Inaliti ye-Belimumab

-Delile

• Ngaphambi kokusebenzisa i-belimumab,
• I-Belimumab ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nanoma yiziphi zalezi zimpawu noma lezo ezisohlwini lwe-HOW section, shayela udokotela wakho ngokushesha:

I-Belimumab isetshenziswa neminye imithi yokwelapha izinhlobo ezithile ze-systemic lupus erythematosus (SLE noma lupus; isifo sokuzivikela komzimba lapho amasosha omzimba ehlasela izingxenye zomzimba ezinempilo njengamalunga, isikhumba, imithambo yegazi, nezitho) kubantu abadala nezingane iminyaka yobudala nangaphezulu. I-Belimumab nayo isetshenziswa neminye imithi yokwelapha i-lupus nephritis (isifo esizimele lapho amasosha omzimba ehlasela izinso) kubantu abadala. I-Belimumab isekilasini lemithi ebizwa ngama-antibody monoclonal. Isebenza ngokuvimba ukusebenza kweprotheni ethile kubantu abane-SLE ne-lupus nephritis.

IBelimumab iza njengempuphu ezohlanganiswa nesisombululo sokujova ngomjovo (emthanjeni) kubantu abadala nezingane ezineminyaka engu-5 nangaphezulu. IBelimumab nayo iza njengesisombululo (uketshezi) ku-autoinjector noma isirinji ekhethiwe yokujova ngomgogodla (ngaphansi kwesikhumba) kubantu abadala. Uma unikezwa ngemithambo yegazi, imvamisa unikezwa okungenani ihora ngudokotela noma umhlengikazi kanye njalo emavikini ama-2 emithamo emithathu yokuqala, bese kuthi kanye emavikini amane. Udokotela wakho uzonquma ukuthi uzoyithola kangaki i-belimumab ngemithambo yegazi ngokusekelwe ekuphenduleni komzimba wakho kulo muthi. Lapho inikezwa ngaphansi kwesikhumba, imvamisa inikezwa kanye ngesonto okungcono ngosuku olufanayo ngesonto ngalinye.

Uzothola umthamo wakho wokuqala ongaphansi komjovo we-belimumab ehhovisi likadokotela wakho. Uma uzobe ujova umjovo we-belimumab wedwa ekhaya noma unomngane noma isihlobo sikufakele umuthi, udokotela wakho uzokukhombisa wena noma umuntu ozokujova umuthi ukuthi ungawujova kanjani. Wena kanye nomuntu ozojova umuthi kufanele futhi ufunde imiyalo ebhaliwe yokusetshenziswa eza nomuthi.

Susa i-autoinjector noma isirinji ekhethiwe kusuka esiqandisini bese uyivumela ukuthi ifinyelele ekamelweni lokushisa emizuzwini engama-30 ngaphambi kokuba ulungele ukujova umjovo we-belimumab. Ungazami ukufudumeza umuthi ngokuwufudumeza ngemicrowave, uwubeke emanzini afudumele, noma nganoma iyiphi enye indlela. Isixazululo kufanele sicacele ku-opalescent futhi singabi nombala ophuzi ophuzi. Shayela usokhemisi wakho uma kunezinkinga ngephakethe noma isipetu futhi ungawufaki umuthi.

Ungajova umjovo we-belimumab ngaphambili kwamathanga noma noma yikuphi esiswini sakho ngaphandle kwenkaba yakho (inkinobho yesisu) nendawo engama-intshi amabili ukuyizungeza. Ungafaki umuthi esikhumbeni esithambile, esilimele, esibomvu, esiqinile, noma esingaphelele. Khetha indawo ehlukile njalo lapho ufaka umuthi.

I-Belimumab ingadala ukusabela okujulile ngesikhathi nangemva kokuthola umuthi. Udokotela noma umhlengikazi uzokubuka eduze ngenkathi uthola ukumuncwa nangemva kokufakwa ukuze aqiniseke ukuthi awuphenduli ngokungathi sína kulowo muthi. Unganikezwa eminye imithi yokwelapha noma yokusiza ukuvimbela ukusabela ku-belimumab. Tshela udokotela wakho noma umhlengikazi ngokushesha uma uhlangabezana nalezi zimpawu ezilandelayo ezingase zivele ngesikhathi sokufakwa ngaphakathi noma ngomjovo ongaphansi komhlaba noma kuze kube yisonto ngemuva kokuthola umuthi: ukuqhuma; ukulunywa; isifuba; ukuvuvukala kobuso, amehlo, umlomo, umphimbo, ulimi, noma izindebe; ubunzima bokuphefumula noma ukugwinya; ukuphefumula noma ukuphefumula okuncane; ukukhathazeka; ukuqhuma; isiyezi; ukuquleka; ikhanda; isicanucanu; imfiva; Ukugodola; ukuquleka; ubuhlungu bemisipha; futhi ukushaya kwenhliziyo okuhamba kancane.

IBelimumab isiza ukulawula i-lupus kepha ayiyelaphi. Udokotela wakho uzokubheka ngokucophelela ukuze abone ukuthi i-belimumab isebenza kanjani kuwe. Kungathatha isikhathi esithile ngaphambi kokuthi uzwe inzuzo ephelele ye-belimumab. Kubalulekile ukutshela udokotela wakho ukuthi uzizwa kanjani ngesikhathi sokwelashwa kwakho.

