Inaliti yeRomidepsin

-Delile

• Ngaphambi kokuthola umjovo we-romidepsin,
• Umjovo weRomidepsin ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha:

Umjovo weRomidepsin usetshenziselwa ukwelapha i-T-cell lymphoma (CTCL; iqembu lomdlavuza wamasosha omzimba aqala ukubonakala njengokuqubuka kwesikhumba) kubantu asebephathwe okungenani omunye umuthi. Umjovo weRomidepsin usetshenziselwa ukwelapha i-peripheral T-cell lymphoma (PTCL; uhlobo lwe-non-Hodgkin's lymphoma) kubantu asebevele belashwa okungenani ngomunye umuthi. Umjovo weRomidepsin usesigabeni semithi ebizwa nge-histone deacetylase (HDAC) inhibitors. Isebenza ngokunciphisa ukukhula kwamangqamuzana omdlavuza.

Umjovo weRomidepsin uza njengempuphu ezohlanganiswa noketshezi oluzofakwa ngaphakathi (emthanjeni) esikhathini esingamahora ama-4 ngudokotela noma unesi. Imvamisa inikezwa ngezinsuku 1, 8, no-15 zomjikelezo wezinsuku ezingama-28. Lo mjikelezo ungaphindaphindwa uma nje umuthi uqhubeka nokusebenza futhi ungabangeli imiphumela emibi kakhulu.

Khuluma nodokotela wakho nganoma yimiphi imiphumela emibi oyitholayo ngenkathi welashwa ngomjovo we-romidepsin. Uma uhlangabezana nemiphumela emibi ethile, udokotela wakho angayeka ukwelashwa kwakho unomphela noma okwesikhashana futhi / noma anciphise umthamo wakho.

Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi yesiguli.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthola umjovo we-romidepsin,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ekujoyineni i-romidepsin, noma imuphi omunye umuthi, noma iziphi izithako zomjovo we-romidepsin. Buza usokhemisi wakho noma uhlole imininingwane yesiguli ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi imishanguzo kadokotela neyokungabhalisi, amavithamini, izithako zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma yikuphi okulandelayo: ama-antibiotic athile afana ne-clarithromycin (Biaxin), i-erythromycin (E.E.S., E-Mycin, Erythrocin), moxifloxacin (Avelox), ne-telithromycin (Ketek); ama-anticoagulants (ama-thinner egazi) afana ne-warfarin (Coumadin, Jantoven); ama-antifungals afana ne-itraconazole (Sporanox), ketoconazole (Nizoral), ne-voriconazole (Vfend); i-cisapride (Propulsid) (ayitholakali e-U.S.); i-dexamethasone; imishanguzo yegciwane lesandulela ngculazi (i-HIV) njenge-atazanavir (Reyataz), indinavir (Crixivan), i-nelfinavir (i-Viracept), i-ritonavir (e-Kaletra, i-Norvir), ne-saquinavir (i-Invirase); imishanguzo yokushaya kwenhliziyo okungajwayelekile njenge-amiodarone (Cordarone), i-disopyramide (i-Norpace), i-dofetilide (iTikosyn), i-procainamide (i-Procanbid, i-Pronestyl), i-quinidine (i-Quinidex), ne-sotalol (i-Betapace, i-Betapace AF); imithi ethile yokuquleka efana ne-carbamazepine (i-Epitol, i-Equetro, iTegretol), i-phenobarbital, ne-phenytoin (i-Dilantin); nefazodone; ipimozide (i-Orap); i-rifabutin (i-Mycobutin); i-rifampin (iRifadin, eRifamate, eRifater, eRimactane); i-rifapentine (Priftin); i-sparfloxacin (iZagam); noma i-thioridazine (Mellaril). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi. Eminye imithi eminingi ingase futhi ihlanganyele nomjovo we-romidepsin, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho naleyo engabonakali kulolu hlu.
• utshele udokotela wakho ukuthi uthatha miphi imikhiqizo yamakhambi, ikakhulukazi iSt John's wort.
• Tshela udokotela wakho uma unesicanucanu, ukuhlanza, noma isifo sohudo ngaphambi kokuba uqale ukwelashwa ngomjovo we-romidepsin. Phinda utshele udokotela wakho uma uke waba nesikhathi esisheshayo se-QT (inkinga yenhliziyo engajwayelekile engadala ukushaya kwenhliziyo okungajwayelekile, ukuquleka, noma ukufa okungazelelwe), ukushaya kwenhliziyo okungajwayelekile noma okusheshayo, i-potassium eningi kakhulu noma i-magnesium egazini lakho , i-hepatitis B (HBV; igciwane elithelela isibindi futhi lingadala ukulimala kwesibindi noma umdlavuza wesibindi), igciwane le-Epstein Barr (i-EBV; igciwane le-herpes elibanga i-mononucleosis elithathelwanayo futhi lihlotshaniswa nomdlavuza othile), noma isibindi, izinso, noma Isifo senhliziyo.
• utshele udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uncelisa. Udokotela wakho angahlola ukuthi ngabe ukhulelwe ngaphambi kokuba uqale ukwelashwa kwakho. Kufanele usebenzise ukulawulwa kokuzalwa ukuvimbela ukukhulelwa ngesikhathi sokwelashwa kwakho ngomjovo we-romidepsin futhi okungenani inyanga eyodwa ngemuva komthamo wakho wokugcina. Kodwa-ke, akufanele usebenzise izindlela zokuvimbela inzalo ze-hormonal (estrogen) (amaphilisi okulawula ukubeletha, amabala, izindandatho, ukufakelwa, noma imijovo) ngoba umjovo we-romidepsin ungamisa le mithi ukuthi isebenze ngendlela efanele. Uma ungowesilisa onomlingani wesifazane ongakhulelwa, qiniseka ukusebenzisa ukulawulwa kokuzalwa ngesikhathi sokwelashwa kwakho ngomjovo we-romidepsin futhi okungenani inyanga eyodwa ngemuva komthamo wakho wokugcina. Khuluma nodokotela wakho ngezindlela zokulawula ukubeletha ongazisebenzisa. Uma ukhulelwa ngenkathi uthola umjovo we-romidepsin, shayela udokotela wakho. Umjovo weRomidepsin ungalimaza umbungu. Akufanele uncelise ngesikhathi sokwelashwa kwakho ngomjovo we-romidepsin futhi okungenani isonto elilodwa ngemuva komthamo wakho wokugcina.
• uma uhlinzwa, kufaka phakathi ukuhlinzwa kwamazinyo, tshela udokotela noma udokotela wamazinyo ukuthi uthola umjovo we-romidepsin.

