Regorafenib

-Delile

• Ngaphambi kokuthatha i-regorafenib,
• I-Regorafenib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SEXWAYISO, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:
• Izimpawu zokudlula ngokweqile zingafaka:

I-Regorafenib ingadala ukulimala kwesibindi, okungaba nzima noma kusongele impilo. Tshela udokotela wakho uma uke waba nesifo sesibindi noma wake waba naso. Uma uhlangabezana nanoma yiziphi kulezi zimpawu ezilandelayo, shayela udokotela wakho ngokushesha: ukuphuzi kwesikhumba noma kwamehlo, isicanucanu, ukuhlanza, umchamo onombala omnyama, izinhlungu engxenyeni engakwesokudla esiswini, ukukhathala okukhulu, ukopha okungavamile noma ukulimaza, ukungabi namandla , ukuphelelwa isifiso sokudla, izimpawu ezifana nomkhuhlane, noma ukushintsha kwemikhuba yokulala.

Gcina onke ama-aphoyintimenti elabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile zelebhu ngaphambi nangesikhathi sokwelashwa kwakho ukuze aqiniseke ukuthi kuphephile yini kuwe ukuthatha i-regorafenib nokuhlola impendulo yomzimba wakho emithini.

I-Regorafenib isetshenziselwa ukwelapha umdlavuza we-colon kanye ne-rectal (umdlavuza oqala emathunjini amakhulu noma i-rectum) esabalele kwezinye izingxenye zomzimba kubantu abangazange baphathwe ngempumelelo ngeminye imithi ethile. Ibuye isetshenziselwe ukwelapha izicubu zomzimba emathunjini (i-GIST; uhlobo lwesimila esikhula esiswini, emathunjini [emathunjini], noma esophagus [ishubhu elihlanganisa umphimbo nesisu]) kubantu abangalashwa ngempumelelo ngomunye umuntu imithi. I-Regorafenib ibuye isetshenziselwe ukwelapha i-hepatocellular carcinoma (HCC; uhlobo lomdlavuza wesibindi) kubantu abake baphathwa nge-sorafenib (Nexafar) phambilini. URegorafenib usesigabeni semithi ebizwa nge-kinase inhibitors. Isebenza ngokuvimba isenzo sephrotheni engavamile ekhombisa ukuthi amangqamuzana omdlavuza ayanda. Lokhu kusiza ukunciphisa noma ukunqanda ukusabalala kwamangqamuzana omdlavuza.

I-Regorafenib iza njengethebhulethi ezothathwa ngomlomo. Imvamisa kuthathwa ngesidlo esinamafutha aphansi (aqukethe ngaphansi kwama-calories angama-600 nangaphansi kwama-30% wamakhalori emafutheni) kanye ngosuku amasonto ama-3 bese weqa isonto elilodwa. Le nkathi yokwelashwa ibizwa ngokuthi umjikelezo, futhi umjikelezo ungaphindwa uma nje udokotela wakho encoma. Thatha i-regorafenib ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-regorafenib njengoba iqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Gwinya wonke amaphilisi; ungawahlukanisi, ungawahlafune noma uwagxoze.

Udokotela wakho anganciphisa umthamo wakho we-regorafenib noma akutshele ukuthi uyeke ukuthatha i-regorafenib isikhathi esithile ngesikhathi sokwelashwa kwakho. Lokhu kuzoya ngokuthi umuthi usebenza kanjani kuwe nakunoma imiphi imiphumela emibi ongase ube nayo. Qhubeka uthathe i-regorafenib noma ngabe uzizwa uphilile. Ungayeki ukuthatha i-regorafenib ngaphandle kokukhuluma nodokotela wakho.

I-Regorafenib ayitholakali emakhemisi okuthengisa. Imithi yakho izothunyelwa kuwe noma kudokotela wakho kusuka ekhemisi ekhethekile. Buza udokotela wakho uma unemibuzo mayelana nokuthi uzowuthola kanjani umuthi wakho.

Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi yesiguli.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-regorafenib,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-regorafenib, noma imuphi omunye umuthi, noma iziphi izithako kumaphilisi e-regorafenib. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, nezithako zokudla okunomsoco, okwenzayo noma ohlela ukukuthatha. Qiniseka ukuthi usho noma ikuphi kokulandelayo: ama-anticoagulants (’’ ama-thinner egazi ’’) afana ne-warfarin (Coumadin, Jantoven); imishanguzo ethize yokubulala izinhlungu efana ne-itraconazole (i-Onmel, i-Sporanox), i-ketoconazole (i-Nizoral), i-posaconazole (i-Noxafil), ne-voriconazole (i-Vfend); imithi ethile yokuquleka efana ne-carbamazepine (Carbatrol, Epitol, Tegretol), phenobarbital, ne-phenytoin (Dilantin, Phenytek); i-atorvastatin (Lipitor, eCaduet); i-clarithromycin (i-Biaxin, ku-Prevpac); i-fluvastatin (Lescol); i-irinotecan (iCamptosar); i-methotrexate (i-Otrexup, i-Rasuvo, i-Trexall); i-rifampin (iRifadin, iRifamate, eRifater); noma i-telithromycin (Ketek). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• utshele udokotela wakho ukuthi uthatha miphi imikhiqizo yamakhambi, ikakhulukazi iSt John's wort. Akufanele uthathe i-wort yaseSt. John ngenkathi uthatha i-regorafenib.
• Tshela udokotela wakho uma unesilonda esingapholi noma uma unezinkinga zokopha noma uke waba nazo, umfutho wegazi ophakeme, ubuhlungu besifuba, noma inhliziyo, isifo sezinso noma sesibindi. Phinda utshele udokotela wakho uma usanda kuhlinzwa.
• utshele udokotela wakho uma ukhulelwe noma uhlela ukukhulelwa. Uma ungowesifazane, akufanele ukhulelwe ngenkathi uthatha i-regorafenib nezinyanga ezi-2 ngemuva komthamo wakho wokugcina. Khuluma nodokotela wakho ngezindlela zokulawula ukubeletha ezizokusebenzela. Uma ungowesilisa, wena nomlingani wakho wesifazane kufanele nisebenzise ukulawulwa kokubeletha ngesikhathi sokwelashwa futhi niqhubeke nokusebenzisa ukubeletha izinyanga ezimbili ngemuva komthamo wakho wokugcina. Uma wena noma umlingani wakho ukhulelwa ngenkathi uthatha i-regorafenib, shayela udokotela wakho. I-Regorafenib ingalimaza umbungu.
• tshela udokotela wakho uma uncelisa. Akufanele uncelise ngesikhathi sokwelashwa kwakho nge-regorafenib futhi kuze kube amasonto ama-2 ngemuva komthamo wakho wokugcina.
• uma uhlinzwa, kufaka phakathi ukuhlinzwa kwamazinyo, tshela udokotela noma udokotela wamazinyo ukuthi uthatha i-regorafenib. Udokotela wakho mhlawumbe uzokutshela ukuthi uyeke ukuthatha i-regorafenib okungenani amasonto amabili ngaphambi kokuhlinzwa kwakho. Udokotela wakho uzokutshela uma kuphephile ukuthi uqale ukuthatha i-regorafenib futhi ngemuva kokuhlinzwa kwakho.

Ungadli isithelo samagilebhisi noma uphuze ijusi lamagilebhisi ngenkathi uthatha lo muthi.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Uma uphuthelwa umthamo we-regorafenib, thatha isilinganiso esilahlekile ngokushesha nje lapho usikhumbula ngalolo suku. Ungathathi imithamo emibili ngosuku olufanayo ukwenza okulahlekile.

I-Regorafenib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ukukhathala
• ubuthakathaka
• ukulahlekelwa isifiso sokudla
• isifo sohudo
• ukuvuvukala, ubuhlungu, nokubomvu kocingo lomlomo wakho noma lomphimbo
• ukuncipha komzimba
• ukuduma noma olunye ushintsho emisindweni yezwi lakho

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SEXWAYISO, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• ubuhlungu besifuba
• ukuphelelwa umoya
• ukukhishwa kwesisu okungavamile noma ukucasuka
• ukusha noma ubuhlungu lapho uchama
• isiyezi noma ukuzwa ukuquleka
• umkhuhlane, ukukhwehlela, umphimbo obuhlungu, ukugodola nezinye izimpawu zokutheleleka
• ukuvuvukala kwesisu
• umkhuhlane omkhulu
• Ukugodola
• isifo sohudo esibi
• ikhanda elibi kakhulu
• ukudlikiza
• ukudideka
• izinguquko embonweni
• umlomo owomile, amajaqamba, noma ukunciphisa ukuchama
• ububomvu, ubuhlungu, amabhamuza, ukopha, noma ukuvuvukala ezintendeni zezandla zakho noma ematheni ezinyawo zakho
• ukuqubuka
• ukuhlanza igazi noma okokuhlanza okubukeka njengezizathu zekhofi
• umchamo obomvana noma onsundu
• izitulo ezibomvu noma ezimnyama (ezilindile)
• ukukhwehlela igazi noma amahlule egazi
• ukuphuma kwegazi okunzima ngokweqile (izikhathi)
• ukopha okungavamile kwesitho sangasese sowesifazane
• ukopha kaningi

I-Regorafenib ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Ungafaki amaphilisi kwezinye iziqukathi, njengamabhokisi amaphilisi ansuku zonke noma amasonto, futhi ungasusi i-desiccant (i-agent yokumisa) esitsheni. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese). Lahla noma imaphi amaphilisi angasetshenziswanga emasontweni ayisikhombisa ngemuva kokuba ibhodlela livulwe okokuqala.

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Izimpawu zokudlula ngokweqile zingafaka:

• ukuqubuka noma ezinye izinguquko zesikhumba
• ukushintsha kwezwi noma ukusikisela
• isifo sohudo
• ukuvuvukala ngaphakathi kwekhala noma umlomo
• umlomo owomile
• ukuncipha kokudla
• ukukhathala

Gcina wonke ama-aphoyintimenti nodokotela wakho. Udokotela wakho uzohlola umfutho wegazi ngaphambi kokuba uqale ukuthatha i-regorafenib futhi njalo ngesikhathi sokwelashwa kwakho.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• Stivarga^®