Inaliti yeDarbepoetin Alfa

-Delile

• Ngaphambi kokusebenzisa umjovo we-darbepoetin alfa,
• Umjovo we-Darbepoetin alfa ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nalezi zimpawu ezilandelayo, noma lezo ezibalwe esigabeni ESIBALULEKILE SESEXWAYISO, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

Zonke iziguli:

Sebenzisa umjovo we-darbepoetin alfa kwandisa ubungozi bokuthi amahlule egazi akhe noma ahambele emilenzeni, emaphashini, noma ebuchosheni. Tshela udokotela wakho uma uke waba nesifo senhliziyo noma wake wahlaselwa yisifo sohlangothi. Shayela udokotela wakho ngokushesha noma uthole usizo oluphuthumayo lwezokwelapha uma uhlangabezana nalezi zimpawu ezilandelayo: ubuhlungu, ubumnene, ubomvu, ukufudumala, kanye / noma ukuvuvukala emilenzeni; ukuphola noma ukuphaphatheka engalweni noma emlenzeni; ukuphelelwa umoya; ukukhwehlela okungeke kuphele noma okuletha igazi; ubuhlungu besifuba; inkathazo engazelelwe yokukhuluma noma ukuqonda inkulumo; ukudideka okungazelelwe; ubuthakathaka obungazelelwe noma ukuba ndikindiki kwengalo noma umlenze (ikakhulukazi ohlangothini olulodwa lomzimba) noma kobuso; ukuhamba ngokungazelelwe ukuhamba, isiyezi, noma ukulahlekelwa ibhalansi noma ukuxhumanisa; noma ukuquleka. Uma welashwa nge-hemodialysis (ukwelashwa ukususa udoti egazini lapho izinso zingasebenzi), ihlule legazi lingakheka ekufinyeleleni kwakho kwemithambo (indawo lapho ishubhu le-hemodialysis lixhuma khona emzimbeni wakho). Tshela udokotela wakho uma ukufinyelela kwakho kwe-vascular kuyeka ukusebenza njengokujwayelekile.

Udokotela wakho uzolungisa umthamo wakho womjovo we-darbepoetin alfa ukuze izinga lakho le-hemoglobin (inani lamaprotheni atholakala kumaseli abomvu egazi) liphakeme nje ngokwanele ukuthi awudingi ukumpontshelwa amaseli abomvu egazi (ukudluliselwa kwamaseli abomvu egazi lomuntu komunye umzimba womuntu ukwelapha i-anemia enamandla). Uma uthola i-darbepoetin alfa eyanele yokwandisa i-hemoglobin yakho iye ezingeni elijwayelekile noma eliseduze, kunengozi enkulu yokuthi uzohlaselwa yisifo sohlangothi noma ube nezinkinga zenhliziyo ezinkulu noma ezisongela ukuphila kubandakanya ukuhlaselwa yinhliziyo, nokwehluleka kwenhliziyo. Shayela udokotela wakho ngokushesha noma uthole usizo oluphuthumayo lwezokwelapha uma uhlangabezana nalezi zimpawu ezilandelayo: ubuhlungu besifuba, ukucindezela ukucindezela, noma ukuqina; ukuphelelwa umoya; isicanucanu, ikhanda elikhanyayo, ukujuluka, nezinye izimpawu zokuqala zesifo senhliziyo; ukungakhululeki noma ubuhlungu ezingalweni, ehlombe, entanyeni, emihlathini, noma emuva; noma ukuvuvukala kwezandla, izinyawo, noma amaqakala.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile zelebhu ukuze ahlole impendulo yomzimba wakho kumjovo we-darbepoetin alfa. Udokotela wakho anganciphisa umthamo wakho noma akutshele ukuthi uyeke ukusebenzisa umjovo we-darbepoetin alfa isikhathi esithile uma ukuhlolwa kukhombisa ukuthi usengozini enkulu yokuthola imiphumela emibi kakhulu. Landela izinkomba zikadokotela wakho ngokucophelela.

Udokotela wakho noma usokhemisi uzokunikeza ishidi lemininingwane yesiguli lomkhiqizi (Umhlahlandlela Wokwelashwa) lapho uqala ukwelashwa nge-darbepoetin alfa futhi isikhathi ngasinye lapho ugcwalisa khona incwadi kadokotela. Funda imininingwane ngokucophelela bese ubuza udokotela noma usokhemisi wakho uma unemibuzo. Ungavakashela futhi iwebhusayithi ye-Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) noma iwebhusayithi yomkhiqizi ukuthola i-Medication Guide.

