I-Dasatinib

-Delile

• Ngaphambi kokuthatha i-dasatinib,
• I-Dasatinib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:
• Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

I-Dasatinib isetshenziselwa ukwelapha uhlobo oluthile lwe-myeloid leukemia engapheli (i-CML; uhlobo lomdlavuza wamaseli amhlophe egazi) njengokwelashwa kokuqala nakubantu abangasakwazi ukuzuza kweminye imithi ye-leukemia kubandakanya i-imatinib (Gleevec) noma kulabo ayikwazi ukuthatha le mithi ngenxa yemiphumela emibi. I-Dasatinib nayo isetshenziselwa ukwelapha uhlobo oluthile lwe-CML engapheli ezinganeni. I-Dasatinib ibuye isetshenziselwe ukwelapha uhlobo oluthile lwe-acute lymphoblastic leukemia (BONKE; uhlobo lomdlavuza wamaseli amhlophe egazi) kubantu abangasakwazi ukuzuza kweminye imithi ye-leukemia noma abangakwazi ukuthatha le mithi ngenxa yemiphumela emibi. I-Dasatinib isekilasini lemithi ebizwa nge-kinase inhibitors. Isebenza ngokuvimba isenzo sephrotheni engavamile ekhombisa ukuthi amangqamuzana omdlavuza ayanda. Lokhu kusiza ukunqanda ukusabalala kwamangqamuzana omdlavuza.

I-Dasatinib iza njengethebhulethi ezothathwa ngomlomo. Imvamisa iphuzwa kanye ngosuku, ekuseni noma kusihlwa, noma kungadlwanga. Thatha i-dasatinib ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-dasatinib njengoba iqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Gwinya wonke amaphilisi; ungawahlukanisi, ungawahlafune noma uwagxoze. Gqoka amagilavu ​​e-latex noma ama-nitrile lapho uphatha amaphilisi acindezelwe ngephutha noma aphukile ukuvimbela ukuxhumana nomuthi.

Udokotela wakho angalungisa umthamo wakho noma ayeke unomphela ukwelashwa kwakho kwe-dasatinib ngokuya ngempendulo yakho ekwelashweni nanoma yimiphi imiphumela emibi oyitholayo. Khuluma nodokotela wakho mayelana nokuthi uzizwa kanjani ngesikhathi sokwelashwa kwakho. Qhubeka uthathe i-dasatinib noma ngabe uzizwa uphilile. Ungayeki ukuthatha i-dasatinib ngaphandle kokukhuluma nodokotela wakho.

Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi yesiguli.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-dasatinib,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-dasatinib, noma imuphi omunye umuthi, noma iziphi izithako ezibhebheni ze-dasatinib. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, kanye nezithako zokudla okunomsoco ozithathayo noma ohlela ukuzithatha. Qiniseka ukuthi usho noma ikuphi kokulandelayo: ama-anticoagulants (’’ ama-thinner egazi ’’) afana ne-warfarin (Coumadin, Jantoven); imithi ye-anthracycline yomdlavuza efana ne-daunorubicin (Cerubidine), doxorubicin (Doxil), ne-epirubicin (Ellence); ezinye izinto zokuvikela ezifana ne-ketoconazole (i-Nizoral), i-itraconazole (i-Onmel, i-Sporanox), ne-voriconazole (i-Vfend); i-clarithromycin (i-Biaxin, ku-PrevPac); i-dexamethasone; imishanguzo ethile esetshenziselwa ukwelapha igciwane lengculazi (i-HIV) njenge-atazanavir (Reyataz), indinavir (Crixivan), i-nelfinavir (i-Viracept), i-ritonavir (i-Norvir), ne-saquinavir (i-Invirase); imithi ethile yokushaya kwenhliziyo okungajwayelekile njenge-amiodarone (Nexterone, Pacerone), disopyramide (Norpace), dofetilide (Tikosyn), flecainide (Tambocor), mexiletine (Mexitil), procainamide, propafenone (Rythmol), quinidine (e-Nuedexta), I-Betapace, i-Betapace AF, i-Sorine), imithi yokwehlisa i-asidi esiswini njenge-cimetidine (Tagamet), i-famotidine (i-Pepcid), i-nizatidine (i-Axid), i-ranitidine (i-Zantac), i-esomeprazole (i-Nexium), i-lansoprazole (i-Prevacid), i-omeprazole (i-Prilosec), i-pantoprazole (Protonix), ne-rabeprazole (AcipHex); nefazodone; i-rifampin (Rimactane, Rifadin, eRifater, eRifamate); kanye ne-telithromycin (Ketek); Eminye imishanguzo eminingi ingaxhumana ne-dasatinib, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho naleyo engabonakali kulolu hlu. Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• uma uthatha ama-antacids, afana ne-aluminium hydroxide / magnesium hydroxide (Maalox), calcium carbonate (Tums), noma i-calcium carbonate ne-magnesium (Rolaids), thatha amahora amabili ngaphambi noma amahora amabili ngemuva kokuthatha i-dasatinib.
• utshele udokotela wakho ukuthi uthatha miphi imikhiqizo yamakhambi, ikakhulukazi iSt John's wort.
• Tshela udokotela wakho uma uke waba nokungezwani ne-lactose (ukungakwazi ukugaya imikhiqizo yobisi), amazinga aphansi e-potassium noma i-magnesium egazini lakho, i-QT syndrome ende (isimo senhliziyo esingadala isiyezi, ukuquleka, noma ukushaya kwenhliziyo okungajwayelekile), izinkinga namasosha akho omzimba, noma isibindi, amaphaphu, noma isifo senhliziyo.
• utshele udokotela wakho uma ukhulelwe noma uhlela ukukhulelwa. Akufanele ukhulelwe ngenkathi uthatha i-dasatinib nezinsuku ezingama-30 ngemuva komthamo wakho wokugcina. Khuluma nodokotela wakho ngezindlela zokulawula ukubeletha ezizokusebenzela. Uma ukhulelwa ngenkathi uthatha i-dasatinib, shayela udokotela wakho. Abesifazane abakhulelwe akufanele baphathe amaphilisi e-dasatinib achotshoziwe noma aphukile. I-Dasatinib ingalimaza umbungu.
• ungancelisi ibele ngenkathi uthatha i-dasatinib namasonto ama-2 ngemuva komthamo wakho wokugcina.
• kufanele wazi ukuthi lo muthi unganciphisa ukuzala kwabesilisa nabesifazane. Khuluma nodokotela wakho ngezingozi zokuthatha i-dasatinib.
• uma uhlinzwa, kufaka phakathi ukuhlinzwa kwamazinyo, tshela udokotela noma udokotela wamazinyo ukuthi uthatha i-dasatinib.

