Imatinib

-Delile

• Ngaphambi kokuthatha imatinib,
• I-Imatinib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu shayela udokotela wakho ngokushesha:
• Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

I-Imatinib isetshenziselwa ukwelapha izinhlobo ezithile ze-leukemia (umdlavuza oqala kumaseli amhlophe egazi) neminye imidlavuza nokuphazamiseka kwamaseli egazi. I-Imatinib ibuye isetshenziselwe ukwelapha izinhlobo ezithile zezicubu zomzimba emathunjini (i-GIST; uhlobo lwesimila olukhula ezindongeni zamaphaseji wokugaya futhi olungasakazeka kwezinye izingxenye zomzimba). I-Imatinib ibuye isetshenziselwe ukwelapha i-dermatofibrosarcoma protuberans (isimila esakheka ngaphansi koqweqwe lwesikhumba) lapho isimila singeke sisuswe ngokuhlinzwa, sesisabalalele kwezinye izingxenye zomzimba, noma sibuya ngemuva kokuhlinzwa. I-Imatinib isekilasini lemithi ebizwa nge-kinase inhibitors. Isebenza ngokuvimba ukusebenza kweprotheni engavamile ekhombisa ukuthi amangqamuzana omdlavuza ayanda. Lokhu kusiza ukunqanda ukusabalala kwamangqamuzana omdlavuza.

I-Imatinib iza njengethebhulethi ezothathwa ngomlomo. Imvamisa kuthathwa ngokudla nengilazi enkulu yamanzi kanye noma kabili ngosuku. Thatha imatinib cishe ngesikhathi esifanayo (ama) nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha imatinib njengoba nje kuqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Gwinya wonke amaphilisi; ungawahlafune noma uwachoboze. Uma uthinta noma uxhumana ngqo nethebulethi echotshoziwe, geza indawo kahle.

Uma ungakwazi ukugwinya amaphilisi e-imatinib, ungabeka wonke amaphilisi owadingayo ngomthamo owodwa engilazini yamanzi noma ujusi we-apula. Sebenzisa ama-milliliters angama-50 (okungaphansi kwama-ounces amabili) ketshezi kuthebhulethi ngayinye eyi-100-mg kanye nama-milliliters angama-200 (okungaphansi kwama-ounces ayisikhombisa) ketshezi kuthebhulethi ngayinye engama-400-mg. Hlanganisa ngesipuni kuze kube yilapho amaphilisi edilika ngokuphelele bese uphuza ingxube ngokushesha.

Uma udokotela wakho ekutshele ukuthi uthathe i-800 mg ye-imatinib, kufanele uthathe amaphilisi ama-2 kwangu-400-mg. Ungathathi amaphilisi ayi-8 kwangu-100-mg. Isembozo sethebhulethi siqukethe i-iron, futhi uzothola i-iron eningi kakhulu uma uthatha amaphilisi ayi-8 kwangu-100-mg.

Udokotela wakho angakhuphula noma anciphise umthamo wakho we-imatinib ngesikhathi sokwelashwa kwakho. Lokhu kuncike ekutheni umuthi usebenza kanjani kuwe nasemiphumeleni oyitholayo. Khuluma nodokotela wakho mayelana nokuthi uzizwa kanjani ngesikhathi sokwelashwa kwakho. Qhubeka uthathe imatinib noma ngabe uzizwa uphilile. Ungayeki ukuthatha imatinib ngaphandle kokukhuluma nodokotela wakho.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha imatinib,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-imatinib, noma imuphi omunye umuthi, noma iziphi izithako ezibhebheni ze-imatinib. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi imishanguzo kadokotela noma engabhaliswanga, amavithamini, kanye nezithako zokudla okunomsoco ozithathayo noma ohlela ukuzithatha.Qiniseka ukuthi usho noma yikuphi okulandelayo: i-acetaminophen (Tylenol), alprazolam (Xanax), amlodipine (Norvasc, eCaduet, Lotrel, Tribenzor, abanye), atazanavir (Reyataz), atorvastatin (Lipitor, eCaduet), carbamazepine (Carbatrol, I-Equetro, Tegretol, abanye), i-clarithromycin (i-Biaxin, e-Prevpac), i-cyclosporine (i-Gengraf, i-Neoral, i-Sandimmune), i-dexamethasone, i-ergotamine (i-Ergomar, e-Migergot, i-Cafergot), i-erythromycin (i-EES, i-Eryc, i-Eryipine, abanye), , fentanyl (Duragesic, Subsys, Fentora, others), fosphenytoin (Cerebyx), indinavir (Crixivan), iron, noma i-iron equkethe izithasiselo, isradipine, itraconazole (Onmel, Sporanox), ketoconazole, lovastatin (Altoprev), metoprolol (Lopoprol) I-XL, eDutoprol), nefazodone, nelfinavir (Viracept), nicardipine (Cardene), nifedipine (Adalat CC, Procardia, abanye), nimodipine (Nymalize), nisoldipine (Sular), oxcarbazepine (Oxtellar XR, Trileptal), phenyarinital (phenobarbital) I-Dilantin, Phenytek), i-pimozide (i-Orap), i-primidone (iMysoline), i-qui i-nidine (eNuedexta), rifabutin (Mycobutin), rifampin (rifadin, rimactane, eRifamate, Rifater), ritonavir (Norvir, eKaletra, Technivie, Viekira), saquinavir (Fortovase, Invirase), simvastatin (Zocor, sirolimus (Rapamune), tacrolimus (Astagraf XL, Envarsus XR, Prograf), telithromycin, triazolam (Halcion), voriconazole (Vfend), ne-warfarin (Coumadin, Jantoven). Eminye imishanguzo eminingi ingaxhumana ne-imatinib, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho nalawo angaveli kulolu hlu. Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• utshele udokotela wakho ukuthi uthatha miphi imikhiqizo yamakhambi, ikakhulukazi iSt John's wort.
• Tshela udokotela wakho uma uke waba nesifo senhliziyo, samaphaphu, se-thyroid, sesinso noma sesibindi.
• utshele udokotela wakho uma ukhulelwe noma uhlela ukukhulelwa. Kuzofanele uthathe ukuhlolwa kokukhulelwa ngaphambi kokuqala ukwelashwa, Akufanele ukhulelwe ngenkathi uthatha imatinib nezinsuku eziyi-14 ngemuva komthamo wakho wokugcina. Khuluma nodokotela wakho ngezindlela zokulawula ukubeletha ongazisebenzisa ngesikhathi sokwelashwa kwakho. Uma ukhulelwa ngenkathi uthatha i-imatinib, shayela udokotela wakho. Imatinib ingalimaza umbungu.
• tshela udokotela wakho uma uncelisa. Akufanele uncelise ibele ngenkathi uthatha i-imatinib nenyanga eyodwa ngemuva komthamo wakho wokugcina.
• uma uhlinzwa, kufaka phakathi ukuhlinzwa kwamazinyo, tshela udokotela noma udokotela wamazinyo ukuthi uthatha i-imatinib.
• kufanele wazi ukuthi i-imatinib ingakwenza ube nesiyezi, ukozele, noma kubangele ukungaboni kahle. Ungashayeli imoto noma usebenzise imishini uze wazi ukuthi lo muthi ukuthinta kanjani.

