Inaliti ye-Bevacizumab

-Delile

• Kusetshenziswa imikhiqizo yomjovo we-Bevacizumab
• Ngaphambi kokuthola umkhiqizo womjovo we-bevacizumab,
• Imikhiqizo yomjovo we-Bevacizumab ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

Umjovo we-Bevacizumab, umjovo we-bevacizumab-awwb, nomjovo we-bevacizumab-bvzr yimithi ye-biologic (imithi eyenziwe ngezinto eziphilayo). Umjovo we-Biosimilar bevacizumab-awwb nomjovo we-bevacizumab-bvzr ufana kakhulu nomjovo we-bevacizumab futhi usebenza ngendlela efanayo nomjovo we-bevacizumab emzimbeni. Ngakho-ke, igama elithi imikhiqizo ye-bevacizumab injection izosetshenziselwa ukumela le mithi kule ngxoxo.

Kusetshenziswa imikhiqizo yomjovo we-Bevacizumab

• ngokuhlanganiswa neminye imithi yokwelapha ngamakhemikhali yokwelapha umdlavuza wekholoni (amathumbu amakhulu) noma i-rectum esabalele kwezinye izingxenye zomzimba;
• ngokuhlanganiswa neminye imithi yokwelashwa ngamakhemikhali ukwelapha izinhlobo ezithile zomdlavuza wamaphaphu osabalale waya ezicutshini eziseduze noma kwezinye izingxenye zomzimba, ezingasuswa ngokuhlinzwa, noma ezibuyile ngemuva kokwelashwa ngeminye imithi ye-chemotherapy;
• ukwelapha i-glioblastoma (uhlobo oluthile lwesimila somdlavuza wobuchopho) olungakathuthuki noma olubuyile ngemuva kokwelashwa ngeminye imithi;
• ngokuhlanganiswa ne-interferon alfa yokwelapha umdlavuza wamangqamuzana omzimba (i-RCC, uhlobo lomdlavuza oqala ezinso) osusakazekele kwezinye izingxenye zomzimba;
• ngokuhlangana neminye imithi yokwelapha ngamakhemikhali yokwelapha umdlavuza womlomo wesibeletho (umdlavuza oqala ekuvulekeni kwesibeletho [isibeletho]) ongakathuthuki noma obuye emuva kokwelashwa ngeminye imithi noma osabalale kwezinye izingxenye zomzimba;
• ngokuhlangana neminye imithi yokwelapha ngamakhemikhali ukwelapha izinhlobo ezithile zama-ovarian (izitho zokuzala zabesifazane lapho kwakhiwa khona amaqanda), ishubhu lesisu (ishubhu elihambisa amaqanda akhishwe ama-ovari liye esibelethweni), kanye ne-peritoneal (ungqimba lwezicubu ezigcwala isisu) umdlavuza lokho akukaze kuthuthuke noma kubuye emuva kokwelashwa neminye imithi; futhi
• ngokuhlanganiswa ne-atezolizumab ukwelapha i-hepatocellular carcinoma (HCC) esakaze noma engasuswa ngokuhlinzwa kubantu abangakaze bathole i-chemotherapy ngaphambili.

Imikhiqizo yomjovo we-Bevacizumab isesigabeni semithi ebizwa ngama-antiangiogenic agents. Basebenza ngokumisa ukwakheka kwemithambo yegazi eletha umoya-mpilo nezakhamzimba kwizicubu. Lokhu kunganciphisa ukukhula nokusabalala kwezimila.

Imikhiqizo yomjovo we-Bevacizumab iza njengesisombululo (uketshezi) ukuphatha kancane emthanjeni. Imikhiqizo yomjovo we-Bevacizumab ilawulwa udokotela noma umhlengikazi ehhovisi lezokwelapha, isikhungo sokumnika, noma isibhedlela. Imikhiqizo yomjovo we-Bevacizumab ivame ukunikezwa kanye njalo emavikini ama-2 noma ama-3. Isikhathi sakho sokulinganisa sizoncika esimweni onaso, eminye imithi oyisebenzisayo, nokuthi umzimba wakho uphendula kahle kanjani ekwelashweni.

