I-Alendronate

-Delile

• I-Alendronate ingahle ingasebenzi kahle futhi ingalimaza i-esophagus (ithubhu phakathi komlomo nesisu) noma ibangele izilonda emlonyeni uma ingathathwa ngokwemiyalelo elandelayo. Tshela udokotela wakho uma ungaqondi, awucabangi ukuthi uzokhumbula, noma awukwazi ukulandela le miyalo:
• Ngaphambi kokuthatha i-alendronate,
• I-Alendronate ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nanoma yiziphi kulezi zimpawu ezilandelayo noma lezo ezibalwe esigabeni SOKUQAPHA OKUKHETHEKILE, shayela udokotela wakho ngokushesha ngaphambi kokuba uthathe enye i-alendronate:
• Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

I-Alendronate isetshenziselwa ukwelapha nokuvimbela i-osteoporosis (isimo lapho amathambo eba mncane futhi abuthakathaka futhi aphuke kalula) kwabesifazane asebedlule esikhathini ('' ushintsho lwempilo, '' ukuphela kwezikhathi zokuya esikhathini) nokwelapha i-osteoporosis emadodeni. I-Alendronate ibuye isetshenziselwe ukwelapha i-osteoporosis emadodeni nakwabesifazane abathatha i-corticosteroids (uhlobo lwemithi engadala i-osteoporosis kwezinye iziguli). I-Alendronate ibuye isetshenziselwe ukwelapha isifo sePaget samathambo (isimo lapho amathambo ethambile futhi ebuthakathaka futhi engahle akhubazeke, abebuhlungu, noma aphuke kalula). I-Alendronate isekilasini lemithi ebizwa ngama-bisphosphonates. Isebenza ngokuvimbela ukuwohloka kwamathambo nokwandisa ukuminyana kwethambo (ukujiya).

I-Alendronate iza njengethebhulethi, ithebhulethi eyi-effervescent, nesisombululo (uketshezi) esizothathwa ngomlomo. Isixazululo ngokuvamile sithathwa esiswini esingenalutho kanye ngesonto ekuseni. Amaphilisi we-5-mg kanye ne-10-mg avame ukuphathwa esiswini esingenalutho kanye ngosuku ekuseni, kanti amaphilisi angama-35-mg kanye nama-70-mg avame ukuphathwa esiswini esingenalutho kanye ngesonto ekuseni. Amathebulethi angama-40-mg avame ukuthathwa kanye ngosuku ekuseni izinyanga eziyisithupha ukwelapha isifo samathambo sikaPaget. Amaphilisi we-effervescent ngokuvamile athathwa esiswini esingenalutho kanye ngesonto ekuseni. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-alendronate njengoba nje kuqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

I-Alendronate ingahle ingasebenzi kahle futhi ingalimaza i-esophagus (ithubhu phakathi komlomo nesisu) noma ibangele izilonda emlonyeni uma ingathathwa ngokwemiyalelo elandelayo. Tshela udokotela wakho uma ungaqondi, awucabangi ukuthi uzokhumbula, noma awukwazi ukulandela le miyalo:

