I-Fingolimod

-Delile

• Ngaphambi kokuthatha i-fingolimod,
• I-Fingolimod ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha:
• Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

I-Fingolimod isetshenziselwa ukuvimbela iziqephu zezimpawu futhi yehlise ukwanda kokukhubazeka kwabantu abadala nezingane ezineminyaka engu-10 nangaphezulu ngamafomu okubuyisela emuva (inkambo yesifo lapho izimpawu zivela khona ngezikhathi ezithile) ze-multiple sclerosis (MS; isifo lapho izinzwa zingasebenzi kahle futhi abantu bangathola ubuthakathaka, ukuba ndikindiki, ukulahleka kokuxhumanisa kwemisipha, nezinkinga ngombono, ukukhuluma, nokulawula isinye). I-Fingolimod isekilasini lemithi ebizwa nge-sphingosine l-phosphate receptor modulators. Isebenza ngokunciphisa isenzo samaseli omzimba angadala ukulimala kwezinzwa.

I-Fingolimod iza njengephilisi elizothathwa ngomlomo. Imvamisa kuthathwa kanye ngosuku noma ngaphandle kokudla. Thatha i-fingolimod ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-fingolimod njengoba nje kuqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

I-Fingolimod ingadala ukuthi ukushaya kwenhliziyo kwehle kubantu abadala nasezinganeni, ikakhulukazi phakathi namahora ayisithupha okuqala ngemuva kokuthatha umthamo wakho wokuqala, nangemva komthamo wokuqala lapho umthamo wanda ezinganeni. Uzothola i-electrocardiogram (ECG; isivivinyo esiqopha umsebenzi kagesi wenhliziyo) ngaphambi kokuthatha umthamo wakho wokuqala futhi namahora ayisithupha ngemuva kokuthatha umthamo. Uzothatha umthamo wakho wokuqala we-fingolimod ehhovisi likadokotela wakho noma kwenye indawo yezokwelapha. Uzodinga ukuhlala esikhungweni sezokwelapha okungenani amahora angu-6 ngemuva kokudla umuthi ukuze ubhekwe. Ungadinga ukuhlala esikhungweni sezokwelapha isikhathi esingaphezu kwamahora ayisithupha noma ubusuku bonke uma unemibandela ethile noma uthatha imishanguzo ethize ekhulisa ubungozi bokuthi ukushaya kwenhliziyo yakho kuzokwehla noma uma ukushaya kwenhliziyo yakho kuhamba kancane kunokulindelekile noma kuqhubeka ukwehla ngemuva kwe-6 yokuqala amahora. Kungase kudingeke nokuthi uhlale esikhungweni sezokwelapha okungenani amahora angu-6 ngemuva kokuthatha umthamo wakho wesibili uma ukushaya kwenhliziyo yakho kwehla kakhulu lapho uthatha umthamo wakho wokuqala. Tshela udokotela wakho uma uba nesiyezi, ukhathala, ubuhlungu besifuba, noma ukushaya kwenhliziyo okuhamba kancane noma okungajwayelekile nganoma yisiphi isikhathi lapho welashwa, ikakhulukazi phakathi namahora angama-24 okuqala ngemuva kokuthatha umthamo wakho wokuqala.

I-Fingolimod ingasiza ekulawuleni i-multiple sclerosis kepha ngeke iyelaphe. Ungayeki ukuthatha i-fingolimod ngaphandle kokukhuluma nodokotela wakho. Uma ungathathi i-fingolimod usuku olungu-1 noma ngaphezulu phakathi namasonto amabili okuqala okwelashwa, isonto elilodwa noma ngaphezulu emasontweni wesithathu nawesine okwelashwa noma amasonto ama-2 noma ngaphezulu ngemuva kwenyanga yokuqala yokwelashwa, khuluma nodokotela wakho ngaphambi uqala ukuyithatha futhi. Ungahle uthole ukushaya kwenhliziyo okwehlisiwe lapho uqala ukuthatha i-fingolimod futhi, ngakho-ke uzodinga ukuqala kabusha imithi ehhovisi likadokotela wakho.

Udokotela wakho noma usokhemisi uzokunikeza ishidi lemininingwane yesiguli lomkhiqizi (Umhlahlandlela Wezokwelapha) lapho uqala ukwelashwa nge-fingolimod futhi isikhathi ngasinye lapho ugcwalisa umuthi wakho. Funda imininingwane ngokucophelela bese ubuza udokotela noma usokhemisi wakho uma unemibuzo. Ungavakashela futhi iwebhusayithi ye-Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) noma iwebhusayithi yomkhiqizi ukuthola i-Medication Guide.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-fingolimod,

