I-antibody ye-Antimitochondrial

Ama-antibodies e-Antimitochondrial (AMA) yizinto (amasosha omzimba) akha i-mitochondria. I-mitochondria iyingxenye ebalulekile yamaseli. Bangumthombo wamandla ngaphakathi kwamaseli. Lokhu kusiza amangqamuzana ukuthi asebenze kahle.

Lo mbhalo ukhuluma ngokuhlolwa kwegazi okusetshenzisiwe ukukala inani le-AMA egazini.

Kudingeka isampula yegazi. Kuvame ukuthathwa emthanjeni. Inqubo ibizwa ngokuthi i-venipuncture.

Umhlinzeki wakho wezokunakekelwa kwempilo angakutshela ukuthi ungadli noma uphuze noma yini kuze kufike emahoreni ayisithupha ngaphambi kokuhlolwa (imvamisa ngobusuku obubodwa).

Lapho inaliti ifakwa ukudonsa igazi, abanye abantu bezwa ubuhlungu obulinganiselayo. Abanye bangazizwa nje ngokuhlatshwa noma ukuzwa okuhlabayo. Ngemuva kwalokho, kungahle kube nokushaywa okuthile.

Ungadinga lokhu kuhlolwa uma unezimpawu zokulimala kwesibindi. Lokhu kuhlolwa kuvame ukusetshenziselwa ukuxilonga i-primary biliary cholangitis, ngaphambili eyayibizwa nge-primary biliary cirrhosis (PBC).

Isivivinyo singasetshenziselwa ukutshela umehluko phakathi kwe-cirrhosis ehlobene nesistimu nezinkinga zesibindi ngenxa yezinye izimbangela njengokuvinjelwa, i-hepatitis yegciwane, noma i-cirrhosis yotshwala.

Ngokuvamile, awekho ama-antibody akhona.

Lokhu kuhlolwa kubalulekile ekuhloleni i-PBC. Cishe bonke abantu abanalesi sifo bazohlolwa ukuthi banalo. Kuyaqabukela ukuthi umuntu ongenasimo abe nemiphumela emihle. Kodwa-ke, abanye abantu abanesivivinyo esihle se-AMA futhi asikho esinye isibonakaliso sesifo sesibindi esingaqhubekela phambili sibe yi-PBC ngokuhamba kwesikhathi.

Imvamisa, kungatholwa imiphumela engajwayelekile ebangelwa ezinye izinhlobo zezifo zesibindi nezinye izifo ezizimele.

Izingozi zokudonswa kwegazi zincane kepha zingafaka:

• Ukopha ngokweqile
• Ukuquleka noma uzizwe unekhanda elincane
• I-hematoma (ukuqoqwa kwegazi ngaphansi kwesikhumba)
• Ukutheleleka (ingozi encane noma kunini lapho isikhumba siphukile)

• Ukuhlolwa kwegazi

Abakwa-Beuers U, uGershwin ME, uGish RG, et al. Ukuguqulwa kwesibizo se-PBC: Kusuka ku-'cirrhosis 'kuya ku' cholangitis '. I-Clin Res Hepatol Gastroenterol. 2015; 39 (5): e57-e59. I-PMID: 26433440 www.ncbi.nlm.nih.gov/pubmed/26433440.

IChernecky CC, iBerger BJ. A. Ku: IChernecky CC, uBerger BJ, ama-eds. Ukuhlolwa Kwelabhoratri Nezinqubo Zokuxilonga. Umhlaka 6. ISt Louis, MO: Elsevier Saunders; 2013: 84-180.

I-Eaton JE, uLindor KD. Isifo sokuqina kwesibindi esiyinhloko. Ku: Feldman M, Friedman LS, Brandt LJ, ama-eds. ISleisenger neFordtran's Gastrointestinal and Liver Disease: IPathophysiology / Diagnosis / Management. Umhlaka 10. IPhiladelphia, PA: Elsevier Saunders; 2016: isahluko 91.

I-Kakar S. Primary biliary cholangitis. Ku: Saxena R, ed. I-Hepatic Pathology Esebenzayo: Indlela Yokuxilonga. Okwesibili. IPhiladelphia, PA: Elsevier; 2018: isahluko 26.

UZhang J, Zhang W, Leung PS, et al. Ukwenza kusebenze okuqhubekayo kwamaseli we-B aqondene ne-autoantigen ku-cirrhosis eyinhloko ye-biliary. I-hepatology. 2014; 60 (5): 1708-1716. I-PMID: 25043065 www.ncbi.nlm.nih.gov/pubmed/25043065.