Qedela ingxenye 3 (C3)

Ukugcwalisa i-C3 ukuhlolwa kwegazi okulinganisa ukusebenza kweprotheni ethile.

Le phrotheni iyingxenye yohlelo lokugcwalisa. Uhlelo lokuncoma luyiqembu lamaprotheni acishe abe ngama-60 akwi-plasma yegazi noma ebusweni bamanye amangqamuzana. Amaprotheni asebenza namasosha akho omzimba futhi abambe iqhaza ekuvikeleni umzimba ezifweni, nokususa amangqamuzana afile nezinto zangaphandle. Imvamisa, abantu bangazuza njengefa ukuswela kwamanye amaprotheni ahambisanayo. Laba bantu bathambekele ezifweni ezithile noma ekuphazamisekeni komzimba.

Kunamaprotheni ayisishiyagalolunye amakhulu ahambisanayo. Zibhalwe ukuthi yi-C1 nge-C9. Lo mbhalo uchaza isivivinyo esilinganisa i-C3.

Igazi likhishwa emthanjeni. Imvamisa, kusetshenziswa umthambo ovela ngaphakathi endololwaneni noma ngemuva kwesandla.

Inqubo imi kanje:

• Isiza sihlanzwa ngesibulali magciwane.
• Umhlinzeki wezempilo usonga ibhande lokunwebeka engalweni engenhla ukufaka ingcindezi endaweni nokwenza umthambo uvuvukale ngegazi.
• Umhlinzeki ufaka kahle inaliti emthanjeni.
• Igazi liqoqelwa esitsheni esingangeni moya noma ithubhu enamathiselwe enalithini. Ibhande lokunwebeka lisusiwe engalweni yakho.
• Lapho igazi seliqoqiwe, inaliti iyasuswa. Indawo yokubhoboza imbozwe ukumisa noma yikuphi ukopha.

Ezinsaneni noma ezinganeni ezincane, ithuluzi elibukhali elibizwa ngokuthi i-lancet lingasetshenziselwa ukubhoboza isikhumba nokusenza siphume igazi.Igazi liqoqelwa kuthubhu encane yengilazi ebizwa nge-pipette, noma kwi-slide noma umugqa wokuhlola. Ibhandishi lingabekwa ngaphezu kwendawo uma kukhona ukopha.

Akukho ukulungiselela okukhethekile okudingekayo.

Lapho inaliti ifakwa ukudonsa igazi, abanye abantu bezwa ubuhlungu obulinganiselayo. Abanye bangazizwa nje ngokuhlatshwa noma ukuzwa okuhlabayo. Ngemuva kwalokho, kungahle kube nokushaywa okuthile.

I-C3 ne-C4 yizinto ezijwayele ukulinganiswa zokuncoma.

Isivivinyo sokugcwalisa singasetshenziswa ukuqapha abantu abanesifo sokuzimela. Kuyenziwa ukubona ukuthi ukwelashwa kwesimo sabo kuyasebenza yini. Lapho uhlelo lokuncoma luvulwa ngesikhathi sokuvuvukala, amazinga wamaprotheni ahambisanayo angahla. Isibonelo, abantu abane-lupus erythematosus esebenzayo bangaba namazinga aphansi kunokujwayelekile amaprotheni wokugcwalisa i-C3 no-C4.

Umsebenzi wokugcwalisa uyahlukahluka emzimbeni wonke. Isibonelo, kubantu abane-arthritis ye-rheumatoid, ukugcwalisa umsebenzi egazini kungaba okujwayelekile noma okuphezulu kunokujwayelekile, kepha kunciphe kakhulu kunokujwayelekile kuketshezi oluhlangene.

Ukuhlolwa kungenziwa futhi ngezimo ezilandelayo:

• Izifo zefungal
• I-Gram septicemia engalungile
• Ukutheleleka ngama-parasitic, njenge-malaria
• I-paroxysmal nocturnal hemoglobinuria (PNH)
• Ukushaqeka

Ububanzi obujwayelekile bungamamiligremu angama-88 kuye kwangama-201 ngedesilitha ngayinye (mg / dL) (0.88 kuye ku-2.01 g / L).

