I-Deferasirox

-Delile

• Ukuthatha amaphilisi e-deferasirox ukumiswa (i-Exjade), landela lezi zinyathelo:
• Ngaphambi kokuthatha i-deferasirox,
• I-Deferasirox ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezishiwo esigabeni ESIBALULEKILE SESEXWAYISO, shayela udokotela wakho ngokushesha:
• Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

I-Deferasirox ingadala umonakalo omkhulu noma osongela impilo ezinso. Ingozi yokuthi uzoba nokulimala kwezinso inkulu uma unezimo eziningi zezokwelapha, noma ugula kakhulu ngenxa yesifo segazi. Tshela udokotela wakho uma uke waba nesifo sezinso noma wake waba naso. Udokotela wakho angakutshela ukuthi ungathathi i-deferasirox. Uma uhlangabezana nanoma yiziphi kulezi zimpawu ezilandelayo, shayela udokotela wakho ngokushesha: ukuncipha kokuchama, ukuvuvukala emaqakaleni, emilenzeni, noma ezinyaweni, ukukhathala ngokweqile, ukuphefumula okuncane, nokudideka. Ezinganeni ezithatha lo muthi, kunengozi eyengeziwe yokuthi uzoba nezinkinga zezinso uma ugula ngenkathi uthatha i-deferasirox futhi uthuthukise isifo sohudo, ukuhlanza, umkhuhlane, noma uyeke ukuphuza uketshezi ngokujwayelekile. Shayela udokotela wakho ngokushesha uma uhlangabezana nalezi zimpawu.

I-Deferasirox nayo ingadala umonakalo omkhulu noma osongela impilo esibindini. Ingozi yokuthi uzoba nokulimala kwesibindi inkulu uma uneminyaka engaphezu kwengama-55 ubudala, noma uma unezinye izimo ezibucayi zezokwelapha. Tshela udokotela wakho uma uke waba nesifo sesibindi noma wake waba naso. Uma uba nezimpawu ezilandelayo, shayela udokotela wakho ngokushesha: ukuphuzi kwesikhumba noma kwamehlo, izimpawu ezinjengomkhuhlane, ukungabi namandla, ukulahlekelwa isifiso sokudla, ubuhlungu engxenyeni engakwesokudla esiswini, noma ukulimaza noma ukopha okungavamile.

I-Deferasirox nayo ingadala ukopha okungathi sína noma impilo okusongela ukopha esiswini noma emathunjini. Ingozi yokuthi uzoba nokopha okukhulu esiswini noma emathunjini ingaba nkulu uma usukhulile, noma ugula kakhulu ngenxa yesimo segazi. Tshela udokotela wakho uma uke waba nezinga eliphansi lama-platelets (uhlobo lweseli legazi oludingekayo ukulawula ukopha), noma uma uthatha noma iyiphi yale mithi elandelayo: ama-anticoagulants (ama-thinner egazi) njenge-warfarin (i-Coumadin , EJantoven); i-aspirin noma eminye imishanguzo yokulwa nokuvuvukala (ama-NSAID) njenge-ibuprofen (Advil, Motrin, abanye) kanye ne-naproxen (Aleve, Naprosyn, abanye); imithi ethile yokuqinisa amathambo afaka i-alendronate (Binosto, Fosamax), etidronate, ibandronate (Boniva), pamidronate, risedronate (Actonel, Atelvia), ne-zoledronic acid (Reclast, Zometa); noma ama-steroids afana ne-dexamethasone, methylprednisolone (A-methapred, Depo-medrol, Medrol, Solu-medrol), noma i-prednisone (iRayos). Uma uhlangabezana nanoma yiziphi kulezi zimpawu ezilandelayo, shayela udokotela wakho ngokushesha: ukushisa izinhlungu zesisu, hlanza lokho okubomvu ngokugqamile noma okubukeka njengezindawo zekhofi, igazi elibomvu elikhanyayo ezihlalweni, noma izitulo ezimnyama noma ezilindile.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda ukuhlolwa kwelabhorethri ngaphambi nangesikhathi sokwelashwa kwakho ukuze aqiniseke ukuthi kuphephile kuwe ukuthatha i-deferasirox nokubona ukuthi ngabe unale miphumela emibi kakhulu yini.

I-Deferasirox isetshenziselwa ukwelapha abantu abadala nezingane ezineminyaka engu-2 nangaphezulu abanensimbi eningi kakhulu emzimbeni wabo ngoba bathole ukumpontshelwa igazi okuningi. Ibuye isetshenziselwe ukwelapha abantu abadala kanye nezingane ezineminyaka eyi-10 nangaphezulu abanensimbi eningi kakhulu emzimbeni wabo ngenxa yesifo segazi esibizwa nge-thalassemia enganciphisi gazi (NTDT). UDefferasirox usesigabeni semithi ebizwa nge-iron chelators. Isebenza ngokunamathisela i-ayoni emzimbeni ukuze ikwazi ukukhishwa (isuswe emzimbeni) endle.

