Lenalidomide

-Delile

• Ngaphambi kokuthatha i-lenalidomide,
• ILenalidomide ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SEXWAYISO, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:
• Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

Ubungozi bezinkinga zokuzalwa ezisongela impilo ezibangelwa yi-lenalidomide:

Kuzo zonke iziguli:

ILenalidomide akumele ithathwe yiziguli ezikhulelwe noma ezingakhulelwa. Kunobungozi obukhulu bokuthi i-lenalidomide izodala ukukhubazeka okukhulu kokuzalwa (izinkinga ezikhona lapho kuzalwa) noma ukufa kwengane engakazalwa.

Uhlelo olubizwa nge-REVLIMID REMS^TM sekuhlelwe ukuthi kuqinisekiswe ukuthi abesifazane abakhulelwe abayithathi i-lenalidomide nokuthi abesifazane abakhulelwa ngenkathi bethatha i-lenalidomide. Zonke iziguli, kufaka phakathi abesifazane abangakwazi ukukhulelwa nabesilisa, bangathola i-lenalidomide kuphela uma bebhaliswe ne-REVLIMID REMS, banesidakamizwa esivela kudokotela obhaliswe nge-REVLIMID REMS, bese begcwalisa incwadi ekhemisi ebhaliswe ne-REVLIMID REMS .

Uzothola ulwazi mayelana nobungozi bokuthatha i-lenalidomide futhi kufanele usayine iphepha lokuvuma elinolwazi elisho ukuthi uyaluqonda lolu lwazi ngaphambi kokuthola umuthi. Uma ungaphansi kweminyaka engu-18 ubudala, umzali noma umnakekeli kufanele asayine iphepha lokuvuma futhi avume ukuqinisekisa ukuthi uhlangabezana nalezi zidingo. Uzodinga ukubona udokotela wakho ngesikhathi sokwelashwa kwakho ukuze ukhulume ngesimo sakho kanye nemiphumela emibi obhekene nayo noma ukuhlolwa okhulelwe njengoba kunconyiwe uhlelo. Ungadinga ukuqedela ucwaningo oluyimfihlo ekuqaleni kokwelashwa kwakho nangezikhathi ezithile ngesikhathi sokwelashwa kwakho ukuze uqiniseke ukuthi uthole nokuthi uyaluqonda lolu lwazi nokuthi ungalandela imiyalo yokuvimbela izingozi ezingathi sína ezinganeni ezingakazalwa.

Tshela udokotela wakho uma ungakuqondi konke otshelwe ngakho mayelana ne-lenalidomide nohlelo lwe-REVLIMID REMS nokuthi ungazisebenzisa kanjani izindlela zokulawula ukubeletha okuxoxwe ngazo nodokotela wakho, noma uma ungacabangi ukuthi uzokwazi ukugcina izikhathi zakho.

Unganikeli ngegazi ngenkathi uthatha i-lenalidomide, nganoma yisiphi isikhathi sokuphumula ekwelashweni kwakho, nangamasonto ama-4 ngemuva komthamo wakho wokugcina.

Ungabelani ngeleneralomide nanoma ngubani omunye umuntu, ngisho nomuntu onezimpawu ezifana nezakho.

Udokotela wakho noma usokhemisi uzokunikeza ishidi lemininingwane yesiguli lomkhiqizi (Umhlahlandlela Wokwelashwa) lapho uqala ukwelashwa nge-lenalidomide futhi isikhathi ngasinye lapho ugcwalisa umuthi wakho. Funda imininingwane ngokucophelela bese ubuza udokotela noma usokhemisi wakho uma unemibuzo. Ungavakashela futhi iwebhusayithi ye-Food and Drug Administration (FDA) (http://www.fda.gov/Drugs), iwebhusayithi yomenzi, noma iwebhusayithi yohlelo lwe-REVLIMID REMS (http://www.revlimidrems.com) ukuthola Umhlahlandlela Wezokwelapha.

