ULedipasvir noSofosbuvir

-Delile

• Ngaphambi kokuthatha i-ledipasvir ne-sofosbuvir,
• I-Ledipasvir ne-sofosbuvir kungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SEXWAYISO, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

Kungenzeka ukuthi usungenwe yi-hepatitis B (igciwane elithelela isibindi futhi lingadala ukulimala kwesibindi), kepha ungabi nazimpawu zesifo. Kulokhu, ukuthatha inhlanganisela ye-ledipasvir ne-sofosbuvir kungakhuphula ubungozi bokuthi uzoba nezimpawu kanti ukutheleleka kwakho kuzoba kubi kakhulu noma kusongele impilo Tshela udokotela wakho uma ngabe uke waba nokutheleleka ngegciwane le-hepatitis B. Udokotela wakho uzokuyalela ukuhlolwa kwegazi ukuze abone ukuthi uke waba nokutheleleka kwesifo sikashukela B. Udokotela wakho uzokuhlola futhi nangezimpawu zokutheleleka kwesifo sokusha kwesibindi kohlobo B ngesikhathi nangezinyanga ezimbalwa ngemuva kokwelashwa kwakho. Uma kunesidingo, udokotela wakho angakunika imithi yokwelapha lesi sifo ngaphambi nangesikhathi sokwelashwa kwakho ngenhlanganisela ye-ledipasvir ne-sofosbuvir. Uma uhlangabezana nalezi zimpawu ezilandelayo ngesikhathi noma ngemuva kokwelashwa kwakho, shayela udokotela wakho ngokushesha: ukukhathala ngokweqile, ukuphuzi kwesikhumba noma kwamehlo, ukulahlekelwa isifiso sokudla, isicanucanu, ukuhlanza, indle ephaphathekile, ubuhlungu besisu, noma umchamo omnyama.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho angalawula izivivinyo ezithile ngaphambi, ngesikhathi, nangemva kokwelashwa kwakho ukuze ahlole impendulo yomzimba wakho ekuhlanganisweni kwe-ledipasvir ne-sofosbuvir.

Khuluma nodokotela wakho ngobungozi (s) bokuthatha inhlanganisela ye-ledipasvir ne-sofosbuvir.

Inhlanganisela ye-ledipasvir ne-sofosbuvir isetshenziswa yodwa noma ihlanganiswe ne-ribavirin (i-Copegus, i-Rebetol, i-Ribasphere, abanye) ukwelapha izinhlobo ezithile ze-hepatitis C engalapheki (ukutheleleka ngegciwane okuqhubekayo okulimaza isibindi) kubantu abadala nezingane ezineminyaka emi-3 ubudala kanye amadala. I-Sofosbuvir isekilasini lemithi elwa namagciwane ebizwa nge-nucleotide polymerase inhibitors. Isebenza ngokunciphisa inani le-virus ye-hepatitis C (HCV) emzimbeni. ULedipasvir usesigabeni semithi elwa namagciwane ebizwa nge-HCV NS5A inhibitors. Isebenza ngokuvimba igciwane elibangela ukusha kwesibindi kohlobo C ekusakazekeni ngaphakathi komzimba.

Inhlanganisela ye-ledipasvir ne-sofosbuvir iza njengethebhulethi namaphilisi okuzothathwa ngomlomo. Imvamisa kuthathwa noma ngaphandle kokudla kanye ngosuku. Thatha i-ledipasvir ne-sofosbuvir ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-ledipasvir ne-sofosbuvir njengoba nje kuqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

I-Ledipasvir kanye ne-sofosbuvir pellets ingagwinywa (ngaphandle kokuhlafunwa) noma ingathathwa nokudla. Ukulungiselela umthamo we-ledipasvir kanye ne-sofosbuvir pellets ngokudla, fafaza lonke iphakethe lamapeletshi kusipuni esisodwa noma ngaphezulu se-spoonful yamakhaza noma ekamelweni lokudla okungekho i-asidi okufana ne-pudding, isiraphu yoshokholethi, amazambane abondiwe, noma u-ayisikhilimu. Thatha yonke ingxube kungakapheli imizuzu engama-30 ufafaze ama-pellets ekudleni. Ukugwema ukunambitheka okumunyu, musa ukuhlafuna ama-pellets.

Qhubeka uthathe i-ledipasvir ne-sofosbuvir noma ngabe uzizwa uphilile. Ubude bokwelashwa kwakho (amasonto ayi-8 kuye kwangama-24) buya ngesimo sakho, ukuthi uphendula kahle kanjani emithini, nokuthi ngabe unemiphumela emibi kakhulu yini. Ungayeki ukuthatha i-ledipasvir ne-sofosbuvir ngaphandle kokukhuluma nodokotela wakho.

Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi yesiguli.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-ledipasvir ne-sofosbuvir,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-ledipasvir noma i-sofosbuvir, noma imuphi omunye umuthi, noma iziphi izithako ezise-ledipasvir kanye namathebulethi e-sofosbuvir noma ama-pellets. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, kanye nezithako zokudla okunomsoco ozithathayo noma ohlela ukuzithatha. Qiniseka ukuthi usho noma ikuphi kokulandelayo: amiodarone (Nexterone, Pacerone); i-digoxin (i-Lanoxin); imithi ethile yomdlavuza; imithi yesifo sikashukela; imithi ethile yokuquleka efana ne-carbamazepine (Carbatrol, Epitol, Equetro, Tegretol), oxcarbazepine (Oxtellar XR, Trileptal), phenobarbital, noma phenytoin (Dilantin, Phenytek); imithi yesilungulela nezilonda; imishanguzo ye-HIV ethathwe ndawonye njenge-efavirenz (Sustiva, e-Atripla), emtricitabine (Emtriva, e-Atripla) kanye ne-tenofovir (Viread, e-Atripla); i-elvitegravir (iSustiva, e-Atripla), i-cobicistat (iTybost, eStribild), i-emtricitabine (i-Emtriva, eStribild), ne-tenofovir (i-Viread, eStribild); i-tenofovir (i-Viread), i-atazanavir (i-Reyataz) ne-ritonavir (i-Norvir); i-tenofovir (i-Viread), i-darunavir (i-Prezista) ne-ritonavir (i-Norvir); i-tenofovir (Viread), lopinavir (eKaletra), ne-ritonavir (Norvir, eKaletra); noma i-tipranavir (Aptivus) ne-ritonavir (i-Norvir); imithi ethile ecindezela amasosha omzimba; i-rifabutin (i-Mycobutin); i-rifampin (iRifadin, iRimactane, eRifamate, eRifater); i-rifapentine (Priftin); i-rosuvastatin (iCrestor); simeprevir (Olysio); i-sofosbuvir (Sovaldi); kanye ne-warfarin (Coumadin, Jantoven). Udokotela wakho angakutshela ukuthi ungathathi i-ledipasvir ne-sofosbuvir uma uthatha eyodwa noma ngaphezulu yale mithi noma angakuqapha ngokucophelela ngemiphumela emibi. Eminye imishanguzo eminingi ingaxhumana ne-ledipasvir ne-sofosbuvir, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho nalawo angaveli kulolu hlu.
• uma uthatha ama-antacids aqukethe i-aluminium hydroxide noma i-magnesium hydroxide (Maalox, Mylanta, Tums, others), thatha amahora amane ngaphambi noma amahora amane ngemuva kokuthatha i-ledipasvir ne-sofosbuvir.
• Tshela udokotela wakho uma uthatha umuthi wokugaya ukudla, isilungulela, noma izilonda (H₂ blockers) njenge-cimetidine, i-ranitidine (i-Zantac), i-famotidine (i-Pepcid, e-Duexis) noma i-nizatidine. Udokotela wakho angakutshela ukuthi ubathathe amahora ayi-12 ngaphambi noma amahora ayi-12 ngemuva kwe-ledipasvir ne-sofosbuvir, noma ngasikhathi sinye lapho uthatha khona i-ledipasvir ne-sofosbuvir.
• utshele udokotela wakho ukuthi uthatha miphi imikhiqizo yamakhambi, ikakhulukazi iSt John's wort. Akufanele uthathe i-wort yaseSt. John ngesikhathi sokwelashwa kwakho nge-ledipasvir ne-sofosbuvir.
• utshele udokotela wakho uma uke wafakelwa isibindi noma unegciwane lengculazi (i-HIV). Futhi, tshela udokotela wakho uma ngabe uke waba nanoma yiluphi uhlobo lwesifo sesibindi ngaphandle kwesifo sokusha kwesibindi kohlobo C, isifo sezinso, noma uku-dialysis.
• tshela udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uncelisa. Uma ukhulelwa ngenkathi uthatha i-ledipasvir ne-sofosbuvir, shayela udokotela wakho. Uma i-ledipasvir ne-sofosbuvir isetshenziswa ngokuhlangana ne-ribavirin, qiniseka ukuthi ufunda imininingwane mayelana nokuqapha ukukhulelwa ku-ribavirin monograph.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Thatha umthamo ongabanjwanga ngokushesha nje lapho uwukhumbula. Kodwa-ke, uma sekuyisikhathi somthamo olandelayo, weqa umthamo ongabanjwanga bese uqhubeka neshejuli yakho ejwayelekile yokulinganisa. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

I-Ledipasvir ne-sofosbuvir kungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ukukhathala
• ikhanda
• ubunzima bokulala noma ukulala
• isicanucanu
• isifo sohudo
• ukukhwehlela
• isiyezi
• ubuhlungu bemisipha
• ukucasuka

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SEXWAYISO, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• ukuqubuka
• amabhamuza
• ukuvuvukala kobuso, izingalo, noma imilenze
• ukuphelelwa umoya
• ukushaqeka
• ubunzima bokugwinya noma ukuphefumula

I-Ledipasvir ne-sofosbuvir kungadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Ungayisebenzisi uma uphawu lokuvulwa kwebhodlela luphukile noma lungekho. Ukugcine ekamelweni lokushisa kude nokukhanya, ukushisa okweqile nomswakama (hhayi endlini yangasese).

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• Harvoni^®