I-Darunavir

-Delile

• Ngaphambi kokuthatha i-darunavir,
• IDarunavir ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, yeka ukuthatha i-darunavir bese ushayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

I-Darunavir isetshenziswa ne-ritonavir (Norvir) kanye neminye imithi yokwelapha ukutheleleka ngegciwane lesandulela ngculazi (HIV) kubantu abadala nasezinganeni ezineminyaka emi-3 nangaphezulu. UDarunavir usesigabeni semithi ebizwa ngama-protease inhibitors. Isebenza ngokunciphisa inani le-HIV egazini. Yize i-darunavir ingayelaphi i-HIV, ingahle yehlise amathuba akho okuba ne-immunodeficiency syndrome (i-AIDS) kanye nezifo ezihlobene ne-HIV ezinjengezifo ezinqala noma umdlavuza. Ukuthatha le mithi kanye nokwenza ucansi oluphephile nokwenza ezinye izinguquko endleleni yokuphila kunganciphisa ingozi yokudlulisela igciwane le-HIV kwabanye abantu.

IDarunavir iza njengethebhulethi nokumiswa ngomlomo (uketshezi) ukuthatha ngomlomo. Imvamisa ithathwa ngokudla nange-ritonavir kanye noma kabili ngosuku. Thatha i-darunavir cishe ngesikhathi esifanayo (ama) nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-darunavir njengoba nje kuqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Ungathathi i-darunavir ngaphandle kwe-ritonavir.

Gwinya amaphilisi wonke ngesiphuzo esifana namanzi noma ubisi. Ungawahlafune amaphilisi.

Nyakazisa ukumiswa kahle ngaphambi kokusebenzisa ngakunye ukuxuba umuthi ngokulinganayo. Sebenzisa isirinji yomlomo oweza nomuthi ukukhipha inani elifanele lokumiswa ebhodleleni. Ungakugwinya ukumiswa ngqo kusuka kusirinji. Geza isirinji ngamanzi bese uyivumela ukuthi yome kahle ngemuva kokusetshenziswa.

IDarunavir ilawula i-HIV kepha ayiyelaphi. Qhubeka uthathe i-darunavir noma ngabe uzizwa uphilile. Ungayeki ukuthatha i-darunavir ngaphandle kokukhuluma nodokotela wakho. Uma uyeka ukuthatha i-darunavir noma ukweqa imithamo, isimo sakho singaba nzima ukwelapha. Lapho ukunikezwa kwakho kwedarunavir kuqala ukwehla, thola okuningi kudokotela noma kukhemisi wakho.

Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi yesiguli.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-darunavir,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-darunavir, ritonavir, imithi ye-sulfa, noma imuphi omunye umuthi, noma iziphi izithako ezikumaphilisi e-darunavir noma ukumiswa. Buza usokhemisi wakho ukuthola uhlu lwezithako noma uma ungenaso isiqiniseko sokuthi umuthi owulwayo yi-sulfa.
• utshele udokotela wakho uma uthatha noma iyiphi yale mithi elandelayo: i-alfuzosin (i-Uroxatral); i-cisapride (Propulsid) (ayitholakali e-U.S.); i-dronedarone (iMultaq); i-elbasvir / grazoprevir (iZepatier); imishanguzo yohlobo lwe-ergot efana ne-dihydroergotamine (iDHE 45, Migranal), i-ergotamine (i-Ergomar, eCafergot, eMigergot), ne-methylergonovine (Methergine); lomitapide (Juxtapid); i-lovastatin (Mevacor, ku-Advicor); i-lurasidone (Latuda), i-midazolam (enikezwe ngomlomo); ipimozide (i-Orap); i-ranolazine (Ranexa); i-rifampin (iRifadin, iRimactane, eRifamate, eRifater); i-sildenafil (uphawu lwe-Revatio kuphela olusetshenziselwa isifo samaphaphu); simvastatin (iZocor, eVytorin); ISt John's wort; noma i-triazolam (Halcion). Udokotela wakho mhlawumbe uzokutshela ukuthi ungathathi i-darunavir. Futhi, uma unesifo sezinso noma sesibindi futhi uthatha i-colchicine (Colcrys, Mitigare, eCol-Probenecid), udokotela wakho uzokutshela ukuthi ungathathi i-darunavir.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, kanye nezithako zokudla okunomsoco ozithathayo noma ohlela ukuzithatha. Qinisekisa ukusho noma yikuphi kwalokhu okulandelayo: ama-anticoagulants (’ama-thinner egazi’) afana ne-apixaban (Eliquis), i-rivaroxaban powder (i-Xarelto), ne-warfarin (i-Coumadin, i-Jantoven); imishanguzo efana ne-itraconazole (i-Onmel, i-Sporanox), i-ketoconazole (i-Nizoral), i-posaconazole (i-Noxafil), ne-voriconazole (i-Vfend); i-artemether / lumefantrine (Coartem); ama-beta blocker afana ne-carvedilol (Coreg), metoprolol (Lopressor, Toprol XL, e-Dutoprol, ku-Lopressor HCT), kanye ne-timolol (Betimol, Istalol, e-Combigan, e-Cosopt, abanye); betamethasone; i-boceprevir (ayisatholakali e-U.S .; eVictrelis); i-bosentan (iTracleer); i-budesonide (Entocort, Pulmicort, Uceris, abanye); i-buprenorphine (iBelbuca, iBuprenex, ama-Butrans, eSuboxone, amanye); i-buprenorphine / naloxone (i-Bunavail, i-Suboxone, i-Zubsolv); buspirone; ama-calcium-channel blocker anjenge-amlodipine (Norvasc, eCaduet), diltiazem (Cardizem CD, Cartia, XT, Diltzac, others), felodipine (Plendil), nicardipine (Cardene), nifedipine (Adalat CC, Afebitab CR, Procardia), kanye i-verapamil (Calan, Covera, Verelan, eTarka); imithi ethile ye-chemotherapy efana ne-dasatinib (Sprycel), nilotinib (Tasigna), vinblastine, ne-vincristine (Marqibo Kit); imishanguzo yokwehlisa i-cholesterol (ama-statins) afana ne-atorvastatin (Lipitor, eCaduet), pravastatin (Pravachol), ne-rosuvastatin (Crestor); i-ciclesonide (i-Alvesco); i-clarithromycin (i-Biaxin, ku-Prevpac); imishanguzo ethile yokudangala njenge-amitriptyline, desipramine (Norpramin), imipramine, nortriptyline, paroxetine (Brisdelle, Paxil, Pexeva), sertraline (Zoloft), ne-trazodone; i-dexamethasone; diazepam (Diastat, Valium); estazolam; i-fentanyl (i-Abstral, i-Duragesic, i-Subsys); i-fluticasone (i-Flonase, i-Flovent, e-Advair); imithi ethile yegciwane le-hepatitis C (HCV) efana ne-glecaprevir / pibrentasvir (Mavyret) ne-simeprevir (ayisatholakali e-U.S.; i-Olysio); eminye imithi ye-HIV kubandakanya i-indinavir (Crixivan), lopinavir / ritonavir (Kaletra), maraviroc (Selzentry), ne-saquinavir (Invirase); izindlela zokuvimbela inzalo ze-hormonal (estrogen) (amaphilisi okulawula ukubeletha, amabala, izindandatho, okufakelwa noma imijovo); imishanguzo yokushaya kwenhliziyo engajwayelekile okubandakanya i-amiodarone (Nexterone, Pacerone), bepridil (ayisatholakali e-US), digoxin (Lanoxin), disopyramide (Norpace), flecainide, lidocaine (Xylocaine), mexiletine, propafenone (Rythmol), ne-quinidine (eNuedexta ); imishanguzo ethile yokuquleka okufana ne-carbamazepine (Carbatrol, Equetro, Tegretol, abanye), clonazepam (Klonopin), phenobarbital, ne-phenytoin (Dilantin, Phenytek); imithi ethile ecindezela amasosha omzimba njenge-cyclosporine (Gengraf, Neoral, Sandimmune), everolimus (Afinitor, Zortress), sirolimus (Rapamune), kanye ne-tacrolimus (Astagraf XL, Prograf); i-methadone (i-Dolophine, i-Methadose); i-methylprednisolone; i-mometasone (Asmanex); omeprazole (Prilosec); i-oxycodone (Xtampza); ama-phosphodiesterase inhibitors (PDE-5 inhibitors) asetshenziselwa ukungasebenzi kahle kwe-erectile njenge-avanafil (Stendra), sildenafil (Viagra), tadalafil (Cialis), ne-vardenafil (i-Levitra, iStaxyn); i-perphenazine; i-prednisone (iRayos); i-quetiapine (iSeroquel); i-rifabutin (i-Mycobutin); i-rifapentine (Priftin); i-risperidone (i-Risperdal); i-salmeterol (iSerevent, e-Advair); i-tadalafil (i-Adcirca); thioridazine; i-ticagrelor (Brilinta); i-tramadol (i-Conzip); i-triamcinolone (i-Nasacort); kanye ne-zolpidem (Ambien, Edluar, Intermezzo). Eminye imishanguzo eminingi ingaxhumana ne-darunavir, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho naleyo engabonakali kulolu hlu. Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• uma uthatha i-didanosine (Videx), thatha ihora eli-1 ngaphambi noma ngemuva kwamahora amabili uthathe i-darunavir.
• utshele udokotela wakho uma uke waba nesifo sikashukela noma ushukela ophakeme wegazi; i-hemophilia (ukuphazamiseka kwegazi lapho igazi lingahlanganisi kahle); i-hepatitis (ukuvuvukala kwesibindi okubangelwa igciwane), i-cirrhosis (isifo esibanga ukusikeka kwezicubu zesibindi), noma esinye isifo sesibindi; noma ukutheleleka okungapheli noma okufika kudlule njenge-cytomegalovirus (CMV; ukutheleleka ngegciwane okungadala izimpawu ezigulini ezinamasosha omzimba abuthakathaka), isifo se-mycobacterium avium complex (MAC; ukutheleleka kwamagciwane okungadala izimpawu ezinzima abantu abane-AIDS), i-pneumonia, noma isifo sofuba (i-TB; uhlobo lokutheleleka kwamaphaphu).
• tshela udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uncelisa. Uma ukhulelwa ngenkathi uthatha i-darunavir, shayela udokotela wakho. Ungancelisi ibele uma unegciwane lesandulela ngculaza noma uthatha i-darunavir.
• kufanele wazi ukuthi i-darunavir inganciphisa ukusebenza kwezindlela zokuvimbela inzalo ngamahomoni (amaphilisi okulawula ukubeletha, amabala, izindandatho, imijovo, noma izimila). Khuluma nodokotela wakho mayelana nokulawulwa kokuzalwa okungewona okwe-hormonalnjengendlela yokuvimbela (idivayisi evimbela isidoda ukuba singene esibelethweni njengekhondomu noma i-diaphragm) ukuvimbela ukukhulelwa ngenkathi uthatha lo muthi. Buza udokotela wakho ukuthi akusize ukhethe indlela yokulawula ukubeletha ezokusebenzela.
• kufanele wazi ukuthi amafutha omzimba wakho angakhuphuka noma ahambele ezindaweni ezahlukahlukene zomzimba wakho njengamabele akho, iqolo elingaphezulu, intamo, isifuba, nesisu. Ukulahleka kwamafutha emilenzeni, ezingalweni nasebusweni nakho kungenzeka.
• kufanele wazi ukuthi ungathola i-hyperglycemia (iyanda kushukela wakho wegazi) ngenkathi uthatha lo muthi, noma ngabe awunaso vele isifo sikashukela. Tshela udokotela wakho ngokushesha uma unezinye zalezi zimpawu ezilandelayo ngenkathi uthatha i-darunavir: ukoma ngokweqile, ukuchama kaningi, ukulamba ngokweqile, ukungaboni kahle, noma ubuthakathaka. Kubaluleke kakhulu ukubiza udokotela wakho ngokushesha uma unezinye zalezi zimpawu, ngoba ushukela wegazi ongelashwa ungadala isimo esibi esibizwa nge-ketoacidosis. I-Ketoacidosis ingasongela impilo uma ingelashwa kusenesikhathi. Izimpawu ze-ketoacidosis zifaka phakathi: umlomo owomile, isicanucanu nokuhlanza, ukuphefumula okuncane, ukuphefumula okunuka izithelo, nokuncipha kokwazi.
• kufanele wazi ukuthi ngenkathi uthatha imishanguzo yokwelapha ukutheleleka nge-HIV, amasosha omzimba wakho angaqina futhi aqale ukulwa nezinye izifo ezazivele zisemzimbeni wakho. Lokhu kungadala ukuthi ube nezimpawu zalezo zifo. Uma unezimpawu ezintsha noma eziya ziba zimbi noma kunini ngesikhathi sokwelashwa kwakho nge-darunavir, qiniseka ukuthi utshela udokotela wakho.