Ungadli isithelo samagilebhisi noma uphuze ijusi lamagilebhisi ngenkathi uthatha lo muthi.

Thatha umthamo ongabanjwanga ngokushesha nje lapho uwukhumbula. Kodwa-ke, uma sekuyisikhathi somthamo olandelayo, weqa umthamo ongabanjwanga bese uqhubeka neshejuli yakho ejwayelekile yokulinganisa. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

I-Imatinib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• isifo sohudo
• isicanucanu
• ukuhlanza
• shintsha ngendlela izinto ezinambitha ngayo
• izilonda zomlomo noma ukuvuvukala emlonyeni
• ukulahlekelwa isifiso sokudla
• ukuncipha komzimba
• isilungulela noma isisu
• umlomo owomile
• ikhanda
• ukuvuvukala okuhlangene noma ubuhlungu
• ubuhlungu bamathambo
• amajaqamba, ama-spasms, noma ubuhlungu
• ukushoshozela, ukushisa. noma umuzwa ohlabayo esikhumbeni
• ubunzima bokulala noma ukulala
• ukujuluka
• amehlo anezinyembezi
• iso elibomvana
• ukuqhuma
• isikhumba esomile
• ukuqubuka
• ukulunywa
• izipikili ziyashintsha
• ukulahleka kwezinwele

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu shayela udokotela wakho ngokushesha:

• ukuvuvukala ezungeze amehlo
• ukuvuvukala kwezandla, izinyawo, amaqakala, noma imilenze engezansi
• ukuzuza kwesisindo ngokungazelelwe
• ukuphelelwa umoya
• ukushaya kwenhliziyo okusheshayo, okungajwayelekile, noma okushaya ngamandla
• ukukhwehlela isikhwehlela esibomvana noma esinegazi
• ukwanda kokuchama, ikakhulukazi ebusuku
• ubuhlungu besifuba
• ukuxebuka, ukushwabana, noma ukuchitha isikhumba
• ukuphuzi kwesikhumba noma kwamehlo
• igazi esitokisini
• ukulimaza noma ukopha okungavamile
• izimpawu ezinjengomkhuhlane, umphimbo obuhlungu, umkhuhlane, ukugodola nezinye izimpawu zokutheleleka
• ukukhathala ngokweqile noma ubuthakathaka
• ubuhlungu besisu noma ukuqunjelwa

I-Imatinib inganciphisa ukukhula ezinganeni. Udokotela wengane yakho uzobuka ukukhula kwakhe ngokucophelela. Khuluma nodokotela wengane yakho ngezingozi zokunikeza i-imatinib enganeni yakho.

I-Imatinib ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese).

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

• isicanucanu
• ukuhlanza
• isifo sohudo
• ukuqubuka
• ukuvuvukala
• ukukhathala ngokweqile
• amajaqamba noma ama-spasms
• ubuhlungu besisu
• ikhanda
• ukulahlekelwa isifiso sokudla

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile zelebhu ukuze ahlole impendulo yomzimba wakho ku-imatinib.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• Gleevec^®