• Tshela udokotela kanye nosokhemisi wakho uma une-allerging ku-fingolimod, Uma ngabe uke waba ne-reaction engathi sína ku-fingolimod noma ezinye izithako kumaphilisi we-fingolimod (ukuqubuka, isifuba, ukuvuvukala kobuso, amehlo, umlomo, umphimbo, ulimi, izindebe, izandla, izinyawo, amaqakala, noma imilenze engezansi), udokotela wakho mhlawumbe uzotshela ukuthi angafingolimod. Futhi, tshela udokotela wakho uma uxabana nanoma imuphi omunye umuthi, noma yiziphi izithako kumaphilisi we-fingolimod. Buza usokhemisi wakho noma uhlole Umhlahlandlela Wezokwelapha ukuthola uhlu lwezithako.
• Tshela udokotela wakho uma uthatha imishanguzo yokushaya kwenhliziyo okungajwayelekile njenge-amiodarone (Nexterone, Pacerone), disopyramide (Norpace), dofetilide (Tikosyn), dronedarone (Multaq), ibutilide (Corvert), procainamide, quinidine (eNuedexta), ne-sotalolide (IBetapace, iSorine, iSotylize). Udokotela wakho mhlawumbe uzokutshela ukuthi ungathathi i-fingolimod uma uthatha eyodwa noma ngaphezulu yale mithi.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi imishanguzo kadokotela nemishanguzo engabhaliswanga, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha ngenkathi welashwa nge-fingolimod Qiniseka ukuthi usho noma ikuphi kokulandelayo: i-beta-blockers efana ne-atenolol (Tenormin, ku-Tenoretic), i-carteolol, i-labetalol (i-Trandate), i-metoprolol (i-Lopressor, i-Toprol-XL, i-Dutoprol, i-Lopressor HCT), i-nadolol (i-Corgard, ku Corzide), nebivolol (Bystolic, e-Byvalson), propranolol (Inderal LA, Innopran XL), ne-timolol; i-diltiazem (Cardizem, Cartia, Tiazac, abanye); i-chlorpromazine; i-citalopram (Celexa); i-digoxin (i-Lanoxin); i-erythromycin (E.E.S., Ery-Tab, PCE, nabanye); i-haloperidol (iHaldol); ketoconazole; imithi yezinkinga zenhliziyo; i-methadone (i-Dolophine, i-Methadose); kanye ne-verapamil (Calan, Verelan, eTarka).Tshela nodokotela wakho ukuthi ngabe uphuza noma iyiphi yale mithi elandelayo, noma uma uke wayisebenzisa esikhathini esedlule: i-corticosteroids efana ne-dexamethasone, i-methylprednisolone, ne-prednisone; imithi yomdlavuza; nemithi yokwenza buthakathaka noma ulawule amasosha omzimba njenge-mitoxantrone, natalizumab (Tysabri), ne-teriflunomide (Aubagio), Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi. Eminye imithi eminingi ingase futhi ihlanganyele ne-fingolimod, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho nalawo angaveli kulolu hlu.
• Tshela udokotela wakho uma uke waba nanoma iyiphi yalezi zimo ezinyangeni eziyisithupha ezedlule: isifo senhliziyo, i-angina (ubuhlungu besifuba), isifo sohlangothi noma ukushaywa unhlangothi, noma ukwehluleka kwenhliziyo. Phinda utshele udokotela wakho uma une-QT syndrome ende (isimo esandisa ingozi yokuhlaselwa ukushaya kwenhliziyo okungajwayelekile okungadala ukuquleka noma ukufa ngokuzumayo) noma isigqi senhliziyo esingajwayelekile. Udokotela wakho angakutshela ukuthi ungathathi i-fingolimod.
• Tshela udokotela wakho uma wake waquleka, wahlaselwa yinhliziyo, wahlaselwa isifo sohlangothi noma waba nesifo sohlangothi esincane, noma ngabe njengamanje unemfiva noma ezinye izimpawu zokutheleleka, uma unesifo esifika sidlule noma esingapheli, futhi uma uke waba nesifo sikashukela noma wake waba naso; ukulala ubuthongo (isimo lapho uyeka kafushane ukuphefumula kaningi ebusuku) noma ezinye izinkinga zokuphefumula; umfutho wegazi ophakeme; uveitis (ukuvuvukala kweso) noma ezinye izinkinga zamehlo; ukushaya kwenhliziyo okuhamba kancane; amazinga aphansi we-potassium noma i-magnesium egazini lakho; umdlavuza wesikhumba, noma isifo senhliziyo noma sesibindi. Phinda utshele udokotela wakho uma usanda kuthola umuthi wokugoma.
• utshele udokotela wakho uma ukhulelwe noma uhlela ukukhulelwa, noma uncelisa. Kufanele usebenzise ukulawulwa kokubeletha ukuvimbela ukukhulelwa ngesikhathi sokwelashwa kwakho nezinyanga ezi-2 ngemuva komthamo wakho wokugcina. Uma ukhulelwa ngenkathi uthatha i-fingolimod noma ezinyangeni ezimbili ngemuva komthamo wakho wokugcina, shayela udokotela wakho.
• awunayo imigomo ngesikhathi sokwelashwa kwakho nge-fingolimod noma izinyanga ezimbili ngemuva komthamo wakho wokugcina ngaphandle kokukhuluma nodokotela wakho. Khuluma nodokotela wengane yakho ngemigomo ingane yakho engadinga ukuyithola ngaphambi kokuqala ukwelashwa kwayo nge-fingolimod.
• Tshela udokotela wakho uma ungakaze ube nochoko futhi awutholanga umuthi wokugomela ubungu. Udokotela wakho angayalela ukuhlolwa kwegazi ukuze abone ukuthi ngabe uchayekile yini ekubhekaneni nenkukhu. Ungadinga ukuthola umuthi wokugomela ubuthi wenkukhu bese ulinda inyanga eyodwa ngaphambi kokuqala ukwelashwa kwakho nge-fingolimod.
• hlela ukugwema ukuvezwa yilanga nokukhanya kwe-UV okungadingekile noma isikhathi eside (njengamadokodo okushuka) nokugqoka izingubo zokuzivikela, izibuko zelanga, kanye nesikrini selanga. I-Fingolimod ingenza isikhumba sakho sizwele kakhulu emiphumeleni eyingozi yokukhanya kwelanga, futhi singakhuphula ubungozi bokuba nomdlavuza wesikhumba.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Thatha umthamo ongabanjwanga ngokushesha nje lapho uwukhumbula. Kodwa-ke, uma sekusondele isikhathi somthamo olandelayo, weqa umthamo ongabanjwanga bese ushayela udokotela wakho ngaphambi kokuthatha umthamo olandelayo. Ungadinga ukuthi ubhekwe njengoba uqala kabusha imithi yakho. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

