Injection ye-infliximab

-Delile

• Imikhiqizo yomjovo we-infliximab isetshenziselwa ukukhulula izimpawu zezifo ezithile ezizimele (izimo lapho amasosha omzimba ehlasela khona izingxenye ezinempilo zomzimba futhi abangele ubuhlungu, ukuvuvukala nokulimala) kufaka phakathi:
• Ngaphambi kokusebenzisa umkhiqizo womjovo we-infliximab,
• Imikhiqizo yomjovo we-infliximab ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Lezi zimpawu ezilandelayo azivamile, kepha uma uhlangabezana nenye yazo, noma lezo ezibalwe KUSEXWAYISO ESIBALULEKILE noma ezingxenyeni ezikhethekile zokuqapha, shayela udokotela wakho ngokushesha:

Umjovo we-infliximab, umjovo we-infliximab-dyyb, kanye nomjovo we-infliximab-abda yimithi ye-biologic (imithi eyenziwe ngezinto eziphilayo). Umjovo we-Biosimilar infliximab-dyyb nomjovo we-infliximab-abda ufana kakhulu nomjovo we-infliximab futhi usebenza ngendlela efanayo nomjovo we-infliximab emzimbeni. Ngakho-ke, igama elithi imikhiqizo yomjovo we-infliximab lizosetshenziselwa ukumela le mithi kule ngxoxo.

Imikhiqizo yomjovo we-infliximab inganciphisa ikhono lakho lokulwa nokutheleleka futhi yenyuse ubungozi bokuthi uthole ukutheleleka okungathi sína, kufaka phakathi ukutheleleka okunzima ngegciwane, amagciwane noma ukhunta okungasabalala emzimbeni wonke. Lezi zifo zingadinga ukwelashwa esibhedlela futhi zingadala nokufa. Tshela udokotela wakho uma uvame ukuthola noma yiluphi uhlobo lokutheleleka noma uma ucabanga ukuthi ungaba nanoma yiluphi uhlobo lokutheleleka manje. Lokhu kufaka ukutheleleka okuncane (njengokusikeka okuvulekile noma izilonda), izifo ezifika zidlule (njengezilonda ezibandayo) kanye nezifo ezingamahlalakhona ezingapheli. Phinda utshele udokotela wakho uma unesifo sikashukela noma yisiphi isimo esithinta amasosha akho omzimba futhi uma uhlala noma owake wahlala ezindaweni ezinjengezigodi zemifula i-Ohio noma iMississippi lapho ukutheleleka okunzima kwefungal kuvame kakhulu. Buza udokotela wakho uma ungazi ukuthi izifo zivame kakhulu yini endaweni yangakini. Phinda utshele udokotela wakho uma uthatha imishanguzo eyehlisa ukusebenza kwamasosha omzimba njenge-abatacept (Orencia); anakinra (Kineret); i-methotrexate (i-Otrexup, i-Rasuvo, i-Trexall, i-Xatmep); ama-steroids afana ne-dexamethasone, i-methylprednisolone (Medrol), i-prednisolone (i-Orapred ODT, i-Pediapred, i-Prelone), noma i-prednisone; noma i-tocilizumab (Actemra).

Udokotela wakho uzokuqapha ngezibonakaliso zokutheleleka ngesikhathi nangemva nje kokwelapha kwakho. Uma unezinye zalezi zimpawu ezilandelayo ngaphambi kokuba uqale ukwelashwa kwakho noma uma uhlangabezana nalezi zimpawu ezilandelayo ngesikhathi noma ngemuva nje kokwelapha kwakho, shayela udokotela wakho ngokushesha: ubuthakathaka; ukujuluka; ukuphefumula kanzima; Umphimbo obuhlungu; ukukhwehlela; ukukhwehlela amafinyila anegazi; imfiva; ukukhathala ngokweqile; izimpawu ezinjengomkhuhlane; isikhumba esifudumele, esibomvu, noma esibuhlungu; isifo sohudo; ubuhlungu besisu; noma ezinye izimpawu zokutheleleka.

