I-Rilpivirine

-Delile

• Ngaphambi kokuthatha i-rilpivirine,
• I-Rilpivirine ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, noma lezo ezisohlwini lwe-SPECIAL PRECAUTIONS section, shayela udokotela wakho ngokushesha:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu yeka ukuthatha i-rilpivirine bese ushayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

I-Rilpivirine isetshenziswa kanye neminye imithi yokwelapha i-human immunodeficiency virus type 1 (HIV-1) kubantu abadala abathile kanye nezingane ezineminyaka engu-12 ubudala nangaphezulu ezinesisindo okungenani esingu-77 lb (35 kg) futhi ezingakatholi ukwelashwa ngezidambisi gciwane esikhathini esedlule. Ibuye isetshenziswe kanye ne-cabotegravir (Vocabria) njengokwelashwa kwesikhashana kokutheleleka nge-HIV-1 kubantu abadala abathile. I-Rilpivirine isekilasini lemithi ebizwa nge-non-nucleoside reverse transcriptase inhibitors (NNRTIs). Isebenza ngokunciphisa inani le-HIV egazini. Yize i-rilpivirine ingayelaphi i-HIV, ingahle inciphise amathuba akho okuba ne-immunodeficiency syndrome (i-AIDS) kanye nezifo ezihlobene ne-HIV ezinjengezifo ezibucayi noma umdlavuza. Ukuthatha le mithi kanye nokwenza ucansi oluphephile nokwenza ezinye izinguquko empilweni kunganciphisa ubungozi bokudlulisela (ukusabalalisa) igciwane le-HIV kwabanye abantu.

I-Rilpivirine iza njengethebhulethi ezothathwa ngomlomo. Imvamisa kuthathwa ngokudla (hhayi nje isiphuzo samaprotheni) kanye ngosuku. Lapho i-rilpivirine ithathwa kanye ne-cabotegravir, ivame ukuthathwa kanye ngosuku ngokudla. Thatha i-rilpivirine wedwa noma ne-cabotegravir ngasikhathi sinye nsuku zonke. I-Rilpivirine ithathwa kanye ne-cabotegravir isikhathi esingangenyanga eyodwa (okungenani izinsuku ezingama-28) ngaphambi kokuqala ukwelashwa ngezinhlobo zomjovo ezisebenza isikhathi eside zale mithi noma izinyanga ezifika kwezimbili uma uhlelo lokwelashwa ngomjovo lungabanjwanga izinsuku ezingaphezu kwezingu-7. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-rilpivirine njengoba nje iyalelwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

IRilpivirine ilawula i-HIV kepha ayiyelaphi. Qhubeka nokudla i-rilpivirine noma ngabe uzizwa uphilile. Ungayeki ukuthatha i-rilpivirine ngaphandle kokukhuluma nodokotela wakho. Lapho ukunikezwa kwakho kwe-rilpivirine kuqala ukwehla, thola okuningi kudokotela wakho noma kusokhemisi. Uma uphuthelwa amanani noma uyeka ukuthatha i-rilpivirine, isimo sakho singaba nzima ukwelashwa.

Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi yesiguli.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-rilpivirine,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-rilpivirine, noma imuphi omunye umuthi, noma iziphi izithako ezikumaphilisi e-rilpivirine. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• utshele udokotela wakho uma uthatha i-dexamethasone (i-Decadron); imishanguzo yokuquleka okubandakanya i-carbamazepine (Carbatrol, Epitol, Euetro, Tegretol, Teril), oxcarbazepine (Trileptal), phenobarbital (Luminal), noma phenytoin (Dilantin, Phenytek); ama-proton pump inhibitors afaka i-dexlansoprazole (Dexilant), i-esomeprazole (Nexium, Vimovo), i-lansoprazole (Prevacid), i-omeprazole (Prilosec), i-pantoprazole (i-Protonix), noma i-rabeprazole (i-Aciphex); i-rifampin (Rifater, Rifamate, Rimactane, Rifadin); i-rifapentine (Priftin); ne-wort yaseSt. Udokotela wakho mhlawumbe uzokutshela ukuthi ungathathi i-rilpivirine uma uthatha eyodwa noma ngaphezulu yale mithi.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma yikuphi okulandelayo: imishanguzo yokubulala izinhlungu, kufaka phakathi i-fluconazole (Diflucan), itraconazole (Sporanox), ketoconazole (Nizoral), posaconazole (Noxafil), ne-voriconazole (Vfend); i-amiodarone (i-Nexterone, i-Pacerone); i-anagrelide (Agrylin); i-chloroquine; i-chlorpromazine; i-cilostazol; i-ciprofloxacin (Cipro); i-citalopram (Celexa); i-clarithromycin (i-Biaxin); i-disopyramide (iNorpace); i-dofetilide (Tikosyn); i-donepezil (i-Aricept); i-erythromycin (i-E-Mycin, i-Eryc, i-Ery-Tab, i-PCE, iPediazole); i-flecainide (iTambocor); i-haloperidol (iHaldol); ibutilide (Corvert); levofloxacin; i-methadone (i-Dolophine); moxifloxacin (Velox); i-nelfinavir (i-Viracept); i-ondansetron (iZuplenz, iZofran); eminye imishanguzo yamaNNRTI yokwelapha i-HIV / AIDS; ipentamidine (NebuPent, Pentam); ipimozide (i-Orap); procainamide; i-quinidine (ku-Nuedexta); i-rifabutin (i-Mycobutin); i-sotalol (iBetapace, iSorine, iSotylize); i-telithromycin (Ketek); futhi thioridazine. Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi. Eminye imishanguzo eminingi ingaxhumana ne-rilpivirine, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho naleyo engabonakali kulolu hlu.
• uma uthatha ama-antacids aqukethe i-calcium, i-magnesium, noma i-aluminium (Maalox, Mylanta, Tums, others), thatha okungenani amahora amabili ngaphambi noma amahora amane ngemuva kwe-rilpivirine.
• uma uthatha umuthi we-indigestion, isilungulela, noma izilonda ezifana ne-cimetidine (Tagamet), i-famotidine (i-Pepcid), i-nizatidine (i-Axid), noma i-ranitidine (i-Zantac), thatha okungenani amahora ayi-12 ngaphambi noma okungenani amahora amane ngemuva kwe-rilpivirine .
• uma uthatha i-didanosine (Videx), yithathe okungenani amahora amabili ngaphambi noma okungenani amahora amane ngemuva kwe-rilpivirine.
• Tshela udokotela wakho uma uke waba nokudangala noma esinye isifo sengqondo, isifo sesibindi, kufaka phakathi i-hepatitis B noma C, noma isifo sezinso.
• utshele udokotela wakho uma ukhulelwe noma uhlela ukukhulelwa. Uma ukhulelwa ngenkathi uthatha i-rilpivirine, shayela udokotela wakho. Tshela udokotela wakho uma uncelisa. Akufanele uncelise ibele uma utheleleke nge-HIV noma uma uphuza i-rilpivirine.
• kufanele wazi ukuthi amafutha omzimba wakho angakhuphuka noma ahambele ezindaweni ezahlukahlukene zomzimba wakho njengamabele akho, iqolo elingaphezulu nentamo, noma phakathi nendawo yomzimba wakho. Ukulahleka kwamafutha emilenzeni, ezingalweni nasebusweni nakho kungenzeka.
• kufanele wazi ukuthi i-rilpivirine ingadala ushintsho emicabangweni yakho, ekuziphatheni, noma empilweni yengqondo. Shayela udokotela wakho ngokushesha uma uba nezimpawu ezilandelayo ngenkathi uthatha i-rilpivirine: ukucindezeleka okusha noma okuba kubi; ukuzizwa udabukile, ungenathemba, ukhathazekile noma ungenakho ukuthula; noma ucabanga ukuzibulala noma ukuhlela noma ukuzama ukwenza kanjalo. Qiniseka ukuthi umndeni wakho uyazi ukuthi yiziphi izimpawu ezingaba zimbi kakhulu ukuze bakwazi ukushayela udokotela wakho uma ungakwazi ukufuna ukwelashwa wedwa.
• kufanele wazi ukuthi ngenkathi uthatha imishanguzo yokwelapha ukutheleleka nge-HIV, amasosha omzimba wakho angaqina futhi aqale ukulwa nezinye izifo ezazivele zisemzimbeni wakho noma zidale ukuthi ezinye izimo zivele. Lokhu kungadala ukuthi uthuthukise izimpawu zalezo zifo noma izimo. Uma unezimpawu ezintsha noma eziya ziba zimbi ngemuva kokuqala ukwelashwa nge-rilpivirine, qiniseka ukuthi utshela udokotela wakho.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Thatha umthamo ongabanjwanga ngokushesha uma uwukhumbula, ngokudla. Kodwa-ke, uma sekudlule amahora angaphezu kwe-12 kusuka kumthamo wakho wokugcina, weqa umthamo ophuthelwe bese uqhubeka nesimiso sakho sokulinganisa. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

I-Rilpivirine ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ubunzima bokulala noma ukulala
• ikhanda
• isicanucanu
• ukuhlanza
• isiyezi
• ubuhlungu besisu
• ukozela

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, noma lezo ezisohlwini lwe-SPECIAL PRECAUTIONS section, shayela udokotela wakho ngokushesha:

• ukuqubuka
• ukuphuzi kwesikhumba noma kwamehlo, ubuhlungu ohlangothini lwesokunene sesisu, isicanucanu, ukuhlanza, indle enombala okhanyayo, umchamo onombala omnyama

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu yeka ukuthatha i-rilpivirine bese ushayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• ukuqubuka kanye umkhuhlane, ukuvuvukala kobuso, izindebe, umlomo, ulimi, noma umphimbo, amabhamuza, inkinga yokuphefumula noma ukugwinya, izilonda zomlomo, ukubomvu noma ukuvuvukala kwamehlo (i-conjunctivitis), ubuhlungu ohlangothini lwesokunene lwesisu (esiswini), noma umchamo onombala omnyama

I-Rilpivirine ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Ukugcine ekamelweni lokushisa kude nokukhanya, ukushisa okweqile nomswakama (hhayi endlini yangasese).

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile zelebhu ukuze ahlole impendulo yomzimba wakho ku-rilpivirine.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Gcina i-rilpivirine esandleni. Ungalindi uze uphelelwe yimithi yokugcwalisa imishanguzo yakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• Edurant^®
• UJuluca^® (njengomkhiqizo ohlanganisiwe oqukethe i-dolutegravir, i-rilpivirine)