I-Umeclidinium ne-Vilanterol Oral Inhalation

-Delile

• Ukuze usebenzise i-inhaler, landela lezi zinyathelo:
• Ngaphambi kokusebenzisa umeclidinium ne-vilanterol,
• I-Umeclidinium ne-vilanterol kungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, yeka ukusebenzisa umeclidinium ne-vilanterol bese ushayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:
• Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

Inhlanganisela ye-umeclidinium ne-vilanterol isetshenziselwa ukulawula ukuphefumula, ukuphefumula, ukukhwehlela, nokuqina kwesifuba okubangelwa yisifo esingapheliyo se-pulmonary disease (COPD; iqembu lezifo ezithinta amaphaphu nemigwaqo yomoya, okubandakanya i-bronchitis engapheli ne-emphysema). I-Umeclidinium isekilasini lemithi ebizwa nge-anticholinergics. IVilanterol isekilasini lemithi ebizwa ngama-beta-agonists asebenza isikhathi eside (LABAs). Le mithi isebenza ngokuphumula nokuvula izindima zomoya emaphashini, okwenza kube lula ukuphefumula.

Inhlanganisela ye-umeclidinium ne-vilanterol iza njengempuphu yokuhogela ngomlomo usebenzisa i-inhaler ekhethekile. Kuvamise ukuhogela kanye ngosuku. Donsa umeclidinium ne-vilanterol ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Sebenzisa umeclidinium ne-vilanterol njengoba nje kuqondisiwe. Ungayisebenzisi ngaphezulu noma ngaphansi kwayo noma uyisebenzise kaningi kunokuyalelwa ngudokotela wakho.

Ungasebenzisi umeclidinium ne-vilanterol inhalation ukwelapha ukuhlaselwa okungazelelwe kwe-COPD. Udokotela wakho uzokunika umuthi osebenza okwesikhashana we-beta agonist njenge-albuterol (Accuneb, Proair, Proventil, Ventolin) ongayisebenzisa ngesikhathi sokuhlaselwa. Uma ngabe ubusebenzisa lolu hlobo lwemithi njalo ngaphambi kokuba uqale ukwelashwa nge-umeclidinium ne-vilanterol, udokotela wakho uzokutshela ukuthi uyeke ukuyisebenzisa njalo kepha uqhubeke nokuyisebenzisa ukuphatha ukuhlaselwa.

I-Umeclidinium ne-vilanterol inhalation akufanele isetshenziselwe ukwelapha i-COPD esheshe yande. Shayela udokotela wakho noma uthole usizo oluphuthumayo lwezokwelapha uma izinkinga zakho zokuphefumula ziba zimbi, uma kufanele usebenzise i-inhaler yakho yokwenza okufushane ukuphatha ukuhlaselwa kwe-COPD kaningi, noma uma i-inhaler yakho esebenza isikhashana ingazinciphisi izimpawu zakho.

I-Umeclidinium ne-vilanterol inhalation ilawula i-COPD kepha ayiyelaphi. Qhubeka nokusebenzisa i-umeclidinium ne-vilanterol noma ngabe uzizwa uphilile. Ungayeki ukusebenzisa umeclidinium ne-vilanterol ngaphandle kokukhuluma nodokotela wakho. Uma uyeka ukusebenzisa umeclidinium ne-vilanterol inhalation, izimpawu zakho zingase zibe zimbi kakhulu.

Ngaphambi kokusebenzisa i-umeclidinium ne-vilanterol inhalation okokuqala, cela udokotela wakho, usokhemisi, noma umelaphi wokuphefumula akubonise ukuthi ungayisebenzisa kanjani i-inhaler. Zijwayeze ukusebenzisa i-inhaler yakho ngenkathi ibuka.

Ukuze usebenzise i-inhaler, landela lezi zinyathelo:

1. Uma uzosebenzisa i-inhaler entsha okokuqala ngqa, isuse ebhokisini nasethreyini le-foil. Gcwalisa izikhala ze- "Tray opened" ne- "Lahla" kwilebula ye-inhaler nosuku owavula ngalo ugqoko nosuku lwamasonto ayisithupha kamuva lapho kufanele ufake khona i-inhaler.
2. Lapho usukulungele ukuhogela umthamo wakho, slayida ikhava phansi ukuze uveze okokukhuluma uze uchofoze. Uma uvula futhi uvale i-inhaler ngaphandle kokusebenzisa umthamo wakho, uzochitha imithi.
3. Ikhawunta izobalwa phansi ngo-1 njalo uma uvula ikhava. Uma i-counter ingabala phansi, i-inhaler yakho ngeke ikunikeze umuthi. Uma i-inhaler yakho ingabali phansi, shayela usokhemisi noma udokotela wakho.
4. Bamba i-inhaler isuke emlonyeni wakho bese uphefumulela ngaphandle ngangokunokwenzeka. Musa ukuphefumulela ngaphandle komlomo.
5. Faka okokukhuluma phakathi kwezindebe zakho, bese uvale izindebe zakho ngokuqinile. Thatha umoya omude, ozinzile, ojulile ngomlomo wakho. Ungaphefumuli ngamakhala akho. Qaphela ukuthi ungavimbeli umoya ophefumulayo ngeminwe yakho.
6. Susa i-inhaler emlonyeni wakho, bese ubamba umoya wakho cishe imizuzwana emi-3 kuye kwengu-4 noma inqobo nje uma ungakwazi kahle. Phefumulela ngaphandle kancane.
7. Unganambitha noma awunakunambitha noma uzwe umuthi okhishwe yi-inhaler. Noma ungakwenzi, musa ukuhogela omunye umthamo. Uma ungaqiniseki ukuthi uthola umthamo wakho we-umeclidinium ne-vilanterol, shayela udokotela wakho noma usokhemisi.
8. Ungahlanza okokukhuluma ngesicubu esomile, uma kudingeka. Slayida ikhava phezu komlomo kuze kufike lapho uzovala khona i-inhaler.

Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi yesiguli.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokusebenzisa umeclidinium ne-vilanterol,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-umeclidinium, i-vilanterol, noma imuphi omunye umuthi, amaprotheni obisi, noma yiziphi izithako ze-umeclidinium kanye ne-vilanterol inhalation. Buza usokhemisi wakho noma uhlole Umhlahlandlela Wezokwelapha ukuthola uhlu lwezithako.
• Tshela udokotela wakho uma usebenzisa enye i-LABA efana ne-arformoterol (Brovana), i-formoterol (i-Perforomist, e-Bevespi Aerosphere, i-Duaklir Pressair, i-Dulera, i-Symbicort), i-indacaterol (i-Arcapta), i-olodaterol (i-Striverdi Respimat, e-Stiolto Respimat), noma i-salmeterol (ISerevent, e-Advair). Udokotela wakho uzokutshela ukuthi imiphi imithi okufanele uyisebenzise nokuthi imiphi imithi okufanele uyeke ukuyisebenzisa.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma ikuphi kokulandelayo: ama-antifungal anjenge-itraconazole (i-Onmel, i-Sporanox, iTolsura), i-ketoconazole, ne-voriconazole (i-Vfend); ama-antihistamine; i-atropine; ama-beta-blocker anjenge-atenolol (Tenormin), labetalol (Trandate), metoprolol (Lopressor, Toprol XL), nadolol (Corgard), nepropranolol (Inderal, Innopran); i-clarithromycin; i-conivaptan (iVaprisol); isisu (‘amaphilisi amanzi’); I-HIV protease inhibitors efana ne-indinavir (Crixivan), lopinavir (eKaletra), nelfinavir (Viracept), ritonavir (Norvir), kanye ne-saquinavir (Invirase); eminye imithi ye-COPD kufaka phakathi i-aclidinium (Tudorza Pressair), ipratropium (Atrovent HFA), ne-tiotropium (Spiriva); imishanguzo yezifo zamathumbu ezicasulayo, ukugula okunyakazayo, isifo sikaParkinson, izilonda, noma izinkinga zomchamo; futhi nefazodone. Phinda utshele udokotela kanye nosokhemisi wakho uma uphuza le mithi elandelayo noma uyekile ukuyiphuza emasontweni amabili edlule: imishanguzo efana ne-amitriptyline, amoxapine, clomipramine (Anafranil), desipramine (Norpramin), doxepin (Silenor, Zonalon), imipramine ( Tofranil), nortriptyline (Pamelor), protriptyline (Vivactil), kanye ne-trimipramine (Surmontil); i-amiodarone (i-Nexterone, i-Pacerone); i-anagrelide (Agrylin); i-chloroquine; i-chlorpromazine; i-cilostazol; i-ciprofloxacin (Cipro); i-citalopram (Celexa); i-clarithromycin; i-disopyramide (iNorpace); i-dofetilide (Tikosyn); i-donepezil (i-Aricept); i-dronedarone (iMultaq); i-escitalopram (iLexapro); i-flecainide (iTambocor); i-fluconazole (iDiflucan); i-haloperidol (iHaldol); ibutilide (Corvert); levofloxacin; i-methadone (i-Dolophine, i-Methadose); moxifloxacin (Avelox); i-ondansetron (iZuplenz, iZofran); i-pentamidine (i-Pentam); ipimozide (i-Orap); procainamide; i-quinidine (ku-Nuedexta); i-sotalol (iBetapace, iSorine, iSotylize); thioridazine; kanye ne-monoamine oxidase (MAO) inhibitors efana ne-isocarboxazid (Marplan), linezolid (Zyvox), phenelzine (Nardil), rasagiline (Azilect), selegiline (Emsam, Zelapar), ne-tranylcypromine (iParnate). Eminye imishanguzo eminingi ingaxhumana ne-umeclidinium ne-vilanterol, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho naleyo engabonakali kulolu hlu. Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• utshele udokotela wakho uma une-asthma. Udokotela wakho uzokutshela ukuthi ungasebenzisi i-umeclidinium ne-vilanterol ngaphandle uma uyisebenzisa kanye nomuthi we-steroid ohogelwayo.
• Tshela udokotela wakho uma uke waba nomfutho wegazi ophakeme noma ukushaya kwenhliziyo okungajwayelekile, ukwandiswa kwe-QT (isigqi senhliziyo esingajwayelekile esingaholela ekuphelelweni amandla, ekulahlekelweni ukwazi, ekuqulekeni, noma ekufeni okungazelelwe), ukuquleka, isifo sikashukela, i-glaucoma (isifo samehlo ), ukugcinwa komchamo (ubunzima bokuchama), izinkinga zeprostate noma isinye, noma inhliziyo, igilo, noma isifo sesibindi.
• utshele udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uncelisa. Uma ukhulelwa ngenkathi usebenzisa i-umeclidinium ne-vilanterol, shayela udokotela wakho.
• kufanele wazi ukuthi i-umeclidinium ne-vilanterol inhalation kwesinye isikhathi kubangela ukuphefumula nobunzima bokuphefumula ngokushesha ngemuva kokuhogela. Uma lokhu kwenzeka, shayela udokotela wakho ngokushesha. Ungasebenzisi i-umeclidinium ne-vilanterol inhalation futhi ngaphandle kokuthi udokotela wakho akutshele ukuthi kufanele.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Donsela umthamo ongekho lapho usukhumbula. Kodwa-ke, uma sekuyisikhathi somthamo olandelayo, weqa umthamo ongabanjwanga bese uqhubeka neshejuli yakho ejwayelekile yokulinganisa. Ungasebenzisi umthamo ongaphezu kowodwa ngosuku futhi ungadonsi umthamo ophindwe kabili ukwenzela owulahlekile.