• Kufanele uthathe i-alendronate ngemuva nje kokuvuka embhedeni ekuseni, ngaphambi kokudla noma ukuphuza noma yini. Ungalokothi uthathe i-alendronate ngesikhathi sokulala noma ngaphambi kokuba uvuke futhi uvuke embhedeni wosuku.
• Ngemuva kokuthatha i-alendronate, ungadli, ungaphuzi, noma uthathe noma imiphi eminye imishanguzo (kufaka phakathi amavithamini noma ama-antacids) okungenani imizuzu engama-30. Musa ukulala phansi okungenani imizuzu engama-30 ngemuva kokuthatha i-alendronate. Hlala ume uqonde noma ume mpo kuze kudlule okungenani imizuzu engama-30 bese udle ukudla kwakho kokuqala kosuku.
• Uma uphuza amaphilisi e-alendronate, gwinya ithebhulethi ngengilazi egcwele (ama-ounces ayisithupha kuya kwayi-8 (amalitha angu-180 kuya kwangu-240) wamanzi angenalutho. Ungalokothi uthathe amaphilisi e-alendronate netiye, ikhofi, ujusi, ubisi, amanzi amaminerali, amanzi akhazimulayo, nanoma yiluphi uketshezi ngaphandle kwamanzi angenalutho. Gwinya wonke amaphilisi; ungazihlukanisi, uzihlafune noma uzichoboze. Ungamunci amaphilisi.
• Uma uthatha isisombululo somlomo se-alendronate, phuza okungenani ama-ounces amabili (60 milliliters [1/4 inkomishi]) yamanzi ngemuva kokuthatha isisombululo somlomo se-alendronate. Ungalokothi uthathe isixazululo se-alendronate netiye, ikhofi, ujusi, ubisi, amanzi amaminerali, amanzi akhazimulayo, noma olunye uketshezi ngaphandle kwamanzi alula.
• Uma uthatha amaphilisi e-alendronate effervescent, qeda i-tablet eyodwa e-effervescent engilazini egcwele (amamitha ayi-120) wamanzi okuphuza angenalutho, angenawo umoya ngaphambi kokuphuza. Ungalokothi uqede amaphilisi e-alendronate effervescent netiye, ikhofi, ujusi, ubisi, amanzi amaminerali, amanzi akhazimulayo, noma olunye uketshezi ngaphandle kwamanzi alula. Linda okungenani imizuzu emi-5 ngemuva kokuphela kwe-effervescence, gxuma ikhambi imizuzwana eyi-10 bese uyiphuza. Ungagwinyi, unganceli, noma uhlafune amaphilisi we-effervescent.

I-Alendronate ilawula isifo samathambo nesifo sePaget samathambo kodwa ayizelaphi lezi zimo. Kungathatha izinyanga ezintathu noma ngaphezulu ngaphambi kokuba ukuqina kwamathambo akho kuqale ukwanda. I-Alendronate iyasiza ekwelapheni nasekuvimbeleni i-osteoporosis kuphela uma nje ithathwa njalo. Qhubeka nokuthatha i-alendronate noma ngabe uzizwa uphilile. Ungayeki ukuthatha i-alendronate ngaphandle kokukhuluma nodokotela wakho, kodwa khuluma nodokotela wakho ngezikhathi ezithile mayelana nokuthi ngabe usadinga ukuthatha i-alendronate.

Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi yesiguli.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-alendronate,

