Ukukhubazeka kokusebenza kweplatelet okuzalwa

Ukukhubazeka kokusebenza kweplatelet okuzalwa kuyizimo ezivimbela ama-clotting element egazini, okuthiwa ama-platelets, ukuthi asebenze ngendlela efanele ngayo. Ama-platelet asiza i-clot yegazi. I-Congenital isho ukubakhona kusukela ekuzalweni.

Ukukhubazeka kokusebenza kweplatelet okuzalwa nakho ukuphazamiseka kokopha okubangela ukunciphisa ukusebenza kweplatelet.

Isikhathi esiningi, abantu abanalezi zinkinga banomlando womndeni wesifo sokopha, njenge:

• I-Bernard-Soulier syndrome yenzeka lapho ama-platelet engenayo into enamathela ezindongeni zemithambo yegazi. Ama-platelet ngokuvamile makhulu futhi enenombolo encishisiwe. Lesi sifo singadala ukopha kakhulu.
• IGlanzmann thrombasthenia yisimo esidalwa ukuntuleka kweprotheni edingekayo ukuze amaplatelet ahlangane. Ama-platelet ngokuvamile angosayizi ovamile nenombolo. Lesi sifo singadala nokopha kakhulu.
• Isifo seplatelet storage pool (esibizwa nangokuthi i-platelet secretion disorder) senzeka lapho izinto ezibizwa ngama-granules ngaphakathi kwama-platelet zingagcinwa noma zikhishwe kahle. Ama-granules asiza amaplatelet ukuthi asebenze kahle. Lesi sifo sidala ukulimazeka noma ukopha kalula.

Izimpawu zingafaka noma yikuphi okulandelayo:

• Ukopha ngokweqile ngesikhathi nangemva kokuhlinzwa
• Izinsini zokopha
• Ukulinyazwa okulula
• Izinkathi ezinzima zokuya esikhathini
• Ukopha ngamakhala
• Ukopha isikhathi eside ngokulimala okuncane

Ukuhlolwa okulandelayo kungasetshenziselwa ukuxilonga lesi simo:

• Qedela ukubalwa kwegazi (CBC)
• Isikhathi esithile se-thromboplastin (PTT)
• Ukuhlolwa kokuhlanganiswa kweplatelet
• Isikhathi se-Prothrombin (PT)
• Ukuhlaziywa komsebenzi wePlatelet
• Ukugeleza kwe-cytometry

Ungadinga ezinye izivivinyo. Izihlobo zakho zingadinga ukuhlolwa.

Akukho ukwelashwa okuqondile kwalezi zinkinga. Kodwa-ke, umhlinzeki wakho wezokunakekelwa kwempilo cishe uzoqapha isimo sakho.

Ungadinga futhi:

• Ukugwema ukuthatha i-aspirin nezinye izidakamizwa ezingezona ukuvuvukala (ama-NSAID), njenge-ibuprofen ne-naproxen, ngoba zingazonakalisa izimpawu zokopha.
• Ukumpontshelwa igazi, njengesikhathi sokuhlinzwa noma izinqubo zamazinyo.

Alikho ikhambi lokukhubazeka kokuzalwa kweplatelet function. Isikhathi esiningi, ukwelashwa kungalawula ukopha.

Izinkinga zingafaka:

• Ukopha kakhulu
• Ukushoda kwe-iron anemia kwabesifazane abase esikhathini

Shayela umhlinzeki wakho uma:

• Unegazi noma ulimele futhi awazi imbangela.
• Ukopha akuphenduli endleleni ejwayelekile yokulawula.

Ukuhlolwa kwegazi kungathola isakhi sofuzo esibhekene nokukhubazeka kweplatelet. Ungafisa ukuthola ukwelulekwa ngezakhi zofuzo uma unomlando womndeni wale nkinga futhi ucabanga ukuba nezingane.

Ukuphazamiseka kwephuli lokugcina iplatelet; I-thrombasthenia kaGlanzmann; Isifo sikaBernard-Soulier; Ukukhubazeka kokusebenza kweplatelet - ukuzalwa

• Ukwakheka kwegazi
• Amahlule egazi

U-Arnold DM, iLungu lePhalamende likaZeller, uSmith JW, uNazy I. Izifo zenombolo yeplatelet: immune thrombocytopenia, neonatal alloimmune thrombocytopenia, ne-posttransfusion purpura. Ku: Hoffman R, Benz EJ, Silberstein LE, et al, ama-eds. I-Hematology: Izimiso Eziyisisekelo Nokuzijwayeza. Umhla wesi-7. IPhiladelphia, PA: Elsevier; 2018: isahluko 131.

IHholo JE. I-hemostasis negazi coagulation. Ku: IHholo JE, kuhleliwe. Incwadi kaGuyton neHholo yePhysical Physiology. Umhlaka 13. IPhiladelphia, PA: Elsevier; 2016: isahluko 37.

I-Nichols WL. Isifo se-Von Willebrand nokungajwayelekile kokopha kweplatelet nokusebenza kwemithambo yegazi. Ku: IGoldman L, iSchafer AI, ama-eds. Imithi yeGoldman-Cecil. Umhla ka-25. IPhiladelphia, PA: Elsevier Saunders; 2016: isahluko 173.