Ukuhlolwa kwe-CPK isoenzymes

Ukuhlolwa kwe-creatine phosphokinase (CPK) isoenzymes kukala izinhlobo ezahlukahlukene ze-CPK egazini. I-CPK iyi-enzyme etholakala ikakhulu enhliziyweni, ebuchosheni nasemisipheni yamathambo.

Kudingeka isampula yegazi. Lokhu kungathathwa emthanjeni. Isivivinyo sibizwa ngokuthi yi-venipuncture.

Uma usesibhedlela, lokhu kuhlolwa kungaphindwa ezinsukwini ezimbili noma ezintathu. Ukukhuphuka noma ukwehla okuphelele kuma-isoenzymes e-CPK noma e-CPK kungasiza umhlinzeki wakho wezokunakekelwa kwempilo ukuthola izimo ezithile.

Akukho ukulungiselela okukhethekile okudingekayo ezimweni eziningi.

Tshela umhlinzeki wakho ngayo yonke imithi oyiphuzayo. Eminye imishanguzo ingaphazamisa imiphumela yokuhlolwa. Izidakamizwa ezingakhuphula izilinganiso ze-CPK zifaka okulandelayo:

• Utshwala
• I-Amphotericin B
• Ama-anesthetics athile
• Cocaine
• Hlanganisa izidakamizwa
• Izitatimende
• Ama-steroid, afana ne-dexamethasone

Lolu hlu aluhlanganisi konke.

Ungase uzwe ubuhlungu obuncane lapho kufakwa inaliti ukuze kudonswe igazi. Abanye abantu bazizwa kuphela ukuzwa okuhlabayo noma okuhlabayo. Ngemuva kwalokho, kungahle kube nokushaywa okuthile.

Lokhu kuhlolwa kwenziwa uma ukuhlolwa kwe-CPK kukhombisa ukuthi inani lakho eliphelele le-CPK liphakeme. Ukuhlolwa kwe-CPK isoenzyme kungasiza ekutholeni ngqo umthombo wezicubu ezilimele.

I-CPK yenziwe ngezinto ezintathu ezihluke kancane:

• I-CPK-1 (ebizwa nangokuthi i-CPK-BB) itholakala kakhulu ebuchosheni nasemaphashini
• I-CPK-2 (ebizwa nangokuthi i-CPK-MB) itholakala kakhulu enhliziyweni
• I-CPK-3 (ebizwa nangokuthi i-CPK-MM) itholakala ikakhulu kwimisipha yamathambo

Amazinga aphezulu kune-ejwayelekile e-CPK-1:

Ngoba i-CPK-1 itholakala kakhulu ebuchosheni nasemaphashini, ukulimala kwenye yalezi zindawo kungakhuphula amazinga e-CPK-1. Amazinga akhuphukile e-CPK-1 angabangelwa:

• Umdlavuza wobuchopho
• Ukulimala kobuchopho (ngenxa yanoma yiluphi uhlobo lokulimala kufaka phakathi, ukushaywa unhlangothi, noma ukopha ebuchosheni)
• Ukwelashwa kwe-Electroconvulsive
• I-infarction yamaphaphu
• Ukudlikiza

Amazinga we-CPK-2 aphakeme kunokujwayelekile:

Amazinga e-CPK-2 anyuka amahora amathathu kuya kwayisithupha ngemuva kokuhlaselwa yisifo senhliziyo. Uma kungekho okunye ukulimala kwemisipha yenhliziyo, ileveli iphakama emahoreni ayi-12 kuye kwangama-24 bese ibuyela kokujwayelekile amahora angama-12 kuye kwangama-48 ngemuva kokushona kwezicubu.

Ukukhuphuka kwamazinga e-CPK-2 nawo angabangelwa:

• Ukulimala kagesi
• Inhliziyo defibrillation (ukushaqisa okunenhliziyo kwenhliziyo ngabasebenzi bezokwelapha)
• Ukulimala kwenhliziyo (ngokwesibonelo, kusuka engozini yemoto)
• Ukuvuvukala kwemisipha yenhliziyo imvamisa kungenxa yegciwane (i-myocarditis)
• Vula ukuhlinzwa kwenhliziyo

Amazinga e-CPK-3 aphakeme kakhulu kunokujwayelekile ajwayele ukuba wuphawu lokulimala kwemisipha noma ukucindezeleka kwemisipha. Zingaba ngenxa ye-:

• Crush ukulimala
• Ukulimala kwemisipha ngenxa yezidakamizwa noma ukunganyakazi isikhathi eside (i-rhabdomyolysis)
• Ukukhubazeka kwemisipha
• I-Myositis (ukuvuvukala kwemisipha yamathambo)
• Ukuthola imijovo eminingi yemisipha
• Ukuhlolwa komsebenzi wakamuva we-nerve ne-muscle (electromyography)
• Ukuquleka kwakamuva
• Ukuhlinzwa kwakamuva
• Ukuzivocavoca okunzima

Izici ezingathinta imiphumela yokuhlolwa zifaka i-catheterization yenhliziyo, imijovo ye-intramuscular, ukuhlinzwa kwamuva, nokuzivocavoca okunamandla nokude noma ukukhubazeka.

Ukuhlolwa kwe-Isoenzyme kwezimo ezithile kucishe kube ngu-90%.

Dala i-phosphokinase - isoenzymes; I-Creatine kinase - isoenzymes; CK - isoenzymes; Ukuhlaselwa yinhliziyo - CPK; Crush - CPK

• Ukuhlolwa kwegazi

U-Anderson JL. Ukuphakama kwesigaba se-St seakyo myocardial infarction nezinkinga ze-infarction ye-myocardial. Ku: IGoldman L, iSchafer AI, ama-eds. Imithi yeGoldman-Cecil. Umhla ka-25. IPhiladelphia, PA: Elsevier Saunders; 2016: isahluko 73.

IMarshall WJ, Day A, Lapsley M. Plasma amaprotheni kanye nama-enzyme. Ku: Marshall WJ, Usuku A, Lapsley M, eds. I-Clinical Chemistry. Umhlaka 8. IPhiladelphia, PA: Elsevier; I-2017: isahluko 16.

INagaraju K, iGladue HS, iLundberg IE. Izifo ezivuthayo zemisipha nezinye i-myopathies. Ku: Firestein GS, Budd RC, Gabriel SE, McInnes IB, O'Dell JR, abahleli. Incwadi kaKelley noFirestein yeRheumatology. Umhlaka 10. IPhiladelphia, PA: Elsevier Saunders; 2017: isahluko 85.

Selcen D. Izifo zemisipha. Ku: IGoldman L, iSchafer AI, ama-eds. Imithi yeGoldman-Cecil. Umhla ka-25. IPhiladelphia, PA: Elsevier Saunders; 2016: isahluko 421.