I-Telaprevir

-Delile

• Ngaphambi kokuthatha i-telaprevir,
• I-Telaprevir ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nanoma yiziphi zalezi zimpawu noma ezinye zalezo ezibalwe esigabeni ESIBALULEKILE SEXWAYISO, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:
• Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

I-Telaprevir ayisatholakali e-United States ngemuva kuka-Okthoba 16, 2014. Uma ngabe uthatha i-telaprevir njengamanje, kufanele ushayele udokotela wakho ukuze axoxe ngokushintshela kolunye ukwelashwa.

I-Telaprevir ingadala ukusabela okunamandla noma okusongela impilo kwesikhumba. Shayela udokotela wakho khona manjalo noma ufune ukwelashwa okuphuthumayo uma uhlangabezana nalezi zimpawu ezilandelayo: ukuqubuka, amabhamuza, noma izilonda esikhunjeni; ukulunywa; imfiva; ukuvuvukala kobuso; izilonda emlonyeni; noma amehlo abomvu, avuvukile, alumayo noma anezinyembezi. Udokotela wakho angakutshela ukuthi uyeke ukuthatha i-telaprevir (futhi mhlawumbe neminye imishanguzo) uma ushintsha isikhumba; ungayeki ukuthatha imishanguzo yakho ngaphandle kokuthi udokotela akutshele ukuthi wenze kanjalo. Uma udokotela wakho ekutshela ukuthi uyeke ukuthatha i-telaprevir ngenxa yokushintsha kwesikhumba, akufanele uyithathe futhi.

I-Telaprevir isetshenziswa kanye neminye imithi emibili (i-ribavirin [i-Copegus, i-Rebetol] ne-peginterferon alfa [Pegasys]) ukwelapha i-hepatitis C engamahlalakhona (ukutheleleka ngegciwane okuqhubekayo okulimaza isibindi) kubantu abangakalashwa ngalesi simo noma Isimo asikwazanga ukwelashwa ngempumelelo nge-ribavirin ne-peginterferon alfa kuphela. UTelaprevir usesigabeni semithi ebizwa nge-protease inhibitors. Isebenza ngokunciphisa inani le-virus ye-hepatitis C (HCV) emzimbeni. I-Telaprevir kungenzeka ingavimbeli ukusakazeka kwesifo sokusha kwesibindi kohlobo C kwabanye abantu.

I-Telaprevir iza njenge-tablet ezothathwa ngomlomo. Imvamisa kuthathwa kabili ngosuku (njalo emahoreni ayi-10 kuye kwayi-14). Kufanele udle isidlo noma isidlo esingamamilimitha angama-20 samafutha kungakapheli imizuzu engama-30 ngaphambi kokuba uthathe i-telaprevir. Izibonelo zokudla (izinhlobo ezijwayelekile, hhayi imikhiqizo enamafutha aphansi noma engewona amafutha) engathathwa nge-telaprevir ifaka phakathi: i-bagel enoshizi kakhilimu, amantongomane we-1/2 wenkomishi, izipuni eziyi-3 zamantongomane, i-1 inkomishi ye-ayisikhilimu, ama-ounces ama-2 ama-American noma i-cheddar ushizi, ama-ounces ama-2 amazambane ama-chips, noma i-1/2 indebe yokuxuba umzila. Buza udokotela wakho ezinye izibonelo zokudla okuqukethe amagremu angama-20 wamafutha ongawadla lapho uthatha i-telaprevir. Ungathathi i-telaprevir ngaphandle kokudla. Thatha i-telaprevir ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-telaprevir njengoba iqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Gwinya wonke amaphilisi; ungazihlukanisi, uzichoboze noma uzihlafune. Uma ungakwazi ukugwinya amaphilisi ephelele, tshela udokotela wakho.

Qhubeka uthathe i-telaprevir noma ngabe uzizwa uphilile. I-Telaprevir kumele ithathwe ihlanganiswe ne-peginterferon alfa ne-ribavirin, imvamisa amasonto ayi-12. I-Peginterferon alfa ne-ribavirin kuvame ukuqhutshwa ngemuva kokuphela kokwelashwa nge-telaprevir. Ungayeki ukuthatha i-telaprevir, i-peginterferon alfa, noma i-ribavirin, ngaphandle uma utshelwe ngudokotela wakho ukuthi wenze njalo.

