Injection ye-Insulin Degludec (rDNA Origin)

-Delile

• Ngaphambi kokusebenzisa i-insulin degludec,
• Lo muthi ungadala ushintsho kushukela wakho wegazi. Kufanele wazi izimpawu zikashukela wegazi ophansi futhi ophakeme nokuthi yini okufanele uyenze uma unalezi zimpawu. I-insulin degludec ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nalezi zimpawu, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:
• I-insulin degludec overdose ingenzeka uma usebenzisa kakhulu i-insulin degludec noma uma usebenzisa inani elifanele le-insulin degludec, kodwa udle okuncane kunokujwayelekile noma uvivinye umzimba kunokujwayelekile. I-insulin degludec overdose ingadala i-hypoglycemia. Uma unezimpawu ze-hypoglycemia, landela imiyalo kadokotela wakho yokuthi yini okufanele uyenze uma uba ne-hypoglycemia. Ezinye izimpawu zokudlula ngokweqile:

I-insulin degludec isetshenziselwa ukwelapha isifo sikashukela sohlobo 1 (isimo lapho umzimba ungakhiqizi i-insulin ngakho-ke awukwazi ukulawula inani likashukela egazini). Ibuye isetshenziselwe ukwelapha abantu abanesifo sikashukela sohlobo lwe-2 (isimo lapho umzimba ungasebenzisi i-insulin ngokwejwayelekile futhi, ngakho-ke, awukwazi ukulawula inani likashukela egazini) abadinga i-insulin ukulawula isifo sikashukela. Ezigulini ezinesifo sikashukela sohlobo 1, i-insulin degludec kufanele isetshenziswe nolunye uhlobo lwe-insulin (i-insulin esebenza okwesikhashana). Ezigulini ezinesifo sikashukela sohlobo lwesibili, i-insulin degludec ingasetshenziswa nolunye uhlobo lwe-insulin noma ngemithi yomlomo yesifo sikashukela. I-insulin degludec yinguqulo esebenza isikhathi eside, eyenziwe ngumuntu ye-insulin yomuntu. I-insulin degludec isebenza ngokufaka i-insulin evamise ukukhiqizwa ngumzimba nokusiza ukuhambisa ushukela egazini uye kwezinye izicubu zomzimba lapho isetshenziselwa khona amandla. Iphinde ime isibindi ekukhiqizeni ushukela owengeziwe.

Ngokuhamba kwesikhathi, abantu abanesifo sikashukela kanye noshukela ophakeme wegazi bangakhula babe nezinkinga ezinkulu noma ezisongela impilo, kufaka phakathi isifo senhliziyo, isifo sohlangothi, izinkinga zezinso, ukulimala kwemizwa nezinkinga zamehlo. Ukusebenzisa imithi, ukwenza izinguquko endleleni ophila ngayo (isb., Ukudla, ukuzivocavoca, ukuyeka ukubhema), nokuhlola njalo ushukela wegazi lakho kungasiza ukuphatha isifo sikashukela futhi kuthuthukise impilo yakho. Lokhu kwelashwa kunganciphisa namathuba akho okuhlaselwa yisifo senhliziyo, isifo sohlangothi, noma ezinye izinkinga ezihlobene nesifo sikashukela njengokuhluleka kwezinso, ukulimala kwemizwa (okundikindiki, imilenze ebandayo noma izinyawo; ukwehla kwekhono lezocansi kwabesilisa nabesifazane), izinkinga zamehlo, kufaka phakathi izinguquko noma ukulahleka kombono, noma isifo sezinsini. Udokotela wakho nabanye abahlinzeki bezokunakekelwa kwezempilo bazokhuluma nawe ngendlela engcono yokuphatha isifo sikashukela.

I-insulin degludec iza njengesisombululo (uketshezi) ukujova ngomgogodla (ngaphansi kwesikhumba). Kujova kanye ngosuku. Kufanele usebenzise i-insulin degludec ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Sebenzisa i-insulin degludec njengoba nje kuqondisiwe. Ungayisebenzisi ngaphezulu noma ngaphansi kwayo noma uyisebenzise kaningi kunokuyalelwa ngudokotela wakho.

