Inaliti ye-Pegloticase

-Delile

• Ngaphambi kokuthola umjovo we-pegloticase,
• Umjovo wePegloticase ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

Umjovo wePegloticase ungadala ukusabela okubucayi noma okusongela impilo. Lokhu kusabela kuvame kakhulu kungakapheli amahora amabili kokuthola ukumnika kepha kungenzeka nganoma yisiphi isikhathi ngenkathi welashwa. Ukufakwa kufanele kunikezwe udokotela noma umhlengikazi endaweni yokunakekelwa kwezempilo lapho lokhu kuphathwa kungaphathwa khona. Ungathola futhi imishanguzo ethile ngaphambi kokufakwa kwakho kwe-pegloticase ukusiza ukuvimbela ukusabela. Udokotela wakho noma unesi uzokubuka ngokucophelela ngenkathi uthola umjovo we-pegloticase futhi isikhashana ngemuva kwalokho. Tshela udokotela wakho uma uhlangabezana nalezi zimpawu ezilandelayo ngesikhathi sokumnika noma ngemuva kokumnika: ubunzima bokugwinya noma ukuphefumula; ukushaya; ukushaqeka; ukuvuvukala kobuso, umphimbo, ulimi noma izindebe; isifuba; ukubomvu okungazelelwe kobuso, intamo noma isifuba esingenhla; ukuqubuka; ukulunywa; ukubomvu kwesikhumba; ukuquleka; isiyezi; ubuhlungu besifuba; noma ukuqina kwesifuba. Uma uthola ukusabela, udokotela wakho anganciphisa noma ayeke ukumnika.

Umjovo wePegloticase ungadala izinkinga ezinkulu zegazi. Tshela udokotela wakho uma unesifo se-glucose-6-phosphate dehydrogenase (G6PD) (isifo segazi esizuzwe njengefa). Udokotela wakho angakuhlolela ukushoda kwe-G6PD ngaphambi kokuthi uqale ukuthola umjovo we-pegloticase. Uma unokuntuleka kwe-G6PD, udokotela wakho mhlawumbe uzokutshela ukuthi awukwazi ukuthola umjovo we-pegloticase. Phinda utshele udokotela wakho uma ungowase-Afrika, iMedithera (kufaka phakathi i-Southern Europe kanye ne-Middle East), noma owe-Southern Asia.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile ukuze ahlole impendulo yomzimba wakho kumjovo we-pegloticase futhi angahle ayeke ukwelashwa kwakho uma umuthi ungasebenzi.

Udokotela wakho noma usokhemisi uzokunikeza ishidi lemininingwane yesiguli lomkhiqizi (Umhlahlandlela Wezokwelapha) lapho uqala ukwelashwa ngomjovo we-pegloticase futhi isikhathi ngasinye lapho uthola umuthi. Funda imininingwane ngokucophelela bese ubuza udokotela noma usokhemisi wakho uma unemibuzo. Ungavakashela futhi iwebhusayithi ye-Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) noma iwebhusayithi yomkhiqizi ukuthola i-Medication Guide.

Umjovo wePegloticase usetshenziselwa ukwelapha i-gout eqhubekayo (ubuhlungu obungazelelwe, obunzima, ubomvu, nokuvuvukala kwilunga elilodwa noma ngaphezulu okubangelwa amazinga aphezulu ngokungajwayelekile wento ebizwa nge-uric acid egazini) kubantu abadala abangakwazi ukuthatha noma abangaphenduli kweminye imithi . Umjovo wePegloticase usesigabeni semithi ebizwa nge-PEGylated uric acid enzyme ethile. Isebenza ngokunciphisa inani le-uric acid emzimbeni. Umjovo wePegloticase usetshenziselwa ukuvikela ukuhlaselwa yi-gout kodwa hhayi ukuwaphatha uma sekwenzekile.

Umjovo wePegloticase uza njengesisombululo (uketshezi) sokujova ngomjovo (emthanjeni) ngudokotela noma umhlengikazi ehhovisi lezokwelapha noma emtholampilo. Imvamisa inikezwa kanye njalo emavikini ama-2. Kuzothatha okungenani amahora ama-2 ukuthi uthole umthamo wakho womjovo we-pegloticase.

Kungathatha izinyanga ezimbalwa ngaphambi kokuba umjovo we-pegloticase uqale ukuvimbela ukuhlaselwa yi-gout. Umjovo wePegloticase ungakhuphula inani lokuhlaselwa yi-gout ezinyangeni ezintathu zokuqala zokwelashwa kwakho. Udokotela wakho angakunikeza omunye umuthi onjenge-colchicine noma umuthi wokulwa nokuvuvukala (i-NSAID) ukuvikela ukuhlaselwa yi-gout ezinyangeni eziyisithupha zokuqala zokwelashwa kwakho. Qhubeka nokuthola umjovo we-pegloticase noma ngabe uhlaselwa yi-gout ngesikhathi sokwelashwa kwakho.

Umjovo wePegloticase ulawula i-gout kepha awuyelaphi. Qhubeka nokuthola imijovo ye-pegloticase noma ngabe uzizwa uphilile. Ungayeki ukuthola imijovo ye-pegloticase ngaphandle kokukhuluma nodokotela wakho.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthola umjovo we-pegloticase,

• Tshela udokotela wakho kanye nosokhemisi uma une-allergies ku-pegloticase, noma imiphi eminye imithi, noma yiziphi izithako zomjovo we-pegloticase. Buza usokhemisi wakho noma uhlole Umhlahlandlela Wezokwelapha ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma yikuphi okulandelayo: allopurinol (Aloprim, Lopurin, Zyloprim) ne febuxostat (Uloric). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• Tshela udokotela wakho uma ngabe uke wahluleka yinhliziyo, unomfutho wegazi ophakeme noma isifo senhliziyo.
• utshele udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uncelisa. Uma ukhulelwa ngenkathi usebenzisa umjovo we-pegloticase, shayela udokotela wakho.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Umjovo wePegloticase ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• isicanucanu
• ukuhlanza
• ukuqunjelwa
• ukulinyazwa
• Umphimbo obuhlungu

Umjovo wePegloticase ungadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthola lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nomjovo we-pegloticase.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• Krystexxa^®