Ukuhlolwa kwamaseli okugula

Ukuhlolwa kweseli lesikela kubheka i-hemoglobin engajwayelekile egazini edala isifo se-sickle cell disease.

Kudingeka isampula yegazi.

Lapho inaliti ifakwa ukudonsa igazi, abanye abantu bezwa ubuhlungu obulinganiselayo. Abanye bazizwa beshaywa noma betinyelwa kuphela. Ngemuva kwalokho, kungahle kube nokushaywa okuthile noma ukulimazeka. Lokhu maduzane kuyaphela.

Lokhu kuhlolwa kwenzelwa ukutshela ukuthi ngabe umuntu une-hemoglobin engajwayelekile edala isifo se-sickle cell kanye nesici se-sickle cell. IHemoglobin yiprotheni enamaseli abomvu egazi athwala umoya-mpilo.

Esifo se-sickle cell, umuntu unezakhi zofuzo ezimbili ze-hemoglobin S ezingavamile. Umuntu onesici se-sickle cell unolunye kuphela lwalezi zofuzo ezingajwayelekile futhi akanazo izimpawu, noma kuphela ezimnene.

Lokhu kuhlolwa akusho umehluko phakathi kwalezi zimo ezimbili. Olunye uvivinyo, olubizwa nge-hemoglobin electrophoresis, luzokwenziwa ukutshela ukuthi umuntu unasiphi isimo.

Umphumela wokuhlolwa ojwayelekile ubizwa ngokuthi yi-negative.

Ububanzi bamanani ajwayelekile bungahluka kancane phakathi kwamalabhorethri ahlukene. Amanye amalebhu asebenzisa izilinganiso ezahlukahlukene noma avivinye amasampula ahlukile. Khuluma nomhlinzeki wakho wezokunakekelwa kwempilo mayelana nencazelo yemiphumela yakho ethile yokuhlolwa.

Umphumela wokuhlolwa ongajwayelekile ukhombisa ukuthi umuntu angaba nenye yalezi:

• Isifo se-Sickle cell
• Isici sesiguli esigulayo

Ukushoda kwe-ayoni noma ukumpontshelwa igazi ezinyangeni ezi-3 ezedlule kungadala umphumela ongemuhle ongewona. Lokhu kusho ukuthi umuntu angaba ne-hemoglobin engajwayelekile yeseli lesikela, kepha lezi ezinye izinto zenza imiphumela yabo yokuhlolwa ibonakale ingeyinhle (ejwayelekile).

Kunengozi encane ethintekayo ekuthatheni igazi lakho. Imithambo nemithambo iyehluka ngobukhulu ukusuka komunye umuntu iye komunye, futhi kusukela kolunye uhlangothi lomzimba kuye kolunye. Ukuthola isampula yegazi kwabanye abantu kungaba nzima kakhulu ukwedlula kwabanye.

Ezinye izingozi ezihambisana nokudonswa igazi zincane, kepha zingafaka:

• Ukopha ngokweqile
• Ukuquleka noma uzizwe unekhanda elincane
• Ukubhoboza okuningi ukuthola imithambo
• I-hematoma (i-blood buildup ngaphansi kwesikhumba)
• Ukutheleleka (ingozi encane noma kunini lapho isikhumba siphukile)

Sickledex; Ukuhlolwa kwe-Hgb S

• Amaseli abomvu egazi, iseli lesikela
• Amaseli abomvu egazi - amaseli amaningi amasikela
• Amaseli abomvu egazi - amangqamuzana amasikela
• Amaseli abomvu egazi - isikela nePappenheimer

USaunthararajah Y, Vichinsky EP. Isifo seSickle cell: izici zokwelashwa kanye nokuphathwa. Ku: Hoffman R, Benz EJ, Silberstein LE, et al, ama-eds. I-Hematology: Izimiso Eziyisisekelo Nokuzijwayeza. Umhla wesi-7. IPhiladelphia, PA: Elsevier; 2018: isahluko 42.