Inaliti yeTocilizumab

-Delile

• Umjovo weTocilizumab usetshenziswa wedwa noma uhlanganiswe neminye imithi yokuqeda izimpawu zezinhlobo ezithile ze-arthritis nezinye izimo ezibandakanya:
• Ngaphambi kokuthola umjovo we-tocilizumab,
• Umjovo weTocilizumab ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SEXWAYISO, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

Ukusebenzisa umjovo we-tocilizumab kunganciphisa ikhono lakho lokulwa nokutheleleka kusuka kubhaktheriya, amagciwane, nesikhunta futhi kwandise ingozi yokuthi uzothola ukutheleleka okungathi sína noma okusongela ukuphila okungase kusabalale emzimbeni. Tshela udokotela wakho uma uvame ukuthola noma yiluphi uhlobo lokutheleleka noma uma une noma ucabanga ukuthi ungahle ube nolunye uhlobo lokutheleleka manje. Lokhu kufaka ukutheleleka okuncane (njengokusikeka okuvulekile noma izilonda), izifo ezifika zidlule (njengezilonda ezibandayo), kanye nezifo eziqhubekayo ezingapheli. Phinda utshele udokotela wakho uma uke waba nesifo sikashukela, i-HIV, noma yisiphi isimo esithinta amasosha akho omzimba, futhi uma uhlala, wake waphila, noma wahambela ezindaweni ezinjengezigodi zase-Ohio naseMississippi River kanye neNingizimu-ntshonalanga lapho izifo zokukhunta ezinzima zivame kakhulu. Buza udokotela wakho uma ungazi ukuthi ngabe lezi zifo zivamile yini endaweni yangakini. Tshela nodokotela wakho uma uthatha: i-abatacept (i-Orencia); i-adalimumab (Humira); anakinra (Kineret); isitifiketi (Cimzia); i-etanercept (Enbrel); i-golimumab (iSimponi); infliximab (i-Remicade); imishanguzo ecindezela amasosha omzimba njenge-azathioprine (Azasan, Imuran), cyclosporine (Gengraf, Neoral, Sandimmune), methotrexate (Otrexup, Trexall, abanye), sirolimus (Rapamune), ne-tacrolimus (Prograf); i-steroids yomlomo efana ne-dexamethasone, i-methylprednisolone, ne-prednisone (i-Rayos); noma i-rituximab (Rituxan). Uma uhlangabezana nalezi zimpawu ezilandelayo, shayela udokotela wakho ngokushesha: umkhuhlane; Ukugodola; ukujuluka; ukuphefumula kanzima; Umphimbo obuhlungu; ukukhwehlela; ukuncipha komzimba; isifo sohudo; ubuhlungu besisu; igazi e-phlegm; ukukhathala ngokweqile; ubuhlungu bemisipha; isikhumba esifudumele, esibomvu, noma esibuhlungu; izilonda esikhumbeni noma emlonyeni; ukuvutha lapho uchama; ukuchama njalo; noma ezinye izimpawu zokutheleleka.

Ungahle utheleleke ngesifo sofuba (i-TB; uhlobo lokutheleleka kwamaphaphu) noma i-hepatitis B (uhlobo lwesifo sesibindi) kodwa ungabi nazimpawu zesifo. Kulokhu, umjovo we-tocilizumab ungakhuphula ubungozi bokuthi ukutheleleka kwakho kuzoba kubi kakhulu futhi uzoba nezimpawu. Udokotela wakho uzohlola isikhumba ukuze abone ukuthi unesifo se-TB esingasebenzi yini futhi angahle ahlele ukuhlolwa kwegazi ukubona ukuthi unesifo se-hepatitis B esingasebenzi yini. Uma kunesidingo, udokotela wakho uzokunika imithi yokwelapha lesi sifo ngaphambi kokuba uqale ukusebenzisa umjovo we-tocilizumab. Tshela udokotela wakho uma ngabe uke waba ne-TB noma isifo sokusha kwesibindi kohlobo B, uma uvakashele noma yiliphi izwe lapho i-TB ijwayelekile, noma uma uke waba seduze komuntu one-TB. Uma unezinye zalezi zimpawu ezilandelayo ze-TB, noma uma uba nalezi zimpawu phakathi nokwelashwa kwakho, shayela udokotela wakho ngokushesha: ukukhwehlela, ubuhlungu besifuba, ukukhwehlela igazi noma amafinyila, ubuthakathaka noma ukukhathala, ukwehla kwesisindo, ukungathandi ukudla, Ukugodola, umkhuhlane, noma ukujuluka ebusuku. Phinda ushayele udokotela wakho ngokushesha uma unanoma iyiphi yalezi zimpawu zesifo sokusha kwesibindi kohlobo B noma uma uba nanoma yiziphi zalezi zimpawu ngesikhathi noma ngemuva kokwelashwa kwakho: ukukhathala ngokweqile, ukuphuzi kwesikhumba noma kwamehlo, ukulahlekelwa isifiso sokudla, isicanucanu, ukuhlanza, izinhlungu zemisipha, umchamo omnyama, ukuhamba kwamathumbu anombala wobumba, umkhuhlane, amakhaza, ubuhlungu besisu, noma ukuqubuka.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzoqapha impilo yakho ngokucophelela ukuze aqiniseke ukuthi awutholi ukutheleleka okungathi sína. Udokotela wakho uzo-oda izivivinyo ezithile zelebhu ngaphambi nangesikhathi sokwelashwa kwakho ukuze ahlole impendulo yomzimba wakho kumjovo we-tocilizumab.