Udokotela wakho noma usokhemisi uzokunikeza ishidi lemininingwane yesiguli lomkhiqizi (Umhlahlandlela Wezokwelapha) lapho uqala ukwelashwa nge-telaprevir futhi isikhathi ngasinye lapho ugcwalisa khona incwadi kadokotela. Funda imininingwane ngokucophelela bese ubuza udokotela noma usokhemisi wakho uma unemibuzo. Ungavakashela futhi iwebhusayithi ye-Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) noma iwebhusayithi yomkhiqizi ukuthola i-Medication Guide.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-telaprevir,

• Tshela udokotela kanye nosokhemisi wakho uma uxabana ne-telaprevir, i-ribavirin (i-Copegus, i-Rebetol), i-peginterferon alfa (i-Pegasys), noma imuphi omunye umuthi, noma iziphi izithako ezikumathebulethi e-telaprevir. Buza usokhemisi wakho noma uhlole Umhlahlandlela Wezokwelapha ukuthola uhlu lwezithako.
• utshele udokotela wakho uma uthatha noma iyiphi yale mithi elandelayo noma imikhiqizo yamakhambi: i-alfuzosin (i-Uroxatral); carbamazepine (Carbatrol, Epitol, Equetro, Tegretol, Teril); i-cisapride (Propulsid) (ayisatholakali e-United States); imithi ye-ergot efana ne-dihydroergotamine (i-DHE 45, i-Migranal), i-ergotamine (i-Ergomar, eCafergot, eMigergot), i-ergonovine, ne-methylergonovine (Methergine); i-lovastatin (Altoprev, Mevacor, ku-Advicor); i-midazolam ethathwe ngomlomo; phenobarbital, phenytoin (Dilantin, Phenytek); ipimozide (i-Orap); i-rifampin (iRifadin, iRimactane, eRifamate, eRifater); i-sildenafil (uphawu lwe-Revatio kuphela olusetshenziselwa isifo samaphaphu); simvastatin (Zocor, eSimcor, eVytorin); ISt John's wort; i-triazolam (iHalcion); kanye ne-tadalafil (i-Adcirca brand kuphela esetshenziselwa isifo samaphaphu). Udokotela wakho mhlawumbe uzokutshela ukuthi ungathathi i-telaprevir uma uthatha eyodwa noma ngaphezulu yale mithi.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, kanye nezithako zokudla okunomsoco ozithathayo noma ohlela ukuzithatha. Qiniseka ukuthi usho noma yikuphi okulandelayo: i-alprazolam (i-Niravam, i-Xanax); ama-anticoagulants (’ama-thinner egazi’) njenge-warfarin (i-Coumadin, i-Jantoven); imishanguzo yokulwa ne-fungal efana ne-itraconazole (i-Onmel, i-Sporanox), i-ketoconazole (i-Nizoral), i-posaconazole (i-Noxafil), noma i-voriconazole (i-Vfend); i-bosentan (iTracleer); i-budesonide (iPulmicort, iRhinocort, eSymbicort); ama-calcium channel blocker afana ne-amlodipine (Norvasc, e-Amturnide, eTekamlo), diltiazem (Cardizem, Cartia XT, Dilacor, Diltzac, Dilt-CD, Tiazac, Taztia XT, abanye), felodipine (Plendil), nicardipine (Cardene), nifedipine (Afeditab CR, Adalat, Procardia), nisoldipine (Sular), kanye ne-verapamil (Calan, Covera, Verelan, eTarka); imishanguzo ethile yokwehlisa i-cholesterol efana ne-atorvastatin (Lipitor, eCaduet, eLiptruzet), i-fluvastatin (Lescol), i-pitavastatin (i-Livalo), i-pravastatin (i-Pravachol), ne-rosuvastatin (i-Crestor); i-clarithromycin (i-Biaxin, ku-Prevpac); i-colchicine (Colcrys, kuCol-probenecid); i-digoxin (i-Lanoxin); i-efavirenz (iSustiva, e-Atripla); i-erythromycin (E.E.S., E-Mycin, abanye); i-escitalopram (iLexapro); i-fentanyl (Abstral, Actiq, Duragesic, Fentora, Lazanda, Subsys); i-fluticasone (e-Advair, Flonase, Flovent); ukwelashwa kwe-hormone replacement (HRT); ama-immunosuppressants afana ne-cyclosporine (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune), noma tacrolimus (Prograf); imithi ye-erectile dysfunction (ED) efana ne-sildenafil (Viagra), i-tadalafil (i-Cialis), noma i-vardenafil (i-Levitra, i-Staxyn); imishanguzo yokushaya kwenhliziyo okungajwayelekile njenge-amiodarone (Cordarone, Pacerone), flecainide, lidocaine (Lidoderm, Lidopen, Xylocaine), propafenone (Rhythmol), noma i-quinidine; i-methadone (i-Dolophine, i-Methadose); umjovo we-midazolam; izinto zokuvimbela inzalo ngomlomo (’amaphilisi okulawula inzalo); i-steroids yomlomo efana ne-dexamethasone, i-methylprednisolone (iDepo-Medrol, iMedrol, iSolu-Medrol), ne-prednisone (iRayos); i-repaglinide (Prandin, ePrandimet); i-rifabutin (i-Mycobutin); i-ritonavir (i-Norvir, e-Kaletra) esetshenziswa ngokuhlangana namanye ama-HIV protease inhibitors anjenge atazanavir (Reyataz), darunavir (Prezista), fosamprenavir (Lexiva), ne lopinavir (e Kaletra); i-salmeterol (iSerevent, e-Advair); i-telithromycin (Ketek); i-tenofovir (iViread, e-Atripla, eSribild, eTruvada); i-trazodone (i-Oleptro); kanye ne-zolpidem (Ambien, Edluar, Intermezzo, Zolpmist). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi. Eminye imishanguzo eminingi ingaxhumana ne-telaprevir, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho naleyo engabonakali kulolu hlu.
• Tshela udokotela wakho uma ngabe ufakelwe isitho somzimba. Phinda utshele udokotela wakho uma uke waba ne-anemia (awenele ngokwanele amaseli abomvu egazini ukuthwala umoya-mpilo uye kuwo wonke umzimba), i-gout (ukuhlaselwa kobuhlungu obuhlangene obubangelwa amazinga aphezulu e-uric acid egazini), i-human immunodeficiency virus (HIV), izinkinga zesistimu yakho yomzimba, i-hepatitis B (HBV) noma isifo sesibindi ngaphandle kwe-hepatitis C ..
• uma uhlinzwa, kufaka phakathi ukuhlinzwa kwamazinyo, tshela udokotela noma udokotela wamazinyo ukuthi uthatha i-telaprevir.
• Tshela udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma kungenzeka ukhulelwe. Uma ungowesilisa, tshela udokotela wakho uma umlingani wakho ekhulelwe, ehlela ukukhulelwa, noma angakhulelwa. I-Telaprevir kumele ithathwe nge-ribavirin, engalimaza umbungu. Kufanele usebenzise izindlela ezimbili zokulawula ukubeletha ukuvimbela ukukhulelwa kuwe noma kumlingani wakho ngesikhathi sokwelashwa kwakho nale mithi nangezinyanga eziyisithupha ngemuva kokwelashwa kwakho. Khuluma nodokotela wakho mayelana nokuthi yiziphi izindlela okufanele uzisebenzise; izindlela zokuvimbela inzalo zamahomoni (amaphilisi okulawula ukubeletha, iziqeshana, okufakelwa, izindandatho, noma imijovo) kungenzeka kungasebenzi kahle kwabesifazane abathatha le mithi futhi kuze kube amasonto amabili ngemuva kokwelashwa. Wena noma umlingani wakho kumele nihlolelwe ukukhulelwa inyanga nenyanga ngesikhathi sokwelashwa kanye nezinyanga eziyisithupha ngemuva kokwelashwa kwakho. Uma wena noma umlingani wakho ukhulelwa ngenkathi uthatha le mithi, shayela udokotela wakho ngokushesha.
• tshela udokotela wakho uma uncelisa.

