Inaliti ye-Arsenic Trioxide

-Delile

• Ngaphambi kokuthola umjovo we-arsenic trioxide,
• Umjovo we-Arsenic trioxide ungadala ukwanda kushukela wakho wegazi. Shayela udokotela wakho ngokushesha uma unanoma iyiphi yalezi zimpawu ezilandelayo ze-hyperglycemia (ushukela ophakeme wegazi):
• Uma ushukela ophakeme wegazi ungelashwa, isimo esibi, esisongela impilo esibizwa nge-ketoacidosis sikashukela singakhula. Thola ukunakekelwa kwezokwelapha ngokushesha uma unanoma iyiphi yalezi zimpawu:
• Umjovo we-Arsenic trioxide ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SESEXWAYISO, shayela udokotela wakho ngokushesha:
• Izimpawu zokudlula ngokweqile zingafaka:

I-Arsenic trioxide kufanele inikezwe kuphela ngaphansi kokuqondisa kukadokotela onolwazi lokwelapha abantu abane-leukemia (umdlavuza wamaseli amhlophe egazi).

I-Arsenic trioxide ingadala iqembu lezimpawu ezibucayi noma ezisongela ukuphila elibizwa nge-APL differentiation syndrome. Udokotela wakho uzokuqapha ngokucophelela ukuze abone ukuthi uyayihlakulela yini le syndrome. Udokotela wakho angakucela ukuthi uzilinganise nsuku zonke emasontweni ambalwa okuqala okwelashwa kwakho ngoba ukuzuza kwesisindo kuyisifo se-APL umahluko wesifo. Uma uhlangabezana nalezi zimpawu ezilandelayo, shayela udokotela wakho ngokushesha: umkhuhlane, ukukhuluphala, ukuphefumula okuncane, ukuphefumula okusebenzayo, ubuhlungu besifuba noma ukukhwehlela. Esibonakalisweni sokuqala sokuthi uthuthukisa isifo sokuhlukaniswa kwe-APL, udokotela wakho uzokunikeza umuthi owodwa noma eminingi yokwelapha lesi sifo.

I-Arsenic trioxide ingadala ukwandiswa kwe-QT (imisipha yenhliziyo ithatha isikhathi eside ukuphinda ivuselele phakathi kwamabhithi ngenxa yokuphazamiseka kukagesi), okungadala izinkinga zesigqi senhliziyo esibi noma esisongela ukuphila. Ngaphambi kokuba uqale ukwelashwa nge-arsenic trioxide, udokotela wakho uzoku-oda i-electrocardiogram (ECG; ukuhlolwa okurekhoda umsebenzi kagesi wenhliziyo) nezinye izivivinyo ukubona ukuthi usuvele unakho ukuphazamiseka kukagesi enhliziyweni yakho noma usengozini enkulu kunokujwayelekile ukuthuthukisa lesi simo. Udokotela wakho uzokuqapha futhi uzo-oda i-ECG nezinye izivivinyo ngesikhathi sokwelashwa kwakho nge-arsenic trioxide. Tshela udokotela wakho uma ngabe uke waba ne-QT prolongation, ukwehluleka kwenhliziyo, ukushaya kwenhliziyo okungajwayelekile, noma amazinga aphansi we-potassium noma i-magnesium egazini lakho. Tshela nodokotela wakho uma uthatha noma iyiphi yale mithi elandelayo: amiodarone (Nexterone, Pacerone), amphotericin (Abelcet, Amphotec, Fungizone), cisapride (Propulsid), disopyramide (Norpace), diuretics ('water pills'), dofetilide ( Tikosyn), erythromycin (EES, E-Mycin, Erythrocin), moxifloxacin (Avelox), pimozide (Orap), procainamide (Procanbid, Pronestyl), quinidine (Quinidex), sotalol (Betapace, Betapace AF), sparfagineine (sparfagine) (Mellaril), kanye ne-ziprasidone (Geodon). Shayela udokotela wakho ngokushesha uma unenhliziyo engajwayelekile noma esheshayo noma uma uquleka ngesikhathi sokwelashwa kwakho nge-arsenic trioxide.

Umjovo we-Arsenic trioxide ungadala i-encephalopathy (ukudideka, izinkinga zememori, nobunye ubunzima obudalwa ukusebenza kobuchopho okungavamile). Tshela udokotela wakho uma uphuza noma wake waphuza utshwala obuningi, uma une-malabsorption syndrome (izinkinga zokumunca ukudla), ukuntuleka kokudla okunempilo, noma uma uthatha i-furosemide (Lasix). Uma uhlangabezana nalezi zimpawu ezilandelayo, shayela udokotela wakho ngokushesha: ukudideka; ukulahlekelwa ukwazi; ukuquleka; izinguquko zokukhuluma; izinkinga ngokuxhumanisa, ukulinganisela, noma ukuhamba; noma izinguquko ezibukwayo njengokuncipha kokubona, izinkinga zokufunda, noma ukubona kabili. Qiniseka ukuthi umndeni wakho noma umnakekeli uyazi ukuthi yiziphi izimpawu ezingaba zimbi kakhulu ukuze bakwazi ukufuna ukwelashwa uma ungakwazi ukuzibiza wedwa.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile ngaphambi nangemva kokubheka impendulo yomzimba wakho ku-arsenic trioxide.