IDefferasirox iza njengethebhulethi, ama-granules, kanye nethebulethi yokumiswa (ithebhulethi ezoncibilika kuketshezi) ukuthatha ngomlomo. Kufanele iphuzwe esiswini esingenalutho kanye ngosuku, okungenani imizuzu engama-30 ngaphambi kokudla, Amaphilisi kanye nama-granules nakho kungathathwa ngesidlo esilula njenge-muffin ephelele kakolweni we-English ene-jelly nobisi olunamafutha, noma isemishi elincane le-turkey isinkwa sikakolweni sonke. Thatha i-deferasirox ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-deferasirox njengoba nje kuqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Imikhiqizo ehlukile yama-deferasirox imuncwa ngumzimba ngezindlela ezihlukile futhi ayinakufakwa esikhundleni somunye. Uma udinga ukushintsha usuka komunye umkhiqizo we-deferasirox uye komunye, udokotela wakho angadinga ukulungisa umthamo wakho. Ngaso sonke isikhathi uma uthola umuthi wakho, hlola ukuqinisekisa ukuthi uwutholile yini umkhiqizo we-deferasirox obubekelwe wona. Buza usokhemisi wakho uma ungaqiniseki ukuthi uthole umuthi ofanele.

Amathebhulethi e-Swallow deferasirox (Jadenu) ngamanzi noma olunye uketshezi. Uma unenkinga yokugwinya ithebhulethi, ungahle uyichoboze bese uhlangana nokudla okuthambile okufana neyogathi noma i-appleauce ngokushesha ngaphambi kokuyithatha. Kodwa-ke, musa ukuchoboza ithebhulethi engu-90 mg (i-Jadenu) usebenzisa ithuluzi lokuchotshozwa elinezingqinamba.

Ukuthatha ama-deferasirox granules (i-Jadenu), ufafaze ama-granules ekudleni okuthambile okufana ne-yogurt noma i-appleauce ngokushesha ngaphambi kokuthatha.

Ukuthatha amaphilisi e-deferasirox ukumiswa (i-Exjade), landela lezi zinyathelo:

1. Njalo qeda amaphilisi wokumiswa kuketshezi ngaphambi kokuwaphuza. Ungahlafunisi noma ugwinye amaphilisi wokumiswa ngokuphelele.
2. Uma uthatha ngaphansi kuka-1000 mg we-deferasirox, gcwalisa inkomishi maphakathi (cishe u-3.5 oz / 100 ml) ngamanzi, ujusi we-apula, noma ijusi le-orange. Uma uthatha ngaphezu kuka-1000 mg we-deferasirox, gcwalisa inkomishi (cishe u-7 oz / 200 ml) ngamanzi, ijusi le-apula, noma ijusi le-orange. Uma ungenaso isiqiniseko sokuthi kufanele uthathe ama-deferasirox angakanani, buza udokotela noma usokhemisi wakho.
3. Faka inani lamaphilisi udokotela wakho okutshele ukuthi uwaphuze enkomishini.
4. Govuza uketshezi okwemizuzu emi-3 ukuqeda ngokuphelele amaphilisi.Ingxube ingaba sikhulu njengoba uyinyakazisa.
5. Phuza uketshezi ngokushesha.
6. Faka inani elincane loketshezi enkomishini engenalutho bese ugoqoza. Shintsha inkomishi ukuze uqede noma imuphi umuthi osengilazini noma oshukumisayo.
7. Phuza lonke uketshezi.

Udokotela wakho angalungisa umthamo wakho we-deferasirox hhayi ngaphezu kwesisodwa njalo ezinyangeni ezi-3 kuya kwezi-6, kuya ngemiphumela yokuhlolwa kwakho kwelabhorethri.

