I-Peginterferon Alfa-2a Injection

-Delile

• Ngaphambi kokusebenzisa i-peginterferon alfa-2a,
• I-Peginterferon alfa-2a ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Lezi zimpawu ezilandelayo azivamile, kepha uma uhlangabezana nezinye zazo, noma lezo ezibalwe esigabeni ESIBALULEKILE SEXWAYISO noma isigaba SOKUQAPHA OKUKHETHEKILE, shayela udokotela wakho ngokushesha:
• Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

I-Peginterferon alfa-2a ingadala noma ibe yimbi le mibandela elandelayo, engahle ibe mibi noma idale ukufa: izifo; ukugula ngengqondo kubandakanya ukucindezeleka, izinkinga zemizwelo nokuziphatha, noma imicabango yokuzilimaza noma ukuzibulala; ukuqala ukusebenzisa izidakamizwa zasemgwaqweni futhi uma ubuzisebenzisa phambilini; ukuphazamiseka kweschemic (izimo lapho kutholakala khona igazi elincane endaweni yomzimba) njenge-angina (ubuhlungu besifuba), isifo senhliziyo, isifo sohlangothi, noma i-colitis (ukuvuvukala kwamathumbu); nokuphazamiseka kokuzilimaza komzimba (izimo lapho amasosha omzimba ahlasela khona ingxenye eyodwa noma ezingaphezulu zomzimba) ezingathinta igazi, amalunga, izinso, isibindi, amaphaphu, imisipha, isikhumba noma indlala yegilo. Tshela udokotela wakho uma unesifo; noma uma uke waba nesifo sokuzivikela komzimba; i-atherosclerosis (ukuncipha kwemithambo yegazi emafutheni anamafutha); umdlavuza; ubuhlungu besifuba; isifo sofuba; isifo sikashukela; isifo senhliziyo; umfutho wegazi ophakeme; i-cholesterol ephezulu; I-HIV (i-human immunodeficiency virus) noma i-AIDS (i-immunodeficiency syndrome); ukushaya kwenhliziyo okungajwayelekile; ukugula kwengqondo kubandakanya ukucindezeleka, ukukhathazeka, noma ukucabanga noma ukuzama ukuzibulala; isifo sesibindi ngaphandle kwesifo sokusha kwesibindi kohlobo B noma C; noma inhliziyo, izinso, amaphaphu noma isifo segilo. Phinda utshele udokotela wakho uma uphuza noma wake waphuza utshwala obuningi, noma uma usebenzisa noma usebenzise izidakamizwa zasemgwaqweni noma usebenzise ngokweqile imithi kadokotela. Uma uhlangabezana nalezi zimpawu ezilandelayo, shayela udokotela wakho ngokushesha: uhudo olunegazi noma ukunyakaza kwamathumbu; ubuhlungu besisu, ubumnene noma ukuvuvukala; ubuhlungu besifuba; ukushaya kwenhliziyo okungajwayelekile; ubuthakathaka; ukulahleka kokuxhumanisa; ukuba ndikindiki; ushintsho esimweni sakho sengqondo noma ekuziphatheni kwakho; ukucindezeleka; ukucasuka; ukukhathazeka; imicabango yokuzibulala noma yokuzilimaza; ukubona izinto ezingekho (ukubona izinto noma ukuzwa amazwi angekho); imizwa evuthayo noma ejabule ngokungavamile; ukulahlekelwa ukuxhumana neqiniso; isimilo esinolaka; ukuphefumula kanzima; umkhuhlane, ukubanda, ukukhwehlela, umphimbo obuhlungu, noma ezinye izimpawu zokutheleleka; ukukhwehlela amafinyila aphuzi noma apinki; ukushisa noma ubuhlungu lapho uchama, noma uchama kaningi; ukopha okungavamile noma ukulimaza; umchamo onombala omnyama; ukunyakaza okukhanyayo okukhanyayo; ukukhathala ngokweqile; ukuphuzi kwesikhumba noma kwamehlo; ubuhlungu obukhulu bemisipha noma obuhlangene; noma ukwanda kwesifo somzimba.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile ukuze ahlole impendulo yomzimba wakho ku-peginterferon alfa-2a.