Khuluma nodokotela wakho ngezingozi zokusebenzisa umjovo we-darbepoetin alfa.

Iziguli ezinomdlavuza:

Ezifundweni zomtholampilo, abantu abanomdlavuza othile abathole umjovo we-darbepoetin alfa bafa ngokushesha noma baba nokukhula kwesimila, ukubuya komdlavuza wabo, noma umdlavuza owasabalala ngokushesha kunabantu abangawutholanga umuthi. Uma unomdlavuza, kufanele uthole isilinganiso esiphansi kakhulu somjovo we-darbepoetin alfa. Kufanele uthole umjovo we-darbepoetin alfa kuphela ukwelapha i-anemia ebangelwa i-chemotherapy uma i-chemotherapy yakho kulindeleke ukuthi iqhubeke okungenani izinyanga ezimbili ngemuva kokuqala ukwelashwa ngomjovo we-darbepoetin alfa futhi uma lingekho ithuba lokuthi umdlavuza wakho uzokwelashwa. Ukwelashwa ngomjovo we-darbepoetin alfa kufanele kumiswe lapho inkambo yakho yamakhemikhali iphela.

Uhlelo olubizwa nge-ESA APPRISE Oncology Programme selusungulwe ukunciphisa ubungozi bokusebenzisa umjovo we-darbepoetin alfa ukwelapha i-anemia edalwa ngamakhemikhali. Udokotela wakho uzodinga ukuqedela ukuqeqeshwa futhi abhalise kulolu hlelo ngaphambi kokuthi uthole umjovo we-darbepoetin alfa. Njengengxenye yalolu hlelo, uzothola imininingwane ebhaliwe mayelana nezingozi zokusebenzisa umjovo we-darbepoetin alfa futhi kuzodingeka usayine ifomu ngaphambi kokuthola umuthi ukukhombisa ukuthi udokotela wakho uxoxe nawe ngezingozi zomjovo we-darbepoetin alfa. Udokotela wakho uzokunikeza imininingwane ethe xaxa ngalolu hlelo futhi uzokuphendula noma imiphi imibuzo onayo ngalolu hlelo nangokwelapha kwakho ngomjovo we-darbepoetin alfa.

Umjovo we-Darbepoetin alfa usetshenziselwa ukwelapha i-anemia (okuyinani elingaphansi kwenani elijwayelekile lamaseli abomvu egazi) kubantu abanesifo sezinso esingalapheki (isimo lapho izinso ziyeka ukusebenza unomphela isikhathi eside). Umjovo we-Darbepoetin alfa nawo usetshenziselwa ukwelapha i-anemia edalwa ukwelashwa ngamakhemikhali kubantu abanezinhlobo ezithile zomdlavuza. IDarbepoetin alfa ayinakusetshenziswa esikhundleni sokufakwa kwegazi elibomvu ukwelapha i-anemia enamandla futhi ayikhonjiswanga ukuthi ithuthukisa ukukhathala noma inhlalakahle engabangelwa yi-anemia. UDarbepoetin alfa usesigabeni semithi ebizwa ngama-erythropoiesis-stimulating agents (ESAs). Isebenza ngokubangela umnkantsha (izicubu ezithambile ngaphakathi kwamathambo lapho kwenziwa khona igazi) ukwenza amangqamuzana egazi abomvu amaningi.

Umjovo we-Darbepoetin alfa uza njengesisombululo (uketshezi) ukujova ngomgogodla (ngaphansi kwesikhumba) noma ngemithambo (emthanjeni). Kuvamise ukujova kanye njalo emavikini ayi-1 kuya kwayi-4. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Sebenzisa umjovo we-darbepoetin alfa njengoba uqondisiwe. Ungayisebenzisi ngaphezulu noma ngaphansi kwayo noma uyisebenzise kaningi kunokuyalelwa ngudokotela wakho.

Udokotela wakho uzokuqala ngomthamo ophansi womjovo we-darbepoetin alfa futhi alungise umthamo wakho kuye ngemiphumela yakho yelabhu nokuthi uzizwa kanjani. Udokotela wakho futhi angakutshela ukuthi uyeke ukusebenzisa umjovo we-darbepoetin alfa isikhashana. Landela le miyalo ngokucophelela.

