I-Tolvaptan (i-sodium ephansi yegazi)

-Delile

• Ngaphambi kokuthatha i-tolvaptan (Samsca),
• ITolvaptan (Samsca) ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SESEXWAYISO, shayela udokotela wakho ngokushesha:
• Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

ITolvaptan (Samsca) ingadala ukuthi izinga le-sodium egazini lakho likhule ngokushesha okukhulu. Lokhu kungadala i-osmotic demyelination syndrome (ODS; ukulimala okukhulu kwezinzwa okungabangelwa ukwanda okusheshayo kwamazinga e-sodium). Tshela udokotela wakho uma uphuza noma wake waphuza utshwala obuningi, uma unenkinga yokungondleki (umzimba awunazo izakhamzimba ezidingekayo empilweni enhle), futhi uma uke waba nesifo sesibindi noma waba nezinga eliphansi ngokweqile le-sodium egazini .

Wena nodokotela wakho nizothatha izinyathelo ezithile zokuqapha ukuzama ukuvimbela i-ODS. Uzoqala ukwelashwa kwakho nge-tolvaptan (Samsca) esibhedlela ukuze udokotela wakho akwazi ukukuqapha eduze. Uma udokotela wakho ekutshela ukuthi uqhubeke uthatha i-tolvaptan (Samsca) ngemuva kokuphuma esibhedlela, akufanele ume bese uqala kabusha ukwelashwa uwedwa. Uzodinga ukubuyela esibhedlela lapho uqala kabusha imithi.

Uzodinga ukuphuza amanzi noma nini lapho womile ukusiza ukuvimbela i-ODS ngenkathi welashwa nge-tolvaptan (Samsca). Udokotela wakho ngeke anikeze i-tolvaptan (Samsca) uma ungakwazi ukuzwa ukuthi womile. Kufanele ube namanzi okuphuza atholakala ngaso sonke isikhathi ngesikhathi sokwelashwa kwakho.

Uma uhlangabezana nanoma yiziphi kulezi zimpawu ezilandelayo ze-ODS, tshela udokotela wakho ngokushesha: ubunzima bokukhuluma, ubunzima bokugwinya, ukuzwa ukuthi ukudla noma iziphuzo kuyabambeka emphinjeni wakho, ukozela, ukudideka, ukuguquka kwemizwelo, ukunyakaza komzimba okunzima ukukulawula, ubuthakathaka yezingalo noma imilenze, noma ukuquleka.

Kufanele wazi ukuthi i-tolvaptan iyatholakala njengethebhulethi (iJynarque) ukubambezela ukwanda kokusebenza kwezinso kubantu abadala abanohlobo oluthile lwesifo sezinso esizuzwe njengefa. Uma unalesi sifo sezinso, akufanele uthathe i-tolvaptan (Samsca). Ngenxa yobungozi bezinkinga zesibindi nge-tolvaptan, i-Jynarque itholakala kuphela ngohlelo olukhethekile lokusabalalisa olukhawulelwe. Le monograph inika kuphela imininingwane ngamaphilisi e-tolvaptan (Samsca) ukwelapha amazinga aphansi e-sodium egazini. Uma usebenzisa lo muthi ukwehlisa ukwanda komsebenzi wezinso zakho, funda i-monograph enesihloko esithi tolvaptan (isifo sezinso).

Udokotela wakho noma usokhemisi uzokunikeza ishidi lemininingwane yesiguli lomkhiqizi (Umhlahlandlela Wezokwelapha) lapho uqala ukwelashwa nge-tolvaptan futhi isikhathi ngasinye lapho ugcwalisa umuthi wakho. Funda imininingwane ngokucophelela bese ubuza udokotela noma usokhemisi wakho uma unemibuzo. Ungavakashela futhi iwebhusayithi ye-Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) noma iwebhusayithi yomkhiqizi ukuthola i-Medication Guide.

Khuluma nodokotela wakho ngengozi yokuthatha i-tolvaptan (Samsca).

I-Tolvaptan (Samsca) isetshenziselwa ukwelapha i-hyponatremia (amazinga aphansi e-sodium egazini) kubantu abanenkinga yenhliziyo (isimo lapho inhliziyo ingakwazi ukupompa igazi elanele kuzo zonke izingxenye zomzimba), i-syndrome ye-hormone elwa namagciwane engafanele (SIADH; isimo lapho umzimba ukhiqiza kakhulu into ethile yemvelo edala ukuthi umzimba ugcine amanzi) noma ezinye izimo. UTolvaptan usesigabeni semithi ebizwa nge-vasopressin V₂ abaphikisi be-receptor. Isebenza ngokwandisa inani lamanzi akhishwe emzimbeni njengomchamo. Ukususa uketshezi emzimbeni kusiza ukukhuphula izinga le-sodium egazini.

ITolvaptan (Samsca) iza njengethebhulethi ezothathwa ngomlomo. Imvamisa kuthathwa kanye ngosuku noma ngaphandle kokudla kungadluli izinsuku ezingama-30. Ekuqaleni kokwelashwa kwakho, uzonikezwa i-tolvaptan (Samsca) ngesikhathi esihleliwe njalo esibhedlela. Uma utshelwa ukuthi uthathe i-tolvaptan (Samsca) ekhaya ngemuva kokukhishwa, kufanele uyithathe cishe ngesikhathi esifanayo nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-tolvaptan (Samsca) njengoba nje kuqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Udokotela wakho kungenzeka akuqale ngomthamo ophansi we-tolvaptan (Samsca) futhi akhuphule kancane umthamo wakho, hhayi kaningi ngaphezu kwesisodwa njalo emahoreni angama-24.

