I-cerebral amyloid angiopathy

I-Cerebral amyloid angiopathy (CAA) yisimo lapho amaprotheni abizwa ngama-amyloid akha khona ezindongeni zemithambo yegazi ebuchosheni. I-CAA inyusa ingozi yokushaywa unhlangothi okubangelwa ukopha nokuwohloka komqondo.

Abantu abane-CAA banamadiphozithi e-amyloid ezindongeni zemithambo yegazi ebuchosheni. Amaprotheni ngokuvamile awafakwa kwenye indawo emzimbeni.

Isici esikhulu sengozi ukukhula kweminyaka. I-CAA ivame ukubonakala kubantu abadala kuneminyaka engama-55. Kwesinye isikhathi, idluliselwa ngemindeni.

I-CAA ingadala ukopha ebuchosheni. Ukopha kuvame ukwenzeka ezingxenyeni ezingaphandle zobuchopho, ezibizwa ngokuthi i-cortex, hhayi ezindaweni ezijulile. Izimpawu zenzeka ngoba ukopha ebuchosheni kulimaza izicubu zobuchopho. Abanye abantu banezinkinga zememori kancane kancane. Lapho kwenziwa i-CT scan, kunezimpawu zokuthi bake bopha ebuchosheni okungenzeka abakuqaphelanga.

Uma kuphuma ukopha okuningi, izimpawu ezisheshayo ziyenzeka futhi zifana nohlangothi. Lezi zimpawu zifaka:

• Ukozela
• Ukuphathwa yikhanda (imvamisa engxenyeni ethile yekhanda)
• Izinguquko zesistimu yezinzwa ezingase ziqale ngokuzumayo, kufaka phakathi ukudideka, i-delirium, ukubona kabili, ukwehla kokubona, izinguquko zemizwa, izinkinga zokukhuluma, ubuthakathaka, noma ukukhubazeka
• Ukuquleka
• Isiphukuphuku noma ikhoma (kuyaqabukela)
• Ukuhlanza

Uma ukuphuma kwegazi kungenamandla noma kusakazekile, izimpawu zingabandakanya:

• Iziqephu zokudideka
• Ukuphathwa ikhanda okufika kudlule
• Ukulahleka kokusebenza kwengqondo (ukuwohloka komqondo)
• Ubuthakathaka noma imizwa engajwayelekile efikayo idlule, futhi ifaka izindawo ezincane
• Ukuquleka

I-CAA kunzima ukuyithola ngokuqiniseka ngaphandle kwesampula sezicubu zobuchopho. Lokhu kuvame ukwenziwa ngemuva kokufa noma lapho kwenziwa i-biopsy yemithambo yegazi yobuchopho.

Ukuhlolwa komzimba kungaba okujwayelekile uma ukuphuma kwegazi kukuncane. Kungaba nezinguquko ezithile zomsebenzi wobuchopho. Kubalulekile ukuthi udokotela abuze imibuzo eningiliziwe mayelana nezimpawu nomlando wezokwelapha. Izimpawu nemiphumela yokuhlolwa ngokomzimba nanoma yikuphi ukuhlolwa kwe-imaging kungadala ukuthi udokotela asole i-CAA.

Ukulingisa ukuhlolwa kwekhanda okungenziwa kufaka phakathi:

• I-CT scan noma i-MRI scan ukuhlola ukopha ebuchosheni
• Ukuskena kwe-MRA ukuhlola ukuphuma kwegazi okukhulu nokukhipha ezinye izimbangela zokopha
• Ukuskena kwe-PET ukubheka okufakwe kuma-amyloid ebuchosheni

Alukho umuthi owaziwayo osebenzayo. Umgomo wokwelashwa ukukhulula izimpawu. Kwezinye izimo, ukuvuselelwa kuyadingeka ngenxa yobuthakathaka noma ukungabi namandla. Lokhu kungafaka ukwelashwa ngokomzimba, ngokomsebenzi, noma ngenkulumo.

Kwesinye isikhathi, kusetshenziswa imithi esiza ukuthuthukisa inkumbulo, njengaleyo yesifo i-Alzheimer.

Ukuquleka, okubizwa nangokuthi iziphonso ze-amyloid, kungaphathwa ngemithi elwa nokuquleka.

Lesi sifo siba sibi kakhulu.

Izinkinga ze-CAA zingafaka:

• Ukuwohloka komqondo
• I-Hydrocephalus (kuyaqabukela)
• Ukuquleka
• Iziqephu eziphindaphindiwe zokopha ebuchosheni

Iya egumbini labezimo eziphuthumayo noma shayela inombolo ephuthumayo yendawo (enjenge-911) uma ulahlekelwe ngokuzumayo ukunyakaza, ukuzwa, ukubona, noma ukukhuluma.

I-Amyloidosis - ubuchopho; I-CAA; I-angiopathy yeCongophilic

• I-Amyloidosis yeminwe
• Imithambo yegazi yobuchopho

UCharidimou A, uBoulouis G, uGurol ME, et al. Imiqondo evelayo ku-angiopathy ye-cerebral amyloid sporadic. Ubuchopho. 2017; 140 (7): 1829-1850. I-PMID: 28334869 pubmed.ncbi.nlm.nih.gov/28334869/.

IGreenberg SM, uCharidimou A.Ukuxilongwa kwe-angiopathy ye-cerebral amyloid: ukuvela kwezinqubo zeBoston. Unhlangothi. 2018; 49 (2): 491-497. I-PMID: 29335334 pubmed.ncbi.nlm.nih.gov/29335334/.

I-Kase CS, iShoamanesh A. Ukopha ngaphakathi kwe-Intracerebral. Ku: Daroff RB, Jankovic J, Mazziotta JC, Pomeroy SL, ama-eds. I-Neurology kaBradley ekwenziweni kwemitholampilo. Umhla wesi-7. IPhiladelphia, PA: Elsevier; 2016: isahluko 66.