I-Tipranavir

-Delile

• Ngaphambi kokuthatha i-tipranavir,
• I-Tipranavir ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SEXWAYISO, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

I-Tipranavir (ethathwe nge-ritonavir [Norvir]) ingadala ukopha ebuchosheni. Lesi simo singasongela impilo. Tshela udokotela wakho uma usanda kuhlinzwa, noma ngabe usanda kulimala nganoma iyiphi indlela. Futhi, tshela udokotela wakho uma unenkinga yokopha njenge-hemophilia (isimo lapho igazi lingavaleki ngokujwayelekile). Tshela udokotela kanye nosokhemisi wakho uma usebenzisa noma iyiphi yale mithi elandelayo: ama-anticoagulants ('ama-thinner egazi') njenge-warfarin (i-Coumadin, i-Jantoven), i-aspirin noma imikhiqizo equkethe i-aspirin, i-cilostazol, i-clopidogrel (i-Plavix), i-dipyridamole (i-Persantine, ku-Aggrenox ), eptifibatide (Integrilin), heparin, nonsteroidal anti-inflammatory drugs (ibuprofen, naproxen), prasugrel (Effient), ticlopidine, noma tirofiban (Aggrastat). Kufanele futhi utshele udokotela wakho kanye nosokhemisi uma uthatha uvithamini E, ngaphandle kwenani eliqukethwe kwi-multivitamin ejwayelekile yansuku zonke. Uma udinga ukuthola ukwelashwa okuphuthumayo nganoma yisiphi isizathu, qiniseka ukuthi utshela bonke odokotela abakuphathisayo ukuthi uthatha i-tipranavir. Shayela udokotela wakho ngokushesha uma uhlangabezana nokulimala okungajwayelekile noma ukopha ngesikhathi sokwelashwa kwakho nge-tipranavir.

I-Tipranavir (ethathwe nge-ritonavir [Norvir]) ingadala ukulimala kwesibindi okungasongela impilo. Tshela udokotela wakho uma uke waba ne-hepatitis (noma ukuvuvukala kwesibindi okubangelwa igciwane) noma esinye isifo sesibindi, noma uma uphuza noma uphuze utshwala. Uma uhlangabezana nanoma yiziphi kulezi zimpawu ezilandelayo, yeka ukuthatha i-tipranavir bese ushayela udokotela wakho ngokushesha: ukukhathala; ubuthakathaka; izimpawu ezinjengomkhuhlane; ukulahlekelwa ukudla; isicanucanu; ukuhlanza; ubuhlungu, ubuhlungu, ukuvuvukala, noma ukuzwela ohlangothini lwakho lokunene ngaphansi kwezimbambo zakho; ukuphuzi kwesikhumba noma kwamehlo; umchamo omnyama (onetayi); noma ukunyakaza kwamathumbu okuphaphathekile.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile ukuze ahlole impendulo yomzimba wakho ku-tipranavir.

Khuluma nodokotela wakho ngezingozi zokuthatha i-tipranavir.

I-Tipranavir isetshenziswa ne-ritonavir (Norvir) kanye neminye imithi yokwelapha ukutheleleka ngegciwane lesandulela ngculaza (i-HIV). UTipranavir usesigabeni semithi ebizwa ngama-protease inhibitors. Isebenza ngokunciphisa inani le-HIV egazini. Yize i-tipranavir ingayelaphi i-HIV, ingahle inciphise amathuba akho okuba ne-immunodeficiency syndrome (i-AIDS) kanye nezifo ezihlobene ne-HIV ezinjengezifo ezibucayi noma umdlavuza. Ukuthatha le mithi kanye nokwenza ucansi oluphephile nokwenza ezinye izinguquko kwimpilo yakho kunganciphisa ingozi yokudlulisela igciwane lesandulela ngculaza kwabanye abantu.

I-Tipranavir iza njenge-capsule nesisombululo somlomo (uketshezi) ukuthatha ngomlomo. Uma i-tipranavir ithathwa ngamaphilisi we-ritonavir noma isisombululo, imvamisa iba kabili ngosuku noma ngaphandle kokudla. Uma i-tipranavir ithathwa ngamaphilisi e-ritonavir, imvamisa iba kabili ngosuku nokudla. Thatha i-tipranavir ne-ritonavir ngezikhathi ezifanayo nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-tipranavir njengoba iqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Ungathathi i-tipranavir ngaphandle kwe-ritonavir.