Umjovo we-Darbepoetin alfa uzosiza ukulawula i-anemia kuphela uma nje uqhubeka nokuyisebenzisa. Kungathatha amasonto ama-2-6 noma ngaphezulu ngaphambi kokuba uzwe inzuzo ephelele yomjovo we-darbepoetin alfa. Qhubeka nokusebenzisa umjovo we-darbepoetin alfa noma ngabe uzizwa uphilile. Ungayeki ukusebenzisa umjovo we-darbepoetin alfa ngaphandle kokukhuluma nodokotela wakho.

Imijovo ye-Darbepoetin alfa inganikezwa udokotela noma umhlengikazi, noma udokotela wakho anganquma ukuthi ungazijova ngokwakho i-darbepoetin alfa, noma ukuthi ungaba nomngane noma isihlobo esinika imijovo. Wena kanye nomuntu ozofaka imijovo kufanele ufunde imininingwane yomkhiqizi yesiguli esiza nomjovo we-darbepoetin alfa ngaphambi kokuyisebenzisa okokuqala ekhaya. Cela udokotela wakho akukhombise noma umuntu ozojova umuthi ukuthi ungawujova kanjani.

Umjovo we-Darbepoetin alfa ufika ngemijovo ekhethiwe nakumabhodlela okuzosetshenziswa ngemijovo elahlwayo. Uma usebenzisa izigaxa zomjovo we-darbepoetin alfa, udokotela wakho noma usokhemisi uzokutshela ukuthi yiluphi uhlobo lwesirinji okufanele ulusebenzise. Ungasebenzisi noma yiluphi olunye uhlobo lwesipontsho ngoba kungenzeka ungatholi inani elifanele lemithi.

Unganyakazisi umjovo we-darbepoetin alfa. Uma unyakazisa umjovo we-darbepoetin alfa kungahle kubukeke sengathi kunamagwebu futhi akufanele kusetshenziswe.

Hlala ujove umjovo we-darbepoetin alfa kusirinji yawo. Ungayilinganisi nganoma yiluphi uketshezi futhi ungayixube neminye imithi.

Ungafaka umjovo we-darbepoetin alfa nomaphi endaweni engaphandle yezingalo zakho ezingaphezulu, isisu sakho ngaphandle kwendawo yamasentimitha ama-2 (5-centimeter) ezungeze inkaba yakho (inkinobho yesisu), ingaphambili lamathanga akho aphakathi, nezindawo ezingaphezulu ezingaphandle ezinqeni zakho. Khetha indawo entsha njalo lapho ujova i-darbepoetin alfa. Ungafaki i-darbepoetin alfa endaweni ethambile, ebomvu, elimele, noma eqinile, noma enezibazi noma amamaki okwelula.

Uma welashwa nge-dialysis (imishanguzo yokususa imfucuza egazini lapho izinso zingasebenzi), udokotela wakho angakutshela ukuthi ujove umuthi ethekwini lakho lokungena elinemithambo (indawo lapho i-dialysis tubing ixhunywe emzimbeni wakho). Buza udokotela wakho uma unemibuzo mayelana nokuthi ungayijova kanjani imithi yakho.

Njalo bheka isisombululo somjovo we-darbepoetin alfa ngaphambi kokusijova. Qiniseka ukuthi isirinji noma igabha oyikhethile ifakwe ilebula elinegama elifanele namandla emithi kanye nosuku lokuphelelwa yisikhathi olungadlulanga. Uma usebenzisa i-vial, hlola ukuze uqiniseke ukuthi inekepisi elinombala, futhi uma usebenzisa isipetu esivele sigcwalisiwe, hlola ukuthi inaliti imbozwe ngesembozo esimpunga nokuthi umkhono wepulasitiki ophuzi awudonselwanga ngenaliti . Futhi hlola ukuthi isisombululo sicacile futhi asinambala futhi asiqukethe izigaxa, ama-flakes, noma izinhlayiya. Uma kunezinkinga ngemithi yakho, shayela usokhemisi wakho futhi ungayijovi.