Ungahle utheleleke ngesifo sofuba (i-TB, ukutheleleka okukhulu kwamaphaphu) noma i-hepatitis B (igciwane elithinta isibindi) kodwa ungabi nazimpawu zesifo. Kulokhu, imikhiqizo yomjovo we-infliximab ingakhuphula ubungozi bokuthi ukutheleleka kwakho kube kubi kakhulu futhi uzoba nezimpawu. Udokotela wakho uzokwenza ukuhlolwa kwesikhumba ukuze abone ukuthi unesifo se-TB esingasebenzi yini futhi anga-oda ukuhlolwa kwegazi ukubona ukuthi unesifo se-hepatitis B esingasebenzi yini. Uma kunesidingo, udokotela wakho uzokunika imithi yokwelapha lesi sifo ngaphambi kokuba uqale ukusebenzisa umkhiqizo womjovo we-infliximab. Tshela udokotela wakho uma uke waba ne-TB noma wake waba nayo, uma wake wahlala noma wavakashela indawo lapho i-TB ijwayeleke khona, noma uma wake waba seduze komuntu one-TB. Uma unezinye zalezi zimpawu ze-TB ezilandelayo, noma uma uba nalezi zimpawu phakathi nokwelashwa kwakho, shayela udokotela wakho ngokushesha: ukukhwehlela, ukwehla kwesisindo, ukulahleka kwethoni yemisipha, umkhuhlane noma ukujuluka ebusuku. Phinda ushayele udokotela wakho ngokushesha uma unanoma iyiphi yalezi zimpawu zesifo sokusha kwesibindi kohlobo B noma uma uba nanoma yiziphi zalezi zimpawu ngesikhathi noma ngemuva kokwelashwa kwakho: ukukhathala ngokweqile, ukuphuzi kwesikhumba noma kwamehlo, ukulahlekelwa isifiso sokudla, isicanucanu noma ukuhlanza, izinhlungu zemisipha, umchamo omnyama, ukuhamba kwamathumbu anombala wobumba, umkhuhlane, amakhaza, ubuhlungu besisu, noma ukuqubuka.

Ezinye izingane, intsha, nabantu abadala abasebancane abathole umkhiqizo womjovo we-infliximab noma imishanguzo efanayo baba nomdlavuza onzima noma osongela ukuphila kubandakanya i-lymphoma (umdlavuza oqala kumaseli alwa nokutheleleka). Abanye besilisa nabasakhulile abesilisa abathathe umkhiqizo we-infliximab noma imishanguzo efanayo bakhulisa i-hepatosplenic T-cell lymphoma (HSTCL), uhlobo lomdlavuza olubi kakhulu oluvame ukubulala esikhathini esifushane.Iningi labantu abathuthukise i-HSTCL babelashelwa isifo sikaCrohn (isimo lapho umzimba uhlasela ulwelwesi lwendlela yokugaya, kubangela ubuhlungu, isifo sohudo, ukuncipha komzimba nomkhuhlane) noma i-ulcerative colitis (isimo esidala ukuvuvukala nezilonda. ulwelwesi lwekholoni [amathumbu amakhulu] ne-rectum) ngomkhiqizo womjovo we-infliximab noma umuthi ofanayo kanye nomunye umuthi obizwa nge-azathioprine (Azasan, Imuran) noma u-6-mercaptopurine (Purinethol, Purixan). Tshela udokotela wengane yakho uma ingane yakho yake yaba nohlobo oluthile lomdlavuza. Uma ingane yakho iba nalezi zimpawu phakathi nokwelashwa kwayo, shayela udokotela wayo ngokushesha: ukuncipha kwesisindo okungachazeki; izindlala ezivuvukile entanyeni, ngaphansi kwekhwapha, noma emgodini; noma ukulimaza okulula noma ukopha. Khuluma nodokotela wengane yakho mayelana nezingozi zokunikeza umkhiqizo womjovo we-infliximab enganeni yakho.

Udokotela wakho noma usokhemisi uzokunikeza ishidi lemininingwane yesiguli lomkhiqizi (Umhlahlandlela Wezokwelapha) lapho uqala ukwelashwa ngomkhiqizo womjovo we-infliximab futhi isikhathi ngasinye uthola umuthi. Funda imininingwane ngokucophelela bese ubuza udokotela noma usokhemisi wakho uma unemibuzo. Ungavakashela futhi iwebhusayithi ye-Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) noma iwebhusayithi yomkhiqizi ukuthola i-Medication Guide.

