Ukujova kwe-Ibritumomab

-Delile

• Ngaphambi kokuthola umjovo we-ibritumomab,
• Umjovo we-Ibritumomab ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nanoma yiziphi izimpawu ezibhalwe esigabeni ESIBALULEKILE SESEXWAYISO noma ezinye zalezi zimpawu ezilandelayo, shayela udokotela wakho ngokushesha:
• Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

Amahora ambalwa ngaphambi komthamo ngamunye womjovo we-ibritumomab, kunikezwa umuthi obizwa nge-rituximab (Rituxan). Ezinye iziguli ziye zaba nokugula okubucayi noma okusongela ukuphila ngenkathi zithola i-rituximab noma ngemuva nje kokuthola i-rituximab. Lokhu kusabela kwenzeke kaningi ngomthamo wokuqala we-rituximab. Ezinye iziguli zife kungakapheli amahora angama-24 ngemuva kokuthola i-rituximab. Tshela udokotela wakho uma une-allergies ku-rituximab noma imishanguzo eyenziwe ngamaprotheni e-murine (igundane), noma uma ungenaso isiqiniseko sokuthi umuthi owugulayo uyenziwe ngamaprotheni e-murine. Phinda utshele udokotela wakho uma uke welashwa ngomuthi owenziwe ngamaprotheni e-murine. Uma kunjalo, ungahle ube nokwenzeka kokungezwani komzimba ne-rituximab. Udokotela wakho uzo-oda izivivinyo ukuze abone ukuthi kungenzeka yini ukuthi une-allergen reaction ku-rituximab.

Udokotela wakho uzokunika imithi ngaphambi kokuthola i-rituximab ukusiza ukuvimbela ukusabela ku-rituximab. Uma uhlangabezana nokusabela ku-rituximab, udokotela wakho angayeka ukukunika umuthi isikhashana noma angakunika kancane. Uma ukusabela kubucayi, udokotela wakho uzomisa ukumnika kwe-rituximab futhi ngeke aqhubeke nokwelashwa kwakho ngomjovo we-ibritumomab. Tshela udokotela wakho ngokushesha uma uhlangabezana nalezi zimpawu ezilandelayo ngesikhathi noma ngemuva nje kokwelapha kwakho nge-rituximab: ukukhwehlela; ubunzima bokuphefumula noma ukugwinya; ukuqina komphimbo; isifuba; ukulunywa; ukuvuvukala kwamehlo, ubuso, izindebe, ulimi, umlomo, noma umphimbo; ubuhlungu esifubeni, emhlathini, engalweni, emuva, noma entanyeni; ukudideka; ukulahlekelwa ukwazi; ukushaya kwenhliziyo okusheshayo; ukujuluka; isikhumba esiphaphathekile; ukuphefumula okusheshayo; ukuncipha kokuchama; noma izandla nezinyawo ezibandayo.

Ukwelashwa ngomjovo we-rituximab kanye ne-ibritumomab kungadala ukwehla okukhulu kwenani lamaseli egazi emzimbeni wakho. Lokhu kwehla kungenzeka emavikini ayi-7 kuya kwayi-9 ngemuva kokwelashwa kwakho futhi kungahlala amasonto ayi-12 noma ngaphezulu. Lokhu kwehla kungadala ukutheleleka okubi noma okusongela impilo noma ukopha. Udokotela wakho ngeke akunikeze umjovo we-ibritumomab uma amangqamuzana akho egazi ethinteke kakhulu ngenxa yomdlavuza, uma ngabe ufakelwe umnkantsha wethambo, uma uhlulekile ukukhiqiza ama-stem cells (amaseli atholakala emnkantsheni wethambo angakhula noma yiluphi uhlobo lwengqamuzana legazi) lokufakelwa umnkantsha wethambo, noma uma usunenani eliphansi lamaseli egazi. Tshela udokotela wakho uma ngabe uthatha noma iyiphi yale mithi elandelayo: ama-anticoagulants (’ama-thinner egazi’) njenge-warfarin (i-Coumadin, i-Jantoven); i-aspirin nezinye izidakamizwa ezingezona ukuvuvukala (ama-NSAID) njenge-ibuprofen (Advil, Motrin) ne-naproxen (Aleve); kanye ne-clopidogrel (i-Plavix). Uma unezinye zalezi zimpawu ezilandelayo, shayela udokotela wakho ngokushesha: isikhumba esiphaphathekile; ubuthakathaka; ukulimaza noma ukopha okungavamile; amabala ansomi noma amabala esikhunjeni; indle emnyama noma enegazi; hlanza okunegazi noma okubukeka njengezizathu zekhofi; isifo sohudo; noma umphimbo obuhlungu, umkhuhlane, amakhaza, ukukhwehlela, noma ezinye izimpawu zokutheleleka.