Khuluma nodokotela wakho ngezingozi zokuthatha i-lenalidomide.

Ezigulini zesifazane:

Uma ungakhulelwa, kuzodingeka uhlangabezane nezimfuneko ezithile ngesikhathi sokwelashwa kwakho nge-lenalidomide.Kufanele usebenzise izindlela ezimbili ezamukelekayo zokulawula ukubeletha amasonto ama-4 ngaphambi kokuba uqale ukuthatha i-lenalidomide, ngesikhathi sokwelashwa kwakho, kufaka phakathi nezikhathi lapho udokotela wakho ekutshela ukuthi uyeke ukuthatha i-lenalidomide okwesikhashana, namasonto ama-4 ngemuva komthamo wakho wokugcina. Udokotela wakho uzokutshela ukuthi yiziphi izindlela zokulawula ukubeletha ezamukelekayo futhi uzokunikeza imininingwane ebhaliwe mayelana nokulawulwa kokuzalwa. Kufanele usebenzise lezi zinhlobo ezimbili zokulawulwa kokubeletha ngaso sonke isikhathi ngaphandle kokuthi ungaqinisekisa ukuthi ngeke ube nokuxhumana ngokocansi nowesilisa amasonto ama-4 ngaphambi kokwelashwa kwakho, ngesikhathi sokwelashwa kwakho, noma yikuphi ukuphazamiseka ekwelashweni kwakho, nasemasontweni amane ngemuva umthamo wakho wokugcina.

Uma ukhetha ukuthatha i-lenalidomide, kungumsebenzi wakho ukugwema ukukhulelwa amasonto ama-4 ngaphambi, phakathi, kanye nasemasontweni amane ngemuva komthamo wakho wokugcina. Kufanele uqonde ukuthi noma yiluphi uhlobo lokulawulwa kokuzalwa lungahluleka. Ngakho-ke, kubaluleke kakhulu ukunciphisa ubungozi bokukhulelwa ngengozi ngokusebenzisa izindlela ezimbili zokulawula ukubeletha. Tshela udokotela wakho uma ungakuqondi konke otshelwe ngakho mayelana nokulawulwa kokuzalwa noma ungacabangi ukuthi uzokwazi ukusebenzisa izindlela ezimbili zokulawula inzalo ngaso sonke isikhathi.

Kufanele ube nokuhlolwa kokukhulelwa okumbili ngaphambi kokuba uqale ukuthatha i-lenalidomide. Uzodinga futhi nokuhlolelwa ukukhulelwa elabhoratri ngezikhathi ezithile ngesikhathi sokwelashwa kwakho. Udokotela wakho uzokutshela ukuthi uzozihlola nini futhi kuphi.

Yeka ukuthatha i-lenalidomide bese ufonela udokotela wakho ngokushesha uma ucabanga ukuthi ukhulelwe, uphuthelwa ukuya esikhathini, unegazi elingavamile lokuya esikhathini, noma uya ocansini ngaphandle kokusebenzisa izindlela ezimbili zokulawula ukubeletha. Uma ukhulelwa ngesikhathi sokwelashwa kwakho noma zingakapheli izinsuku ezingama-30 ukwelashwa kwakho, udokotela wakho ezoxhumana nohlelo lwe-REVLIMID REMS, umkhiqizi weleneralomide, kanye ne-Food and Drug Administration (FDA). Uzokhuluma nodokotela ogxile ezinkingeni ngesikhathi sokukhulelwa ongakusiza wenze izinqumo ezilungele wena nengane yakho. Imininingwane ngempilo yakho nangempilo yengane yakho izosetshenziselwa ukusiza odokotela ukuthi bafunde kabanzi ngemiphumela ye-lenalidomide ezinganeni ezingakazalwa.