• Tshela udokotela wakho kanye nosokhemisi uma une-alendronate noma yimuphi omunye umuthi.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi imishanguzo kadokotela neyokungabhalisi, amavithamini, izithako zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma yikuphi kokulandelayo: i-angiogenesis inhibitors efana ne-bevacizumab (Avastin), everolimus (Afinitor, Zortress), pazopanib (Votrient), sorafenib (Nexavar), noma sunitinib (Sutent); i-aspirin nezinye izidakamizwa ezingezona ukuvuvukala (ama-NSAID) njenge-ibuprofen (Advil, Ibu-Tab, Motrin, abanye) kanye ne-naproxen (Aleve, Naprelan, Naprosyn, abanye); i-chemotherapy yomdlavuza; noma i-oral steroids efana ne-dexamethasone, methylprednisolone (Medrol), ne-prednisone (i-Rayos). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• uma uthatha noma imuphi omunye umuthi kubandakanya izithasiselo, amavithamini, noma ama-antacids ngomlomo, thatha okungenani imizuzu engama-30 ngemuva kokuthatha i-alendronate.
• Tshela udokotela wakho uma ungakwazi ukuhlala uqonde noma ume mpo okungenani imizuzu engama-30, uma ngabe uke waba nezinga eliphansi le-calcium egazini lakho, ingozi yokuphefumula ukudla noma uketshezi emaphashini, noma uma unenkinga ngesisu sakho. Udokotela wakho angakutshela ukuthi akufanele uthathe i-alendronate.
• Tshela udokotela wakho uma uthola ukwelashwa ngemisebe noma uma udla ukudla okunomkhawulo we-sodium (uma uthatha amaphilisi e-effervescent); futhi uma uke waba ne-anemia noma (wake waba nesimo lapho amangqamuzana abomvu egazi engalethi umoya-mpilo owenele kuzo zonke izingxenye zomzimba); izinga eliphansi levithamini D emzimbeni wakho; ubunzima bokugwinya; isilungulela; izilonda noma ezinye izinkinga zesisu; umdlavuza; noma yiluphi uhlobo lokutheleleka, ikakhulukazi emlonyeni wakho; izinkinga ngomlomo wakho, ngamazinyo, noma ngezinsini noma yisiphi isimo esivimba igazi lakho ekunqandeni ngokujwayelekile; noma isifo samazinyo noma sezinso.
• tshela udokotela wakho uma ukhulelwe noma uncelisa. Tshela nodokotela wakho uma uhlela ukukhulelwa nganoma yisiphi isikhathi ngokuzayo, ngoba i-alendronate ingahlala emzimbeni wakho iminyaka ngemuva kokuyeka ukuyithatha. Shayela udokotela wakho uma ukhulelwa ngesikhathi noma ngemuva kokwelashwa kwakho.
• kufanele wazi ukuthi i-alendronate ingadala i-osteonecrosis yomhlathi (i-ONJ, isimo esibi sethambo lomhlathi), ikakhulukazi uma uhlinzwa noma ukwelashwa ngenkathi uthatha umuthi. Udokotela wamazinyo kufanele ahlole amazinyo akho futhi enze noma yiziphi izindlela zokwelashwa ezidingekayo, kufaka phakathi ukuhlanza noma ukulungisa amazinyo okufakelwa angalungile, ngaphambi kokuba uqale ukuthatha i-alendronate. Qiniseka ukuthi uxubha amazinyo futhi uhlanza umlomo wakho kahle ngenkathi uthatha i-alendronate. Khuluma nodokotela wakho ngaphambi kokuthola noma yikuphi ukwelashwa kwamazinyo ngenkathi uthatha lo muthi.
• kufanele wazi ukuthi i-alendronate ingadala ubuhlungu obukhulu bethambo, imisipha, noma amalunga. Ungaqala ukuzwa lobu buhlungu kungakapheli izinsuku, izinyanga, noma iminyaka ngemuva kokuqala ukuthatha i-alendronate. Yize lolu hlobo lobuhlungu lungaqala ngemuva kokuthi uthathe i-alendronate isikhathi esithile, kubalulekile ukuthi wena nodokotela wakho nazi ukuthi kungabangelwa yi-alendronate. Shayela udokotela wakho khona manjalo uma uzwa ubuhlungu obukhulu noma kunini ngesikhathi sokwelashwa kwakho ne-alendronate. Udokotela wakho angakutshela ukuthi uyeke ukuthatha i-alendronate futhi ubuhlungu bakho bungaphela ngemuva kokuyeka ukuthatha umuthi.
• khuluma nodokotela wakho ngezinye izinto ongazenza ukuvimbela ukukhumuzeka kwamathambo ekukhuleni noma ekukhuleni. Udokotela wakho mhlawumbe uzokutshela ukuthi ugweme ukubhema nokuphuza utshwala obuningi futhi ulandele uhlelo olujwayelekile lokuzivocavoca umzimba.

Kufanele udle futhi uphuze ukudla okuningi neziphuzo ezicebile nge-calcium novithamini D ngenkathi uthatha i-alendronate. Udokotela wakho uzokutshela ukuthi yikuphi ukudla neziphuzo okungumthombo omuhle walezi zinongo nokuthi zingaki izinsizakalo ozidingayo usuku ngalunye. Uma ukuthola kunzima ukudla okwanele kulokhu kudla, tshela udokotela wakho. Uma kunjalo, udokotela wakho angakunikeza noma ancome ukuthi kufakwe isengezo.

