I-Teriflunomide

-Delile

• Ngaphambi kokuthatha i-teriflunomide,
• I-Teriflunomide ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SEXWAYISO, yeka ukuthatha i-teriflunomide bese ushayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

I-Teriflunomide ingadala ukulimala kwesibindi okungathi sína noma okusongela ukuphila, okungadinga ukufakelwa kwesibindi. Ingozi yokulimala kwesibindi ingakhuphuka kubantu abathatha eminye imishanguzo eyaziwa ngokudala ukulimala kwesibindi, nakubantu asebavele benesifo sesibindi. Tshela udokotela wakho uma unesifo sesibindi. Udokotela wakho angakutshela ukuthi ungathathi i-teriflunomide. Tshela udokotela wakho kanye nosokhemisi ngayo yonke imithi oyiphuzayo ukuze bakwazi ukubheka ukuthi ngabe ikhona yini imishanguzo yakho engakhuphula ubungozi bokuthi uzoba nokulimala kwesibindi ngesikhathi ukwelashwa kwakho nge-teriflunomide. Uma uhlangabezana nanoma yiziphi kulezi zimpawu ezilandelayo, shayela udokotela wakho ngokushesha: isicanucanu, ukuhlanza, ukukhathala ngokweqile, ukopha okungavamile noma ukulimaza, ukungabi namandla, ukulahlekelwa isifiso sokudla, ubuhlungu engxenyeni engenhla kwesokudla yesisu, ukuphuzi kwesikhumba noma kwamehlo , umchamo onombala omnyama, noma izimpawu ezifana nomkhuhlane. Uma kusolwa ukulimala kwesibindi, udokotela wakho angayeka i-teriflunomide futhi angakunika ukwelashwa okuzosiza ukususa i-teriflunomide ngokushesha okukhulu emzimbeni wakho.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile ngaphambi kokuba uqale ukwelashwa kwakho futhi njalo ngesikhathi sokwelashwa kwakho ukuze uhlole impendulo yomzimba wakho ku-teriflunomide.

Ungathathi i-teriflunomide uma ukhulelwe noma uhlela ukukhulelwa. I-Teriflunomide ingalimaza umbungu. Akufanele uqale ukuthatha i-teriflunomide uze uthathe ukuhlolwa kokukhulelwa ngemiphumela emibi futhi udokotela wakho ekutshela ukuthi awukhulelwe. Kufanele usebenzise indlela ephumelelayo yokulawula ukubeletha ngaphambi kokuthi uqale ukuthatha i-teriflunomide, ngenkathi welashwa nge-teriflunomide, futhi kuze kube yiminyaka emibili ukwelashwa, kuze kube ukuhlolwa kwegazi kukhombisa ukuthi unamazinga aphansi ngokwanele we-teriflunomide egazini lakho. Uma isikhathi sakho sesihambile, uphuthelwa yisikhathi, noma ucabanga ukuthi ungakhulelwa ngesikhathi sokwelashwa kwakho nge-teriflunomide noma iminyaka emi-2 ngemuva kokwelashwa kwakho, shayela udokotela wakho ngokushesha. Uma ungowesilisa futhi umlingani wakho angakhulelwa, wena nomlingani wakho kufanele nisebenzise ukulawulwa kokubeletha okusebenzayo ngesikhathi sokwelashwa kwakho. Uma wena noma umlingani wakho uhlela ukukhulelwa noma ungakhulelwa, khuluma nodokotela wakho mayelana nokwelashwa okuzosiza ukususa i-teriflunomide ngokushesha okukhulu emzimbeni wakho ngemuva kokuyeka ukuthatha umuthi.

Udokotela wakho noma usokhemisi uzokunikeza ishidi lemininingwane yesiguli lomkhiqizi (Umhlahlandlela Wezokwelapha) lapho uqala ukwelashwa nge-teriflunomide futhi isikhathi ngasinye lapho ugcwalisa umuthi wakho. Funda imininingwane ngokucophelela bese ubuza udokotela noma usokhemisi wakho uma unemibuzo. Ungavakashela futhi iwebhusayithi ye-Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) noma iwebhusayithi yomkhiqizi ukuthola i-Medication Guide.

Khuluma nodokotela wakho ngezingozi zokuthatha i-teriflunomide.