I-insulin degludec ilawula isifo sikashukela, kepha ayiselaphi. Qhubeka nokusebenzisa i-insulin degludec noma ngabe uzizwa uphilile. Ungayeki ukusebenzisa i-insulin degludec ngaphandle kokukhuluma nodokotela wakho. Ungashintsheli kolunye uhlobo noma uhlobo lwe-insulin noma ushintshe umthamo wanoma yiluphi uhlobo lwe-insulin oyisebenzisayo ngaphandle kokukhuluma nodokotela wakho. Njalo hlola ilebula le-insulin ukuze uqiniseke ukuthi uthola uhlobo olulungile lwe-insulin ekhemisi.

I-insulin degludec ingena ezibayeni zokufaka ezithandwayo. Qiniseka ukuthi uyazi ukuthi uluhlobo luni lwesitsha i-insulin degludec yakho engenayo nokuthi iziphi ezinye izinto, njengezinaliti, ozodinga ukujova umuthi wakho. Qiniseka ukuthi ufunda futhi uqonde imiyalelo yomkhiqizi. Cela udokotela wakho noma usokhemisi ukuthi akubonise ukuthi uyisebenzisa kanjani ipeni. Landela izinkomba ngokucophelela, futhi njalo wenze ukuhlolwa kokuphepha ngaphambi kokusetshenziswa.

Ungalokothi usebenzise izinaliti noma izibaya. Ungadlulisi umuthi esirinji. Uma usebenzisa ipeni le-insulin, hlala njalo ngenaliti ngemuva nje kokujova umthamo wakho. Phonsa izinaliti nemijovo esitsheni esingamelana nokubhoboza. Buza udokotela wakho noma usokhemisi ukuthi ungasilahla kanjani isitsha esingamelana nokubhoboza.

Musa ukuxuba i-insulin degludec futhi ungahlanganisi i-insulin degludec nanoma yiluphi olunye uhlobo lwe-insulin.

Ungafaka i-insulin degludec yakho engalweni yakho ephezulu, ethangeni, noma esiswini. Ungalokothi ujove i-insulin degludec emthanjeni noma emisipheni. Shintsha (jikelezisa) indawo yokujova ngaphakathi kwendawo ekhethiwe ngomthamo ngamunye; zama ukugwema ukujova isiza esifanayo kaningi ngaphezu kwesisodwa njalo emavikini ayi-1 kuye kwayi-2.

Hlala ubheka i-insulin degludec yakho ngaphambi kokuyifaka. Kufanele icace futhi ingenambala. Ungayisebenzisi i-insulin degludec yakho uma inemibala, inamafu, noma iqukethe izinhlayiya eziqinile, noma uma usuku lokuphelelwa yisikhathi ebhodleleni seludlulile.