Uma uphuthelwa umthamo we-alendronate kanye-nsuku zonke, ungathathi ngokuhamba kosuku. Yeqa umthamo ophuthelwe uthathe umthamo owodwa ekuseni ngakusasa njengenjwayelo. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

Uma uphuthelwa umthamo we-alendronate kanye ngesonto, thatha umthamo ekuseni ngemuva kokukhumbula. Bese ubuyela ekuthatheni umthamo owodwa kanye ngesonto ngosuku lwakho oluhleliwe njalo. Ungalokothi uthathe umthamo ophindwe kabili ukwenzela okulahlekile, futhi ungalokothi uthathe umthamo ongaphezu kowodwa ngosuku olulodwa.

I-Alendronate ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• isicanucanu
• ubuhlungu besisu
• ukuqunjelwa
• isifo sohudo
• igesi
• ukuqunjelwa noma ukugcwala esiswini
• shintsha emandleni okunambitha ukudla
• ikhanda
• isiyezi
• ukuvuvukala kwamalunga, izandla, noma imilenze
• ukuphazamiseka kwemisipha, ukudikiza, noma amajaqamba

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nanoma yiziphi kulezi zimpawu ezilandelayo noma lezo ezibalwe esigabeni SOKUQAPHA OKUKHETHEKILE, shayela udokotela wakho ngokushesha ngaphambi kokuba uthathe enye i-alendronate:

• isilungulela esisha noma esiba sibi kakhulu
• ubunzima bokugwinya
• ubuhlungu ngokugwinya
• ubuhlungu besifuba
• Ukuhlanza okunegazi noma ukugabha okubukeka njengezindawo zekhofi
• okumnyama, okulindile, noma okokuchitha okunegazi
• imfiva
• amabhamuza noma isikhumba esixobukayo
• ukuqhuma (kungenziwa kube kubi kakhulu ngokukhanya kwelanga)
• ukulunywa
• isifuba
• ukuvuvukala kwamehlo, ubuso, izindebe, ulimi, noma umphimbo
• ukuphefumula kanzima
• ukushaqeka
• izinsini ezibuhlungu noma ezivuvukele
• ukukhululeka kwamazinyo
• ukuba ndikindiki noma ukuzwa okusindayo emhlathini
• ukwelashwa kabi komhlathi
• ubuhlungu beso
• ubuhlungu obubuhlungu, obuhlungu ezinqulwini, emgodini, noma emathangeni

Ukuthatha imithi ye-bisphosphonate efana ne-alendronate ye-osteoporosis kungakhuphula ubungozi bokuthi uzophula amathambo akho ethanga. Ungabuzwa ubuhlungu okhalweni lwakho, emgodini, noma emathangeni amasonto ambalwa noma izinyanga ngaphambi kokuphuka kwamathambo, futhi ungathola ukuthi elilodwa noma womabili amathambo akho ethanga aphukile yize ungazange uwe noma wehlelwe okunye ukuhlukumezeka. Akujwayelekile ukuthi ithambo lamathanga liphuke kubantu abaphilile, kepha abantu abane-osteoporosis bangalimaza leli thambo noma ngabe bengathathi i-alendronate. Khuluma nodokotela wakho ngezingozi zokuthatha i-alendronate.

I-Alendronate ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese). Ungafaki isixazululo se-alendronate.

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, nikeza isisulu ingilazi egcwele yobisi bese ushayela isikhungo sendawo sakho sokulawula ubuthi ku-1-800-222-1222. Uma isisulu siwile noma singaphefumuli, shayela abezimo eziphuthumayo zendawo ku-911. Ungavumeli isisulu ukuba silale phansi futhi ungazami ukwenza isisulu sihlanze.

Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

• isilungulela
• isicanucanu
• ubuhlungu besisu
• Ukuhlanza okunegazi noma ukugabha okubukeka njengezindawo zekhofi
• ubunzima bokugwinya noma ubuhlungu lapho ugwinya
• indle enegazi noma emnyama neyokulinda

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho angalawula izivivinyo ezithile zebhu ukuze ahlole impendulo yomzimba wakho ku-alendronate.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• IBinosto^®
• I-Fosamax^®

• I-Fosamax^® I-Plus D (equkethe i-Alendronate, iCholecalciferol)