I-Riociguat

-Delile

• Ngaphambi kokuthatha i-riociguat,
• I-Riociguat ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nanoma yiziphi zalezi zimpawu noma lezo esigabeni esikhethekile SOKUQAPHA, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

Ungathathi i-riociguat uma ukhulelwe noma uhlela ukukhulelwa. I-Riociguat ingalimaza umbungu. Uma uhlanganyela ocansini futhi ukwazi ukukhulelwa, akufanele uqale ukuthatha i-riociguat kuze kube yilapho ukuhlolwa kokukhulelwa kubonise ukuthi awukhulelwe. Kufanele usebenzise izindlela ezinokwethenjelwa zokulawulwa kokubeletha ngesikhathi sokwelashwa nangenyanga eyodwa ngemuva kokumisa i-riociguat. Musa ukuya ocansini olungaphephile. Khuluma nodokotela wakho ngezindlela zokulawula ukubeletha ezisebenzayo futhi ezizokusebenzela. Shayela udokotela wakho ngokushesha uma uphuthelwa ukuya esikhathini noma ucabanga ukuthi ungakhulelwa ngenkathi uthatha i-riociguat.

Uma ungumzali noma umnakekeli wowesifazane owayengakafiki ebusheni, hlola ingane yakho njalo ukuze ubone ukuthi ingabe ikhona yini izimpawu zokuthomba (amabele efihlekile, izinwele zasesidlangalaleni) futhi yazise udokotela wayo nganoma yiziphi izinguquko. Ingane yakho ingafinyelela ebusheni ngaphambi kokuya esikhathini okokuqala.

Ngenxa yobungozi bokukhubazeka kokuzalwa, i-riociguat itholakala kuphela ngohlelo olukhethekile lokusabalalisa olukhawulelwe. Uhlelo olubizwa nge-Adempas Risk Evaluation and Mitigation Strategies (REMS) Program lusungulelwe zonke iziguli zesifazane ukuqinisekisa ukuthi zivivinywa ukukhulelwa njalo ngenyanga ngesikhathi sokwelashwa nangenyanga eyodwa ngemuva kokumisa i-riociguat. Iziguli zabesifazane zingathola i-riociguat kuphela uma zibhaliswe ne-Adempas REMS Program. Ngesikhathi sokubhalisa uzokhetha ikhemisi ekhethekile eqinisekisiwe ezokuthumela imithi yakho. Buza udokotela wakho uma unemibuzo mayelana nokuthi uzowuthola kanjani umuthi wakho.

Udokotela wakho noma usokhemisi uzokunikeza ishidi lemininingwane yesiguli lomkhiqizi (Umhlahlandlela Wezokwelapha) lapho uqala ukwelashwa nge-riociguat futhi isikhathi ngasinye lapho ugcwalisa umuthi wakho. Funda imininingwane ngokucophelela bese ubuza udokotela noma usokhemisi wakho uma unemibuzo. Ungavakashela futhi iwebhusayithi ye-Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) ukuthola uMhlahlandlela Wezokwelapha.

Khuluma nodokotela wakho ngezingozi zokuthatha i-riociguat.

I-Riociguat isetshenziselwa ukwelapha umfutho wegazi ophakeme wamaphaphu (PAH; umfutho wegazi ophakeme ezitsheni ezihambisa igazi emaphashini). I-Riociguat ibuye isetshenziselwe ukwelapha umfutho wegazi ophakeme we-thromboembolic pulmonary (CTEPH; umfutho wegazi ophakeme emithanjeni yamaphaphu obangelwa amahlule egazi anciphisa noma avimbe ukugeleza kwegazi) kubantu abadala abangakwazi ukuhlinzwa noma kulabo abaphathwa ngokuhlinzwa abaqhubeka nokuba negazi eliphezulu lamaphaphu amazinga engcindezi ngemuva kokuhlinzwa. I-Riociguat ingathuthukisa ikhono lokuzivocavoca kubantu abane-PAH ne-CTEPH futhi inganciphisa ukwanda kwezimpawu kubantu abane-PAH. URiociguat usesigabeni semithi ebizwa ngokuthi i-soluble guanylate cyclase (sGC) stimulators. Isebenza ngokuxegisa imithambo yegazi emaphashini ukuvumela igazi ukuba ligeleze kalula.

I-Riociguat iza njengethebhulethi ezothathwa ngomlomo. Imvamisa kuthathwa ngokudla noma ngaphandle kokudla izikhathi ezintathu ngosuku. Thatha i-riociguat cishe ngesikhathi esifanayo (ama) nsuku zonke futhi ubeke imithamo yakho cishe ngamahora ayisithupha kuye kwayi-8. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-riociguat njengoba nje kuqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Uma ungakwazi ukugwinya ithebhulethi ngokuphelele, ungayichoboza ithebhulethi bese uxuba okuqukethwe namanzi amancane noma ukudla okuthambile okufana ne-appleauce. Gwinya ingxube ngemuva nje kokuyixuba.