Khuluma nodokotela wakho ngezingozi zokusebenzisa umkhiqizo womjovo we-infliximab.

Imikhiqizo yomjovo we-infliximab isetshenziselwa ukukhulula izimpawu zezifo ezithile ezizimele (izimo lapho amasosha omzimba ehlasela khona izingxenye ezinempilo zomzimba futhi abangele ubuhlungu, ukuvuvukala nokulimala) kufaka phakathi:

• i-rheumatoid arthritis (isimo lapho umzimba uhlasela khona amalunga ayo, ubangele ubuhlungu, ukuvuvukala, nokulahleka komsebenzi) nalo elashwa nge-methotrexate (Rheumatrex, Trexall),
• Isifo sikaCrohn (isimo lapho umzimba uhlasela ulwelwesi lomgudu wokugaya ukudla, ubangele ubuhlungu, isifo sohudo, ukwehla kwesisindo, nomkhuhlane) kubantu abadala nezingane ezineminyaka engu-6 noma ngaphezulu ezingakathuthuki lapho ziphathwa ngeminye imithi,
• i-ulcerative colitis (isimo esidala ukuvuvukala nezilonda kulwelwesi lwamathumbu amakhulu) kubantu abadala nezingane ezineminyaka engu-6 noma ngaphezulu ezingazange zithuthuke lapho ziphathwa ngeminye imithi,
• i-ankylosing spondylitis (isimo lapho umzimba uhlasela khona amalunga omgogodla nezinye izindawo okubangela ubuhlungu nokulimala ngokuhlanganyela),
• i-plaque psoriasis (isifo sesikhumba lapho kwakhiwa khona amabala abomvu, anezikhala ezindaweni ezithile zomzimba) kubantu abadala lapho ezinye izindlela zokwelapha zingafaneleki kahle,
• kanye ne-psoriatic arthritis (isimo esidala ubuhlungu bamalunga nokuvuvukala nezikali esikhunjeni).

Imikhiqizo yomjovo we-infliximab isekilasini lemithi ebizwa nge-tumor necrosis factor-alpha (TNF-alpha) inhibitors. Basebenza ngokuvimba isenzo se-TNF-alpha, into esemzimbeni ebangela ukuvuvukala.

Imikhiqizo yomjovo we-infliximab iza njengempuphu ezoxutshwa namanzi oyinyumba futhi ifakwe ngomjovo (emthanjeni) ngudokotela noma unesi. Imvamisa inikezwa ehhovisi likadokotela kanye njalo emavikini amabili kuya kwayisishiyagalombili, kaningi ekuqaleni kokwelashwa kwakho futhi kaningi njengoba ukwelashwa kwakho kuqhubeka. Kuzothatha cishe amahora amabili ukuthi uthole wonke umthamo wakho we-infliximab, umkhiqizo womjovo.

Imikhiqizo yomjovo we-infliximab ingadala ukusabela okubi kakhulu, kufaka phakathi ukusabela okweqile ngesikhathi sokumnika kanye namahora amabili ngemuva kwalokho. Udokotela noma umhlengikazi uzokuqapha ngalesi sikhathi ukuze aqiniseke ukuthi awunampendulo ebucayi emithini. Unganikezwa eminye imithi yokwelapha noma yokuvimbela ukusabela kumkhiqizo womjovo we-infliximab. Tshela udokotela wakho noma umhlengikazi ngokushesha uma uhlangabezana nalezi zimpawu ezilandelayo ngesikhathi noma ngemuva nje kokumnika kwakho: isifuba; ukuqubuka; ukulunywa; ukuvuvukala kobuso, amehlo, umlomo, umphimbo, ulimi, izindebe, izandla, izinyawo, amaqakala, noma imilenze engezansi; ubunzima bokuphefumula noma ukugwinya; ukuqhuma; isiyezi; ukuquleka; imfiva; Ukugodola; ukuquleka; ukulahleka kombono; nobuhlungu besifuba.