I-Teriflunomide isetshenziselwa ukwelapha abantu abadala abanezinhlobo ezahlukahlukene ze-multiple sclerosis (MS; isifo lapho izinzwa zingasebenzi kahle futhi abantu bangathola ubuthakathaka, ukuba ndikindiki, ukulahleka kokuhlangana kwemisipha, nezinkinga ngombono, ukukhuluma, nokulawula isinye) kufaka phakathi :

• i-syndrome ehlukanisiwe nomtholampilo (i-CIS; iziqephu zezimpawu zemizwa ezihlala okungenani amahora angama-24),
• amafomu wokubuyisela emuva (inkambo yesifo lapho izimpawu zivela khona ngezikhathi ezithile), noma
• amafomu wesibili aqhubekayo (inkambo yesifo lapho ukubuyela emuva kwenzeka kaningi).

I-Teriflunomide isekilasini lemithi ebizwa ngama-immunomodulatory agents. Kucatshangwa ukuthi kusebenza ngokunciphisa ukuvuvukala nokunciphisa isenzo samaseli omzimba angadala ukulimala kwezinzwa.

I-Teriflunomide iza njengethebhulethi ezothathwa ngomlomo. Imvamisa kuthathwa kanye ngosuku noma ngaphandle kokudla. Thatha i-teriflunomide ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-teriflunomide njengoba nje kuqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

I-Teriflunomide ingasiza ekulawuleni izimpawu ze-multiple sclerosis, kepha ayiyelaphi. Qhubeka uthathe i-teriflunomide noma ngabe uzizwa uphilile. Ungayeki ukuthatha i-teriflunomide ngaphandle kokukhuluma nodokotela wakho.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-teriflunomide,

• Tshela udokotela wakho kanye nosokhemisi uma une-aleji ku-teriflunomide (ukuqubuka, isifuba, ukuphefumula okuncane, ukuvuvukala kobuso, amehlo, umlomo, umphimbo, ulimi, izindebe, izandla, izinyawo, amaqakala, noma imilenze engezansi), leflunomide (Arava) , noma imuphi omunye umuthi, noma iziphi izithako kumathebulethi e-teriflunomide. Buza usokhemisi wakho noma uhlole Umhlahlandlela Wezokwelapha ukuthola uhlu lwezithako.
• Tshela udokotela wakho uma uthatha i-leflunomide (Arava). Udokotela wakho mhlawumbe uzokutshela ukuthi ungathathi i-teriflunomide uma uthatha lo muthi.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi uyayisho imithi efakwe kuhlu esigabeni ESIBALULEKILE SESEXWAYISO nanoma yikuphi okulandelayo: i-alosetron (Lotronex); ama-anticoagulants (’ama-thinner egazi’) njenge-warfarin (i-Coumadin, i-Jantoven); i-atorvastatin (Lipitor, eCaduet); i-cefaclor; i-cimetidine (Tagamet); i-ciprofloxacin (Cipro); i-duloxetine (iCymbalta); i-eltrombopag (i-Promacta); i-furosemide (i-Lasix); gefitinib (Iressa); ketoprofen; imithi engadala ukulimala kwezinzwa njengemithi yomdlavuza, i-HIV, noma i-AIDS; eminye imithi ecindezela amasosha omzimba njenge-azathioprine (Azasan, Imuran), cyclosporine (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune), ne-tacrolimus (Astagraf, Envarsus XR, Prograf); i-methotrexate (i-Otrexup, i-Rasuvo, i-Trexall); mitoxantrone; i-nateglinide (i-Starlix); izinto zokuvimbela inzalo ngomlomo (amaphilisi okuvimbela inzalo); i-paclitaxel (i-Abraxane, i-Taxol); i-penicillin G; i-pioglitazone (Actos, ku-Actoplus Met, eDuetact); i-pravastatin (Pravachol); i-repaglinide (Prandin, ePrandimet); i-rifampin (iRifadin, iRimactane, eRifamate, eRifater); i-rosiglitazone (i-Avandia); i-rosuvastatin (iCrestor); simvastatin (iZocor, eVytorin); theophylline (Elixophyllin, Theo-24, Uniphyl, nabanye); i-tizanidine (iZanaflex); kanye ne-zidovudine (Retrovir, eCombivir, eTrizivir). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi. Eminye imishanguzo eminingi ingaxhumana ne-teriflunomide, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho naleyo engabonakali kulolu hlu.
• Tshela udokotela wakho uma unesifo manje, kufaka phakathi ukutheleleka okuqhubekayo okungapheli, noma uma uke waphathwa kabi esikhunjeni ngemuva kokuthatha omunye umuthi; isifo sikashukela; izinkinga zokuphefumula; umdlavuza noma ezinye izimo ezithinta umnkantsha noma amasosha omzimba; umfutho wegazi ophakeme; i-peripheral neuropathy (ukundikindiki, ukushisa noma ukuncinza ezandleni noma ezinyaweni ezizwakala zihlukile kwizimpawu zakho ze-MS); noma isifo sezinso.
• tshela udokotela wakho uma uncelisa. Ungancelisi ibele ngenkathi uthatha i-teriflunomide.
• uma umlingani wakho ehlela ukukhulelwa, kufanele ukhulume nodokotela wakho ngokumisa i-teriflunomide nokuthola ukwelashwa okusiza ukususa le mithi emzimbeni wakho ngokushesha okukhulu. Uma umlingani wakho engahleleli ukukhulelwa, wena nomlingani wakho kufanele nisebenzise indlela ephumelelayo yokulawula ukubeletha ngesikhathi sokwelashwa kwakho nge-teriflunomide futhi kuze kube yiminyaka emibili ukwelashwa, kuze kube ukuhlolwa kwegazi kukhombisa ukuthi unamazinga aphansi ngokwanele we-teriflunomide igazi.
• uma uhlinzwa, kufaka phakathi ukuhlinzwa kwamazinyo, tshela udokotela noma udokotela wamazinyo ukuthi uthatha i-teriflunomide.
• kungenzeka ukuthi usungenwe yisifo sofuba (i-TB; ukutheleleka okungathi sína kwamaphaphu) kodwa ungabi nazimpawu zesifo. Tshela udokotela wakho uma uke waba ne-TB noma wake waba nayo, uma wake wahlala noma wavakashela izwe lapho i-TB ijwayelekile khona, noma uma wake waba seduze komuntu one-TB noma owake waba nayo. Ngaphambi kokuba uqale ukwelashwa kwakho nge-teriflunomide, udokotela wakho uzokuhlolela isikhumba ukuze abone ukuthi unayo yini i-TB. Uma une-TB, udokotela wakho uzokwelapha lesi sifo ngaphambi kokuba uqale ukuthatha i-teriflunomide.
• ungenayo imigomo ngaphandle kokukhuluma nodokotela wakho ngenkathi uthatha i-teriflunomide futhi izinyanga ezingama-6 ngemuva kokuyeka ukuyithatha.
• kufanele wazi ukuthi i-teriflunomide ingadala umfutho wegazi ophezulu. Kufanele uhlolwe umfutho wegazi ngaphambi kokuqala ukwelashwa futhi njalo ngenkathi uthatha lo muthi.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Thatha umthamo ongabanjwanga ngokushesha nje lapho uwukhumbula. Kodwa-ke, uma sekuyisikhathi somthamo olandelayo, weqa umthamo ongabanjwanga bese uqhubeka neshejuli yakho ejwayelekile yokulinganisa. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

