I-leukoencephalopathy eqhubekayo ehlukahlukene

I-leukoencephalopathy eqhubekayo ye-multifocal (PML) isifo esingajwayelekile esilimaza okokusebenza (i-myelin) okumboza futhi kuvikele izinzwa odabeni olumhlophe lobuchopho.

Igciwane likaJohn Cunningham, noma i-JC virus (JCV) lidala i-PML. Igciwane le-JC laziwa nangokuthi yi-human polyomavirus 2. Ngeminyaka eyi-10, iningi labantu selithelelekile ngaleli gciwane yize lingakaze libangele izimpawu. Kodwa abantu abanamasosha omzimba abuthakathaka basengozini yokuthola i-PML. Izimbangela zesistimu yomzimba ebuthakathaka zifaka:

• I-HIV / AIDS (imbangela engejwayelekile kakhulu ye-PML manje ngenxa yokuphathwa kangcono kwe-HIV / AIDS).
• Imithi ethile ecindezela amasosha omzimba abizwa ngama-antibody monoclonal. Imithi enjalo ingasetshenziselwa ukuvimbela ukwenqatshwa kokufakelwa komzimba noma ukwelashwa i-multiple sclerosis, i-rheumatoid arthritis nezinye izifo ezizimele, kanye nezimo ezihlobene.
• Umdlavuza, njenge-leukemia ne-Hodgkin lymphoma.

Izimpawu zingafaka noma yikuphi okulandelayo:

• Ukulahleka kokudidiyelwa, ubuhlanya
• Ukulahleka kwekhono lolimi (aphasia)
• Ukulahleka kwememori
• Izinkinga zombono
• Ubuthakathaka bemilenze nezingalo okuya ngokuya kuba kubi
• Ubuntu buyashintsha

Umhlinzeki wezokunakekelwa kwempilo uzokwenza ukuhlolwa komzimba abuze ngezimpawu.

Ukuhlolwa kungafaka:

• I-Brain biopsy (ezimweni ezingavamile)
• Ukuhlolwa kwe-Cerebrospinal fluid kwe-JCV
• I-CT scan yobuchopho
• I-Electroencephalogram (EEG)
• I-MRI yobuchopho

Kubantu abane-HIV / AIDS, ukwelashwa okuqinisa amasosha omzimba kungaholela ekululameni ezimpawu ze-PML. Azikho ezinye izindlela zokwelapha ezibonakale zisebenza kahle ku-PML.

I-PML yisimo esisongela impilo. Ngokuya ngokuthi isifo sinzima kangakanani, abantu abangafinyelela kwengxenye yabantu abatholakala ukuthi bane-PML bafa ezinyangeni ezimbalwa zokuqala. Khuluma nomhlinzeki wakho ngezinqumo zokunakekelwa.

PML; Igciwane likaJohn Cunningham; I-JCV; I-polyomavirus yomuntu 2; Igciwane le-JC

• Indaba empunga nomhlophe yobuchopho
• Leukoencephalopathy

UBerger JR, uNath A. Cytomegalovirus, igciwane le-Epstein-Barr, kanye nokutheleleka ngamagciwane okuhamba kancane kohlelo lwemizwa oluphakathi. Ku: IGoldman L, iSchafer AI, ama-eds. Imithi yeGoldman-Cecil. Umhla ka-26. IPhiladelphia, PA: Elsevier; 2020: isahluko 346.

ITan CS, Koralnik IJ. I-JC, i-BK, namanye ama-polyomaviruses: i-leukoencephalopathy eqhubekayo ye-multifocal (PML). Ku: Bennett JE, Dolin R, Blaser MJ, ama-eds. Mandell, Douglas, kanye neBennett's Principles and Practice of Infectious Diseases. Umhlaka 9. IPhiladelphia, PA: Elsevier; 2020: isahluko 144.