Ungasebenzisi imijovo ekhethiwe, imijovo elahlwayo, noma izitsha zomjovo we-darbepoetin alfa ngaphezu kwesikhathi esisodwa. Lahla imijovo esetshenzisiwe esitsheni esingamelana nokubhoboza. Buza udokotela wakho noma usokhemisi ukuthi ungasilahla kanjani isitsha esingamelana nokubhoboza.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokusebenzisa umjovo we-darbepoetin alfa,

• Tshela udokotela kanye nosokhemisi wakho uma une-aleji ku-darbepoetin alfa, i-epoetin alfa (i-Epogen, i-Procrit), noma imuphi omunye umuthi, noma iziphi izithako zomjovo we-darbepoetin alfa.Buza usokhemisi wakho noma uhlole Umhlahlandlela Wezokwelapha ukuthola uhlu lwezithako. Uma uzosebenzisa imijovo oyikhethile, tshela udokotela wakho uma wena noma umuntu ozojova umuthi unalesi sifo ku-latex.
• Tshela udokotela wakho uma uke waba nomfutho wegazi ophakeme noma uke waba ne-red cell aplasia (PRCA; uhlobo lwe-anemia enamandla engahle iqhamuke ngemuva kokwelashwa nge-ESA efana ne-darbepoetin alfa injection noma i-epoetin alfa injection). Udokotela wakho angakutshela ukuthi ungasebenzisi umjovo we-darbepoetin alfa.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi imishanguzo kadokotela neyokungabhalisi, amavithamini, izithako zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• utshele udokotela wakho uma uke wahlaselwa yisifo sokuwa noma wake waquleka. Uma usebenzisa umjovo we-darbepoetin alfa ukwelapha i-anemia ebangelwa yisifo sezinso esingalapheki, tshela udokotela wakho uma uke waba nomdlavuza noma wake waba nawo.
• tshela udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uncelisa. Uma ukhulelwa ngenkathi usebenzisa umjovo we-darbepoetin alfa, shayela udokotela wakho.
• ngaphambi kokuhlinzwa, kufaka phakathi ukuhlinzwa kwamazinyo, tshela udokotela noma udokotela wamazinyo ukuthi welashwa ngomjovo we-darbepoetin alfa. Kubaluleke kakhulu ukutshela udokotela wakho ukuthi usebenzisa umjovo we-darbepoetin alfa uma ngabe uhlinzekwa ngomthambo we-coronary bypass graft (CABG) ukwelapha inkinga yethambo. Udokotela wakho angakunika i-anticoagulant ('blood thinner') ukuvimbela amahlule ukuba akhe ngesikhathi sokuhlinzwa.

Udokotela wakho angakunikeza ukudla okukhethekile ukusiza ukulawula umfutho wegazi lakho nokusiza ukukhuphula amazinga akho wensimbi ukuze umjovo we-darbepoetin alfa usebenze kahle ngangokunokwenzeka. Landela lezi zinkomba ngokucophelela bese ubuza udokotela wakho noma udokotela wezokudla uma unemibuzo.

Shayela udokotela wakho akubuze ukuthi wenzeni uma uphuthelwa umthamo womjovo we-darbepoetin alfa. Ungasebenzisi umthamo ophindwe kabili ukwenza okulahlekile.

Umjovo we-Darbepoetin alfa ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ukukhwehlela
• ubuhlungu besisu
• ububomvu, ukuvuvukala, ukulimaza, ukulunywa, noma isigaxa lapho wajova khona i-darbepoetin alfa

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nalezi zimpawu ezilandelayo, noma lezo ezibalwe esigabeni ESIBALULEKILE SESEXWAYISO, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• ukuqubuka
• ukulunywa
• ukuphefumula kanzima noma ukugwinya
• isifuba
• ukushaqeka
• ukuvuvukala kobuso, umphimbo, ulimi, izindebe, amehlo, izandla, izinyawo, amaqakala noma imilenze engezansi
• ishayela ngokushesha
• ukukhathala ngokweqile
• ukungabi namandla
• isiyezi
• ukuquleka
• isikhumba esiphaphathekile

Umjovo we-Darbepoetin alfa ungadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile noma ungazizwa kahle ngenkathi usebenzisa lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi ebhokisini efike kuyo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Lapho nje isirinji noma isirinji ekhethiwe seyikhishiwe ebhokisini layo, yigcine imboziwe ukuyivikela ekukhanyeni kwegumbi kuze kube yilapho kunikezwa umthamo. Gcina umjovo we-darbepoetin alfa esiqandisini, kepha ungawumisi. Lahla noma imuphi umuthi ofriziwe.

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Gcina wonke ama-aphoyintimenti nodokotela wakho. Udokotela wakho uzoqapha umfutho wegazi lakho kaningi ngesikhathi sokwelashwa kwakho ngomjovo we-darbepoetin alfa.

Ngaphambi kokwenza noma yiluphi uvivinyo lwelabhoratri, tshela udokotela wakho kanye nabasebenzi belebhuthi ukuthi usebenzisa umjovo we-darbepoetin alfa.

Ungavumeli omunye umuntu asebenzise imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• I-Aranesp^®