ILumacaftor ne-Ivacaftor

-Delile

• Ngaphambi kokuthatha i-lumacaftor ne-ivacaftor,
• ILumacaftor ne-ivacaftor kungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha:
• Izimpawu zokudlula ngokweqile zingafaka:

ILumacaftor ne-ivacaftor kusetshenziselwa ukwelapha izinhlobo ezithile ze-cystic fibrosis (isifo esizalwa naso esidala izinkinga ngokuphefumula, ukugaya ukudla, nokuzala) kubantu abadala nezingane ezineminyaka engu-2 nangaphezulu. ILumacaftor isekilasini lemithi ebizwa ngokuthi i-cystic fibrosis transmembrane conductance regulator (CFTR) yokulungisa. I-Ivacaftor isekilasini lemithi ebizwa nge-cystic fibrosis transmembrane conductance regulator (CFTR) potentiators.Yomibili le mithi isebenza ngokwenza ngcono ukusebenza kweprotheni emzimbeni ukunciphisa ukwakheka komfinyela obukhulu emaphashini nokwenza ngcono ezinye izimpawu ze-cystic fibrosis.

Inhlanganisela ye-lumacaftor ne-ivacaftor iza njengethebhulethi nanjengama-granules okuzothathwa ngomlomo. Imvamisa kuthathwa ngokudla okunamafutha kabili ngosuku, ukuhlukaniswa kwamahora ayi-12. Thatha i-lumacaftor ne-ivacaftor ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-lumacaftor ne-ivacaftor njengoba nje kuqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Ukulungiselela umthamo we-lumacaftor kanye ne-ivacaftor granules, hlanganisa lonke iphakethe lamagremu ku-1 ithisipuni (5 ml) wokudla okuthambile noma oketshezi (kubanda noma ekamelweni lokushisa) njenge-yogurt, i-appleauce, i-pudding, ubisi noma ijusi. Thatha yonke ingxube kungakapheli ihora eli-1 lokuxuba ama-granules nokudla noma uketshezi.

Thatha i-lumacaftor ne-ivacaftor ngokudla okunamafutha okufana namaqanda, ukwatapheya, amantongomane, ibhotela, ibhotela lamantongomane, i-pizza yoshizi, ubisi lonke neminye imikhiqizo yobisi ephelele efana noshizi ne-yogurt egcwele yamafutha. Khuluma nodokotela wakho mayelana nokunye ukudla okunamafutha ongakudla ne-lumacaftor ne-ivacaftor.

ILumacaftor ne-ivacaftor ilawula i-cystic fibrosis kepha ayiyelaphi. Qhubeka uthathe i-lumacaftor ne-ivacaftor noma ngabe uzizwa uphilile. Ungayeki ukuthatha i-lumacaftor ne-ivacaftor ngaphandle kokukhuluma nodokotela wakho.

Uma ungathathi i-lumacaftor ne-ivacaftor izinsuku eziyi-7 noma ngaphezulu, ungaqali ukuyithatha futhi ngaphandle kokukhuluma nodokotela wakho. Udokotela wakho angadinga ukushintsha umthamo wakho walo muthi noma eminye imithi oyiphuzayo.

Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi yesiguli.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-lumacaftor ne-ivacaftor,