Imikhiqizo yomjovo we-infliximab ingasiza ekulawuleni izimpawu zakho, kepha ngeke iselaphe isimo sakho. Udokotela wakho uzokubuka ngokucophelela ukubona ukuthi imikhiqizo yokujova ye-infliximab ikusebenzela kanjani. Uma unesifo samathambo noma isifo sikaCrohn, udokotela wakho angakhuphula inani lemithi oyitholayo, uma kudingeka. Uma unesifo sikaCrohn futhi isimo sakho singakathuthuki ngemuva kwamasonto e-14, udokotela wakho angayeka ukukuphatha ngomkhiqizo womjovo we-infliximab. Kubalulekile ukutshela udokotela wakho ukuthi uzizwa kanjani ngesikhathi sokwelashwa kwakho.

Imikhiqizo yomjovo we-infliximab nayo kwesinye isikhathi isetshenziselwa ukwelapha i-Behcet's syndrome (izilonda emlonyeni nasemalungwini ezitho zangasese nokuvuvukala kwezingxenye ezahlukahlukene zomzimba). Khuluma nodokotela wakho mayelana nezingozi zokusebenzisa lo muthi ngesimo sakho.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokusebenzisa umkhiqizo womjovo we-infliximab,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-infliximab, infliximab-axxq, infliximab-dyyb, infliximab-abda, noma imiphi imithi eyenziwe ngamaprotheni e-murine (igundane), noma imiphi eminye imithi, noma iziphi izithako ku-infliximab, infliximab-dyyb, noma umjovo we-infliximab-abda. Buza udokotela noma usokhemisi wakho uma ungazi ukuthi umuthi owugulayo uyenziwe ngamaprotheni e-murine. Buza usokhemisi wakho noma uhlole Umhlahlandlela Wezokwelapha ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi imishanguzo kadokotela neyokungabhalisi, amavithamini, izithako zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi uyayisho imishanguzo ebhalwe esigabeni ESIBALULEKILE SEXWAYISO nanoma yikuphi okulandelayo: ama-anticoagulants (ama-blood thinner) afana ne-warfarin (Coumadin), i-cyclosporine (i-Gengraf, i-Neoral, i-Sandimmune), ne-theophylline (i-Elixophyllin, i-Theo-24, i-Theochron) . Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• Tshela udokotela wakho uma ngabe uke wahlushwa yinhliziyo noma wake wahluleka (isimo lapho inhliziyo ingakwazi ukupompa igazi elanele kwezinye izingxenye zomzimba). Udokotela wakho angakutshela ukuthi ungasebenzisi umkhiqizo womjovo we-infliximab.
• Tshela udokotela wakho uma uke welashwa nge-phototherapy (ukwelashwa kwe-psoriasis okubandakanya ukuveza isikhumba ekukhanyeni kwe-ultraviolet) futhi uma unesifo esithinta uhlelo lwakho lwezinzwa, njenge-multiple sclerosis (MS; ukudidiyela, ukuba buthakathaka, nokuba ndikindiki ngenxa yokulimala kwezinzwa), isifo i-Guillain-Barre (ukubuthakathaka, ukuluma, nokukhubazeka okungenzeka ngenxa yokulimala okungazelelwe kwemizwa) noma i-optic neuritis (ukuvuvukala kwemizwa ethumela imiyalezo isuka esweni iye ebuchosheni); ukuba ndikindiki, ukushiswa noma ukuncinza kunoma iyiphi ingxenye yomzimba wakho; ukuquleka; isifo esingelapheki samaphaphu (COPD; iqembu lezifo ezithinta amaphaphu nemigwaqo yomoya); noma yiluphi uhlobo lomdlavuza; izinkinga zokopha noma izifo ezithinta igazi lakho; noma isifo senhliziyo.
• utshele udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uncelisa. Uma ukhulelwa ngenkathi usebenzisa umkhiqizo womjovo we-infliximab, shayela udokotela wakho. Uma usebenzisa umkhiqizo womjovo we-infliximab ngesikhathi sokukhulelwa kwakho, qiniseka ukuthi ukhuluma nodokotela wengane yakho ngalokhu ngemuva kokuzalwa kwengane yakho. Ingane yakho ingadinga ukuthola imigomo ethile sekwedlule isikhathi kunokujwayelekile.
• uma uhlinzwa, kufaka phakathi ukuhlinzwa kwamazinyo, tshela udokotela noma udokotela wamazinyo ukuthi usebenzisa umkhiqizo womjovo we-infliximab.
• tshela udokotela wakho uma usanda kuthola umuthi wokugoma. Phinda uhlole nodokotela wakho ukuthi ngabe udinga ukuthola noma yimiphi imigomo. Ungabi nayo imigomo ngaphandle kokukhuluma nodokotela wakho. Kubalulekile ukuthi abantu abadala nezingane bathole yonke imigomo efanele iminyaka ngaphambi kokuqala ukwelashwa nge-infliximab.
• kufanele wazi ukuthi ungaba nokubambezeleka kokungazwani komzimba ngemuva kwezinsuku ezi-3 kuye kwezi-12 ngemuva kokuthola umkhiqizo womjovo we-infliximab. Tshela udokotela wakho uma uhlangabezana nalezi zimpawu ezilandelayo ezinsukwini ezimbalwa noma ngaphezulu ngemuva kokwelashwa kwakho: ubuhlungu bemisipha noma obuhlangene; imfiva; ukuqubuka; isifuba; ukulunywa; ukuvuvukala kwezandla, ubuso, noma izindebe; ubunzima bokugwinya; Umphimbo obuhlungu; nekhanda.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Imikhiqizo yomjovo we-infliximab ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• isicanucanu
• isilungulela
• ikhanda
• ikhala eligijimayo
• amabala amhlophe emlonyeni
• ukulunywa kwesitho sangasese sowesifazane, ukushisa, nobuhlungu, noma ezinye izimpawu zokutheleleka ngemvubelo
• ukuqhuma