IDefferasirox isusa insimbi eyengeziwe emzimbeni wakho kancane ngokuhamba kwesikhathi. Qhubeka uthathe i-deferasirox noma ngabe uzizwa uphilile. Ungayeki ukuthatha i-deferasirox ngaphandle kokukhuluma nodokotela wakho.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-deferasirox,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-deferasirox, noma imiphi eminye imithi, noma iziphi izithako ezikumaphilisi e-deferasirox, ama-granules, noma amaphilisi okumiswa. Buza udokotela wakho noma usokhemisi uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi imishanguzo kadokotela neyokungabhalisi, amavithamini, izithako zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi uyayisho imithi efakwe kuhlu kusigaba ESIBALULEKILE SESEXWAYISO nanoma yikuphi okulandelayo: i-alosetron (Lotronex), i-aprepitant (iCinvanti, i-Emend), i-budesonide (i-Entocort, i-Pulmicort, i-Uceris, e-Symbicort), i-buspirone, i-cholestyramine (i-Prevalite), i-colesevelam (Welchol), colestipol (Colestid), conivaptan (Vaprisol), cyclosporine (Gengraf, Neoral, Sandimmune), darifenacin (Enablex), darunavir (Prezista, e-Prezcobix), dasatinib (Sprycel), dihydroergotamine (DHE 45, Migranone (Multaq), duloxetine (Cymbalta), eletriptan (Relpax), eplerenone (Inspra), ergotamine (Ergomar, eCafergot, Migergot), everolimus (Afinitor, Zortress), felodipine, fentanyl (Actiq, Duragesic, Subsysic, (I-Arnuity Ellipta, Flovent, eBreo Ellipta, Advair), izindlela zokuvimbela inzalo zamahomoni (amaphilisi okulawula ukubeletha, amabala, izindandatho, noma imijovo), indinavir (Crixivan), lopinavir (eKaletra), lovastatin (Altoprev), lurasidone (Latuda), maravirococ (Selzentry), midazolam, nisoldipine (Sular), paclitax el (Abraxane, Taxol), phenytoin (Dilantin, Phenytek), phenobarbital, pimozide (Orap), quetiapine (Seroquel), quinidine (eNuedexta), ramelteon (Rozerem), repaglinide (Prandin, e Prandimet), rifampin (Radampin) , eRifamate, eRifater), ritonavir (Norvir, eKaletra, Technivie, Viekira Pak), saquinavir (Invirase), sildenafil (Revatio, Viagra), simvastatin (Flolopid, Zocor, eVytorin), siroliumus (Rapamuneus), tacrol I-Astagraf, i-Envarsus, i-Prograf), i-theophylline (Theo-24), i-ticagrelor (i-Brilinta), i-tipranavir (i-Aptivus), i-tizanidine (i-Zanaflex), i-triazolam (i-Halcion), i-tolvaptan (i-Samsca) ne-vardenafil (i-Levitra, i-Staxyn). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• uma uthatha ama-antiacid aqukethe i-aluminium afana ne-Amphojel, Alternagel, Gaviscon, Maalox, noma Mylanta, thatha amahora amabili ngaphambi noma ngemuva kwe-deferasirox.
• utshele udokotela wakho ukuthi yimiphi imikhiqizo yamakhemikhali oyithathayo, ikakhulukazi i-melatonin, noma izithasiselo ze-caffeine.
• Tshela udokotela wakho uma une-myelodysplastic syndrome (inkinga enkulu ngomnkantsha wamathambo onobungozi obukhulu bokuba nomdlavuza), noma umdlavuza. Udokotela wakho angakutshela ukuthi ungathathi i-deferasirox.
• utshele udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uncelisa. Uma ukhulelwa ngenkathi uthatha i-deferasirox, shayela udokotela wakho.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Thatha umthamo ongabanjwanga kamuva ngosuku, okungenani amahora amabili ngemuva kokudla kwakho kokugcina nemizuzu engama-30 ngaphambi kokudla. Kodwa-ke, uma sekuyisikhathi somthamo olandelayo noma uma ungeke ukwazi ukuthatha i-deferasirox esiswini esingenalutho, weqa umthamo ophuthelwe bese uqhubeka nesimiso sakho sokulinganisa. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

I-Deferasirox ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ubuhlungu besisu
• isicanucanu
• ukuhlanza
• isifo sohudo

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezishiwo esigabeni ESIBALULEKILE SESEXWAYISO, shayela udokotela wakho ngokushesha:

• ukulahlekelwa ukuzwa
• izinkinga zokubona
• ukuqubuka, isifuba, isikhumba esihlabayo noma esikhanyayo, umkhuhlane, ama-lymph node avuvukile
• ubunzima bokuphefumula noma ukugwinya; ukuvuvukala kobuso, umphimbo, ulimi, izindebe, noma amehlo; ukushaqeka
• ukulimaza noma ukopha okungavamile

I-Deferasirox ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese).

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

• ukuphuzi kwesikhumba noma kwamehlo
• ubuhlungu engxenyeni engenhla kwesokudla yesisu
• ukulimaza noma ukopha okungavamile
• ukungabi namandla
• ukulahlekelwa isifiso sokudla
• izimpawu ezinjengomkhuhlane
• isifo sohudo
• isicanucanu
• ukuhlanza
• ukuncipha kokuchama
• ukuvuvukala kwemilenze noma amaqakala

Gcina wonke ama-aphoyintimenti nodokotela wakho. Uzodinga ukuba nezivivinyo zokuzwa nezamehlo ngaphambi kokuqala ama-deferasirox futhi kanye ngonyaka ngenkathi uthatha lo muthi.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• I-Exjade^®
• Jadenu^®