Khuluma nodokotela wakho mayelana nokudla isithelo samagilebhisi nokuphuza ijusi lamagilebhisi ngenkathi uthatha lo muthi.

Uma uthatha i-darunavir kanye ngosuku futhi uphuthelwa umthamo ngaphansi kwamahora ayi-12, thatha umthamo ongabanjwanga ngokushesha nje lapho uwukhumbula bese uthatha umthamo olandelayo ngesikhathi esihleliwe. Kodwa-ke, uma uphuthelwa umthamo ngaphezu kwamahora we-12, weqa umthamo ophuthelwe bese uqhubeka nesimiso sakho sokulinganisa. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

Uma uthatha i-darunavir kabili ngosuku futhi uphuthelwa umthamo ngaphansi kwamahora ayisithupha, thatha umthamo ongabanjwanga ngokushesha nje lapho uwukhumbula bese uthatha umthamo olandelayo ngesikhathi esihleliwe. Kodwa-ke, uma uphuthelwa umthamo ngaphezu kwamahora we-6, weqa umthamo ophuthelwe bese uqhubeka neshejuli yakho ejwayelekile yokulinganisa. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

IDarunavir ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ikhanda
• isifo sohudo
• ukuhlanza
• ubuhlungu besisu
• ukuqunjelwa

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, yeka ukuthatha i-darunavir bese ushayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• ukuqubuka
• isikhumba esihlabayo noma esishayayo
• izilonda zomlomo
• amehlo abomvu, avuvukile, alumayo noma anezinyembezi
• ubuhlungu bemisipha noma obuhlangene
• imfiva
• ukuvuvukala, ubumnene, ubomvu, noma ezinye izimpawu zokutheleleka
• isicanucanu
• ukukhathala ngokweqile
• ukulahlekelwa isifiso sokudla
• ubuhlungu engxenyeni engenhla kwesokudla yesisu
• ukuphuzi kwesikhumba noma kwamehlo
• indle ephaphathekile noma emnyama

IDarunavir ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese).

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile ukuze aqiniseke ukuthi kuphephile yini kuwe ukuthatha i-darunavir nokuhlola ukuphendula komzimba wakho ku-darunavir.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• I-Prezista^®
• I-Prezcobix^® (equkethe iDarunavir, Cobicistat)

• TMC-114