I-amyloidosis yesibili yesistimu

I-Secondary systemic amyloidosis yisifo lapho amaprotheni angajwayelekile akhela khona ezicutshini nasezithweni. Ukuqubuka kwamaprotheni angajwayelekile kubizwa ngokuthi ama-amyloid deposits.

Okwesibili kusho ukuthi kwenzeka ngenxa yesinye isifo noma isimo. Isibonelo, lesi simo sivame ukwenzeka ngenxa yokutheleleka kwesikhathi eside (okungapheli) noma ukuvuvukala. Ngokuphambene nalokho, i-amyloidosis eyinhloko isho ukuthi asikho esinye isifo esidala isimo.

I-systemic isho ukuthi lesi sifo sithinta umzimba wonke.

Imbangela ngqo ye-systemic amyloidosis ayaziwa. Kungenzeka ukuthi uthuthukise i-amyloidosis yesibili uma unesifo sesikhathi eside noma ukuvuvukala.

Lesi simo kungenzeka nge:

• I-Ankylosing spondylitis - uhlobo lwe-arthritis oluthinta kakhulu amathambo namalunga emgogodleni
• I-Bronchiectasis - isifo lapho imigwaqo yomoya emikhulu emaphashini ilinyazwa ukutheleleka okungamahlalakhona
• I-osteomyelitis engapheli - ukutheleleka kwethambo
• ICystic fibrosis - isifo esibangela amafinyila aminyene, anamathelayo ukwakha emaphashini, umgudu wokugaya ukudla, nakwezinye izindawo zomzimba, okuholela ekuthelelekeni okungapheli kwamaphaphu
• Umkhuhlane ojwayelekile waseMedithera - isifo esizuzwe njengefa semfiva ephindaphindiwe nokuvuvukala okuvame ukuthinta ulwelwesi lwesisu, isifuba noma amalunga
• I-hairy cell leukemia - uhlobo lomdlavuza wegazi
• Isifo se-Hodgkin - umdlavuza wezicubu ze-lymph
• I-juvenile idiopathic arthritis - isifo samathambo esithinta izingane
• I-myeloma eminingi - uhlobo lomdlavuza wegazi
• I-Reiter syndrome - iqembu lezimo ezibangela ukuvuvukala nokuvuvukala kwamalunga, amehlo, nezinhlelo zomchamo nezangasese)
• Isifo samathambo
• Isystemic lupus erythematosus - isifo sokuzilimaza
• Isifo sofuba

Izimpawu zesystemic amyloidosis yesibili zincike ekutheni yiziphi izicubu zomzimba ezithintekayo kuma-protein deposits. Lezi zimali zilimaza izicubu ezivamile. Lokhu kungaholela ezimpawu noma izimpawu zalesi sifo, kufaka phakathi:

• Ukopha esikhunjeni
• Ukukhathala
• Ukushaya kwenhliziyo okungajwayelekile
• Ubuntofontofo bezandla nezinyawo
• I-Rash
• Ukuphelelwa umoya
• Ukugwinya ubunzima
• Izandla noma imilenze evuvukile
• Kuvuvukele ulimi
• Ukubamba isandla okuntekenteke
• Ukwehla kwesisindo

Umhlinzeki wezokunakekelwa kwempilo uzokwenza ukuhlolwa komzimba abuze ngezimpawu zakho.

Ukuhlolwa okungenziwa kufaka phakathi:

• I-ultrasound yesisu (ingakhombisa isibindi esivuvukile noma ubende)
• I-biopsy noma ukufisa kwamafutha ngaphansi kwesikhumba (amafutha angaphansi)
• I-biopsy ye-rectum
• I-biopsy yesikhumba
• I-biopsy yomnkantsha wethambo
• Ukuhlolwa kwegazi, kufaka phakathi i-creatinine ne-BUN
• I-Echocardiogram
• I-Electrocardiogram (ECG)
• Isivinini sokuqhuba imizwa
• Ukuhlolwa komchamo

Isimo esibangela i-amyloidosis kufanele silashwe. Kwezinye izimo, i-colchicine yezidakamizwa noma umuthi we-biologic (umuthi owelapha amasosha omzimba) uyabekwa.

Ukuthi umuntu wenza kahle kangakanani kuya ngokuthi yiziphi izitho ezithintekayo. Futhi kuya ngokuthi, ngabe isifo esisibangelayo singalawulwa yini. Uma lesi sifo sihilela inhliziyo nezinso, singaholela ekuhlulekeni kwesitho nasekufeni.

Izinkinga zempilo ezingabangelwa i-amyloidosis yesibili yesistimu zifaka:

• Ukwehluleka kwe-Endocrine
• Ukwehluleka kwenhliziyo
• Ukuhluleka kwezinso
• Ukwehluleka kokuphefumula

Shayela umhlinzeki wakho uma unezimpawu zalesi simo. Okulandelayo yizimpawu ezinkulu ezidinga usizo lwezokwelapha ngokushesha:

• Ukopha
• Ukushaya kwenhliziyo okungajwayelekile
• Ubudikadika
• Ukuphelelwa umoya
• Ukuvuvukala
• Ukubamba okuntekenteke

Uma unesifo esaziwa ukuthi sandisa ubungozi bakho kulesi simo, qiniseka ukuthi uselashwa. Lokhu kungasiza ukuvimbela i-amyloidosis.

I-Amyloidosis - uhlelo lwesibili; I-AA amyloidosis

• I-Amyloidosis yeminwe
• Amyloidosis ebusweni
• Amasosha omzimba

UGertz MA. I-Amyloidosis. Ku: IGoldman L, iSchafer AI, ama-eds. Imithi yeGoldman-Cecil. Umhla ka-25. IPhiladelphia, PA: Elsevier Saunders; 2016: isahluko 188.

UPapa R, uLachmann HJ. Okwesibili, i-AA, i-Amyloidosis. IRheum Dis Clin eNyakatho Am. 2018; 44 (4): 585-603. I-PMID: 30274625 www.ncbi.nlm.nih.gov/pubmed/30274625.