Udokotela wakho kanye nosokhemisi bazokunikeza ishidi lemininingwane yesiguli lomkhiqizi (Umhlahlandlela Wezokwelapha) lapho uqala ukwelashwa nge-peginterferon alfa-2a futhi isikhathi ngasinye lapho ugcwalisa umuthi wakho. Funda imininingwane ngokucophelela bese ubuza udokotela noma usokhemisi wakho uma unemibuzo. Ungavakashela futhi iwebhusayithi ye-Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) noma iwebhusayithi yomkhiqizi ukuthola i-Medication Guide.

Khuluma nodokotela wakho ngezingozi zokusebenzisa i-peginterferon alfa-2a.

I-Peginterferon alfa-2a isetshenziswa yodwa noma ihlanganiswe neminye imithi yokwelapha ukutheleleka okungapheli (kwesikhathi eside) kwesifo sokusha kwesibindi kohlobo C (ukuvuvukala kwesibindi okubangelwa igciwane) kubantu abakhombisa izimpawu zokulimala kwesibindi. I-Peginterferon alfa-2a nayo isetshenziselwa ukwelapha ukutheleleka okungapheli kwe-hepatitis B (ukuvuvukala kwesibindi okubangelwa igciwane) kubantu abakhombisa izimpawu zokulimala kwesibindi. I-Peginterferon alfa-2a isekilasini lemithi ebizwa ngama-interferon. I-Peginterferon iyinhlanganisela ye-interferon ne-polyethylene glycol, esiza i-interferon ukuthi ihlale isebenza emzimbeni wakho isikhathi eside. I-Peginterferon isebenza ngokunciphisa inani le-virus ye-hepatitis C (HCV) noma i-hepatitis B virus (HBV) emzimbeni. I-Peginterferon alfa-2a ingahle ingelaphi i-hepatitis C noma i-hepatitis B noma ikuvikele ekutholeni izinkinga ze-hepatitis C noma i-hepatitis B efana ne-cirrhosis (scarring) yesibindi, ukwehluleka kwesibindi, noma umdlavuza wesibindi. I-Peginterferon alfa-2a kungenzeka ingavimbeli ukusabalala kwesifo sokusha kwesibindi kohlobo C noma isifo sokusha kwesibindi kohlobo B kwabanye abantu.

I-Peginterferon alfa-2a iza njengesisombululo (uketshezi) esitsheni, isirinji ekhethiwe, ne-autoinjector elahlwayo yokujova ngomgogodla (ungqimba lwamafutha ngaphansi kwesikhumba). Kuvamise ukujova kanye ngesonto, ngosuku olufanayo lweviki, nangesikhathi esifanayo sosuku. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Sebenzisa i-peginterferon alfa-2a njengoba nje kuqondisiwe. Ungayisebenzisi kakhulu noma kancane le mithi noma uyisebenzise kaningi kunokuyalelwa ngudokotela wakho.

Udokotela wakho kungenzeka akuqale ngomthamo ojwayelekile we-peginterferon alfa-2a. Udokotela wakho anganciphisa umthamo wakho uma uhlangabezana nemiphumela emibi yomuthi. Qiniseka ukuthi utshela udokotela wakho ukuthi uzizwa kanjani ngenkathi welashwa bese ubuza udokotela noma usokhemisi wakho uma unemibuzo mayelana nenani lemithi okufanele uyithathe.

Qhubeka nokusebenzisa i-peginterferon alfa-2a noma ngabe uzizwa uphilile. Ungayeki ukusebenzisa i-peginterferon alfa-2a ngaphandle kokukhuluma nodokotela wakho.

Sebenzisa kuphela uhlobo nohlobo lwe-interferon olunqunywe udokotela wakho. Ungasebenzisi olunye uhlobo lwe-interferon noma ushintshe phakathi kwe-peginterferon alfa-2a ezitsheni, amasirinji agcwalisiwe, kanye nama-autoinjectors alahlwayo ngaphandle kokukhuluma nodokotela wakho. Uma ushintshela kuhlobo oluhlukile noma uhlobo lwe-interferon, umthamo wakho ungadinga ukuguqulwa.

Ungazijova i-peginterferon alfa-2a ngokwakho noma umngane noma isihlobo sikunikeze imijovo. Ngaphambi kokusebenzisa i-peginterferon alfa-2a okokuqala ngqa, wena kanye nomuntu ozonikeza imijovo kufanele nifunde imininingwane yomenzi wesiguli esiza nayo. Buza udokotela wakho noma usokhemisi ukuthi akubonise noma umuntu ozobe ejova umuthi ukuthi ungawujova kanjani. Uma omunye umuntu ezokujova ngemithi, qiniseka ukuthi uyazi ukuthi angazigwema kanjani izingcwecwe zezinaliti ngengozi ukuvimbela ukusakazeka kwesifo sokusha kwesibindi.

