I-Avatrombopag

-Delile

• Ngaphambi kokuthatha i-avatrombopag,
• I-Avatrombopag ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu shayela udokotela wakho ngokushesha:
• Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

I-Avatrombopag isetshenziselwa ukwelapha i-thrombocytopenia (inani eliphansi lama-platelets [uhlobo lweseli legazi elidingekayo ekunqandeni igazi]) kubantu abanesifo esingapheli (esiqhubekayo) sesibindi abahlelelwe ukuba nenqubo yezokwelapha noma yamazinyo ukusiza ukuvimbela izinkinga zokopha. Ibuye isetshenziselwe ukwelapha i-thrombocytopenia kubantu abane-immune thrombocytopenia engapheli (i-ITP; isimo esiqhubekayo esingadala ukulimazeka noma ukopha okungavamile ngenxa yenani eliphansi ngokweqile lama-platelet egazini) abangazange basizwe ngolunye ukwelashwa. I-Avatrombopag isekilasini lemithi ebizwa nge-thrombopoietin (TPO) receptor agonists. Isebenza ngokwenza umzimba ukhiqize amaplatelets amaningi.

I-Avatrombopag iza njengethebhulethi ukuthatha ngomlomo. Ukwelashwa kwe-thrombocytopenia kubantu abanezifo ezingapheli zesibindi abahlelelwe ukuthi babe nenqubo, kuvame ukuthathwa ngokudla kanye ngosuku izinsuku ezinhlanu, kuqala izinsuku eziyi-10 kuye kwezingu-13 ngaphambi kwenqubo. Ekwelapheni i-thrombocytopenia kubantu abane-ITP, kuvame ukuthathwa kanye nsuku zonke ngokudla isikhathi eside njengokuyalelwa. Thatha i-avatrombopag ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-avatrombopag njengoba nje iqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi yesiguli.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-avatrombopag,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-avatrombopag, noma imuphi omunye umuthi, noma iziphi izithako ezibhebheni ze-avatrombopag. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi imishanguzo kadokotela neyokungabhalisi, amavithamini, izithako zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma ikuphi kokulandelayo: amiodarone (Nexterone, Pacerone); i-aprepitant (Hlela); ezinye izinto zokuvikela ezifana ne-fluconazole, i-itraconazole (i-Onmel, i-Sporanox), i-ketoconazole, noma i-voriconazole (i-Vfend); carbamazepine (Carbatrol, Epitol, Equetro, Tegretol, Teril); i-clarithromycin (i-Biaxin, ku-Prevpac); i-diltiazem (iCardizem, iCartia, iDiltzac, iTaztia); enzalutamide (Xtandi); i-erythromycin (i-EES, i-Erythrocin, abanye; imishanguzo ethile yokwelapha i-HIV efana ne-efavirenz (Sustiva, e-Atripla), indinavir (Crixivan), nelfinavir (Viracept), noma nevirapine (Viramune); phenobarbital; phenytoin (Dilantin, Phenytut); I-Mycobutin); i-rifampin (i-Rifadin, i-Rimactane, e-Rifamate, e-Rifater); i-ritonavir (i-Norvir, e-Kaletra, abanye), noma i-saquinavir (i-Invirase); i-nefazodone; ne-verapamil (i-Calan, i-Covera, i-Verelan). nge-avatrombopag, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho naleyo engabonakali kulolu hlu. Udokotela wakho kungadingeka ukuthi ashintshe imithamo yemithi yakho noma akuqaphe ngokucophelela imiphumela emibi.
• utshele udokotela wakho ukuthi uthatha miphi imikhiqizo yamakhambi, ikakhulukazi iSt John's wort.
• utshele udokotela wakho uma uke waba negazi noma uke waba negazi, noma isimo sofuzo esingaholela kumahlule egazi.
• utshele udokotela wakho uma ukhulelwe, noma uhlele ukukhulelwa. Uma ukhulelwa ngenkathi uthatha i-avatrombopag, shayela udokotela wakho.
• tshela udokotela wakho uma uncelisa. Udokotela wakho mhlawumbe uzokutshela ukuthi ungancelisi ngesikhathi sokwelashwa kwakho namasonto amabili ngemuva komthamo wakho wokugcina.

Ungadli isithelo samagilebhisi noma uphuze ijusi lamagilebhisi ngenkathi usebenzisa lo muthi.

Uma uthatha i-avatrombopag ukwelapha i-thrombocytopenia ngaphambi nje kwenqubo, thatha isilinganiso esilahlekile ngokushesha nje lapho usikhumbula. Uma sekusondele isikhathi somthamo olandelayo, weqa umthamo ongabanjwanga bese uqhubeka nesimiso sakho sokulinganisa, kepha qiniseka ukuthi uqeda ukuthatha yonke imithi (noma ingathathwanga izinsuku ezi-5 zilandelana). Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

Uma uthatha i-avatrombopag ukwelapha i-immune thrombocytopenia engapheli, thatha isilinganiso esilahlekile ngokushesha nje lapho usikhumbula. Uma sekusondele isikhathi somthamo olandelayo, weqa umthamo ophuthelwe bese uqhubeka nesimiso sakho sokulinganisa okujwayelekile. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

I-Avatrombopag ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ukukhathala ngokweqile
• ikhanda
• ukopha ngamakhala noma ukopha kwezinsini
• ubuhlungu obuhlangene

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu shayela udokotela wakho ngokushesha:

• ivuvukile, ibuhlungu, ibomvu, noma ithenda lomlenze
• ukuphefumula, ukushisa komzimba, ukukhwehlela, ubuhlungu besifuba, noma ukushaya kwenhliziyo okusheshayo
• ubuhlungu besisu noma isisa
• ukuvuvukala kwezandla noma izinyawo

I-Avatrombopag ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese).

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

• ivuvukile, ibuhlungu, ibomvu noma ithenda umlenze
• ukuphefumula, ukukhwehlela, ubuhlungu besifuba, ukushaya kwenhliziyo okusheshayo
• ubuhlungu besisu noma isisa

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile zelebhu ngaphambi kokuqala ukwelashwa ukunquma umthamo wakho we-avatrombopag nangosuku lwenqubo.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

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