Khuluma nodokotela wakho ngezingozi zokuthatha i-arsenic trioxide.

I-Arsenic trioxide isetshenziswa ngokuhlangana ne-tretinoin ukwelapha i-acute promyelocytic leukemia (APL; uhlobo lomdlavuza lapho kunamaseli egazi amaningi kakhulu egazini nasemnkantsheni wethambo) kubantu abathile njengokwelapha kokuqala. Ibuye isetshenziselwe ukwelapha i-APL kubantu abathile abangazange basizwe ezinye izinhlobo zamakhemikhali noma isimo sabo esithuthukile kodwa saphinde saba sibi kulandela ukwelashwa nge-retinoid nezinye izinhlobo zokwelashwa ngamakhemikhali. I-Arsenic trioxide isekilasini lemithi ebizwa ngama-anti-neoplastics. Isebenza ngokunciphisa noma ngokumisa ukukhula kwamangqamuzana omdlavuza.

I-Arsenic trioxide iza njengesisombululo (uketshezi) ukujojelwa emthanjeni ngudokotela noma ngumhlengikazi ehhovisi lezokwelapha noma emtholampilo. I-Arsenic trioxide ivame ukujovwa ngaphezu kwehora eli-1 kuye kwele-2, kepha ingajovwa ngaphezu kwamahora ama-4 uma kutholakala imiphumela emibi ngesikhathi sokufakwa. Imvamisa inikezwa kanye ngosuku isikhathi esithile.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthola umjovo we-arsenic trioxide,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-arsenic trioxide, noma imuphi omunye umuthi, noma iziphi izithako zomjovo we-arsenic trioxide. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi imishanguzo kadokotela neyokungabhalisi, amavithamini, izithako zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi uyayisho imithi efakwe kuhlu esigabeni ESIBALULEKILE SESEXWAYISO. Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• utshele udokotela wakho uma uke waba nesifo sesibindi noma sezinso.
• tshela udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uma uhlela ukuba nobaba wengane. Uma ungowesifazane, kuzodingeka uthathe ukuhlolwa kokukhulelwa ngaphambi kokuqala ukwelashwa futhi usebenzise izilawuli zokubeletha ukuvimbela ukukhulelwa ngesikhathi sokwelashwa kwakho futhi okungenani izinyanga eziyisithupha ngemuva komthamo wakho wokugcina. Uma ungowesilisa, wena nomlingani wakho wesifazane kufanele nisebenzise ukulawulwa kokubeletha okusebenzayo ngenkathi nithola umjovo we-arsenic trioxide nezinyanga ezi-3 ngemuva komthamo wokugcina. Uma wena noma umlingani wakho ukhulelwa ngenkathi usebenzisa lo muthi, shayela udokotela wakho. Khuluma nodokotela wakho mayelana nokusebenzisa ukubeletha ukuvimbela ukukhulelwa ngesikhathi sokwelashwa kwakho nge-arsenic trioxide. I-Arsenic trioxide ingalimaza umbungu.
• tshela udokotela wakho uma uncelisa.Udokotela wakho mhlawumbe uzokutshela ukuthi ungancelisi ngesikhathi sokwelashwa kwakho namasonto amabili ngemuva komthamo wakho wokugcina.
• kufanele wazi ukuthi lo muthi unganciphisa ukuzala emadodeni. Khuluma nodokotela wakho ngezingozi zokuthola i-arsenic trioxide.
• uma uhlinzwa, kufaka phakathi ukuhlinzwa kwamazinyo, tshela udokotela noma udokotela wamazinyo ukuthi uthola i-arsenic trioxide.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Umjovo we-Arsenic trioxide ungadala ukwanda kushukela wakho wegazi. Shayela udokotela wakho ngokushesha uma unanoma iyiphi yalezi zimpawu ezilandelayo ze-hyperglycemia (ushukela ophakeme wegazi):

• ukoma ngokweqile
• ukuchama kaningi
• indlala eyeqile
• ubuthakathaka
• ukungaboni kahle

Uma ushukela ophakeme wegazi ungelashwa, isimo esibi, esisongela impilo esibizwa nge-ketoacidosis sikashukela singakhula. Thola ukunakekelwa kwezokwelapha ngokushesha uma unanoma iyiphi yalezi zimpawu:

• umlomo owomile
• isicanucanu nokuhlanza
• ukuphelelwa umoya
• umoya onuka izithelo
• kwehle ukwazi

Umjovo we-Arsenic trioxide ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ukukhathala ngokweqile
• isiyezi
• ikhanda
• isifo sohudo
• ukuvuvukala kwezingalo, izandla, izinyawo, amaqakala, noma imilenze engezansi
• ukuqubuka
• ukulunywa

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SESEXWAYISO, shayela udokotela wakho ngokushesha:

• ukulimaza noma ukopha okungavamile
• uhlanza olunegazi noma olubukeka njengezizathu zekhofi
• indle emnyama futhi elindile noma equkethe igazi elibomvu elikhanyayo
• ukuncipha kokuchama
• isifuba

Umjovo we-Arsenic trioxide ungadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthola lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Izimpawu zokudlula ngokweqile zingafaka:

• isithuthwane
• ubuthakathaka bemisipha
• ukudideka

Buza udokotela wakho noma usokhemisi uma unemibuzo mayelana nomjovo we-arsenic trioxide.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

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