Ungajova i-peginterferon alfa-2a noma yikuphi esiswini noma emathangeni akho, ngaphandle kwenkaba yakho (inkinobho yesisu) kanye nasesinqeni. Sebenzisa indawo ehlukile ngomjovo ngamunye. Ungasebenzisi indawo efanayo yomjovo izikhathi ezimbili zilandelana. Ungafaki i-peginterferon alfa-2a endaweni lapho isikhumba sibuhlungu khona, sibomvu, silimele, sinezibazi, sinegciwane, noma sijwayelekile nganoma iyiphi indlela.

Uma ungawutholi umthamo ophelele obekiwe ngenxa yenkinga (njengokuvuza eduze kwendawo yokujova), shayela udokotela wakho.

Ungalokothi usebenzise amasirinji, izinaliti, noma izitsha ze-peginterferon alfa-2a. Lahla izinaliti nemijovo esetshenzisiwe esitsheni esingamelana nokubhoboza. Khuluma nodokotela wakho noma usokhemisi mayelana nokuthi ungasilahla kanjani isitsha esingamelana nokubhoboza.

Ngaphambi kokusebenzisa i-peginterferon alfa-2a, bheka isixazululo esitsheni, isirinji ekhethiwe, noma i-autoinjector eduze. Unganyakazisi izitsha, amasirinji, noma ama-autoinjectors aqukethe i-peginterferon alfa-2a. Umuthi kufanele ucace futhi ungabi nezinhlayiya ezintantayo. Bheka isitsha noma isirinji ukuze uqiniseke ukuthi akukho kuvuza futhi uhlole usuku lokuphelelwa yisikhathi. Ungasisebenzisi isixazululo uma siphelelwe yisikhathi, sigqamile, sinamafu, siqukethe izinhlayiya, noma sisesitsheni esivuzayo noma isirinji. Sebenzisa isixazululo esisha, bese ukhombisa esonakele noma esiphelelwe yisikhathi kudokotela noma kusokhemisi.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokusebenzisa i-peginterferon alfa-2a,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-peginterferon alfa-2a, amanye ama-alpha interferon, noma imiphi eminye imithi, i-benzyl alcohol, noma i-polyethylene glycol (i-PEG). Buza udokotela wakho ukuthi awunasiqiniseko sokuthi umuthi owugulisayo yi-alpha interferon.
• Tshela udokotela wakho uma wake wathola umjovo we-interferon alfa wokwelapha ukutheleleka kwe-hepatitis C.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma yikuphi okulandelayo: imishanguzo ethile ye-HIV noma i-AIDS njenge-abacavir (iZiagen, e-Epzicom, eTrizivir), didanosine (ddI noma iVidex), emtricitabine (Emtriva, eTruvada), lamivudine (Epivir, eCombivir, e-Epzicom, e-Trizivir), e-stavudine (e-Zerit), e-tenofovir (e-Viread, e-Truvada), e-zalcitabine (HIVID), nase-zidovudine (Retrovir, e-Combivir, e-Trizivir); i-methadone (i-Dolophine, i-Methadose); i-mexiletine (Mexitil); naproxen (Aleve, Anaprox, Naprosyn, abanye); i-riluzole (Rilutek); i-tacrine (i-Cognex); i-telbivudine (Tyzeka); kanye ne-theophylline (TheoDur, abanye). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi. Eminye imishanguzo eminingi ingaxhumana ne-peginterferon alfa-2a, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho naleyo engabonakali kulolu hlu.
• Tshela udokotela wakho noma usokhemisi uma ngabe uke wafakelwa isitho somzimba (ukuhlinzwa ukufaka esinye isitho emzimbeni). Phinda utshele udokotela wakho uma ngabe uke waba nanoma yimiphi imibandela eshiwo esigabeni ESIBALULEKILE SEXWAYISO noma okunye kwalokhu okulandelayo: i-anemia (amaseli abomvu egazi awalethi umoya-mpilo owanele kwezinye izingxenye zomzimba), noma izinkinga ngamehlo akho noma amanyikwe.
• utshele udokotela wakho uma ukhulelwe, hlela ukukhulelwa noma ukuncelisa. I-Peginterferon alfa-2a ingalimaza umbungu noma ikwenze uphuphume (ulahlekelwe yingane yakho). Khuluma nodokotela wakho ngokusebenzisa isilawuli sokubeletha ngenkathi uthatha lo muthi. Akufanele uncelise ibele ngenkathi uthatha lo muthi.
• uma uhlinzwa, kufaka phakathi ukuhlinzwa kwamazinyo, tshela udokotela noma udokotela wamazinyo ukuthi uthatha i-peginterferon alfa-2a.
• kufanele wazi ukuthi i-peginterferon alfa-2a ingakwenza ube nesiyezi, udideke noma uzele. Ungashayeli imoto noma usebenzise imishini uze wazi ukuthi lo muthi ukuthinta kanjani.
• ungaphuzi utshwala ngenkathi uthatha i-peginterferon alfa-2a. Utshwala bungenza isifo sakho sesibindi sibe sibi kakhulu.
• kufanele wazi ukuthi ungahlangabezana nezimpawu ezinjengomkhuhlane njengekhanda, umkhuhlane, ukugodola, ukukhathala, izinhlungu zemisipha, nobuhlungu bamalunga ngesikhathi sokwelashwa kwakho nge-peginterferon alfa-2a. Uma lezi zimpawu ziyakhathaza, buza udokotela wakho ukuthi kufanele yini uthathe izinhlungu zokuthenga nokunciphisa imfiva ngaphambi kokujova umthamo ngamunye wepeginterferon alfa-2a. Ungahle ufune ukujova i-peginterferon alfa-2a ngesikhathi sokulala ukuze ukwazi ukulala ngezimpawu.