Udokotela wakho angakuqala ngomthamo ophansi we-riociguat futhi akhuphule kancane umthamo wakho, hhayi ngaphezu kwesisodwa njalo emavikini amabili. Udokotela wakho anganciphisa umthamo wakho uma uba nemiphumela emibi.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-riociguat,

• Tshela udokotela wakho kanye nosokhemisi uma une-allergies ku-riociguat, noma imuphi omunye umuthi, noma iziphi izithako ezibhebheni ze-riociguat. Buza usokhemisi wakho noma uhlole Umhlahlandlela Wezokwelapha ukuthola uhlu lwezithako.
• Tshela udokotela wakho uma uthatha noma usanda kuthatha i-nitrate efana ne-isosorbide dinitrate (Isordil, ku-BiDil), isosorbide mononitrate (Monoket), noma i-nitroglycerin (Nitro-Dur, Nitromist, Nitrostat, Minitran, Rectiv, others) ,; i-phosphodiesterase inhibitors (PDE-5) efana ne-avanafil (Stendra), sildenafil (Revatio, Viagra), tadalafil (Adcirca, Cialis), noma vardenafil (Levitra, Staxyn); noma uma uthatha i-dipyridamole (Persantine, ku-Aggrenox), noma i-theophylline (Theo-24, Theochron, Theolair, abanye). Udokotela wakho mhlawumbe uzokutshela ukuthi ungathathi i-riociguat uma uthatha lo muthi owodwa noma ngaphezulu. Ungathathi i-riociguat kungakapheli amahora angama-24 ngaphambi noma ngemuva kokuthatha i-sildenafil noma kungakapheli amahora angama-24 ngaphambi noma amahora we-48 ngemuva kokuthatha i-tadalafil.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma yikuphi okulandelayo: ama-antifungal athile afana ne-itraconazole (Onmel, Sporanox) ne-ketoconazole (i-Extina, i-Nizoral, i-Xolegel); Ama-HIV protease inhibitors afaka i-ritonavir (iNorvir, eKaletra); imithi ethile yokuquleka efana ne-carbamazepine (Epitol, Equetro, Tegretol, abanye), phenobarbital, ne phenytoin (Dilantin, Phenytek); nemithi yomfutho wegazi ophezulu. Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• uma uthatha ama-antacids aqukethe i-aluminium hydroxide noma i-magnesium hydroxide (Maalox, Mylanta, Tums, others), thatha ihora eli-1 ngaphambi noma ihora eli-1 ngemuva kokuthatha i-riociguat.
• utshele udokotela wakho ukuthi uthatha miphi imikhiqizo yamakhambi, ikakhulukazi iSt John's wort.
• Tshela udokotela wakho uma une-hypertension yamaphaphu ene-idiopathic interstitial pneumonia (PH-IIP; isifo samaphaphu). Udokotela wakho mhlawumbe uzokutshela ukuthi ungathathi i-riociguat.
• utshele udokotela wakho uma njengamanje ubhema noma uqala noma uyeka ukubhema ngesikhathi sokwelashwa. Phinda utshele udokotela wakho uma usanda kuba nohudo, ukuhlanza, noma ukujuluka kakhulu okungenzeka ukuthi kubangele ukomisa (ukulahlekelwa inani elikhulu loketshezi lomzimba); noma yikuphi ukuphuma kwegazi emaphashini akho; uma uke waba nenqubo yokukuyekisa ukukhwehlela igazi; uma unengcindezi yegazi ephansi, isifo se-pulmonary veno-occlusive (ukuvinjelwa kwemithambo emaphashini); noma isifo senhliziyo, sezinso, noma sesibindi.
• tshela udokotela wakho uma uncelisa. Ungancelisi ibele ngenkathi uthatha i-riociguat.
• kufanele wazi ukuthi i-riociguat ingadala isizungu nekhanda elikhanyayo. Ungashayeli imoto noma usebenzise imishini uze wazi ukuthi lo muthi ukuthinta kanjani.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Yeqa umthamo ophuthelwe bese uqhubeka nesimiso sakho sokulinganisa esivamile. Uma uphuthelwa ukuthatha i-riociguat izinsuku ezingaphezu kwezingu-3, ​​shayela udokotela wakho. Udokotela wakho angafuna ukuqala kabusha imithi yakho ngomthamo ophansi.

I-Riociguat ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ikhanda
• ukuqunjelwa
• isilungulela
• isisu esibuhlungu
• isicanucanu
• ukuhlanza
• isifo sohudo
• ukuvuvukala kwezandla zakho, imilenze, izinyawo, namaqakala

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nanoma yiziphi zalezi zimpawu noma lezo esigabeni esikhethekile SOKUQAPHA, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• ukukhwehlela upinki, isikhwehlela esibandayo noma igazi
• ukuquleka
• ubuhlungu besifuba
• ukuphelelwa umoya

I-Riociguat ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese).

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Gcina wonke ama-aphoyintimenti nodokotela wakho. Udokotela wakho uzohlola umfutho wegazi lakho njalo ngesikhathi sokwelashwa kwakho nge-riociguat.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• I-Adempas^®