I-Ombitasvir, iParitaprevir, iRitonavir, neDasabuvir

-Delile

• Ngaphambi kokuthatha i-ombitasvir, paritaprevir, ritonavir, ne-dasabuvir,
• I-Ombitasvir, i-paritaprevir, i-ritonavir, ne-dasabuvir ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SESEXWAYISO, shayela udokotela wakho ngokushesha:

I-Ombitasvir, paritaprevir, ritonavir, ne-dasabuvir ayisatholakali e-United States.

Kungenzeka ukuthi usungenwe yi-hepatitis B (igciwane elithelela isibindi futhi lingadala ukulimala kwesibindi) kepha ungabi nazimpawu zesifo. Kulokhu, ukuthatha inhlanganisela ye-ombitasvir, i-paritaprevir, i-ritonavir, ne-dasabuvir kungandisa ubungozi bokuthi ukutheleleka kwakho kuzoba kubi kakhulu noma kusongele impilo futhi uzoba nezimpawu. Tshela udokotela wakho uma ngabe uke waba nokutheleleka ngegciwane le-hepatitis B. Udokotela wakho uzokuyalela ukuhlolwa kwegazi ukuze abone ukuthi uke waba nokutheleleka kwesifo sikashukela B. Udokotela wakho uzokuhlola futhi nangezimpawu zokutheleleka kwesifo sokusha kwesibindi kohlobo B ngesikhathi nangezinyanga ezimbalwa ngemuva kokwelashwa kwakho. Uma kunesidingo, udokotela wakho angakunika imithi yokwelapha lesi sifo ngaphambi nangesikhathi sokwelashwa kwakho ngokuhlanganiswa kwe-ombitasvir, paritaprevir, ritonavir, ne-dasabuvir. Uma uhlangabezana nalezi zimpawu ezilandelayo ngesikhathi noma ngemuva kokwelashwa kwakho, shayela udokotela wakho ngokushesha: ukukhathala ngokweqile, ukuphuzi kwesikhumba noma kwamehlo, ukulahlekelwa isifiso sokudla, isicanucanu noma ukuhlanza, indle ephaphathekile, ubuhlungu besisu, noma umchamo omnyama.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho angalawula izivivinyo ezithile ngaphambi, ngesikhathi, nangemva kokwelashwa kwakho ukuze ahlole impendulo yomzimba wakho ekuhlanganisweni kwe-ombitasvir, paritaprevir, ritonavir, ne-dasabuvir.

Khuluma nodokotela wakho ngobungozi (s) bokuthatha inhlanganisela ye-ombitasvir, paritaprevir, ritonavir, ne-dasabuvir.

Inhlanganisela ye-ombitasvir, i-paritaprevir, i-ritonavir, ne-dasabuvir isetshenziswa yodwa noma ihlanganiswe ne-ribavirin (i-Copegus, i-Rebetol) ukwelapha ukutheleleka okungapheli (kwesikhathi eside) kwe-hepatitis C (ukuvuvukala kwesibindi okubangelwa igciwane). I-Ombitasvir igciwane le-hepatitis C (HCV) NS5A inhibitor. Isebenza ngokuvimba igciwane elibangela ukusha kwesibindi kohlobo C ekusakazekeni ngaphakathi komzimba. I-Paritaprevir iyi-protease inhibitor. Isebenza ngokunciphisa inani le-HCV emzimbeni. I-Ritonavir iyi-protease inhibitor. Kuyasiza ukukhulisa inani le-paritaprevir emzimbeni ukuze umuthi ube nomthelela omkhulu. I-Dasabuvir iyi-non-nucleoside NS5B polymerase inhibitor. Isebenza ngokunciphisa inani le-HCV emzimbeni. Akwaziwa ukuthi i-ombitasvir, paritaprevir, ritonavir, noma i-dasabuvir ivimbela ukusakazeka kwesifo sokusha kwesibindi kohlobo C kwabanye abantu.