Gwinya wonke amaphilisi; ungawahlafune noma uwachoboze. Uma ungakwazi ukugwinya amaphilisi, tshela udokotela noma usokhemisi.

I-Tipranavir iyasiza ukulawula ukutheleleka nge-HIV kepha ayiyelaphi. Qhubeka uthathe i-tipranavir noma ngabe uzizwa uphilile. Ungayeki ukuthatha i-tipranavir ngaphandle kokukhuluma nodokotela wakho. Uma uyeka ukuthatha i-tipranavir noma ukweqa imithamo, isimo sakho singase sibe nzima ukwelashwa. Lapho ukunikezwa kwakho kwe-tipranavir kuqala ukwehla, thola okuningi kudokotela noma kusokhemisi wakho.

Buza udokotela wakho noma usokhemisi ikhophi lemininingwane yomkhiqizi yesiguli. Funda lolu lwazi ngokucophelela bese ubuza udokotela noma usokhemisi wakho uma unemibuzo.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-tipranavir,

• Tshela udokotela kanye nosokhemisi wakho uma une-aleji ku-tipranavir, ritonavir (Norvir, e-Kaletra), imithi ye-sulfa, noma imiphi eminye imithi, noma iziphi izithako ezikuma-capsranavir capsule noma isixazululo. Buza usokhemisi wakho uma ungaqiniseki ukuthi umuthi owugulayo uyimithi ye-sulfa. Futhi, cela usokhemisi wakho ukuthola uhlu lwezithako eziku-tipranavir capsules noma isixazululo.
• utshele udokotela wakho uma uthatha noma iyiphi yale mithi elandelayo noma imikhiqizo yamakhambi: i-alfuzosin (i-Uroxatral); i-cisapride (Propulsid) (ayisatholakali e-U.S.); imithi ye-ergot yemigraines efana ne-dihydroergotamine (i-DHE 45, i-Migranal), i-ergoloid mesylate (i-Hydergine), i-ergotamine (i-Ergomar, eCafergot, eMigergot, abanye), noma i-methylergonovine (Methergine); imishanguzo ethile yokushaya kwenhliziyo okungajwayelekile kufaka phakathi i-amiodarone (Nexterone, Pacerone), i-flecainide, i-propafenone (i-Rythmol), noma i-quinidine (e-Nuedexta); i-lovastatin (Altoprev), i-lurasidone (iLatuda); i-midazolam ngomlomo; ipimozide (i-Orap); i-rifampin (iRifadin, iRimactane, eRifamate, eRifater); i-sildenafil (i-Revatio) yokwelashwa komfutho wegazi ophezulu we-pulmonary, i-simvastatin (iZocor, eVytorin); ISt John's wort; kanye ne-triazolam (Halcion). Udokotela wakho mhlawumbe uzokutshela ukuthi ungathathi i-tipranavir uma uthatha eyodwa noma ngaphezulu yale mithi.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi uyayisho imishanguzo ebhalwe esigabeni ESIBALULEKILE SESEXWAYISO nanoma yikuphi okulandelayo: imishanguzo yokubulala amagciwane efana ne-fluconazole (Diflucan), itraconazole (Onmel, Sporanox), ketoconazole (Extina, Nizoral, Xolegel), noma i-voriconazole (Vfend); i-boceprevir (ayisatholakali e-U.S .; eVictrelis); i-bosentan (iTracleer); ama-calcium-channel blockers afana ne-diltiazem (Cardizem, Cartia, Diltzac, Taztia, Tiazac, abanye), felodipine, nicardipine, nisoldipine (Sular), noma i-verapamil (Calan, Covera, Verelan, abanye); imithi yokwehlisa i-cholesterol ('statins') efana ne-atorvastatin (Lipitor, eCaduet) ne-rosuvastatin (Crestor); i-clarithromycin (i-Biaxin, ku-Prevpac); i-colchicine (Colcrys, Mitigare, ku-Col-Probenecid); i-desipramine (i-Norpramin); i-disulfiram (i-Antabuse); i-estrogen therapy yokwelashwa; i-fluticasone (Flonase, Flovent, e-Advair, eDymista); ama-immunosuppressants afana ne-cyclosporine (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune), noma tacrolimus (Astagraf, Envarsus XR, Prograf, abanye); imishanguzo yesifo sikashukela efana ne-glimepiride (i-Amaryl, e-Duetact), i-glipizide (i-Glucotrol), i-glyburide (i-Diabeta, i-Glynase, abanye), i-pioglitazone (i-Actos, e-Actoplus Met, e-Duetact, e-Oseni), i-repaglinide (i-Prandin, e-Prandimet), noma i-tolbutamide; imithi ethile yokungasebenzi kahle kwe-erectile kufaka phakathi i-sildenafil (Viagra), i-tadalafil (i-Adcirca, i-Cialis), noma i-vardenafil (i-Levitra, i-Staxyn); imishanguzo ethile yokuquleka okubalwa i-carbamazepine (Carbatrol, Epitol, Equetro, Tegretol, Teril), phenobarbital, phenytoin (Dilantin, Phenytek), ne-valproic acid (Depakene); eminye imishanguzo ye-HIV kubandakanya i-abacavir (iZiagen, e-Epzicom, e-Trizivir), i-atazanavir (Reyataz, e-Evotaz), i-dolutegravir (iTivicay, eJuluca), i-enfuvirtide (Fuzeon); i-etravirine (Intelence); i-fosamprenavir (Lexiva), lopinavir (eKaletra), i-raltegravir (Isentress), ne-saquinavir (i-Invirase); i-meperidine (i-Demerol); i-methadone (i-Dolophine, i-Methadose); i-metronidazole (i-Flagyl, ePylera); i-omeprazole (Prilosec, eZegerid); i-quetiapine (iSeroquel); i-rifabutin (i-Mycobutin); i-salmeterol (iSerevent, e-Advair); i-serotonin reuptake inhibitors ekhethiwe (SSRIs) efana ne-fluoxetine (i-Prozac, i-Sarafem, i-Selfemra, e-Symbyax), i-paroxetine (i-Brisdelle, i-Paxil, i-Pexeva), noma i-sertraline (i-Zoloft); i-telaprevir (ayisatholakali e-U.S .; i-Incivek); ne-trazodone. Eminye imishanguzo eminingi ingaxhumana ne-tipranavir, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho nalawo angaveli kulolu hlu. Qiniseka ukuthi ukhuluma nodokotela wakho noma usokhemisi ngaphambi kokuba uqale ukuthatha noma yimiphi imithi emisha ngenkathi welashwa nge-tipranavir. Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• uma uthatha i-didanosine (Videx), yithathe amahora amabili ngaphambi noma ngemuva kwamahora amabili uthathe i-tipranavir.
• uma uthatha ama-antacids, thatha ihora eli-1 ngaphambi noma ngemuva kwamahora ama-2 uthathe i-tipranavir.
• utshele udokotela wakho uma uke waba nesifo sikashukela noma ushukela ophakeme wegazi; i-cholesterol ephezulu yegazi noma i-triglycerides (amafutha egazi); noma ukutheleleka okufika kudlule njengesifo sofuba (i-TB), i-cytomegalovirus (CMV), i-herpes, i-Mycobacterium avium, i-shingles, noma i-pneumonia.
• kufanele wazi ukuthi abanye abantu abanesifo sikashukela bakhula ukuwohloka kwesifo sikashukela ngenkathi bethatha i-tipranavir. Uma unesifo sikashukela, kubalulekile ukuqapha ngokucophelela ushukela wegazi ngenkathi uthatha i-tipranavir bese ushayela udokotela wakho uma ushukela wegazi lakho uba nzima ukuwulawula. Udokotela wakho angadinga ukushintsha imithi yakho yesifo sikashukela noma akunikeze imithi emisha yokulawula ushukela wegazi lakho.
• utshele udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uncelisa. Uma ukhulelwa ngenkathi uthatha i-tipranavir, shayela udokotela wakho. Ungancelisi ibele uma utheleleke nge-HIV noma uthatha i-tipranavir.
• kufanele wazi ukuthi i-tipranavir inganciphisa ukusebenza kahle kokuvimbela inzalo ngamahomoni (amaphilisi okulawula ukubeletha, amabala, izindandatho nemijovo). Uzodinga ukusebenzisa enye indlela yokuvimbela inzalo ukuvimbela ukukhulelwa ngenkathi uthatha i-tipranavir. Khuluma nodokotela wakho ngezinye izindlela zokuvimbela ukukhulelwa ngenkathi uthatha lo muthi.
• uma uhlinzwa, kufaka phakathi ukuhlinzwa kwamazinyo, tshela udokotela noma udokotela wamazinyo ukuthi uthatha i-tipranavir.
• hlela ukugwema ukuvezwa yilanga ngokungadingekile noma isikhathi eside futhi ugqoke izingubo zokuzivikela, izibuko zelanga, nesikhumba selanga. I-Tipranavir ingenza isikhumba sakho sizwele ekukhanyeni kwelanga.
• kufanele wazi ukuthi amafutha akho omzimba angakhuphuka noma ahambele ezindaweni ezahlukahlukene zomzimba wakho njengasemuva kwentamo yakho namahlombe aphezulu (’buffalo hump’), isisu, namabele. Umzimba wakho ungalahlekelwa amanoni ezingalweni, emilenzeni, ebusweni nasezinqeni. Khuluma nodokotela wakho uma ubona noma yiziphi zalezi zinguquko emafutheni omzimba wakho.
• kufanele wazi ukuthi ungathola i-hyperglycemia (iyanda kushukela wakho wegazi) ngenkathi uthatha lo muthi, noma ngabe awunaso vele isifo sikashukela. Tshela udokotela wakho ngokushesha uma unanoma iyiphi yalezi zimpawu ezilandelayo ngenkathi uthatha i-tipranavir: ukoma ngokweqile, ukuchama njalo, ukulamba ngokweqile, ukungaboni kahle, noma ubuthakathaka. Kubaluleke kakhulu ukubiza udokotela wakho ngokushesha uma unezinye zalezi zimpawu, ngoba ushukela wegazi ongelashwa ungadala isimo esibi esibizwa nge-ketoacidosis. I-Ketoacidosis ingasongela impilo uma ingelashwa kusenesikhathi. Izimpawu ze-ketoacidosis zifaka phakathi umlomo owomile, isicanucanu nokuhlanza, ukuphefumula okuncane, ukuphefumula okunuka izithelo, nokuncipha kokwazi.
• kufanele wazi ukuthi ngenkathi uthatha imishanguzo yokwelapha ukutheleleka nge-HIV, amasosha omzimba wakho angaqina futhi aqale ukulwa nezinye izifo ezazivele zisemzimbeni wakho. Lokhu kungadala ukuthi ube nezimpawu zalezo zifo. Uma unezimpawu ezintsha noma eziba zimbi noma kunini ngesikhathi sokwelashwa kwakho nge-tipranavir, qiniseka ukuthi utshela udokotela wakho.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Thatha umthamo ophuthelwe kanye ne-ritonavir ngokushesha nje lapho uwukhumbula. Kodwa-ke, uma sekuyisikhathi somthamo olandelayo, weqa umthamo ongabanjwanga bese uqhubeka neshejuli yakho ejwayelekile yokulinganisa. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