Ezigulini zesilisa:

ILenalidomide ikhona esidunjini sakho lapho uphuza lo muthi. Kufanele njalo usebenzise ikhondomu ye-latex, noma ngabe une-vasectomy (ukuhlinzwa okuvimbela owesilisa ekubangeleni ukukhulelwa), ngaso sonke isikhathi lapho uhlangana ngokocansi nowesifazane okhulelwe noma okwazi ukukhulelwa ngenkathi uthatha i-lenalidomide, nganoma yisiphi isikhathi sokuphumula ekwelashweni kwakho, nangamasonto ama-4 ngemuva komthamo wakho wokugcina. Tshela udokotela wakho uma uhlanganyela ocansini nowesifazane ngaphandle kokusebenzisa ikhondomu noma uma umlingani wakho ecabanga ukuthi kungenzeka ukuthi ukhulelwe ngesikhathi welashwa nge-lenalidomide.

Unganikeli isidoda ngenkathi uthatha i-lenalidomide, nganoma yisiphi isikhathi sokuphumula ekwelashweni kwakho, nangamasonto ama-4 ngemuva komthamo wakho wokugcina.

Ezinye izingozi zokuthatha i-lenalidomide:

I-Lenalidomide ingadala ukwehla kwenani lezinhlobo ezithile zamaseli egazi emzimbeni wakho. Udokotela wakho uzo-oda ukuhlolwa kwe-laboratory njalo ngesikhathi sokwelashwa kwakho ukuze abone ukuthi inani lamaseli egazi lehle kangakanani. Udokotela wakho anganciphisa umthamo wakho, aphazamise ukwelashwa kwakho, noma akwelaphe ngeminye imithi noma imishanguzo uma ukwehla kwamaseli akho egazi kunzima. Uma uhlangabezana nalezi zimpawu ezilandelayo, tshela udokotela wakho ngokushesha: umphimbo obuhlungu, umkhuhlane, amakhaza nezinye izimpawu zokutheleleka; ukulinyazwa okulula noma ukopha; izinsini zokopha; noma ukopha ngamakhala.

Uma uthatha i-lenalidomide ne-dexamethasone ukwelapha i-myeloma eminingi, kunengozi eyengeziwe yokuthi uzokwakha ihlule legazi emlenzeni wakho elingase lingene egazini liye emaphashini akho, noma uhlaselwe yinhliziyo noma isifo sohlangothi. Udokotela wakho angahle anikeze omunye umuthi ozothathwa kanye ne-lenalidomide ukunciphisa le ngozi. Tshela udokotela wakho uma ubhema, uma ngabe uke waba negazi elinzima, futhi uma uke waba nomfutho wegazi ophakeme noma amanoni aphezulu egazini lakho. Phinda utshele udokotela wakho ngayo yonke imithi oyiphuzayo ngoba imishanguzo ethile ingakhuphula ubungozi bokuthi uzoba negazi lapho uthatha i-lenalidomide ene-dexamethasone efaka i-darbepoetin (Aranesp), i-epoetin alfa (i-Epogen, i-Procrit), nemithi equkethe i-estrogen efana ukwelashwa okubuyisela ama-hormone noma izindlela zokuvimbela inzalo ze-hormonal (amaphilisi okulawula ukubeletha, amabala, izindandatho, okufakelwa noma imijovo). Uma uhlangabezana nalezi zimpawu ezilandelayo, tshela udokotela wakho ngokushesha: ukuphefumula okuncane; ubuhlungu besifuba obungasakazeka ezandleni, entanyeni, emuva, emhlathini noma esiswini; ukukhwehlela; ububomvu noma ukuvuvukala engalweni noma emlenzeni; ukujuluka; isicanucanu; ukuhlanza; ubuthakathaka obungazelelwe noma ukuba ndikindiki, ikakhulukazi ohlangothini olulodwa lomzimba; ikhanda; ukudideka; noma ubunzima ngombono, ukukhuluma, noma ukulinganisela.