Qaphela: Amabanga wamanani ajwayelekile angahluka kancane kumalabhorethri ahlukile. Khuluma nomhlinzeki wakho mayelana nencazelo yemiphumela yakho ethile yokuhlolwa.

Izibonelo ezingenhla zibonisa izilinganiso ezivamile zemiphumela yalezi zivivinyo. Amanye ama-laboratories asebenzisa izilinganiso ezahlukahlukene noma angahlola izinhlobo ezahlukene.

Umsebenzi owengeziwe wokuncoma ungabonakala ku:

• Umdlavuza
• I-ulcerative colitis

Ukwehla komsebenzi wokuncoma kungabonakala ku:

• Ukutheleleka kwamagciwane (ikakhulukazi iNeisseria)
• Isifo sokuqina kwesibindi
• I-Glomerulonephritis
• Isibindi
• I-angioedema yefa
• Ukwenqatshwa kokufakelwa izinso
• I-Lupus nephritis
• Ukungondleki
• Uhlelo lupus erythematosus
• Okuvamile kuzuze njengefa ukugcwalisa ukusilela
  
  

Izingozi ezihambisana nokudonswa igazi zincane, kepha zingafaka:

• Ukopha ngokweqile
• Ukuquleka noma uzizwe unekhanda elincane
• I-hematoma (ukuqoqwa kwegazi ngaphansi kwesikhumba)
• Ukutheleleka (ingozi encane noma kunini lapho isikhumba siphukile)

Umphelelisi we-cascade uchungechunge lwezinto ezenzeka egazini. I-cascade isebenzisa amaprotheni ahambisanayo. Umphumela uba yunithi yokuhlasela edala izimbobo kulwelwesi lwamagciwane, ibabulale. I-C3 inamathela kubhaktheriya bese iwabulala ngqo.

C3

• Ukuhlolwa kwegazi

IChernecky CC, iBerger BJ. I-C3 complement (beta-1c-globulin) - i-serum. Ku: IChernecky CC, iBerger BJ, ama-eds. Ukuhlolwa Kwelabhoratri Nezinqubo Zokuxilonga. Umhlaka 6. ISt Louis, MO: Elsevier Saunders; 2013: 267-268.

Ama-Holers VM. Gcwalisa kanye nokwamukela kwayo: ukuqonda okusha kusifo somuntu. U-Annu Rev Immunol. 2014; 32: 433-459. I-PMID: 24499275 www.ncbi.nlm.nih.gov/pubmed/24499275.

IMassey HD, iMcPherson RA, iHuber SA, uJenny NS. Abalamuli bokuvuvukala: umphelelisi. Ku: McPherson RA, Pincus MR, abahleli. UHenry’s Clinical Diagnosis and Management by Laboratory Methods. Umhla ka-23. ISt Louis, MO: Elsevier; I-2017: isahluko 47.

IMerle NS, iSonto SE, iFremeaux-Bacchi V, iRoumenina LT. Gcwalisa ingxenye yohlelo I - izindlela zamangqamuzana zokwenza kusebenze kanye nomthethonqubo. Ngaphambili i-Immunol. 2015; 6: 262. I-PMID: 26082779 www.ncbi.nlm.nih.gov/pubmed/26082779.

IMerle NS, uNoe R, iHalbwachs-Mecarelli L, iFremeaux-Bacchi V, iRoumenina LT. Gcwalisa uhlelo ingxenye II: indima ekuvikeleni umzimba. Ngaphambili i-Immunol. 2015; 6: 257. I-PMID: 26074922 www.ncbi.nlm.nih.gov/pubmed/26074922.

UMorgan BP, uHarris CL. Ukugcwalisa, okubhekiswe ekwelashweni kwezifo ezivuthayo nezikhukhulayo. Nat Rev Izidakamizwa. 2015; 14 (12): 857-877. PMID: 26493766 www.ncbi.nlm.nih.gov/pubmed/26493766.