I-Urticaria pigmentosa

I-Urticaria pigmentosa yisifo sesikhumba esikhiqiza amabala esikhumba esimnyama nokunwaya okubi kakhulu. Isifuba singakhula lapho lezi zindawo zesikhumba zigcotshwa.

I-Urticaria pigmentosa ivela lapho kunamaseli amaningi kakhulu okuvuvukala (amaseli amangqamuzana) esikhunjeni. Amaseli amangqamuzana amangqamuzana omzimba asiza umzimba ukulwa nezifo. Amaseli amancane enza futhi akhiphe i-histamine, edala ukuthi izicubu eziseduze zivuvuke futhi zivuthe.

Izinto ezingadala ukukhishwa kwe-histamine nezimpawu zesikhumba zifaka:

• Ukuhlikihla isikhumba
• Izifo
• Ukuzivocavoca umzimba
• Ukuphuza iziphuzo ezishisayo, ukudla ukudla okubabayo
• Ukukhanya kwelanga, ukuchayeka emakhazeni
• Imithi, efana ne-aspirin noma amanye ama-NSAID, i-codeine, i-morphine, i-x-ray udayi, eminye imithi ye-anesthesia, utshwala

I-Urticaria pigmentosa ivame kakhulu ezinganeni. Kungenzeka futhi kubantu abadala.

Uphawu oluyinhloko amabala ansundu esikhunjeni. Lezi zinhlamvu ziqukethe amaseli abizwa ngama-mastocyte. Lapho ama-mastocyte ekhipha i-histamine yamakhemikhali, ama-patches akhula abe ngamaqhubu afana nesidleke. Izingane ezincane zingase zihlakulele ibhamuza eligcwele uketshezi uma iqhubu liklwebhekile.

Ubuso bungabuye bubomvu ngokushesha.

Ezimweni ezimbi kakhulu, lezi zimpawu zingavela:

• Uhudo
• Ukuquleka (okungavamile)
• Ubuhlungu bekhanda
• Isondo
• Ukushaya kwenhliziyo okusheshayo

Umhlinzeki wezempilo uzohlola isikhumba. Umhlinzeki angasola i-urticarial pigmentosa lapho amaqebelengwane esikhumba ehlikihlwa futhi ephakanyiswa amaqhubu (isifuba). Lokhu kubizwa ngokuthi uphawu lwe-Darier.

Ukuhlolwa kokuhlola lesi simo yilesi:

• Skin biopsy ukubheka inani eliphakeme lamaseli omzimba
• Umchamo we-histamine
• Ukuhlolwa kwegazi kokubalwa kwamaseli egazi namazinga we-tryptase yegazi (i-tryptase iyi-enzyme etholakala kumaseli amangqamuzana)

Imithi ye-antihistamine ingasiza ekunciphiseni izimpawu ezinjengokulunywa nokukhuzwa. Khuluma nomhlinzeki wakho mayelana nokuthi yiluphi uhlobo lwe-antihistamine okufanele ulusebenzise. Ama-Corticosteroids asetshenziswe esikhumbeni nasekwelashweni okulula angasetshenziswa kwezinye izimo.

Umhlinzeki wakho angahle anikeze ezinye izinhlobo zemithi yokwelapha izimpawu zezinhlobo ezinzima nezingajwayelekile ze-urticaria pigmentosa.

I-Urticaria pigmentosa iya ngokuthomba cishe engxenyeni eyodwa yezingane ezithintekile. Izimpawu zivame ukuba ngcono kwabanye njengoba zikhula zibe abantu abadala.

Kubantu abadala, i-urticaria pigmentosa ingaholela ku-systemic mastocytosis. Lesi yisimo esibi kakhulu esingathinta amathambo, ubuchopho, izinzwa, kanye nohlelo lokugaya ukudla.

Izinkinga eziyinhloko ukungaphatheki kahle ngokulunywa nokukhathazeka ngokubonakala kwamabala. Ezinye izinkinga ezifana nohudo nokuquleka akuvamile.

Ukulunywa yizinambuzane nakho kungadala ukusabela okubi komzimba kubantu abane-urticaria pigmentosa. Buza umhlinzeki wakho ukuthi kufanele uphathe i-epinephrine kit ongayisebenzisa uma uthola i-bee sting.

Shayela umhlinzeki wakho uma ubona izimpawu ze-urticaria pigmentosa.

I-Mastocytosis; I-Mastocytoma

• I-Urticaria pigmentosa ekhwapheni
• I-Mastocytosis - isabalalisa ukusikeka
• I-Urticaria pigmentosa esifubeni
• I-Urticaria pigmentosa - ukusondela

I-Chapman MS. I-Urticaria. Ku: Habif TP, Dinulos JGH, Chapman MS, Zug KA, ama-eds. Izifo Zesikhumba: Ukuxilongwa Nokulashwa. Umhla wesi-4. IPhiladelphia, PA: Elsevier; 2018: isahluko 3.

UChen D, uGeorge TI. I-Mastocytosis. Ku: Hsi ED, ed. I-Hematopathology. 3rd ed. IPhiladelphia, PA: Elsevier; 2018: isahluko 20.

UPaige DG, uWakelin SH. Isifo sesikhumba. Ku: Kumar P, Clark M, ama-eds. I-Kumar and Clarke's Clinical Medicine. Umhlaka 9. IPhiladelphia, PA: Elsevier; I-2017: isahluko 31.