I-Lenalidomide isetshenziselwa ukwelapha uhlobo oluthile lwe-myelodysplastic syndrome (iqembu lezimo lapho umnkantsha wethambo ukhiqiza khona amaseli egazi angafakwanga kahle futhi angavezi amaseli wegazi anele). ILenalidomide nayo isetshenziswa kanye ne-dexamethasone ukwelapha abantu abane-multiple myeloma (uhlobo lomdlavuza womnkantsha). Ibuye isetshenziselwe ukwelapha abantu abane-myeloma eminingi ngemuva kokufakwa kwe-hematopoietic stem-cell (HSCT; inqubo lapho kukhishwa khona amaseli athile egazi emzimbeni bese ibuyiselwa emzimbeni). ILenalidomide isetshenziselwa ukwelapha abantu abane-mantle cell lymphoma (umdlavuza okhula ngokushesha oqala kumaseli amasosha omzimba) abelashwe nge-bortezomib (Velcade) kanye nomunye umuthi owodwa. ILenalidomide akufanele isetshenziselwe ukwelapha abantu abane-leukemia engapheli (uhlobo lomdlavuza wamangqamuzana amhlophe egazi aqhubeka ngokuya ngokuhamba kwesikhathi) ngaphandle kokuthi babambe iqhaza esivivinyweni somtholampilo (ucwaningo lokucwaninga ukubona ukuthi umuthi ungasetshenziswa ngokuphepha yini futhi ukuphatha kahle isimo esithile). ILenalidomide isekilasini lemithi ebizwa ngama-immunomodulatory agents. Isebenza ngokusiza umongo wethambo ukuthi ukhiqize amangqamuzana egazi ajwayelekile nangokubulala amaseli angajwayelekile emnkantsheni wethambo.

ILenalidomide iza njengephilisi elizothathwa ngomlomo. Lapho i-lenalidomide isetshenziselwa ukwelapha i-myelodysplastic syndrome, imvamisa ithathwa ngokudla noma ngaphandle kokudla kanye ngosuku. Lapho i-lenalidomide isetshenziselwa ukwelapha ama-myeloma amaningi noma ama-mantle cell lymphoma, imvamisa ithathwa ngokudla noma ngaphandle kokudla kanye nsuku zonke ezinsukwini ezingama-21 zokuqala zomjikelezo wezinsuku ezingama-28. Lapho i-lenalidomide isetshenziselwa ukwelapha i-myeloma eminingi ngemuva kwe-HSCT, imvamisa ithathwa ngokudla noma ngaphandle kokudla kanye nsuku zonke izinsuku ezingama-28 zomjikelezo wezinsuku ezingama-28. Uhlobo lwemijikelezo yezinsuku ezingama-28 lungaphindwa njengoba kunconywe udokotela wakho ngokuya ngempendulo yomzimba wakho kulo muthi. Thatha i-lenalidomide ngasikhathi sosuku nsuku zonke oyithatha. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-lenalidomide njengoba nje kuqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Gwinya wonke amaphilisi ngamanzi amaningi; ungawaphuli, ungawahlafune, noma uwavule. Phatha ama-capsule kancane ngangokunokwenzeka. Uma uthinta i-lenalidomide capsule ephukile noma umuthi ose-capsule, geza leyo ndawo yomzimba wakho ngensipho namanzi. Uma umuthi osemgodleni ungena emlonyeni, ekhaleni, noma emehlweni, uwugeze ngamanzi amaningi.