I-Teriflunomide ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ukulahleka kwezinwele
• isifo sohudo
• ukufiphala kwamehlo
• ubuhlungu bamazinyo
• induna
• ubuhlungu obuhlangene noma besisipha
• ukukhathazeka
• ukuncipha komzimba

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SEXWAYISO, yeka ukuthatha i-teriflunomide bese ushayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• ukushaya kwenhliziyo okusheshayo, okungajwayelekile, noma okuhamba kancane
• ikhanda
• isiyezi
• isikhumba esiphaphathekile
• ukudideka
• umkhuhlane, ukukhwehlela, umphimbo obuhlungu, ukugodola nezinye izimpawu zokutheleleka
• ukuba ndikindiki, ukushiswa, noma ukuncinza ezandleni, ezingalweni, ezinyaweni noma emilenzeni
• ukulahleka kwethoni yemisipha
• ubuthakathaka noma ubunzima emilenzeni
• isikhumba esibandayo, esimpunga
• isikhumba esibomvu, esixobukayo, noma esishisayo
• ukuqubuka
• isifuba
• ukulunywa
• ubunzima bokugwinya
• ukuvuvukala kobuso, amehlo, umlomo, umphimbo, ulimi, noma izindebe
• ukuphelelwa umoya
• ukuqubuka okungenzeka kube nemfiva, ukuvuvukala kwezindlala, noma ukuvuvukala kobuso
• isisu, uhlangothi, noma ubuhlungu emuva

I-Teriflunomide ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese).

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• I-Aubagio^®