Udokotela wakho noma usokhemisi uzokunikeza ishidi lemininingwane yesiguli lomkhiqizi (Umhlahlandlela Wezokwelapha) lapho uqala ukwelashwa ngomjovo we-tocilizumab futhi njalo lapho uthola umuthi. Funda imininingwane ngokucophelela bese ubuza udokotela noma usokhemisi wakho uma unemibuzo. Ungavakashela futhi iwebhusayithi ye-Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) noma iwebhusayithi yomkhiqizi ukuthola i-Medication Guide.

Khuluma nodokotela wakho ngezingozi zokusebenzisa umjovo we-tocilizumab.

Umjovo weTocilizumab usetshenziswa wedwa noma uhlanganiswe neminye imithi yokuqeda izimpawu zezinhlobo ezithile ze-arthritis nezinye izimo ezibandakanya:

• i-rheumatoid arthritis (isimo lapho umzimba uhlasela khona amalunga ayo, ubangele ubuhlungu, ukuvuvukala, nokulahlekelwa ngumsebenzi) kubantu abangazange basizwe ezinye izidakamizwa zokuguqula izifo (DMARDs) eziguqula izifo,
• i-giant cell arteritis (isimo esidala ukuvuvukala kwemithambo yegazi, ikakhulukazi ekhanda nasekhanda),
• i-polyarticular juvenile idiopathic arthritis (i-PJIA; uhlobo lwesifo samathambo ebuntwaneni oluthinta amalunga amahlanu noma ngaphezulu phakathi nezinyanga eziyisithupha zokuqala zesimo, kubangele ubuhlungu, ukuvuvukala, kanye nokulahleka komsebenzi) ezinganeni ezineminyaka emibili noma ngaphezulu ubudala.
• i-systemic juvenile idiopathic arthritis (i-SJIA; isimo ezinganeni esidala ukuvuvukala ezindaweni ezahlukahlukene zomzimba, okubangela umkhuhlane, ubuhlungu bamalunga nokuvuvukala, ukulahleka komsebenzi, nokubambezeleka kokukhula nentuthuko) ezinganeni ezineminyaka engu-2 ubudala noma ngaphezulu,
• i-cytokine release syndrome (ukusabela okunzima futhi okungenzeka kusongele impilo) okwenzeka kubantu abadala nezingane ezineminyaka engu-2 noma ngaphezulu ngemuva kokuthola ukumunca okuthile kwe-immunotherapy.

Umjovo weTocilizumab usesigabeni semithi ebizwa nge-interleukin-6 (IL-6) receptor inhibitors. Isebenza ngokuvimba umsebenzi we-interleukin-6, into esemzimbeni ebangela ukuvuvukala.

Umjovo weTocilizumab uza njengesisombululo (uketshezi) sokujova ngomjovo (emthanjeni) engalweni yakho ngudokotela noma umhlengikazi ehhovisi lezokwelapha noma emtholampilo wabangalaliswa esibhedlela noma njengesirinji ekhethiwe yokujova ngomgogodla (ngaphansi kwesikhumba) wedwa ku ekhaya. Lapho i-tocilizumab inikezwa ngemithambo yokwelapha i-rheumatoid arthritis noma i-polyarticular juvenile idiopathic arthritis, ivame ukunikezwa kanye njalo emavikini amane. Lapho i-tocilizumab inikezwa ngemithambo yokwelapha i-systemic juvenile idiopathic arthritis, ivame ukunikezwa kanye njalo emavikini ayi-1 noma amabili. Lapho i-tocilizumab inikezwa ngemithambo yokwelapha i-cytokine release syndrome, imvamisa inikezwa kanye, kepha imithamo eyengeziwe engama-3 inganikezwa okungenani ngamahora ayi-8 ngokuhlukana. Kuzothatha cishe ihora elilodwa ukuthi uthole umthamo wakho womjovo we-tocilizumab ngemithambo yegazi. Lapho i-tocilizumab inikezwa ngaphansi kwesikhumba ukwelapha i-rheumatoid arthritis noma i-giant cell arteritis, ivame ukunikezwa kanye ngesonto noma kanye njalo ngesonto.