Eminye imiphumela emibi ingaba mibi. Lezi zimpawu ezilandelayo azivamile, kepha uma uhlangabezana nenye yazo, noma lezo ezibalwe KUSEXWAYISO ESIBALULEKILE noma ezingxenyeni ezikhethekile zokuqapha, shayela udokotela wakho ngokushesha:

• noma yiluphi uhlobo lokuqubuka, kufaka phakathi ukuqubuka ezihlathini noma ezingalweni okuba kubi kakhulu elangeni
• ubuhlungu besifuba
• ukushaya kwenhliziyo okungajwayelekile
• ubuhlungu ezingalweni, emhlane, entanyeni, noma emhlathini
• ubuhlungu besisu
• ukuvuvukala kwezinyawo, amaqakala, isisu, noma imilenze ephansi
• ukuzuza kwesisindo ngokungazelelwe
• ukuphelelwa umoya
• ukufiphala kombono noma ukushintsha kombono
• ubuthakathaka obungazelelwe bengalo noma bomlenze (ikakhulukazi ohlangothini olulodwa lomzimba) noma lobuso
• ubuhlungu bemisipha noma bamalunga
• ukuba ndikindiki noma ukuncinza kunoma iyiphi ingxenye yomzimba
• ukudideka okungazelelwe, ukukhathazeka ukukhuluma, noma ukukhathazeka ukuqonda
• ukuhamba ngokuzumayo
• isiyezi noma ukuquleka
• ukulahlekelwa ibhalansi noma ukuxhumanisa
• ngokuzumayo, ikhanda elibi kakhulu
• isithuthwane
• ukuphuzi kwesikhumba noma kwamehlo
• umchamo onombala omnyama
• ukulahlekelwa isifiso sokudla
• ubuhlungu engxenyeni engenhla kwesokudla yesisu
• ukulimaza noma ukopha okungavamile
• igazi esitokisini
• isikhumba esiphaphathekile
• okubomvu, amabala anezikhala noma amaqhuqhuva agcwaliswa ubomvu esikhunjeni

Umjovo we-infliximab ungakhuphula ingozi yokuba ne-lymphoma (umdlavuza oqala kumaseli alwa nokutheleleka) neminye imidlavuza. Khuluma nodokotela wakho ngezingozi zokuthola umkhiqizo womjovo we-infliximab.

Imikhiqizo yomjovo we-infliximab ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi usebenzisa lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Udokotela wakho uzogcina umuthi ehhovisi lakhe.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho anga-oda izivivinyo ezithile zaselebhu ukuhlola impendulo yomzimba wakho kumkhiqizo womjovo we-infliximab.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• Avsola^® (I-Infliximab-axxq)
• I-Inflectra^® (I-infliximab-dyyb)
• I-Remicade^® (I-Infliximab)
• I-Renflexis^® (I-Infliximab-abda)

• I-anti-tumor Necrosis Factor-alpha
• I-anti-TNF-alpha
• cA2