• Tshela udokotela wakho kanye nosokhemisi uma une-allergies ku-lumacaftor ne-ivacaftor, noma imuphi omunye umuthi, noma iziphi izithako ezikumaphilisi e-lumacaftor nakuma-ivacaftor noma ama-granules. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi imishanguzo kadokotela noma engabhaliswanga, amavithamini, kanye nezithako zokudla okunomsoco ozithathayo noma ohlela ukuzithatha. Qiniseka ukuthi usho noma yikuphi okulandelayo: ama-antifungal athile afana ne-itraconazole (Onmel, Sporanox), ketoconazole, posaconazole (Noxafil), ne-voriconazole (Vfend); ama-antibiotic athile afana ne-clarithromycin (i-Biaxin, e-Prevpac), i-erythromycin (i-E.E.S., i-Erythrocin, i-Eryped, abanye), i-rifabutin (i-Mycobutin) ne-rifampin (i-Rifadin, i-Rifamate, i-Rifater, i-Rimactane); imithi ethile yesifo sikashukela njenge-chlorpropamide (i-Diabinese), i-glimepiride (i-Amaryl, e-Duetact), i-glipizide (i-Glucotrol), i-glyburide (i-Diabeta, i-Glynase, e-Glucovance), i-repaglinide (i-Prandin), i-tolazamide ne-tolbutamide; i-digoxin (i-Lanoxin); ibuprofen (Advil, Motrin, kuVicoprofen); ama-immunosuppressants athile afana ne-cyclosporine (Gengraf, Neoral, Sandimmune), everolimus (Afinitor, Zortress), sirolimus (Rapamune) kanye ne-tacrolimus (Astagraf, Prograf); i-midazolam; i-montelukast (i-Singulair); i-methylprednisolone (iMedrol); i-prednisone (iRayos); ama-proton pump inhibitors (PPIs) athile afana ne-esomeprazole (Nexium, eVimovo), i-lansoprazole (Prevacid, e-Prevpac), ne-omeprazole (Prilosec, eZegerid); i-ranitidine (iZantac); imithi ethile yokuquleka efana ne-carbamazepine (Carbatrol, Epitol, Equetro, Tegretol, Teril), phenobarbital, ne-phenytoin (Dilantin, Phenytek); ezinye ze-serotonin reuptake inhibitors (SSRIs) ezikhethiwe ezifana ne-citalopram (Celexa), i-escitalopram (Lexapro), ne-sertraline (i-Zoloft); i-triazolam (iHalcion); kanye ne-warfarin (Coumadin, Jantoven). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi. Eminye imishanguzo eminingi ingaxhumana ne-lumacaftor ne-ivacaftor, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho naleyo engabonakali kulolu hlu.
• utshele udokotela wakho ukuthi uthatha miphi imikhiqizo yamakhambi, ikakhulukazi iSt John's wort. Udokotela wakho mhlawumbe uzokutshela ukuthi ungathathi i-wort yaseSt.John ngenkathi uthatha i-lumacaftor ne-ivacaftor.
• utshele udokotela wakho uma ngabe uke waba nezinkinga zokuphefumula noma izimo, ukufakelwa isitho somzimba, noma isibindi noma isifo sezinso.
• kufanele wazi ukuthi i-lumacaftor ne-ivacaftor kungehlisa ukusebenza kwezindlela zokuvimbela inzalo zamahomoni (amaphilisi okulawula ukubeletha, amabala, izindandatho, imijovo, okufakelwa, noma amadivayisi we-intrauterine). Khuluma nodokotela wakho ngezinye izindlela zokulawula ukubeletha ezizokusebenzela ngenkathi uthatha i-lumacaftor ne-ivacaftor.
• tshela udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uncelisa. Uma ukhulelwa ngenkathi uthatha i-lumacaftor ne-ivacaftor, shayela udokotela wakho.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Uma ukhumbula umthamo ongabanjwanga kungakapheli amahora angu-6 wesikhathi obehlelelwe ukuwuthatha, thatha umthamo ophuthelwe khona manjalo. Kodwa-ke, uma kudlule amahora angaphezu kwayi-6 kusukela esikhathini ovame ukuthatha ngaso i-lumacaftor ne-ivacaftor, weqa umthamo ongabanjwanga bese uqhubeka nesimiso sakho sokulinganisa ngokujwayelekile. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

ILumacaftor ne-ivacaftor kungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ukuphelelwa umoya
• ukuqina kwesifuba noma ubuhlungu
• izinkinga zokuphefumula
• isifo sohudo
• igesi
• ukukhathala ngokweqile
• ukuqubuka
• izikhathi ezingajwayelekile, ezingabanjwanga, ezisindayo noma ezibuhlungu zokuya esikhathini, ikakhulukazi kwabesifazane abathatha izindlela zokuvimbela inzalo zamahomoni
• ukuphuma kwamakhala, ukuthimula, ukukhwehlela, umphimbo obuhlungu, noma izimpawu ezifana nomkhuhlane
• Umphimbo obuhlungu
• ikhala eligcwele noma eligijimayo
• ikhanda

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha:

• isicanucanu
• ukuhlanza
• ukulahlekelwa isifiso sokudla
• ubuhlungu engxenyeni engenhla kwesokudla yesisu
• umchamo omnyama
• ukudideka
• ukuphuzi kwesikhumba noma kwamehlo

ILumacaftor kanye ne-ivacaftor kungadala i-cataract (ukufiphazwa kwelensi yeso okungadala izinkinga zamehlo) ezinganeni nasebusheni. Izingane nentsha ethatha i-lumacaftor ne-ivacaftor kufanele babonane nodokotela wamehlo ngaphambi nangesikhathi belashwa. Khuluma nodokotela wengane yakho ngezingozi zokunikeza i-lumacaftor ne-ivacaftor enganeni yakho.

ILumacaftor ne-ivacaftor kungadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese).

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Izimpawu zokudlula ngokweqile zingafaka:

• ikhanda
• ukuqubuka

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzoku-oda ukuhlolwa kwelebhu ngaphambi kokuba uqale ukwelashwa kwakho ukuze ubone ukuthi isimo sakho singelashwa yini nge-lumacaftor ne-ivacaftor njengoba kufanele sisetshenziswe kuphela kubantu abanokwakheka okuthile kofuzo. Udokotela wakho uzoku-oda ukuhlolwa kwamehlo nokuhlolwa okuthile kwelebhu ngaphambi nangesikhathi sokwelashwa kwakho ukuze uhlole impendulo yomzimba wakho ku-lumacaftor ne-ivacaftor. Umfutho wegazi lakho kufanele uhlolwe njalo ngenkathi uthatha lo muthi.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• I-Orkambi^®