Qiniseka ukuthi uphuza uketshezi oluningi okungenani izinsuku ezi-3 kulandela umthamo ngamunye womjovo we-romidepsin.

Khuluma nodokotela wakho ngokudla isithelo samagilebhisi nokuphuza ijusi lamagilebhisi ngenkathi uthola lo muthi.

Umjovo weRomidepsin ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• isicanucanu
• ukuhlanza
• isifo sohudo
• ukuqunjelwa
• ubuhlungu besisu
• izilonda zomlomo
• ikhanda
• umqondo oshintshiwe wokunambitha
• ukulahlekelwa isifiso sokudla
• ukulunywa

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha:

• ukukhathala noma ubuthakathaka
• isikhumba esiphaphathekile
• ukuphelelwa umoya
• ubuhlungu besifuba
• ukushaya kwenhliziyo okungajwayelekile
• uzizwe unesiyezi noma uqulekile
• ukulinyazwa okulula noma ukopha
• umkhuhlane, ukukhwehlela, izimpawu ezinjengomkhuhlane, ubuhlungu bemisipha, ukuvuthwa kokuchama, izinkinga zesikhumba eziya ziba zimbi, nezinye izimpawu zokutheleleka (kungenzeka ezinsukwini ezingama-30 ngemuva kokwelashwa kwakho)
• ukuqubuka
• isikhumba esishayayo noma esikhanyayo
• ukuvuvukala kwezandla, izinyawo, amaqakala, noma imilenze engezansi

Umjovo weRomidepsin ungadala izinkinga zokuzala. Khuluma nodokotela wakho ngezingozi zokuthola lo muthi uma ungathanda ukuba nezingane.

Umjovo weRomidepsin ungadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthola lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile zelebhu ukuze ahlole impendulo yomzimba wakho kumjovo we-romidepsin.

Buza usokhemisi wakho noma imiphi imibuzo onayo ngomjovo we-romidepsin.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

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