Inhlanganisela ye-ombitasvir, i-paritaprevir, i-ritonavir, ne-dasabuvir iza njengamaphilisi okuzothathwa ngomlomo. Lo muthi uza ephaketheni elinezinsuku ezingama-28 zemithi. Iphakethe ngalinye ledosi lansuku zonke linezinhlobo ezahlukene zamaphilisi, amabili aqukethe inhlanganisela ye-ombitasvir, paritaprevir, ne-ritonavir namanye amabili aqukethe i-dasabuvir. Thatha i-ombitasvir, i-paritaprevir, ne-ritonavir (amaphilisi ama-2) ne-dasabuvir (ithebhulethi eli-1) njalo ekuseni ngokudla, bese uphuza i-dasabuvir (ithebhulethi elilodwa) njalo kusihlwa ngokudla. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-ombitasvir, i-paritaprevir, i-ritonavir, ne-dasabuvir ngasikhathi sinye nsuku zonke. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Inhlanganisela ye-ombitasvir, i-paritaprevir, i-ritonavir, ne-dasabuvir ilawula i-HCV kepha ayiyelaphi. Qhubeka uthathe i-ombitasvir, paritaprevir, ritonavir, ne-dasabuvir noma ngabe uzizwa uphilile. Ubude bokwelashwa kwakho (amasonto ayi-12 kuye kwangama-24) buya ngesimo sakho, ukuthi uphendula kahle kangakanani emithini, nokuthi ngabe unemiphumela emibi kakhulu yini. Ungayeki ukuthatha i-ombitasvir, paritaprevir, ritonavir, ne-dasabuvir ngaphandle kokukhuluma nodokotela wakho.

Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi yesiguli.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-ombitasvir, paritaprevir, ritonavir, ne-dasabuvir,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-ombitasvir, paritaprevir, ritonavir, dasabuvir, noma imuphi omunye umuthi, noma iziphi izithako kuma-ombitasvir, paritaprevir, ritonavir, kanye namaphilisi e-dasabuvir. Uma uke waba nokusabela okungathi sína noma okusongela ukuphila ku-ritonavir (ukuqubuka, ukushaywa ngamabhalane noma ukuxebuka kwesikhumba), udokotela wakho uzotshela ukuthi angathathi i-ombitasvir, paritaprevir, ritonavir, ne-dasabuvir. Buza usokhemisi wakho noma uhlole Umhlahlandlela Wezokwelapha ukuthola uhlu lwezithako.
• tshela udokotela wakho uma uthatha i-alfuzosin (Uroxatral); i-atorvastatin (Lipitor, eCaduet); carbamazepine (Carbatrol, Epitol, Equetro, Tegretol); i-cisapride (Propulsid; ayisatholakali e-U.S.); i-dronedarone (iMultaq); i-efavirenz (iSustiva, e-Atripla); imithi equkethe i-ergot efana ne-dihydroergotamine mesylate (D.H 45, Migranal), ergotamine (Ergomar, eCafergot, eMigergot), ne-methylergonovine (Methergine); izindlela zokuvimbela inzalo ze-ethinyl estradiol ezifana namathebulethi athile (‘amaphilisi okulawula ukuzalwa’), amabala, izindandatho zesitho sangasese sowesifazane, neminye imikhiqizo ye-esthinyl estradiol; everolimus (Afinitor, Zortress); gemfibrozil (Lopid); i-lovastatin (Altoprev); i-lurasidone (Latuda); i-midazolam (ngomlomo); i-phenobarbital; i-phenytoin (iDilantin, Phenytek); ipimozide (i-Orap); i-ranolazine (Ranexa); i-rifampin (iRifadin, iRimactane, eRifamate, eRifater); i-sildenafil (i-Revatio) yokwelashwa komfutho wegazi ophezulu we-pulmonary; simvastatin (iZocor, eVytorin); i-sirolimus (i-Rapamune); ISt John's wort; i-tacrolimus (i-Astagraf XL, i-Envarsus XR, i-Prograf); noma i-triazolam (Halcion). Futhi, tshela udokotela wakho uma uthatha i-colchicine (Colcrys, Mitigare) futhi unesifo sesibindi noma sezinso. Udokotela wakho mhlawumbe uzokutshela ukuthi ungathathi i-ombitasvir, paritaprevir, ritonavir, ne-dasabuvir uma uthatha eyodwa noma ngaphezulu yale mithi.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma ikuphi kokulandelayo: alprazolam (Xanax); i-acetaminophen ne-hydrocodone (i-Anexsia, i-Zyfrel); i-angiotensin receptor blocker (ARB) efana ne-candesartan (Atacand, e-Atacand HCT), losartan (Cozaar, e-Hyzaar), ne-valsartan (Diovan, eDiovan HCT, Exforge); i-buprenorphine ne-naloxone (i-Suboxone, iZubsolv); ama-calcium channel blocker afana ne-amlodipine (Norvasc, eCaduet), diltiazem (Cardizem, Cartia), nifedipine (Adalat, Afeditab), ne-verapamil (Calan, Verelan); i-carisoprodol (iSoma); i-cyclobenzaprine (Amrix); i-cyclosporine (Gengraf, Neoral, Sandimmune); diazepam (Valium); i-fluticasone (i-Flonase, i-Flovent, e-Advair); i-furosemide (i-Lasix); imishanguzo yokushaya kwenhliziyo okungajwayelekile njenge-amiodarone (Nexterone, Pacerone), bepridil (ayisatholakali e-U.S.), disopyramide (Norpace), flecainide, lidocaine (Xylocaine), mexiletine, propafenone (Rythmol), noma i-quinidine (eNuedexta); ketoconazole; i-metformin (iGlucophage, iRiomet); omeprazole (Prilosec); i-pravastatin (Pravachol); i-quetiapine (iSeroquel); i-rilpivirine (i-Edurant; eComplera, e-Odefsey); i-ritonavir (i-Norvir, e-Kaletra) isetshenziswa ngokuhlangana namanye ama-HIV protease inhibitors anjenge atazanavir (Reyataz), darunavir (Prezista), ne lopinavir (e Kaletra); i-rosuvastatin (iCrestor); i-salmeterol (iSerevent, e-Advair); kanye ne-voriconazole (Vfend). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• utshele udokotela wakho uma unanoma yiluphi uhlobo lwesifo sesibindi ngaphandle kwe-hepatitis C. Udokotela wakho angakutshela ukuthi ungathathi i-ombitasvir, paritaprevir, ritonavir, ne-dasabuvir.
• Tshela udokotela wakho uma ngabe uke wafakelwa isibindi, i-anemia (inani eliphansi kunalelo elijwayelekile lamaseli abomvu egazi), noma igciwane lesandulela ngculaza lomzimba (HIV).
• utshele udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uncelisa. Uma ukhulelwa ngenkathi uthatha i-ombitasvir, paritaprevir, ritonavir, ne-dasabuvir, shayela udokotela wakho.
• kufanele wazi ukuthi i-ombitasvir, i-paritaprevir, i-ritonavir, ne-dasabuvir inganciphisa ukusebenza kwezindlela zokuvimbela inzalo zamahomoni (amaphilisi okulawula ukubeletha, amabala, izindandatho, ukufakelwa, imijovo, kanye nezinto zangaphakathi). Sebenzisa enye indlela yokulawula ukubeletha ngenkathi uthatha i-ombitasvir, paritaprevir, ritonavir, ne-dasabuvir kanye namasonto amabili ngemuva komthamo wakho wokugcina. Khuluma nodokotela wakho ngezinhlobo zokulawulwa kokubeletha ezizokusebenzela ngesikhathi nangemva kokwelashwa kwakho nge-ombitasvir, paritaprevir, ritonavir, ne-dasabuvir.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Uma uphuthelwa umthamo we-ombitasvir, i-paritaprevir, ne-ritonavir, thatha umthamo owulahlekile ngesidlo ngokushesha nje lapho usikhumbula. Kodwa-ke, uma kungaphezu kwamahora we-12 kusukela ngesikhathi obekufanele uthathe umthamo wakho, weqa umthamo ophuthelwe bese uqhubeka nesimiso sakho sokulinganisa. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

Uma uphuthelwa umthamo we-dasabuvir, thatha isilinganiso esilahlekile ngesidlo ngokushesha nje lapho usikhumbula. Kodwa-ke, uma kungaphezu kwamahora we-6 kusukela ngesikhathi obekufanele uthathe umthamo wakho, weqa umthamo ongabanjwanga bese uqhubeka neshejuli yakho ejwayelekile yokulinganisa. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

I-Ombitasvir, i-paritaprevir, i-ritonavir, ne-dasabuvir ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ubunzima bokulala noma ukulala

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SESEXWAYISO, shayela udokotela wakho ngokushesha:

• ukuqubuka
• ukubomvu kwesikhumba
• ukulunywa
• ubuthakathaka

I-Ombitasvir, i-paritaprevir, i-ritonavir, ne-dasabuvir ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi ebhokisini efike kuyo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese).

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help.Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• I-Viekira Pak^® (njengomkhiqizo ohlanganisiwe oqukethe i-Ombitasvir, iParitaprevir, iRitonavir, iDasabuvir)