Injection Engaphezulu

-Delile

• Ngaphambi kokusebenzisa umjovo we-exenatide,
• Lo muthi ungadala ushintsho kushukela wakho wegazi. Kufanele wazi izimpawu zikashukela wegazi ophansi futhi ophakeme nokuthi yini okufanele uyenze uma unalezi zimpawu.
• Umjovo we-Exenatide ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nanoma yiziphi kulezi zimpawu ezilandelayo noma lezo ezibalwe esigabeni ESIBALULEKILE SEZIXWAYISO, yeka ukusebenzisa i-exenatide bese ushayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:
• Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

Umjovo we-Exenatide ungakhuphula ubungozi bokuthi uzoba nezicubu zomgudu wegilo, kufaka phakathi i-medullary thyroid carcinoma (MTC; uhlobo lomdlavuza wegilo). Izilwane zaselabhorethri ezinikezwe izicubu ezingaphezulu zathola izicubu, kepha akwaziwa ukuthi lo muthi ukwengeza ingozi yezimila kubantu. Tshela udokotela wakho ukuthi ngabe wena noma omunye emndenini wakho une-MTC noma i-Multiple Endocrine Neoplasia syndrome type 2 (MEN 2; isimo esidala izicubu ezingxenyeni ezingaphezu kweyodwa emzimbeni). Uma kunjalo, udokotela wakho uzokutshela ukuthi ungasebenzisi umjovo we-exenatide. Uma uhlangabezana nalezi zimpawu ezilandelayo, shayela udokotela wakho ngokushesha: isigaxa noma ukuvuvukala entanyeni; ukushaqeka; ubunzima bokugwinya; noma ukuphefumula okuncane.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho angalawula izivivinyo ezithile ukuze ahlole impendulo yomzimba wakho ukuthi ingakanani.

Udokotela wakho noma usokhemisi uzokunikeza ishidi lemininingwane yesiguli lomkhiqizi (Umhlahlandlela Wezokwelapha) lapho uqala ukwelashwa ngomjovo okhipha isikhathi eside futhi isikhathi ngasinye lapho ugcwalisa khona incwadi kadokotela. Funda imininingwane ngokucophelela bese ubuza udokotela noma usokhemisi wakho uma unemibuzo. Ungavakashela futhi iwebhusayithi ye-Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) noma iwebhusayithi yomkhiqizi ukuthola i-Medication Guide.

Khuluma nodokotela wakho ngezingozi zokusebenzisa umjovo we-exenatide.

I-Exenatide isetshenziswa kanye nokudla nokuzivocavoca ukwelapha uhlobo lwesifo sikashukela sohlobo lwesibili (isimo lapho umzimba ungasebenzisi i-insulin ngokujwayelekile ngakho-ke awukwazi ukulawula inani likashukela egazini). I-Exenatide isekilasini lemithi ebizwa nge-incretin mimetics. Isebenza ngokuvuselela amanyikwe ukukhipha i-insulin lapho amazinga kashukela egazi ephezulu. I-insulin isiza ukuhambisa ushukela egazini uye kwezinye izicubu zomzimba lapho usetshenziselwa khona amandla. I-Exenatide ibambezela ukukhishwa kwesisu futhi ibangele nokwehla kwesifiso sokudla. I-Exenatide ayisetshenziselwa ukwelapha isifo sikashukela sohlobo 1 (isimo lapho umzimba ungakhiqizi i-insulin ngakho-ke awukwazi ukulawula inani likashukela egazini). I-Exenatide ayisetshenziswa esikhundleni se-insulin ukwelapha abantu abanesifo sikashukela abadinga i-insulin.

Ngokuhamba kwesikhathi, abantu abanesifo sikashukela kanye noshukela ophakeme wegazi bangakhula babe nezinkinga ezinkulu noma ezisongela impilo, kufaka phakathi isifo senhliziyo, isifo sohlangothi, izinkinga zezinso, ukulimala kwemizwa nezinkinga zamehlo. Ukusebenzisa imithi, ukwenza izinguquko endleleni ophila ngayo (isb., Ukudla, ukuzivocavoca, ukuyeka ukubhema), nokuhlola njalo ushukela wegazi lakho kungasiza ukuphatha isifo sikashukela futhi kuthuthukise impilo yakho. Lokhu kwelashwa kunganciphisa namathuba akho okuhlaselwa yisifo senhliziyo, isifo sohlangothi, noma ezinye izinkinga ezihlobene nesifo sikashukela njengokuhluleka kwezinso, ukulimala kwemizwa (okundikindiki, imilenze ebandayo noma izinyawo; ukwehla kwekhono lezocansi kwabesilisa nabesifazane), izinkinga zamehlo, kufaka phakathi izinguquko noma ukulahleka kombono, noma isifo sezinsini. Udokotela wakho nabanye abahlinzeki bezokunakekelwa kwezempilo bazokhuluma nawe ngendlela engcono yokuphatha isifo sikashukela.