I-Fingolimod ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ubuthakathaka
• ukuhlungu obusemhlane
• ubuhlungu ezandleni noma ezinyaweni
• isifo sohudo
• ubuhlungu besisu
• isicanucanu
• ikhanda noma i-migraine
• ukulahleka kwezinwele

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha:

• ukushaya kwenhliziyo okuhamba kancane
• ukuqubuka, isifuba, ukulunywa; ukuvuvukala kobuso, iso, umlomo, umphimbo, ulimi noma izindebe; noma ubunzima bokugwinya noma ukuphefumula
• umphimbo obuhlungu, ubuhlungu bomzimba, umkhuhlane, amakhaza, ukukhwehlela, nezinye izimpawu zokutheleleka nangesikhathi sokwelashwa nangezinyanga ezimbili ngemuva kokwelashwa kwakho
• ikhanda, ukuqina kwentamo, umkhuhlane, ukuzwela ekukhanyeni, isicanucanu, noma ukudideka ngenkathi welashwa nangezinyanga ezi-2 ngemuva kokwelashwa kwakho
• ukuzwa okubuhlungu, okushisayo, okundikindiki noma okushoshozelayo esikhunjeni, ukuzwela ukuthinta, ukuqubuka, noma ukulunywa ngesikhathi sokwelashwa nangezinyanga ezimbili ngemuva kokwelashwa kwakho
• ikhanda elibuhlungu ngokuzumayo, ukudideka, izinguquko kumbono, noma ukuquleka
• ukufiphala, izithunzi, noma indawo engaboni maphakathi nombono wakho; ukuzwela ekukhanyeni; umbala ongavamile kumbono wakho noma ezinye izinkinga zombono
• izinguquko kumvukuzane ekhona; indawo entsha emnyama esikhunjeni; izilonda ezingapholi; ukukhula kwesikhumba sakho njenge-bump engahle icwebezele, imhlophe ngebala, ibala lesikhumba, noma i-pinki, noma olunye uguquko esikhunjeni sakho
• ubuthakathaka ohlangothini olulodwa lomzimba noma ubuthakathaka bezingalo noma imilenze obuba bucayi ngokuhamba kwesikhathi; izinguquko emcabangweni wakho, ememori, noma ekulinganiseni; ukudideka noma izinguquko zobuntu; noma ukuphelelwa amandla
• ukuphefumula okusha noma okuya kuba kubi kakhulu
• isicanucanu, ukuhlanza, ukungathandi ukudla, ubuhlungu besisu, ukuphuzi kwesikhumba noma kwamehlo, noma umchamo omnyama

I-Fingolimod ingakhuphula ingozi yokuba nomdlavuza wesikhumba kanye ne-lymphoma (umdlavuza oqala kumaseli alwa nokutheleleka). Khuluma nodokotela wakho ngezingozi zokuthatha lo muthi.

Ukwanda okungazelelwe kweziqephu zezimpawu ze-MS nokwanda kokukhubazeka kungenzeka ezinyangeni ezi-3 kuya kwezi-6 ngemuva kokuyeka ukuthatha i-fingolimod. Tshela udokotela wakho uma izimpawu zakho ze-MS ziba zimbi kakhulu ngemuva kokumisa i-fingolimod.

I-Fingolimod ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese).

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

• ukushaya kwenhliziyo okuphuzile noma okungajwayelekile

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile zelebhu, kanye nokuhlolwa kwesikhumba namehlo, futhi uzobheka umfutho wegazi lakho ngaphambi nangesikhathi sokwelashwa kwakho ukuze aqiniseke ukuthi kuphephile yini kuwe ukuqala ukuthatha noma ukuqhubeka nokuthatha i-fingolimod.

Ngaphambi kokwenza noma yiluphi uvivinyo lwelabhoratri, tshela udokotela wakho kanye nabasebenzi belebhuthi ukuthi uthatha i-fingolimod.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• Gilenya^®