Ukuhlolwa komchamo okungu-17-hydroxycorticosteroids

Ukuhlolwa kwe-17-hydroxycorticosteroids (17-OHCS) kukala izinga le-17-OHCS emchameni.

Kudingeka isampula yamahora angama-24. Uzodinga ukuqoqa umchamo wakho ngaphezu kwamahora angama-24. Umhlinzeki wakho wezempilo uzokutshela ukuthi ungakwenza kanjani lokhu. Landela imiyalo ngqo.

Umhlinzeki uzokuyalela, uma kunesidingo, ukuthi umise imithi engaphazamisa ukuhlolwa. Lokhu kungafaka:

• Amaphilisi okulawula inzalo aqukethe i-estrogen
• Imithi elwa namagciwane ethile
• Ama-Glucocorticoids

Ukuhlolwa kuhilela ukuchama okuvamile kuphela. Akukho ukungakhululeki.

I-17-OHCS ingumkhiqizo owakhiwa lapho isibindi nezinye izicubu zomzimba zidiliza i-steroid hormone cortisol.

Lokhu kuhlolwa kungasiza ukuthola ukuthi umzimba ukhiqiza i-cortisol eningi kakhulu. Ukuhlolwa kungasetshenziselwa ukuxilonga i-Cushing syndrome. Lesi yisifo esenzeka lapho umzimba unezinga eliphakeme njalo le-cortisol.

Umthamo womchamo kanye nomchamo creatinine uvame ukwenziwa nge-17-OHCS test ngasikhathi sinye. Lokhu kusiza umhlinzeki ahumushe isivivinyo.

Lokhu kuhlolwa akwenziwa kaningi manje. Ukuhlolwa kwamahhala komchamo we-cortisol ukuhlolwa okungcono kwesifo seCushing.

Amanani ajwayelekile:

• Owesilisa: 3 kuya ku-9 mg / amahora angu-24 (8.3 kuye ku-25 µmol / 24 amahora)
• Owesifazane: 2 kuya ku-8 mg / 24 amahora (5.5 kuya ku-22 22mol / 24 amahora)

Ububanzi bamanani ajwayelekile bungahluka kancane phakathi kwamalabhorethri ahlukene. Amanye amalebhu asebenzisa izilinganiso ezahlukahlukene noma avivinye amasampula ahlukile. Khuluma nomhlinzeki wakho mayelana nencazelo yemiphumela yakho ethile yokuhlolwa.

Izinga eliphakeme kunejwayelekile le-17-OHCS lingakhombisa:

• Uhlobo lwe-Cushing syndrome olubangelwa isimila ku-adrenal gland ekhiqiza i-cortisol
• Ukucindezeleka
• Ukwelashwa kwe-Hydrocortisone
• Ukungondleki
• Ukukhuluphala ngokweqile
• Ukukhulelwa
• Imbangela yehomoni yengcindezi ephezulu yegazi
• Ukucindezeleka okukhulu ngokomzimba noma ngokomzwelo
• Isimila endlaleni yebhinqa noma kwenye indawo emzimbeni esikhipha i-hormone ebizwa nge-adrenocorticotropic hormone (ACTH)

Izinga eliphansi kunokujwayelekile le-17-OHCS lingakhombisa:

• Izindlala ze-Adrenal azikhiqizi ngokwanele amahomoni azo
• Indlala yamapayipi ayikhiqizi ngokwanele amahomoni ayo
• Ukushoda kwe-enzyme eyifa
• Ukuhlinzwa kwangaphambilini ukususa i-adrenal gland

Ukuchama ngaphezu kwamalitha ama-3 ngosuku (i-polyuria) kungenza umphumela wesivivinyo uphakeme yize ukukhiqizwa kwe-cortisol kuyinto ejwayelekile.

Azikho izingozi ngalokhu kuhlolwa.

I-17-OH corticosteroids; 17-OHCS

IChernecky CC, iBerger BJ. I-17-hydroxycorticosteroids (17-OHCS) - umchamo wamahora angama-24. Ku: IChernecky CC, iBerger BJ, ama-eds. Ukuhlolwa Kwelabhoratri Nezinqubo Zokuxilonga. Umhlaka 6. ISt Louis, MO: Elsevier Saunders; 2013: 659-660.

UJuszczak A, uMorris DG, uGrossman AB, uNieman LK. I-Cushing’s syndrome. Ku: Jameson JL, De Groot LJ, de Kretser DM, et al, abahleli. I-Endocrinology: Eyabantu Abadala Neyengane. Umhla wesi-7. IPhiladelphia, PA: Elsevier Saunders; 2016: isahluko 13.