Udokotela wakho noma usokhemisi uzokunikeza ishidi lemininingwane yesiguli lomkhiqizi (Umhlahlandlela Wezokwelapha) lapho uqala ukwelashwa nge-exenatide futhi isikhathi ngasinye lapho ugcwalisa umuthi wakho. Funda imininingwane ngokucophelela bese ubuza udokotela noma usokhemisi wakho uma unemibuzo. Ungavakashela futhi iwebhusayithi ye-Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) ukuthola uMhlahlandlela Wezokwelapha.

Khipha ukukhishwa ngokushesha (Byetta^®) iza njengesisombululo (uketshezi) ngepeni lokufaka elifakiwe ukuze ujove ngaphansi (ngaphansi kwesikhumba). Ukukhishwa okwandisiwe okwenziwe isikhathi eside (ukusebenza isikhathi eside) (Bydureon^®) iza njengempuphu ezoxubaniswa noketshezi esitsheni noma ipeni lokufaka elithandwayo ukujova ngomgogodla. Isixazululo sokukhishwa ngokushesha esivame ukujova kabili ngosuku kungakapheli imizuzu engama-60 ngaphambi kokudla kwasekuseni nakusihlwa; ungayifaki ngemuva kokudla. Udokotela wakho kungenzeka akuqale ngomthamo ophansi womjovo okhishwa ngokushesha futhi angakushintshela epeni ngomthamo ophakeme wemithi uma ukulawulwa ushukela egazini kungazange kuthuthuke ngemuva kokusebenzisa isikhathi esingangenyanga eyodwa. Isixazululo sokukhishwa okwandisiwe sifakwa kanye ngesonto nganoma yisiphi isikhathi sosuku ngaphandle kokubheka ukudla. Sebenzisa ukukhishwa okwandisiwe okungaphezulu ngosuku olufanayo evikini ngalinye nganoma yisiphi isikhathi sosuku. Ungaguqula usuku lweviki olusebenzisela ukukhishwa okwandisiwe uma sekuyizinsuku ezi-3 noma ngaphezulu selokhu usebenzise umthamo wakho wokugcina. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Sebenzisa umjovo we-exenatide njengoba nje uqondisiwe. Ungayisebenzisi ngaphezulu noma ngaphansi kwayo noma uyisebenzise kaningi kunokuyalelwa ngudokotela wakho.

Uma ushintsha kusuka ekukhishweni okwedlulele okwedlulele kuya ekukhululweni kokukhishwa okwandisiwe, amazinga akho kashukela (ushukela) angakhuphuka okwesikhashana amasonto ama-2 kuye kwayi-4 ngemuva kwalolu shintsho.

I-Exenatide ilawula isifo sikashukela kepha ayiselaphi. Qhubeka nokusebenzisa ngokweqile noma ngabe uzizwa uphilile. Ungayeki ukusebenzisa i-exenatide ngaphandle kokukhuluma nodokotela wakho.

Uma usebenzisa i-exenatide ukukhishwa ngokushesha (Byetta^®) izibaya zokufaka ezifakiwe, uzodinga ukuthenga izinaliti ngokwehlukana. Buza udokotela wakho noma usokhemisi ukuthi iziphi izinhlobo zezinaliti ozodinga ukujova umuthi wakho. Qiniseka ukuthi ufunda futhi uqonde imiyalelo yomkhiqizi yokujova i-exenatide usebenzisa ipeni. Futhi qiniseka ukuthi uyazi ukuthi ungasetha kanjani ipeni elisha futhi nini. Cela udokotela wakho noma usokhemisi ukuthi akubonise ukuthi uyisebenzisa kanjani ipeni. Landela izinkomba ngokucophelela. Ungalokothi ususe igobolondo esibayeni noma uzame ukwengeza noma yiluphi olunye uhlobo lomuthi ku-cartridge.

Hlala ubheka isisombululo sakho sangaphezulu ngaphambi kokusijova. Kufanele icace bha, ingenambala, futhi ibe uketshezi njengamanzi. Ungasebenzisi i-exenatide uma inombala, inamafu, ijiyile, noma iqukethe izinhlayiya eziqinile, noma uma usuku lokuphelelwa yisikhathi ebhodleleni seludlulile. Ungahlanganisi i-exenatide ne-insulin emjovo owodwa.

Ungalokothi usebenzise izinaliti futhi ungalokothi wabelane ngezinaliti noma izibaya. Susa njalo inaliti ngemuva nje kokujova umthamo wakho. Lahla izinaliti esitsheni esingamelana nokubhoboza. Buza udokotela wakho noma usokhemisi ukuthi ungasilahla kanjani isitsha esimelana nokubhoboza.