I-Tipranavir ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• isifo sohudo
• ukuncipha komzimba
• ikhanda
• ubuhlungu besisu

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SEXWAYISO, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• umkhuhlane, ukubanda, ukukhwehlela, noma ezinye izimpawu zokutheleleka
• ukuqubuka
• ubomvu, ukuqhuma, noma ukuxebuka kwesikhumba
• ukulunywa
• ukuqina komphimbo
• ukuphelelwa umoya
• ubuthakathaka, ukuba ndikindiki nobuhlungu, ezandleni nasezinyaweni
• ukuphefumula kanzima noma ukugwinya
• ubuhlungu bemisipha noma bamalunga noma ukuqina

I-Tipranavir ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina amabhodlela angavuliwe ama-tipranavir capsules esiqandisini. Gcina amabhodlela avuliwe wamaphilisi we-tipranavir ekamelweni lokushisa, futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese). Gcina isisombululo se-tipranavir ekamelweni lokushisa. Ungafaki esiqandisini noma umise isixazululo se-tipranavir. Maka usuku ovula ngalo ibhodlela le-tipranavir kulebula; uma umuthi ungasetshenziswanga zingakapheli izinsuku ezingama-60, lahla umuthi osele.

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile zelebhu ukuze ahlole impendulo yomzimba wakho ku-tipranavir.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• I-Aptivus^®