Ukwelashwa ngomjovo we-rituximab kanye ne-ibritumomab kungadala ukusabela okungathi sína noma okubulalayo kwesikhumba. Lokhu kusabela kungenzeka ngemuva kwezinsuku ezimbalwa ngemuva kokwelashwa noma izinyanga ezi-4 ngemuva kokwelashwa. Tshela udokotela wakho khona manjalo uma uthuthuka esikhunjeni noma ngaphakathi emlonyeni noma ekhaleni, ekuqubukeni noma ekuhlubukeni kwesikhumba. Udokotela wakho ngeke akunikeze umjovo we-ibritumomab uma uthuthukisa lezi zimpawu.

Ngemuva kokuthola umthamo wakho wokuqala womjovo we-ibritumomab, udokotela wakho uzoku-oda ukuskena kwe-imaging (izivivinyo ezibonisa isithombe sakho konke noma ingxenye yengaphakathi lomzimba) ukubona ukuthi umuthi usabalale kanjani emzimbeni wakho. Uma umuthi ungazange usabalale emzimbeni wakho njengoba bekulindelekile, ngeke uthole umthamo wakho wesibili womjovo we-ibritumomab.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzoku-oda izivivinyo ezithile ngesikhathi sokwelashwa kwakho nezinyanga ezi-3 ngemuva kokwelashwa kwakho ukuhlola impendulo yomzimba wakho kumjovo we-ibritumomab.

Khuluma nodokotela wakho ngezingozi zokuthola umjovo we-ibritumomab.

Umjovo we-Ibritumomab usetshenziswa ne-rituximab (Rituxan) ukwelapha izinhlobo ezithile ze-non-Hodgkin's lymphoma (NHL; umdlavuza oqala kumaseli amasosha omzimba) ongazange uthuthuke noma oye waba mubi ngemuva kokwelashwa neminye imithi. Ibuye isetshenziselwe ukwelapha izinhlobo ezithile ze-NHL kubantu abenze ngcono ngemuva kokwelashwa ngeminye imithi ye-chemotherapy. Umjovo we-Ibritumomab usesigabeni semithi ebizwa ngama-antibody monoclonal anama-radioisotopes. Isebenza ngokunamathisela kumaseli womdlavuza nokukhulula imisebe yokulimaza amaseli omdlavuza.

Umjovo we-Ibritumomab uza njengoketshezi oluzofakwa emthanjeni ngaphezu kwemizuzu eyishumi ngudokotela oqeqeshelwe ukwelapha iziguli ngemithi enemisebe. Inikezwa njengengxenye yemithi ethile yokwelashwa komdlavuza. Ngosuku lokuqala lwemithi yokwelashwa, umthamo we-rituximab unikezwa futhi umthamo wokuqala womjovo we-ibritumomab unikezwa amahora angaphezu kwama-4 ngemuva kwalokho. Ukufanekisa ukuskena ukubona ukuthi umjovo we-ibritumomab usabalale kanjani emzimbeni kwenziwa amahora angama-48 kuye kwangama-72 ngemuva kokuthi umthamo womjovo we-ibritumomab unikezwe. Ukuskena okungeziwe kungenziwa uma kudingeka phakathi nezinsuku ezimbalwa ezizayo. Uma imiphumela yokuskena (s) ikhombisa ukuthi umjovo we-ibritumomab usabalale emzimbeni njengoba bekulindelekile, umthamo wesibili we-rituximab nomthamo wesibili womjovo we-ibritumomab uzonikezwa ezinsukwini eziyi-7 kuya kweziyi-9 ngemuva kokunikezwa imithamo yokuqala.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthola umjovo we-ibritumomab,