Kufanele kuthathe imizuzu engama-90 ukuthi uthole umthamo wakho wokuqala womkhiqizo womjovo we-bevacizumab. Udokotela noma umhlengikazi uzokubheka eduze ukuze abone ukuthi umzimba wakho uphendula kanjani ku-bevacizumab. Uma ungenazo izinkinga ezinkulu lapho uthola umthamo wakho wokuqala womkhiqizo womjovo we-bevacizumab, imvamisa kuzothatha imizuzu engama-30 kuye kwangama-60 ukuthi uthole umthamo wakho ngamunye osele womuthi.

Imikhiqizo yomjovo we-Bevacizumab ingadala ukusabela okukhulu ngesikhathi sokufakwa komuthi. Uma uhlangabezana nalezi zimpawu ezilandelayo, tshela udokotela wakho ngokushesha: ubunzima bokuphefumula noma ukuphefumula kanzima, ukugodola, ukuqhaqhazela, ukujuluka, ikhanda, ubuhlungu besifuba, isiyezi, ukuzwa ukuquleka, ukugeleza, ukulunywa, ukuqubuka noma isifuba. Udokotela wakho kungadingeka ukuthi anciphise ukumnika kwakho, noma abambezele noma ayeke ukwelashwa kwakho uma uhlangabezana nalezi noma eminye imiphumela emibi.

Umjovo we-Bevacizumab (Avastin) kwesinye isikhathi usetshenziselwa ukwelapha ukonakala okumanzi okuhlobene nobudala (i-AMD; isifo esiqhubekayo seso esidala ukulahlekelwa yikhono lokubona ngqo phambili futhi singenza kube nzima kakhulu ukufunda, ukushayela, noma ukwenza okunye imisebenzi yansuku zonke). Khuluma nodokotela wakho ngezingozi zokusebenzisa i-bevacizumab ukwelapha isimo sakho.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthola umkhiqizo womjovo we-bevacizumab,

• Tshela udokotela kanye nosokhemisi wakho uma une-aleji ku-bevacizumab, bevacizumab-awwb, bevacizumab-bvzr, noma imuphi omunye umuthi, noma iziphi izithako emikhiqizweni yomjovo we-bevacizumab.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi imishanguzo kadokotela neyokungabhalisi, amavithamini, izithako zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho ama-anticoagulants (ama-thinner egazi) njenge-warfarin (i-Coumadin, i-Jantoven); kanye ne-sunitinib (Sutent). Tshela nodokotela wakho uma uthatha noma ngabe wake wathatha i-anthracycline (uhlobo lwe-chemotherapy olusetshenziselwa umdlavuza webele nezinye izinhlobo ze-leukemia) njenge-daunorubicin (Cerubidine), doxorubicin, epirubicin (Ellence), noma idarubicin (Idamycin) . Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• utshele udokotela wakho uma uke welashwa ngemisebe yokwelashwa ngemisebe ohlangothini lwesobunxele lwesifuba noma ukhalo; futhi uma uke waba nomfutho wegazi ophakeme noma owehlisiwe, ukuhluleka kwenhliziyo, noma yisiphi isimo esithinta inhliziyo yakho noma imithambo yegazi (amashubhu ahambisa igazi phakathi kwenhliziyo nezinye izingxenye zomzimba). Futhi, tshela udokotela wakho uma usanda kukhwehlela igazi.
• kufanele wazi ukuthi imikhiqizo yomjovo we-bevacizumab ingadala ukungabi nenzalo kwabesifazane (kunzima ukukhulelwa); noma kunjalo, akufanele ucabange ukuthi awukwazi ukukhulelwa. Tshela udokotela wakho uma ukhulelwe noma uhlela ukukhulelwa. Kufanele usebenzise ukulawulwa kokuzalwa ukuvimbela ukukhulelwa ngesikhathi sokwelashwa kwakho ngomkhiqizo womjovo we-bevacizumab futhi okungenani izinyanga eziyisithupha ngemuva komthamo wakho wokugcina.Uma ukhulelwa ngenkathi usebenzisa umkhiqizo womjovo we-bevacizumab, shayela udokotela wakho. I-Bevacizumab ingalimaza umbungu futhi inyuse ingozi yokulahleka kokukhulelwa.
• tshela udokotela wakho uma uncelisa. Akufanele uncelise ngesikhathi sokwelashwa kwakho ngomkhiqizo womjovo we-bevacizumab futhi okungenani izinyanga eziyisithupha ngemuva komthamo wakho wokugcina.
• kufanele wazi ukuthi lo muthi ungadala ukwehluleka kwe-ovari. Khuluma nodokotela wakho ngengozi yokungabi nenzalo kwabesifazane ebangelwa yi-bevacizumab. Khuluma nodokotela wakho ngezingozi zokusebenzisa umkhiqizo womjovo we-bevacizumab.
• utshele udokotela wakho uma usanda kuhlinzwa noma uma uhlela ukuhlinzwa, kufaka phakathi ukuhlinzwa kwamazinyo. Uma uhlelelwe ukuhlinzwa, udokotela wakho uzomisa ukwelashwa kwakho ngomkhiqizo womjovo we-bevacizumab okungenani izinsuku ezingama-28 ngaphambi kokuhlinzwa. Uma usanda kuhlinzwa, akufanele uthole umkhiqizo womjovo we-bevacizumab kuze kudlule okungenani izinsuku ezingama-28 futhi kuze kube yilapho indawo iselapheke ngokuphelele.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Uma uphuthelwa i-aphoyintimenti yokuthola umthamo womkhiqizo womjovo we-bevacizumab, shayela udokotela wakho ngokushesha okukhulu.