I-Exenatide ingalawulwa ethangeni (umlenze ongaphezulu), isisu (isisu), noma ingalo ephezulu. Sebenzisa isiza esihlukile ngomjovo ngamunye, cishe amayintshi angu-1 (2.5 amasentimitha) kude nomjovo wangaphambilini kepha endaweni efanayo (isibonelo, ithanga). Sebenzisa wonke amasayithi atholakalayo endaweni efanayo ngaphambi kokushintshela kwenye indawo (ngokwesibonelo, ingalo ephezulu). Ungayisebenzisi indawo efanayo yokujova kaningi ngaphezu kwesisodwa njalo ngenyanga.

Ungafaka i-exentadine ne-insulin enwetshiwe endaweni efanayo yomzimba, kepha imijovo akufanele inikezwe eduze komunye nomunye.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokusebenzisa umjovo we-exenatide,

• Tshela udokotela wakho kanye nosokhemisi uma une-aleji ye-exenatide, noma imiphi eminye imithi, noma iziphi izithako zomjovo we-exenatide. Buza usokhemisi wakho noma uhlole Umhlahlandlela Wezokwelapha ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi imishanguzo kadokotela neyokungabhalisi, amavithamini, izithako zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Kubaluleke kakhulu ukutshela udokotela wakho ngayo yonke imithi oyiphuzayo ngomlomo ngoba i-exenatide ingashintsha indlela umzimba wakho oyithatha ngayo le mithi. Qiniseka ukuthi usho noma yikuphi okulandelayo: i-angiotensin-converting enzyme (ACE) inhibitors efana ne-benazepril (Lotensin), i-captopril (i-Capoten), i-enalapril (i-Vasotec), i-fosinopril (i-Monopril), i-lisinopril (i-Prinivil, i-Zestril), i-moexipcil ( , i-perindopril, (i-Aceon), i-quinapril (i-Accupril), i-ramipril (i-Altace), ne-trandolapril (i-Mavika); isisu (‘amaphilisi amanzi’); i-aspirin nezinye izidakamizwa ezingezona ukuvuvukala (ama-NSAID) njenge-ibuprofen (Advil, Motrin) ne-naproxen (Aleve, Naprosyn); i-lovastatin (Altoprev, ku-Advicor); imithi yomfutho wegazi ophakeme; i-insulin noma eminye imishanguzo yokwelapha isifo sikashukela njenge-sulfonylureas efana ne-chlorpropamide (i-Diabinese), i-glimepiride (i-Amaryl, e-Avandaryl, e-Duetact), i-glipizide (i-Glucotrol), i-glyburide (i-DiaBeta, i-Glucovance), i-tolazamide, ne-tolbutamide, ne-warfarin (i-Coumadin , EJantoven). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• uma uthatha izinto zokuvimbela inzalo ngomlomo (amaphilisi okuvimbela inzalo) noma ama-antibiotic, ziphuze okungenani ihora elilodwa ngaphambi kokusebenzisa umjovo okhulayo. Uma utshelwe ukuthi thatha le mithi ngokudla, yiphuze nokudla noma isinongo ngesikhathi lapho ungasebenzisi i-exenatide.
• Tshela udokotela wakho uma uphuza noma wake waphuza utshwala obuningi, futhi uma uhlangabezana nesicanucanu, ukuhlanza, nohudo noma ucabanga ukuthi kungenzeka uphelelwe amanzi emzimbeni, noma uma uba nalezi zimpawu noma kunini ngesikhathi sokwelashwa kwakho. Phinda utshele udokotela wakho ukuthi wake wafakelwa izinso noma ngabe uke waba nezinkinga ezinzima zesisu, kufaka phakathi i-gastroparesis (ukuhamba kancane kokudla kusuka esiswini kuya emathunjini amancane) noma ezinye izinkinga ukugaya ukudla; i-pancreatitis (ukuvuvukala kwamanyikwe), ama-gallstones (amadiphozi aqinile akha i-gallbladder), noma izinga eliphakeme lama-triglycerides (amafutha) egazini, noma amanyikwe, isibindi noma isifo sezinso.
• utshele udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uncelisa. Uma ukhulelwa ngenkathi usebenzisa i-exenatide, shayela udokotela wakho.
• buza udokotela wakho mayelana nokusetshenziswa okuphephile kweziphuzo ezidakayo ngenkathi uthatha i-exenatide.
• buza udokotela wakho ukuthi yini okufanele uyenze uma ugula, uba nesifo noma umkhuhlane, uba nengcindezi engajwayelekile, noma ulimele. Lezi zimo zingathinta ushukela wegazi lakho kanye nenani le-exenatide ongayidinga.

Qiniseka ukuthi ulandela zonke izincomo zokuzivocavoca nezokudla ezenziwa ngudokotela wakho noma udokotela odlayo. Kubalulekile ukudla ukudla okunempilo.