• Tshela udokotela kanye nosokhemisi wakho uma une-allergies ku-ibritumomab, noma imiphi imithi eshiwo esigabeni ESIBALULEKILE SESEXWAYISO, noma imiphi eminye imithi, noma yiziphi izithako zomjovo we-ibritumomab. Buza udokotela wakho noma usokhemisi uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi imishanguzo kadokotela neyokungabhalisi, amavithamini, izithako zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi uyayisho imithi efakwe kuhlu esigabeni ESIBALULEKILE SESEXWAYISO. Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• tshela udokotela wakho uma ngabe uke waba nesimo esithile sezempilo noma wake waba naso.
• utshele udokotela wakho uma ukhulelwe noma uhlela ukukhulelwa. Akufanele ukhulelwe ngenkathi uthola ibritumomab. Uma ungowesifazane, kuzodingeka uthathe ukuhlolwa kokukhulelwa ngaphambi kokuqala ukwelashwa futhi usebenzise izilawuli zokubeletha ukuvimbela ukukhulelwa ngesikhathi sokwelashwa kwakho nezinyanga eziyi-12 ngemuva komthamo wakho wokugcina. Uma ungowesilisa onomlingani wesifazane, sebenzisa ukulawulwa kokuzalwa ukuvimbela ukukhulelwa ngesikhathi sokwelashwa kwakho nezinyanga eziyi-12 ngemuva komthamo wakho wokugcina. Uma wena noma umlingani wakho ukhulelwa ngenkathi uthola umjovo we-ibritumomab, shayela udokotela wakho ngokushesha. Umjovo we-Ibritumomab ungalimaza umbungu.
• tshela udokotela wakho uma uncelisa noma uhlela ukuncelisa. Akufanele uncelise ibele ngenkathi uthola ibritumomab nezinyanga eziyisithupha ngemuva komthamo wakho wokugcina.
• kufanele wazi ukuthi lo muthi unganciphisa ukuzala kwabesilisa nabesifazane. Khuluma nodokotela wakho ngezingozi zokuthola ibritumomab.
• uma uhlinzwa, kufaka phakathi ukuhlinzwa kwamazinyo, tshela udokotela noma udokotela wamazinyo ukuthi uthole umjovo we-ibritumomab.
• awunayo imigomo ngesikhathi sokwelashwa nangezinyanga eziyi-12 ngemuva komthamo wakho wokugcina ngaphandle kokukhuluma nodokotela wakho kuqala.
• kufanele wazi ukuthi i-radioactivity esilinganisweni sesibili somjovo we-ibritumomab ingaba khona emzimbeni wakho wamanzi kuze kube yisonto ngemuva kokuthola umthamo. Ukuvimbela ukusakazeka kwemisebe ekusabalaleni kubantu abasondelene kakhulu nawe, kufanele uqiniseke ukuthi ugeza izandla zakho kahle ngemuva kokusebenzisa indlu yangasese, sebenzisa ikhondomu njalo uma uya ocansini, futhi ugweme ukuqabula okujulile. Landela lezi zixwayiso ngesikhathi sokwelashwa kwakho nezinsuku eziyi-7 ngemuva kokuthola umthamo wakho wesibili womjovo we-ibritumomab.
• kufanele wazi ukuthi umjovo we-ibritumomab uqukethe i-albhamuin (umkhiqizo owenziwe ngegazi lomnikeli bukhoma). Yize kunamathuba amancane kakhulu okuthi amagciwane angasatshalaliswa ngegazi, awekho amacala ezifo ezibangelwa amagciwane avela kulo mkhiqizo abikiwe.
• kufanele wazi ukuthi uma uthola umjovo we-ibritumomab, umzimba wakho ungakha amasosha omzimba (izinto ezisegazini ezisiza amasosha omzimba ukuthi aqonde futhi ahlasele izinto zangaphandle) ekunciphiseni amaprotheni. Uma wenza la ma-antibodies, ungahle ube nokusabela okweqile uma uthatha imishanguzo eyenziwe ngamaprotheni e-murine, noma le mithi kungenzeka ingakusebenzeli kahle. Ngemuva kokwelashwa kwakho ngomjovo we-ibritumomab, qiniseka ukuthi utshela bonke odokotela bakho ukuthi welashwa ngomjovo we-ibritumomab.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Shayela udokotela wakho ngokushesha uma ungakwazi ukugcina i-aphoyintimenti yokuthola umjovo we-ibritumomab.

Umjovo we-Ibritumomab ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• isicanucanu
• ukuhlanza
• ubuhlungu besisu noma ukuvuvukala
• ukuqunjelwa
• isilungulela
• ukulahlekelwa isifiso sokudla
• ikhanda
• ukukhathazeka
• isiyezi
• ubunzima bokulala noma ukulala
• iqolo, ukuhlangana, noma ubuhlungu bemisipha
• ukuqhuma

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nanoma yiziphi izimpawu ezibhalwe esigabeni ESIBALULEKILE SESEXWAYISO noma ezinye zalezi zimpawu ezilandelayo, shayela udokotela wakho ngokushesha:

• ububomvu, ubumnene, noma isilonda esivulekile endaweni lapho umjovo wafakwa khona

Abanye abantu abathole umjovo we-ibritumomab bahlakulela ezinye izinhlobo zomdlavuza ezifana ne-leukemia (umdlavuza oqala kumaseli amhlophe egazi) kanye ne-myelodysplastic syndrome (isimo lapho amangqamuzana egazi engakhuli ngokujwayelekile) phakathi neminyaka embalwa yokuqala ngemuva kokuthola umuthi. Khuluma nodokotela wakho ngezingozi zokuthola lo muthi.

Umjovo we-Ibritumomab ungadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthola lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

• isikhumba esiphaphathekile
• ubuthakathaka
• ukuphelelwa umoya
• ukukhathala ngokweqile
• ukulimaza noma ukopha okungavamile
• amabala ansomi noma amabala esikhunjeni
• umphimbo obuhlungu, umkhuhlane, amakhaza, ukukhwehlela, nezinye izimpawu zokutheleleka

Buza udokotela wakho noma usokhemisi noma imiphi imibuzo onayo mayelana nomjovo we-ibritumomab.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• UZevalin^®