I-Umeclidinium ne-vilanterol kungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ukuzamazama kwengxenye yomzimba wakho ongeke ukwazi ukuyilawula
• uvalo
• ikhala eligobayo, umphimbo obuhlungu
• ukuqunjelwa
• isifo sohudo
• ubuhlungu ezingalweni noma emilenzeni
• ukuphazamiseka kwemisipha
• ubuhlungu bentamo
• ukuhlungu obusemhlane
• ubuhlungu obuhlangene
• ubuhlungu besisu
• ikhanda
• isicanucanu
• isiyezi
• ubuhlungu bamazinyo

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, yeka ukusebenzisa umeclidinium ne-vilanterol bese ushayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• ukuqubuka
• isifuba
• ukulunywa
• ukuvuvukala kobuso, umlomo, noma ulimi
• ukushaya kwenhliziyo okushaya ngamandla, okusheshayo, noma okungajwayelekile
• ubuhlungu besifuba
• ubuhlungu beso, ubomvu, noma ukungaphatheki kahle; ukungaboni kahle; ukubona ama-halos noma imibala ekhanyayo ezungeze amalambu, kwesinye isikhathi kuhambisana nesicanucanu nokuhlanza
• ubunzima bokuchama noma ukuchama emfudlaneni obuthakathaka noma emaceleni
• ukuchama kaningi noma okubuhlungu

I-Umeclidinium ne-vilanterol kungadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi usebenzisa lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi kusigaqa se-foil efikile, ivaliwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Ukugcine ekamelweni lokushisa kude nelanga, ukushisa okweqile nomswakama (hhayi endlini yangasese). Lahla i-inhaler ngemuva kwamasonto ayisithupha uyisusile kutrayi le-foil noma ngemuva kokuthi kusetshenziswe lonke iblister (lapho isibali sedosi sifunda u-0), noma yikuphi okuza kuqala.

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

• isithuthwane
• ubuhlungu besifuba
• ukuphelelwa umoya
• isiyezi
• ukushesha, ukushaya ngamandla, noma ukushaya kwenhliziyo okungajwayelekile
• uvalo
• ikhanda
• ukuzamazama kwengxenye yomzimba wakho ongeke ukwazi ukuyilawula
• amajaqamba noma ubuthakathaka
• umlomo owomile
• kushisa, komile, kufutha isikhumba
• isicanucanu
• ukukhathala ngokweqile
• ubunzima bokulala noma ukulala
• ukungaboni kahle
• abafundi abahlanzekile
• ukubona izinto noma ukuzwa amazwi angekho (hallucinating)

Gcina wonke ama-aphoyintimenti nodokotela wakho.

Ngaphambi kokwenza noma yiluphi uvivinyo lwe-laboratory (ikakhulukazi lezo ezibandakanya i-methylene blue), tshela udokotela wakho nabasebenzi be-laboratory ukuthi usebenzisa i-umeclidinium ne-vilanterol.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• U-Anoro Ellipta^® (equkethe umeclidinium, vilanterol)