Imikhiqizo yomjovo we-Bevacizumab ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• isiyezi
• ukulahlekelwa isifiso sokudla
• isilungulela
• shintsha emandleni okunambitha ukudla
• isifo sohudo
• ukuncipha komzimba
• izilonda esikhumbeni noma emlonyeni
• izwi liyashintsha
• zanda noma zehla izinyembezi
• ikhala eligcwele noma eligijimayo
• ubuhlungu bemisipha noma bamalunga
• inkinga yokulala

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• ukuphuma kwamakhala noma ukopha ezinsinini zakho; ukukhwehlela noma ukuphalaza igazi noma okokusebenza okubukeka njengezizathu zekhofi; ukopha okungavamile noma ukulimaza; ukwanda kokuhamba kokuya esikhathini noma ukuphuma kwegazi esithweni sangasese; umchamo obomvana, obomvu, noma onsundu; okubomvu noma okulindile ukunyakaza kwamathumbu amnyama; noma ikhanda, isiyezi, noma ubuthakathaka
• ubunzima bokugwinya
• inkulumo ehamba kancane noma enzima
• ukuquleka
• ubuthakathaka noma ukuba ndikindiki kwengalo noma komlenze
• ubuhlungu besifuba
• ubuhlungu ezingalweni, entanyeni, emhlathini, esiswini, noma emuva emuva
• ukuphefumula okuncane noma ukuphefumula
• isithuthwane
• ukukhathala ngokweqile
• ukudideka
• ushintsho kumbono noma ukulahleka kombono
• umphimbo obuhlungu, umkhuhlane, amakhaza nezinye izimpawu zokutheleleka
• ukuvuvukala kobuso, amehlo, isisu, izandla, izinyawo, amaqakala noma imilenze engezansi
• ukuzuza kwesisindo okungaqondakali
• umchamo onamagwebu
• ubuhlungu, ubumnene, imfudumalo, ubomvu, noma ukuvuvukala emlenzeni owodwa kuphela
• ububomvu, ukulunywa, noma ukukala kwesikhumba
• ubuhlungu besisu, ukuqunjelwa, isicanucanu, ukuhlanza, ukuqhaqhazela noma umkhuhlane

Imikhiqizo yomjovo we-Bevacizumab ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthola lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Gcina wonke ama-aphoyintimenti nodokotela wakho. Udokotela wakho uzohlola umfutho wegazi lakho futhi avivinye umchamo wakho njalo ngenkathi welashwa ngomkhiqizo womjovo we-bevacizumab.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• U-Avastin^® (bevacizumab)
• UMvasi^® (bevacizumab-awwb)
• Zirabev^® (i-bevacizumab-bvzr)