Uzothola umthamo wakho wokuqala ongaphansi komjovo we-tocilizumab ehhovisi likadokotela wakho. Uma uzobe ujova umjovo we-tocilizumab wedwa ekhaya noma unomngane noma isihlobo sikufakele umuthi, udokotela wakho uzokukhombisa wena noma umuntu ozokujova umuthi ukuthi ungawujova kanjani. Wena kanye nomuntu ozojova umuthi kufanele futhi ufunde imiyalo ebhaliwe yokusetshenziswa eza nomuthi.

Emizuzwini engama-30 ngaphambi kokuba usukulungele ukujova umjovo we-tocilizumab, kuzodingeka ukuthi ususe umuthi esiqandisini, uwukhiphe ebhokisini lawo, bese uyivumela ukuthi ifinyelele ekamelweni lokushisa. Lapho ususa isipontsho esivele safakwa ebhokisini, qaphela ukuthi ungathinti iminwe yokuthinta kusirinji. Ungazami ukufudumeza umuthi ngokuwufudumeza ngemicrowave, uwubeke emanzini afudumele, noma nganoma iyiphi enye indlela.

Ungasusi ikepisi kusirinji efakiwe ngenkathi umuthi ufudumala. Isikhwama kufanele ungasusi ngaphezu kwemizuzu engu-5 ngaphambi kokujova umuthi. Ungayishintshi ikepisi ngemuva kokuyisusa. Ungayisebenzisi isirinji uma uyilahla phansi.

Hlola isirinji efakiwe ukuze uqiniseke ukuthi usuku lokuphelelwa yisikhathi oluprintwe kwiphakethe alukwedluli, Ubambe isirinji ngenaliti emboziwe ekhomba phansi, ubhekisise uketshezi olukusirinji. Okuketshezi kufanele kucace noma kuphuzi ngokukhanyayo futhi akufanele kube namafu noma kungabi nebala noma kuqukethe izigaxa noma izinhlayiya. Shayela usokhemisi wakho uma kunezinkinga ngephakethe noma isipetu futhi ungawufaki umuthi.

Ungajova umjovo we-tocilizumab ngaphambili kwamathanga noma noma yikuphi esiswini sakho ngaphandle kwenkaba yakho (inkinobho yesisu) nendawo engama-intshi amabili ukuyizungeza. Uma omunye umuntu ejova umuthi wakho, indawo engaphandle yezingalo ezingaphezulu nayo ingasetshenziswa. Ungawufaki umuthi esikhumbeni esithambile, esilimele, esibomvu, esiqinile, noma esingaphelele, noma esinezibazi, izinsumpa noma imihuzuko. Khetha indawo ehlukile njalo lapho ufaka umuthi, okungenani u-1 intshi kude nendawo oyisebenzise ngaphambili. Uma umthamo ophelele ungafakiwe, shayela udokotela wakho noma usokhemisi.

Ungayisebenzisi imijovo ekhethiwe ye-tocilizumab futhi ungaphindi amajojo ngemuva kokuyisebenzisa. Lahla noma imiphi imijovo esetshenzisiwe esitsheni esingamelana nokubhoboza bese ubuza usokhemisi wakho ukuthi usilahla kanjani isitsha.

