I-Glucarpidase

-Delile

• Ngaphambi kokuthatha i-glucarpidase,
• I-Glucarpidase ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

I-Glucarpidase isetshenziselwa ukuvimbela imiphumela eyingozi ye-methotrexate (Rheumatrex, Trexall) ezigulini ezinesifo sezinso ezithola i-methotrexate yokwelapha izinhlobo ezithile zomdlavuza. IGlucarpidase isekilasini lemithi ebizwa ngama-enzyme. Isebenza ngokusiza ukudiliza nokususa i-methotrexate emzimbeni.

IGlucarpidase iza njengempuphu ezoxubaniswa noketshezi futhi ijojowe ngomjovo (emthanjeni). Imvamisa inikezwa ngaphezu kwemizuzu engu-5 njengomthamo wesikhathi esisodwa. I-Glucarpidase inikezwa kanye ne-leucovorin (omunye umuthi osetshenziselwa ukuvimbela imiphumela eyingozi ye-methotrexate) kuze kube yilapho ukuhlolwa kwelabhoratri kukhombisa ukuthi ukwelashwa akusadingeki.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-glucarpidase,

• Tshela udokotela wakho kanye nosokhemisi uma une-allergies ku-glucarpidase, noma imiphi eminye imithi, noma iziphi izithako zomjovo we-glucarpidase. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma ikuphi kokulandelayo: i-folic acid (i-Folicet, kuma-multivitamini); i-levoleucovorin (Fusilev); noma i-pemetrexed (Alimta). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• uma uthola i-leucovorin, kufanele inikezwe okungenani amahora ama-2 ngaphambi noma amahora amabili ngemuva kwe-glucarpidase.
• tshela udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uncelisa. Uma ukhulelwa ngenkathi uthatha i-glucarpidase, shayela udokotela wakho.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

I-Glucarpidase ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• isicanucanu
• ukuhlanza

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• imfiva
• Ukugodola
• ukuqhuma noma ukuzwa kushisa
• ukuqubuka
• isifuba
• ukulunywa
• ukuqina komphimbo noma ukuphefumula kanzima
• imizwa yokuba ndikindiki, ukuhayiza, ukubhoboza, ukushisa, noma ukukhasa esikhunjeni
• ikhanda

I-Glucarpidase ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile zelebhu ukuze ahlole impendulo yomzimba wakho ku-glucarpidase.

Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana ne-glucarpidase.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• Voraxaze^®