Ungasebenzisi i-insulin degludec kwiphampu yangaphandle ye-insulin.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokusebenzisa i-insulin degludec,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-insulin (Humulin, Novolin, abanye), noma iziphi izithako eziku-insulin degludec, noma eminye imithi. Buza usokhemisi wakho noma hlola imininingwane yesiguli somkhiqizi ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi imishanguzo kadokotela nemishanguzo ongayinikiwe, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyiphuzayo. Qinisekisa ukusho noma yikuphi kokulandelayo: i-albuterol (i-Accuneb, i-Proair, i-Proventil, abanye); i-angiotensin-converting enzyme inhibitors (i-ACE inhibitors) efana ne-benazepril (i-Lotensin, eLotrel), i-captopril, i-enalapril (i-Vasotec, ngesi-Vaseretic), i-fosinopril, i-lisinopril (e-Prinzide, e-Zestoretic), i-moexipril (Univasc, in I-Aceon, ePrestalia), i-quinapril (i-Accupril, ngesi-Accuretic, ngesiQuinaretic), i-ramipril (i-Altace), ne-trandolapril (i-Mavik, eTarka); ama-angiotensin receptor blockers (ama-ARB) afana ne-azilsartan (Edarbi, e-Edarbyclor), amakhandlela (Atacand, e-Atacand HCT), eprosartan (Teveten), irbesartan (Avapro, e-Avalide), losartan (Cozaar, e-Hyzaar), telmisartan Micard eMicardis HCT, eTwynsta), i-valsartan (iDiovan, eDiovan HCT, e-Exforge); i-antipsychotic efana ne-clozapine (Clozaril, Fazaclo, Versacloz) ne-olanzapine (iZyprexa, e-Symbyax); ama-beta-blocker anjenge-atenolol (Tenormin, in Tenoretic), labetalol (Trandate), metoprolol (Lopressor, Toprol XL, eDutoprol, eLopressor HCT), nadolol (Corgard, eCorzide), nepropranolol (Hemangeol, Inderal LA, Innopran I-XL); imithi yokwehlisa i-cholesterol efana ne-fenofibrate (i-Antara, i-Lipofen, i-TriCor, i-Triglide), i-gemfibrozil (i-Lopid), ne-niacin (i-Niacor, i-Niaspan, e-Advicor, e-Simcor); clonidine (Catapres, Catapres-TTS, Kapvay, eClorpres, abanye); i-danazol; i-disopyramide (iNorpace); isisu (‘amaphilisi amanzi’); i-fluoxetine (i-Prozac, i-Sarafem, i-Selfemra, ku-Symbyax); i-glucagon; i-guanethidine; Ama-HIV protease inhibitors afaka i-atazanavir (Reyataz, e-Evotaz), indinavir (Crixivan), lopinavir (e-Kaletra), i-nelfinavir (i-Viracept), i-ritonavir (i-Norvir, i-Kaletra, i-Viekira Pak), ne-saquinavir (i-Invirase); i-isoniazid (iLaniazid, eRifamate, eRifater); i-lithium (i-Lithobid); imithi yesifuba somoya nemikhuhlane; imithi yesifo sikashukela; ukwelashwa kwama-menopausal hormone kanye nezindlela zokuvimbela inzalo ze-hormonal (amaphilisi okuvimbela inzalo, amabala, izindandatho, imijovo, noma izinto zokufakelwa); imithi yokugula ngengqondo kanye nesicanucanu; i-monoamine oxidase (MAO) inhibitors kufaka phakathi i-isocarboxazid (Marplan), i-phenelzine (i-Nardil), i-selegiline (i-Eldepryl, i-Emsam, i-Zelapar) ne-tranylcypromine (i-Parnate); i-octreotide (iSandostatin); i-pioglitazone (Actos, e-Actoplus Met, eDuetact, ezinye); ipentamidine (NebuPent, Pentam); i-pentoxifylline (Pentoxil); i-pramlintide (Symlin); i-propoxyphene (ayitholakali e-U.S.); qamba kabusha; i-rosiglitazone (i-Avandia, e-Avandamet, e-Avandaryl); ubuhlungu be-salicylate buqeda njenge-aspirin, i-choline magnesium trisalicylate, i-choline salicylate, i-diflunisal, i-magnesium salicylate (i-Doan's, abanye), ne-salsalate; somatropin (Genotropin, Humatrope, Nutropin, Serostim, abanye); ama-steroids afana ne-dexamethasone, i-methylprednisolone (Medrol), ne-prednisone (i-Rayos); i-sulfa antibiotic; i-terbutaline; nemithi yegilo. Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• Tshela udokotela wakho uma ngabe uke waba nomonakalo wezinzwa obangelwa yisifo sakho sikashukela, noma ezinye izimo zezokwelapha, kubandakanya inhliziyo, isibindi noma isifo sezinso.
• utshele udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uncelisa. Uma ukhulelwa ngenkathi usebenzisa i-insulin degludec, shayela udokotela wakho.
• uma uhlinzwa, kufaka phakathi ukuhlinzwa kwamazinyo, tshela udokotela noma udokotela wamazinyo ukuthi usebenzisa i-insulin degludec.
• utshwala bungadala ushintsho kushukela wegazi. Buza udokotela wakho mayelana nokusetshenziswa okuphephile kweziphuzo ezidakayo ngenkathi usebenzisa i-insulin degludec.
• buza udokotela wakho ukuthi wenzeni uma ugula, uba nengcindezi engajwayelekile, noma ushintsha indlela odla ngayo, ukuzivocavoca umzimba noma uhlelo lomsebenzi. Lezi zinguquko zingathinta ushukela wegazi lakho nenani le-insulin oyodinga.
• buza udokotela wakho ukuthi kufanele uhlole kaningi kangakanani ushukela wegazi lakho. Yazi ukuthi i-hypoglycemia ingathinta ikhono lakho lokwenza imisebenzi efana nokushayela bese ubuza udokotela wakho ukuthi udinga ukuhlola ushukela wegazi ngaphambi kokushayela noma ukusebenzisa imishini.