Qaphela ikakhulukazi ukuphuza uketshezi olwanele ngesikhathi sokwelashwa kwakho ngalo muthi.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Uma ukhumbula umthamo ongabanjwanga kungakapheli amahora angu-6 wesikhathi obehlelelwe ukuwuthatha, thatha isilinganiso esilahlekile ngesiphuzo noma ukudla (okuqukethe cishe amagremu angama-20 wamafutha) khona manjalo. Kodwa-ke, uma kungaphezu kwamahora angu-6 kusukela wawuzophuza umthamo, weqa umthamo ophuthelwe bese uqhubeka nesimiso sakho sokulinganisa. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

I-Telaprevir ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• isicanucanu
• ukuhlanza
• isifo sohudo
• shintsha emandleni okunambitha
• ukulunywa
• ama-hemorrhoids
• ukungakhululeki, ukushisa, noma ukulunywa eduze kwendunu

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nanoma yiziphi zalezi zimpawu noma ezinye zalezo ezibalwe esigabeni ESIBALULEKILE SEXWAYISO, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• isikhumba esiphaphathekile
• isiyezi
• ukuphelelwa umoya
• ukukhathala
• ubuthakathaka
• ukoma okwandisiwe
• umchamo onombala omnyama
• umlomo owomile
• kunciphise imvamisa yokuchama noma inani
• unenkinga yokudla noma uhlanza kakhulu noma uhudo.

I-Telaprevir ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese).

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

• isicanucanu
• isifo sohudo
• ukuhlanza
• ikhanda
• ukulahlekelwa isifiso sokudla
• izinguquko ekunambithekeni

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile zelebhu ukuze ahlole impendulo yomzimba wakho ku-telaprevir.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• Incivek^®