba kungakhombisa:

• Umlenze ovuvukile noma ingalo
• Ukwehla komoya kuzwakala emaphashini
• Ukushaya kwenhliziyo okusheshayo

Umhlinzeki wezokunakekelwa kwempilo futhi angayalela ukuhlolwa kwegazi ukubheka ukuthi unezinga eliphansi le-antithrombin III.

Ihlule legazi liphathwa ngemithi yokuncipha kwegazi (ebizwa nangokuthi ama-anticoagulants). Udinga ukuthi uphuze isikhathi esingakanani le mithi kuya ngokuthi i-clot yegazi yayimbi kangakanani nezinye izinto. Xoxa ngalokhu nomhlinzeki wakho.

Lezi zinsizakusebenza zinganikeza imininingwane eminingi ngokushoda kwe-antithrombin III yokuzalwa:

• Inhlangano Kazwelonke Yezinkinga Ezingajwayelekile - rarediseases.org/rare-diseases/antithrombin-deficiency
• Isethenjwa sasekhaya seNLM Genetics - ghr.nlm.nih.gov/condition/hereditary-antithrombin-deficiency

Iningi labantu linomphumela omuhle uma lihlala emithini elwa namagciwane.

Amahlule egazi angadala ukufa. Amahlule egazi emaphashini ayingozi kakhulu.

Bona umhlinzeki wakho uma unezimpawu zalesi simo.

Lapho umuntu kutholakala ukuthi unenkinga ye-antithrombin III, wonke amalungu omndeni asondele kufanele ahlolwe lesi sifo. Izidakamizwa zokuncipha kwegazi zingavimbela amahlule egazi ekwakheni nasekuvimbeleni izinkinga ekunqandeni.

Ukushoda - i-antithrombin III - izalwe; Ukuntuleka kwe-Antithrombin III - okuzalwa naso

• Igazi le-venous

U-Anderson JA, Hogg KE, Weitz JI. Izimo ezingenakunyakaziswa. Ku: Hoffman R, Benz EJ, Silberstein LE, et al, ama-eds. I-Hematology: Izimiso Eziyisisekelo Nokuzijwayeza. Umhla wesi-7. IPhiladelphia, PA: Elsevier Saunders; 2018: isahluko 140.

I-Schafer AI. Izinkinga ze-thrombotic: izifunda ezingenakunyakaziswa. Ku: IGoldman L, iSchafer AI, ama-eds. Imithi yeGoldman-Cecil. Umhla ka-25. IPhiladelphia, PA: Elsevier Saunders; 2016: isahluko 176.