Qiniseka ukuthi ulandela zonke izincomo zokuzivocavoca nezokudla ezenziwa ngudokotela wakho noma udokotela odlayo. Kubalulekile ukudla ukudla okunempilo nokudla cishe inani elifanayo lokudla cishe ngezikhathi ezifanayo usuku ngalunye. Ukweqa noma ukubambezela ukudla noma ukushintsha inani noma uhlobo lokudla okudlayo kungadala izinkinga ngokulawulwa kukashukela egazini lakho.

Jova umthamo ophuthelwe ngokushesha nje lapho uwukhumbula. Kodwa-ke, uma kungaphansi kwamahora ayisishiyagalombili ngaphambi komthamo olandelayo, weqa umthamo ophuthelwe bese uqhubeka neshejuli yakho ejwayelekile yokulinganisa. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

Lo muthi ungadala ushintsho kushukela wakho wegazi. Kufanele wazi izimpawu zikashukela wegazi ophansi futhi ophakeme nokuthi yini okufanele uyenze uma unalezi zimpawu. I-insulin degludec ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ububomvu, ukuvuvukala, ubuhlungu, noma ukulunywa endaweni yokujova
• ukuqina kwesikhumba (ukwakha amafutha) noma ukucindezeleka okuncane esikhunjeni (ukonakala kwamafutha)
• ukuzuza kwesisindo

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nalezi zimpawu, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• ukuqubuka, isifuba, noma ukulunywa emzimbeni wonke
• isifuba
• ukuphefumula kanzima noma ukugwinya
• ukuphelelwa umoya
• ukujuluka
• ukuvuvukala kwamehlo, ubuso, izindebe, ulimi, umphimbo, izandla, noma izinyawo
• ubuthakathaka bemisipha

I-insulin degludec ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi usebenzisa lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ingena futhi ingafinyeleleki ezinganeni. Gcina izibaya ze-insulin ezingavulwanga esiqandisini. Ungalokothi uvumele i-insulin degludec iqhwa; ungasebenzisi i-insulin degludec efriziwe yancibilikiswa. I-insulin degludec efrijiwe engavulwa ingagcinwa kuze kube usuku oluboniswa kwilebula lenkampani.

Uma isiqandisi singatholakali (isibonelo, uma useholidini), gcina izibaya ekamelweni lokushisa, kude nelanga eliqondile nokushisa okukhulu kuze kube yizinsuku ezingama-56. Izibaya ezivuliwe kufanele zigcinwe ekamelweni lokushisa futhi zingasetshenziswa kuze kube yizinsuku ezingama-56 ngemuva kokusetshenziswa kokuqala. Lahla noma iyiphi i-insulini evezwe ukushisa noma amakhaza amakhulu.

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

I-insulin degludec overdose ingenzeka uma usebenzisa kakhulu i-insulin degludec noma uma usebenzisa inani elifanele le-insulin degludec, kodwa udle okuncane kunokujwayelekile noma uvivinye umzimba kunokujwayelekile. I-insulin degludec overdose ingadala i-hypoglycemia. Uma unezimpawu ze-hypoglycemia, landela imiyalo kadokotela wakho yokuthi yini okufanele uyenze uma uba ne-hypoglycemia. Ezinye izimpawu zokudlula ngokweqile:

• ukulahlekelwa ukwazi
• isithuthwane

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Ushukela wegazi kanye ne-hemoglobin eglycosylated (HbA1c) kufanele ihlolwe njalo ukuthola impendulo yakho ku-insulin degludec. Udokotela wakho uzokutshela nokuthi ungayihlola kanjani impendulo yakho kulo muthi ngokulinganisa amazinga kashukela egazini lakho ekhaya. Landela le miyalo ngokucophelela.

Kufanele njalo ufake isongo lokuhlonza isifo sikashukela ukuze uqiniseke ukuthi uthola ukwelashwa okufanele esimeni esiphuthumayo. Ungavumeli omunye umuntu asebenzise imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• UTresiba^®
• I-Ryzodeg^® (njengomkhiqizo ohlanganisiwe oqukethe i-Insulin Degludec ne-Insulin Aspart)
• I-Xultophy^® (njengomkhiqizo ohlanganisiwe oqukethe i-Insulin Degludec neLiraglutide)