Ungadli isithelo samagilebhisi noma uphuze ijusi lamagilebhisi ngenkathi uthatha lo muthi.

Yeqa umthamo ophuthelwe bese uqhubeka nesimiso sakho sokulinganisa esivamile. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

I-Dasatinib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ubuhlungu bemisipha
• ubuthakathaka
• ubuhlungu obuhlangene
• ubuhlungu, ukushisa noma ukuncinza ezandleni noma ezinyaweni
• ukuqubuka
• ukubomvu kwesikhumba
• ukukhipha isikhumba
• ukuvuvukala, ukubomvu, nobuhlungu ngaphakathi emlonyeni
• izilonda zomlomo
• isifo sohudo
• isicanucanu
• ukuhlanza
• ukuqunjelwa
• ubuhlungu besisu noma ukuvuvukala
• ukulahlekelwa isifiso sokudla
• ukuncipha komzimba

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• umkhuhlane, umphimbo obuhlungu, amakhaza, kanye / noma ezinye izimpawu zokutheleleka
• ukuvuvukala kwamehlo, izandla, izingalo, izinyawo, amaqakala noma imilenze engezansi
• ukuzuza kwesisindo ngokungazelelwe
• ukuphefumula kanzima, ikakhulukazi lapho ulele phansi
• ukukhwehlela isikhwehlela esibomvana noma esinegazi
• ukukhwehlela okomile
• ubuhlungu besifuba obuba bucayi lapho ukhwehlela, uthimula, noma uphefumula kakhulu
• ingcindezi yesifuba
• isiyezi
• ukuquleka
• ukushaya kwenhliziyo okusheshayo, okungajwayelekile, noma okushaya ngamandla
• ikhanda
• ukukhathala
• ukudideka
• ukukhuliswa kwesifuba kwesikhashana (ezinganeni)
• ukulimaza noma ukopha okungavamile
• indle emnyama neyokulinda
• igazi elibomvu endle
• ukuhlanza okunegazi
• izinto zokuhlanza ezibukeka njengezizathu zekhofi
• inkulumo ehamba kancane noma enzima
• ubuthakathaka noma ukuba ndikindiki kwengalo noma komlenze

I-Dasatinib ingadala ukukhula okucothayo noma ubuhlungu bamathambo ezinganeni. Udokotela wengane yakho uzoqapha ukukhula kwengane yakho ngokucophelela ngenkathi ethatha i-dasatinib. Khuluma nodokotela wakho ngezingozi zokunikeza ingane yakho lo muthi.

I-Dasatinib ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese).

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

• ukulimaza noma ukopha okungavamile
• umkhuhlane, umphimbo obuhlungu, amakhaza, kanye / noma ezinye izimpawu zokutheleleka
• ukuphelelwa umoya
• ukushaya kwenhliziyo okusheshayo
• ikhanda
• isikhumba esiphaphathekile
• ukudideka
• ukukhathala

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile zelebhu ngaphambi nangesikhathi sokwelashwa kwakho ukuze ahlole impendulo yomzimba wakho ku-dasatinib.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• I-Sprycel^®