Udokotela wakho noma usokhemisi uzokunikeza ishidi lemininingwane yesiguli lomkhiqizi (Umhlahlandlela Wezokwelapha) lapho uqala ukwelashwa nge-belimumab futhi isikhathi ngasinye lapho ugcwalisa umuthi wakho. Funda imininingwane ngokucophelela bese ubuza udokotela noma usokhemisi wakho uma unemibuzo. Ungavakashela futhi iwebhusayithi ye-Food and Drug Administration (FDA) http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm noma iwebhusayithi yomkhiqizi ukuthola i-Medication Guide.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokusebenzisa i-belimumab,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-belimumab, noma imiphi eminye imithi, noma yiziphi izithako zomjovo we-belimumab. Buza usokhemisi wakho noma uhlole Umhlahlandlela Wezokwelapha ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma yikuphi okulandelayo: i-cyclophosphamide emithanjeni; nama-antibody monoclonal noma eminye imithi ye-biologic. Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• Tshela udokotela wakho uma unesifo noma ngabe uke waba nokutheleleka okuhlala kubuya, ukudangala noma imicabango yokuzilimaza noma ukuzibulala, noma umdlavuza.
• utshele udokotela wakho uma ukhulelwe noma uhlela ukukhulelwa. Akwaziwa ukuthi ukuthatha i-belimumab ngesikhathi sokukhulelwa kungalimaza ingane yakho engakazalwa. Uma ukhetha ukuvimbela ukukhulelwa, kufanele usebenzise ukulawulwa kokubeletha okusebenzayo ngesikhathi sokwelashwa kwakho nge-belimumab nezinyanga ezine ngemuva komthamo wakho wokugcina. Khuluma nodokotela wakho ngezindlela zokulawula ukubeletha ongazisebenzisa ngesikhathi sokwelashwa kwakho. Uma ukhulelwa ngesikhathi sokwelashwa kwakho nge-belimumab, shayela udokotela wakho.
• tshela udokotela wakho uma uncelisa.
• uma uhlinzwa, kufaka phakathi ukuhlinzwa kwamazinyo, tshela udokotela noma udokotela wamazinyo ukuthi usebenzisa i-belimumab.
• ungenayo imigomo ngaphandle kokukhuluma nodokotela wakho. Tshela udokotela wakho uma uthole umuthi wokugoma ezinsukwini ezingama-30 ezedlule.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Uma uphuthelwa i-aphoyintimenti yokuthola ukumnika kwe-belimumab, shayela udokotela wakho ngokushesha okukhulu.

Uma uphuthelwa umthamo wakho ongaphansi komjovo we-belimumab, jovelela umthamo ongabanjwanga ngokushesha nje lapho uwukhumbula. Ngemuva kwalokho ,jova umthamo wakho olandelayo ngesikhathi sakho esihleliwe njalo noma uqhubeke nokufakwa kwesonto masonto ngokususelwa osukwini olusha olufakiwe. Musa ukujova umthamo ophindwe kabili ukwenzela okulahlekile. Shayela udokotela noma usokhemisi wakho uma udinga usizo lokunquma ukuthi uzojova nini umjovo we-belimumab.

I-Belimumab ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• isicanucanu
• isifo sohudo
• ikhanda noma i-migraine
• ubunzima bokulala noma ukulala
• ububomvu, ukulunywa, ukuvuvukala, ubuhlungu, ukushintsha kombala, noma ukucasuka endaweni yokujova
• ubuhlungu ezandleni noma emilenzeni
• ikhala eligijimayo

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nanoma yiziphi zalezi zimpawu noma lezo ezisohlwini lwe-HOW section, shayela udokotela wakho ngokushesha:

• ukuqubuka
• isifuba
• ukulunywa
• ukuphelelwa umoya
• ukuvuvukala kobuso, umphimbo, ulimi, izindebe namehlo
• ukuphefumula kanzima noma ukugwinya
• umkhuhlane, umphimbo obuhlungu, amakhaza, ukukhwehlela, nezinye izimpawu zokutheleleka
• kufudumele; isikhumba esibomvu, noma esibuhlungu noma izilonda emzimbeni wakho
• ucabanga ukuzilimaza noma ukuzibulala wena noma abanye, noma ukuhlela noma ukuzama ukwenza kanjalo
• ukucindezeleka okusha noma okubandayo noma ukukhathazeka
• izinguquko ezingavamile ekuziphatheni kwakho noma emoyeni
• esebenza ngemicabango eyingozi
• ukuchama kaningi, okubuhlungu, noma okunzima
• umchamo onamafu noma onamandla
• ukukhwehlela amafinyila
• umbono uyashintsha
• ukulahleka kwememori
• kunzima ukucabanga kahle
• kunzima ukukhuluma noma ukuhamba
• isiyezi noma ukulahlekelwa ibhalansi

I-Belimumab ingakhuphula ubungozi bakho bomdlavuza othile. Ucwaningo luye lwabonisa ukuthi abantu abathola i-belimumab babesengozini yokufa ngezimbangela ezahlukahlukene kunalabo abangathathanga i-belimumab. Khuluma nodokotela wakho ngezingozi zokuthola lo muthi.

I-Belimumab ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi usebenzisa lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi ephaketheni efike ngalo, kude nokukhanya, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Unganyakazisi ama-autoinjectors noma amasirinji akhethiwe aqukethe i-belimumab. Gcina umjovo we-belimumab esiqandisini; ungafrizi. Gwema ukuvezwa ukushisa. Imijovo ingagcinwa ngaphandle kwesiqandisi (kufika ku-30 ​​° C) kuze kufike emahoreni ayi-12 uma ivikelwe elangeni. Ungawasebenzisi ama-syringe futhi ungawabeki esiqandisini uma engafakiwe esiqandisini isikhathi esingaphezu kwamahora ayi-12. Lahla noma imuphi umuthi osuphelelwe yisikhathi noma ongasadingeki. Khuluma nosokhemisi wakho ngokulahlwa okufanele kwemithi yakho.

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Gcina wonke ama-aphoyintimenti nodokotela wakho.

Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nomjovo we-belimumab.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• UBenlysta^®