Umjovo weTocilizumab ungasiza ukulawula izimpawu zakho, kepha ngeke uselaphe isimo sakho. Udokotela wakho uzokubuka ngokucophelela ukuze abone ukuthi umjovo we-tocilizumab usebenza kanjani kuwe. Udokotela wakho angalungisa umthamo wakho noma abambezele ukwelashwa kwakho uma unezinguquko ezithile emiphumeleni yakho yaselebhu. Kubalulekile ukutshela udokotela wakho ukuthi uzizwa kanjani ngesikhathi sokwelashwa kwakho.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthola umjovo we-tocilizumab,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-tocilizumab, noma imiphi eminye imithi, noma yiziphi izithako zomjovo we-tocilizumab. Buza usokhemisi wakho noma uhlole Umhlahlandlela Wezokwelapha ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi uyayisho imithi efakwe kuhlu esigabeni ESIBALULEKILE SESEXWAYISO nanoma yikuphi okulandelayo: ama-anticoagulants ('blood thinner') afana ne-warfarin (Coumadin, Jantoven); i-aspirin nezinye izidakamizwa ezingezona ukuvuvukala (ama-NSAID) njenge-ibuprofen (Advil, Motrin, abanye) ne-naproxen (Aleve, Naprosyn, abanye); imithi yokwehlisa i-cholesterol (ama-statins) njenge-atorvastatin (Lipitor, eCaduet), i-lovastatin (i-Altoprev, ku-Advicor), ne-simvastatin (iZocor, eVytorin); izinto zokuvimbela inzalo ngomlomo (amaphilisi okuvimbela inzalo); noma i-theophylline (i-Elixophyllin, i-Theo-24, abanye). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi. Eminye imishanguzo eminingi ingaxhumana nomjovo we-tocilizumab, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imishanguzo oyiphuzayo, ngisho nalawo angaveli kulolu hlu.
• utshele udokotela wakho uma uke waba nomdlavuza noma wake waba nawo; i-diverticulitis (izikhwama ezincane emgqeni wamathumbu amakhulu angavuvukala); izilonda esiswini noma emathunjini akho; i-cholesterol ephezulu ne-triglycerides; noma isiphi isimo esithinta isistimu yezinzwa efana ne-multiple sclerosis (MS; isifo lapho izinzwa zingasebenzi kahle futhi abantu bangathola ubuthakathaka, ukuba ndikindiki, ukulahlekelwa ukuhlangana kwemisipha nezinkinga ngombono, ukukhuluma, nokulawula isinye) noma ukuvuvukala okungamahlalakhona ukuqeda i-polyneuropathy (CIDP; ukuphazamiseka kwamasosha omzimba kanye nezinzwa); noma isifo sesibindi.
• utshele udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uncelisa. Uma ukhulelwa ngenkathi uthola umjovo we-tocilizumab, shayela udokotela wakho.
• uma uhlinzwa, kufaka phakathi ukuhlinzwa kwamazinyo, tshela udokotela noma udokotela wamazinyo ukuthi uthola umjovo we-tocilizumab.
• buza udokotela wakho ukuthi kufanele yini ugonywe ngaphambi kokuba uqale ukwelashwa ngomjovo we-tocilizumab. Uma kungenzeka, yonke imigomo yokugoma izingane kufanele yenziwe isesikhathini ngaphambi kokuqala ukwelashwa. Ungabi nayo imigomo ngesikhathi sokwelashwa kwakho ngaphandle kokukhuluma nodokotela wakho.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Uma uphuthelwa i-aphoyintimenti ukuthola ukumnika i-tocilizumab, shayela udokotela wakho.

Uma ukhohlwa ukujova umthamo omncane we-tocilizumab, faka umthamo ongabanjwanga ngokushesha nje lapho uwukhumbula. Kodwa-ke, uma sekuyisikhathi somthamo olandelayo, weqa umthamo ongabanjwanga bese uqhubeka neshejuli yakho ejwayelekile yokulinganisa. Musa ukujova umthamo ophindwe kabili ukwenzela okulahlekile. Shayela udokotela noma usokhemisi wakho uma ungazi ukuthi uzofaka nini umjovo we-tocilizumab.

Umjovo weTocilizumab ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ikhanda
• ikhala eligobayo noma ukuthimula
• ububomvu, ukulunywa, ubuhlungu, noma ukuvuvukala endaweni lapho kwafakwa khona i-tocilizumab

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SEXWAYISO, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• ukuqubuka
• ukuqhuma
• isifuba
• ukulunywa
• ukuvuvukala kwamehlo, ubuso, izindebe, ulimi, umphimbo, izingalo, izandla, izinyawo, amaqakala noma imilenze engezansi
• ukuphefumula kanzima noma ukugwinya
• ubuhlungu besifuba
• isiyezi noma ukuquleka
• umkhuhlane, ubuhlungu obuqhubekayo bendawo esiswini, noma ushintsho kwimikhuba yamathumbu
• amehlo aphuzi noma isikhumba; ubuhlungu besisu sangaphezulu kwesokudla; ukulinyazwa noma ukopha okungachazwanga; ukulahlekelwa ukudla; ukudideka; umchamo ophuzi noma onsundu; noma indle ephaphathekile

I-Tocilizumab ingakhuphula ubungozi bokuthuthukisa izinhlobo ezithile zomdlavuza. Khuluma nodokotela wakho ngezingozi zokuthola lo muthi.

Umjovo weTocilizumab ungadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthola lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi ephaketheni efike ngalo, kude nokukhanya, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina umjovo we-tocilizumab esiqandisini, kepha ungawumisi. Gcina imijovo oyikhethile yomile. Lahla noma imuphi umuthi osuphelelwe yisikhathi noma ongasadingeki. Khuluma nosokhemisi wakho ngokulahlwa okufanele kwemithi yakho.

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nomjovo we-tocilizumab.

Ungavumeli omunye umuntu asebenzise imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• I-Actemra^®