Uma uphuthelwa umthamo we-exenatide injection ekhishwa ngokushesha (Byetta^®), weqa umthamo ophuthelwe bese uqhubeka nesimiso sakho sokulinganisa okujwayelekile. Musa ukujova umthamo ophindwe kabili ukwenzela okulahlekile.

Uma uphuthelwa umthamo womjovo wokukhipha owandisiwe (Bydureon^®), Sebenzisa umthamo ongabanjwanga ngokushesha nje lapho uwukhumbula bese uqhubeka nesimiso sakho esijwayelekile samasonto onke. Kodwa-ke, uma kunezinsuku ezingaphansi kwezingu-3 (amahora angu-72) kuze kufike umthamo wakho olandelayo ohleliwe, weqa umthamo ongabanjwanga bese uqhubeka nesimiso sakho sokulinganisa okuvamile. Ungasebenzisi umthamo ophindwe kabili ukwenza okulahlekile.

Lo muthi ungadala ushintsho kushukela wakho wegazi. Kufanele wazi izimpawu zikashukela wegazi ophansi futhi ophakeme nokuthi yini okufanele uyenze uma unalezi zimpawu.

Umjovo we-Exenatide ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• isicanucanu
• ukuhlanza
• isifo sohudo
• ukuqunjelwa
• umuzwa we-jittery
• isiyezi
• isilungulela
• ikhanda
• ubuthakathaka
• ukujuluka

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nanoma yiziphi kulezi zimpawu ezilandelayo noma lezo ezibalwe esigabeni ESIBALULEKILE SEZIXWAYISO, yeka ukusebenzisa i-exenatide bese ushayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• ubuhlungu obuqhubekayo obuqala ngaphezulu kwesobunxele noma maphakathi nesisu kepha bungasabalala buye ngemuva noma ngaphandle kokuphalaza
• isifuba
• ukuqubuka
• ukulunywa
• ukuphefumula kanzima noma ukugwinya
• ubuhlungu bomjovo, ukuvuvukala, amabhamuza, ukulunywa, noma amaqhuqhuva
• ukuvuvukala kobuso, umphimbo, ulimi, izindebe, amehlo, izandla, izinyawo, amaqakala noma imilenze engezansi
• Ubuhlungu endaweni yesisu esiphakathi nendawo ephezulu noma engenhla, isicanucanu, ukuhlanza, imfiva, noma ukuphuzi kwesikhumba noma kwamehlo
• izinguquko kumbala noma enanini lomchamo
• ukuchama kaningi noma ngaphansi kunokujwayelekile
• ukuvuvukala kwezingalo, izandla, izinyawo, amaqakala, noma imilenze engezansi
• ukuncipha kokudla

I-Exenatide ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi usebenzisa lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina izibaya zamanzi ezingasetshenziswanga emabhokisini azo oqobo esiqandisini esivikelwe ekukhanyeni. Uma ususetshenzisiwe, gcina izibaya ezingaphandle ekamelweni lokushisa (kuze kufike kuma-77 ° F [25 ° C]) zivikelwe ekukhanyeni. Ungafrizi. Ungasebenzisi i-exenatide uma ngabe iqandisiwe. Ungagcini izibaya ezingaphandle ngenaliti enamathiselwe. Gcina izibaya ezingaphandle lapho izingane zingafinyeleli khona.

Lapho usohambweni, qiniseka ukuthi ugcina izibaya ezingaphezulu zomile. Izibaya ezingasetshenziswanga kufanele zifakwe esiqandisini noma zigcinwe lapho kubanda khona phakathi kuka-36 ° F kuye ku-46 ° F (2 ° C kuye ku-8 ° C). Amapeni asetshenziswayo angagcinwa ekamelweni lokushisa kuze kufike ku-77 ° F (25 ° C) (hhayi egumbini leglavu lemoto noma kwenye indawo eshisayo).

Bhala usuku owaqala ngalo ukusebenzisa ipeni elingaphezulu, bese ulilahla ngemuva kwezinsuku ezingama-30, noma ngabe kukhona isixazululo esisele esibayeni.

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

• isisu esibuhlungu kakhulu
• isicanucanu
• ukuhlanza okukhulu
• isiyezi
• izimpawu ze-hypoglycemia

Ushukela wakho wegazi kanye ne-hemoglobin eglycosylated (HbA1c) kufanele ihlolwe njalo ukuthola impendulo yakho ku-exenatide. Udokotela wakho uzokutshela nokuthi ungayihlola kanjani impendulo yakho kulo muthi ngokulinganisa amazinga egazi lakho noma umchamo ekhaya. Landela le miyalo ngokucophelela.

Ungavumeli omunye umuntu asebenzise imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• Bydureon^®
• I-Byetta^®