Phuza uketshezi oluningi ngenkathi uthatha lo muthi.

Uma ukhumbula umthamo ongabanjwanga isikhathi esingaphezu kwezinsuku ezi-2 ngemuva kokuhlelelwa ukuwufaka, jovelela umthamo ongabanjwanga ngokushesha nje lapho uwukhumbula. Bese ujove umthamo wakho olandelayo ngosuku lwakho oluhleliwe njalo ngesonto elilandelayo. Uma kudlule izinsuku ezingaphezu kwezingu-2 kusukela ngosuku obehlelelwe ngalo ukujova umuthi, buza udokotela wakho noma usokhemisi ukuthi yini okufanele uyenze. Ungasebenzisi umthamo ophindwe kabili noma usebenzise umthamo ongaphezu kowodwa evikini elingu-1 ukwenza umthamo ophuthelwe.

I-Peginterferon alfa-2a ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ukulimaza, ubuhlungu, ububomvu, ukuvuvukala, noma ukucasuka endaweni lapho ujove khona i-peginterferon alfa-2a
• isisu esibuhlungu
• ukuhlanza
• isilungulela
• umlomo owomile
• ukulahlekelwa isifiso sokudla
• ukuncipha komzimba
• isifo sohudo
• isikhumba esomile noma esilumayo
• ukulahleka kwezinwele
• ubunzima bokulala noma ukulala
• ukukhathala
• ubuthakathaka
• ubunzima bokugxila noma bokukhumbula
• ukujuluka
• isiyezi

Eminye imiphumela emibi ingaba mibi. Lezi zimpawu ezilandelayo azivamile, kepha uma uhlangabezana nezinye zazo, noma lezo ezibalwe esigabeni ESIBALULEKILE SEXWAYISO noma isigaba SOKUQAPHA OKUKHETHEKILE, shayela udokotela wakho ngokushesha:

• ukungaboni kahle, ukushintsha kombono, noma ukulahleka kombono
• ubuhlungu beqolo
• ukuqubuka
• isifuba
• ukuvuvukala kobuso, umphimbo, ulimi, izindebe, amehlo, izandla, izinyawo, amaqakala noma imilenze engezansi
• ubunzima bokugwinya
• ukushaqeka

I-Peginterferon alfa-2a ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Yigcine esiqandisini, kodwa ungayifaki iqhwa. Ungashiyi i-peginterferon alfa-2a ngaphandle kwesiqandisi amahora angaphezu kwama-24 (usuku olungu-1). Gcina i-peginterferon alfa-2a kude nokukhanya.

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Uma isisulu singawile, shayela udokotela okuyalele lo muthi. Udokotela angahle afune uku-oda izivivinyo zelebhu.

Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

• ukukhathala
• ukopha okungajwayelekile noma ukulinyazwa
• umkhuhlane, umphimbo obuhlungu, amakhaza, ukukhwehlela, noma ezinye izimpawu zokutheleleka

Ungavumeli omunye umuntu asebenzise imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• Pegasys^®