Udokotela wakho angadinga ukuphazamisa ukwelashwa kwakho noma anciphise umthamo wakho uma uhlangabezana nemiphumela ethile emibi. Qiniseka ukuthi utshela udokotela wakho ukuthi uzizwa kanjani ngenkathi welashwa nge-lenalidomide.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-lenalidomide,

• Tshela udokotela kanye nosokhemisi wakho uma une-aleji ye-lenalidomide, noma imiphi eminye imithi, noma yiziphi izithako ezikuma-capsule e-lenalidomide. Buza usokhemisi wakho noma uhlole Umhlahlandlela Wezokwelapha ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi uyayisho imithi efakwe kuhlu esigabeni ESIBALULEKILE SESEXWAYISO kanye ne-digoxin (Lanoxin). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• Tshela udokotela wakho uma ungabekezelelani ne-lactose futhi uma uke waba nesifo sezinso, segilo noma sesibindi noma wake waba naso. Phinda utshele udokotela wakho uma wake waphuza i-thalidomide (Thalomid) futhi waba nokuqubuka ngesikhathi sokwelashwa kwakho.
• tshela udokotela wakho uma uncelisa noma uhlela ukuncelisa.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Uma kube ngaphansi kwamahora angu-12 kusukela behlelelwe ukuthatha umthamo, thatha umthamo ongabanjwanga ngokushesha nje lapho uwukhumbula. Uma sekudlule amahora angaphezu kwe-12, weqa umthamo ongabanjwanga bese uqhubeka nesimiso sakho sokulinganisa esivamile. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

ILenalidomide ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• isifo sohudo
• ukuqunjelwa
• ubuhlungu besisu
• ukulahlekelwa isifiso sokudla
• ukuncipha komzimba
• ubuthakathaka
• isiyezi
• shintsha emandleni okunambitha
• ubuhlungu noma ukushiswa kolimi, umlomo, noma umphimbo
• ukuncipha komuzwa wokuthinta
• ukushisa noma ukuncinza ezandleni noma ezinyaweni
• ubunzima bokulala noma ukulala
• ukudana
• ubuhlungu obuhlangene, besisipha, bethambo, noma beqolo
• ukuchama okubuhlungu, okuvamile, noma okuphuthumayo
• ukujuluka
• isikhumba esomile
• ukukhula kwezinwele okungavamile kwabesifazane
• ukuzamazama okungalawuleki kwengxenye yomzimba
• ukuncipha kwesifiso sobulili noma ikhono

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SEXWAYISO, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• ukuvuvukala kobuso, umphimbo, ulimi, izindebe, amehlo, izingalo, izandla, izinyawo, amaqakala noma imilenze engezansi
• ukuphefumula kanzima noma ukugwinya
• ukushaqeka
• okusheshayo, okuhamba kancane, okushaya ngamandla, noma ukushaya kwenhliziyo okungajwayelekile
• isithuthwane
• ukuqubuka
• ubuhlungu besikhumba
• ukushwabana, ukuxebuka, noma ukuchitha isikhumba
• izindlala ezivuvukile entanyeni
• amajaqamba
• ubuhlungu engxenyeni engenhla kwesokudla yesisu
• ukuphuzi kwesikhumba noma kwamehlo
• umchamo onombala omnyama
• ukukhathala
• ukuchama okunegazi, okunamafu, noma okubuhlungu
• ukwanda noma ukwehla kokuchama

Uma uthatha i-lenalidomide ukwelapha i-myeloma eminingi futhi uthola ne-melphalan (Alkeran) noma ukufakelwa kwe-cell stem yegazi, ungaba nengozi enkulu yokuthola umdlavuza omusha. Khuluma nodokotela wakho ngezingozi zokuthatha i-lenalidomide. Udokotela wakho uzokuhlolela umdlavuza omusha ngenkathi welashwa nge-lenalidomide.

I-Lenalidomide ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese). Buyisela noma imuphi umuthi osuphelelwe yisikhathi noma ongasadingeki kudokotela wakho, ekhemisi ekunikeze umuthi, noma kumenzi.

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

• ukulunywa
• isifuba
• ukuqubuka

Gcina wonke ama-aphoyintimenti nodokotela wakho. Udokotela wakho anga-oda izivivinyo ezithile ngaphambi nangesikhathi sokwelashwa kwakho ukuze ahlole impendulo yomzimba wakho ku-lenalidomide.

Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• Ukubuyiselwa^®