Khuluma nodokotela wakho ngalokho okufanele ukwenze ngemuva kokuyeka ukuthatha i-tolvaptan (Samsca). Cishe uzodinga ukunciphisa inani loketshezi oliphuzayo, futhi udokotela wakho uzokuqapha ngokucophelela ngalesi sikhathi.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-tolvaptan (Samsca),

• Tshela udokotela kanye nosokhemisi wakho uma unegciwane ku-tolvaptan (Samsca, Jynarque), noma imiphi eminye imithi, noma iziphi izithako ezikumathebulethi e-tolvaptan. Buza usokhemisi wakho noma uhlole Umhlahlandlela Wezokwelapha ukuthola uhlu lwezithako.
• Tshela udokotela wakho uma uthatha ama-antifungal athile afana ne-ketoconazole (Nizoral) noma i-itraconazole (Sporanox); i-clarithromycin (i-Biaxin); imishanguzo ethile ye-HIV efana ne-indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir), noma i-saquinavir (Invirase); i-desmopressin (dDAVP, Ukuqina); nefazodone; noma i-telithromycin (Ketek). Udokotela wakho angakutshela ukuthi ungathathi i-tolvaptan (Samsca) uma uphuza eyodwa noma ngaphezulu yale mithi.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, kanye nezithako zokudla okunomsoco ozithathayo noma ohlela ukuzithatha. Qiniseka ukuthi usho noma ikuphi kokulandelayo: ama-angiotensin-converting enzyme (ACE) inhibitors anjenge benazepril (Lotensin, eLotrel), captopril, enalapril (Vasotec, in Vaseretic), fosinopril, lisinopril (Prinivil, Zestril, in Zestoretic), moexipr , perindopril, (quinapril (Accupril, in Accuretic, in Quinaretic), ramipril (Altace), and trandolapril (Tarka); angiotensin II receptor blockers such as candesartan (Atacand), eprosartan, irbesartan (Avapro, in Avalide), losartan , eHyzaar), olmesartan (Benicar, eBenicar HCT, eTribenzor), telmisartan (Micardis, eTwynsta), nase-valsartan (Diovan, Prexxartan, e-Entresto, e-Exforge); i-aprepitant (Emend); ama-barbiturate afana ne-phenobarbital; carbamaria (Carbatrol, Equetro, Tegretol); cyclosporine (Gengraf, Neoral, Sandimmune); desmopressin (dDAVP, Minirin, Noctiva), digoxin (Lanoxin); diltiazem (Cardizem, Diltzac, Tiazac); isisu (amaphilisi wamanzi); i-erythromycin ( I-ERYC, i-Erythrocin, i-PCE); i-fluconazole (iDiflucan); i-phenytoin (i-Dilant ku); izithako ze-potassium; i-rifabutin (i-Mycobutin); i-rifampin (Rimactane, Rifadin, eRifater, eRifamate); i-rifapentine (Priftin); kanye ne-verapamil (Calan, Verelan, eTarka). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi. Eminye imishanguzo eminingi ingaxhumana ne-tolvaptan (Samsca), ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho naleyo engabonakali kulolu hlu.
• utshele udokotela wakho ukuthi yimiphi imikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha, ikakhulukazi iSt John's wort.
• Tshela udokotela wakho uma unesifo sezinso futhi ungavezi umchamo, uma uhlanza kakhulu noma uhudo, noma uma ulahlekelwe uketshezi oluningi emzimbeni wakho futhi uzizwa unesiyezi noma uqulekile. Udokotela wakho mhlawumbe uzokutshela ukuthi ungathathi i-tolvaptan (Samsca). Udokotela wakho mhlawumbe ngeke anikeze i-tolvaptan (Samsca) uma izinga lakho le-sodium kufanele lenyuswe ngokushesha okukhulu.
• tshela udokotela wakho uma ngabe uke waba nezinga eliphakeme le-potassium egazini lakho.
• utshele udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uncelisa. Uma ukhulelwa ngenkathi uthatha i-tolvaptan (Samsca), shayela udokotela wakho.

Ungadli isithelo samagilebhisi noma uphuze ijusi lamagilebhisi ngenkathi uthatha lo muthi.

Thatha umthamo ongabanjwanga ngokushesha nje lapho uwukhumbula. Kodwa-ke, uma sekuyisikhathi somthamo olandelayo, weqa umthamo ongabanjwanga bese uqhubeka neshejuli yakho ejwayelekile yokulinganisa. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

ITolvaptan (Samsca) ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ukoma
• umlomo owomile
• ukuchama kaningi, ngokweqile
• ukuqunjelwa

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SESEXWAYISO, shayela udokotela wakho ngokushesha:

• ukulahlekelwa isifiso sokudla
• isicanucanu
• ukuhlanza
• imfiva
• ngizizwa ngingaphilile
• ukukhathala okungajwayelekile noma ubuthakathaka
• ukulunywa
• ukuphuzi kwesikhumba noma kwamehlo
• umchamo omnyama
• ubuhlungu engxenyeni engenhla kwesokudla yesisu
• isifo sohudo
• ukungakwazi ukuphuza ngokwejwayelekile
• isiyezi
• ukuquleka
• uhlanza olunegazi noma olubukeka njengezizathu zekhofi
• indle enegazi noma emnyama neyokulinda
• ukuvuvukala kobuso, umphimbo, ulimi, izindebe, amehlo, izandla, izinyawo, amaqakala noma imilenze engezansi
• ukushaqeka
• isifuba
• ukuqubuka

ITolvaptan (Samsca) ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese).

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

• ukuchama ngokweqile
• ukoma ngokweqile
• isiyezi
• ukuquleka

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho anga-oda izivivinyo ezithile zelebhu ukuze ahlole impendulo yomzimba wakho ku-tolvaptan (Samsca).

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• USamsca^®