Ukujova kweMepolizumab

-Delile

• Ngaphambi kokuthola umjovo we-mepolizumab,
• Umjovo weMepolizumab ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nanoma yiziphi zalezi zimpawu noma lezo ezisohlwini lwe-SPECIAL PRECAUTIONS section, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

Umjovo weMepolizumab usetshenziswa kanye neminye imithi yokuvimbela ukuphefumula, ukuphefumula kanzima, ukuqina kwesifuba, nokukhwehlela okubangelwa yisifuba somoya ezinganeni ezithile ezineminyaka engu-6 nangaphezulu kanye nabantu abadala abane-asthma engalawulwa ngemithi yabo (s) yamanje. Ibuye isetshenziselwe ukwelapha i-eosinophilic granulomatosis nge-polyangiitis (i-EGPA; isimo esifaka phakathi isifuba somoya, amazinga aphezulu amaseli egazi amhlophe, nokuvuvukala kwemithambo yegazi) kubantu abadala. Umjovo weMepolizumab uphinde usetshenziselwe ukwelapha i-hypereosinophilic syndrome (HES; iqembu lokuphazamiseka kwegazi okwenzeka ngamazinga aphezulu amaseli amhlophe egazi) kubantu abadala nezingane ezineminyaka engu-12 nangaphezulu abanesimo sezinyanga eziyisithupha noma ngaphezulu. Umjovo weMepolizumab usesigabeni semithi ebizwa ngama-antibody monoclonal. Isebenza ngokuvimba ukusebenza kwento ethile yemvelo emzimbeni edala izimpawu zesifuba somoya.

Umjovo weMepolizumab uza njengesirinji ekhethiwe, i-autoinjector ekhethiwe, noma njengempuphu ezohlanganiswa namanzi bese ujovwa ngomgogodla (ngaphansi nje kwesikhumba). Imvamisa inikezwa kanye njalo emavikini amane. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Sebenzisa umjovo we-mepolizumab njengoba uqondisiwe. Ungayifaki ngaphezulu noma ngaphansi kwayo noma uyijoje kaningi kunokuyalelwa ngudokotela wakho. Udokotela wakho uzonquma ubude bokwelashwa kwakho ngokuya ngesimo sakho nokuthi uphendula kahle kanjani emithini.

Ungathola umthamo wakho wokuqala womjovo we-mepolizumab ehhovisi likadokotela wakho. Ngemuva kwalokho, udokotela wakho angakuvumela noma umnakekeli anikeze imijovo ekhaya. Ngaphambi kokusebenzisa umjovo we-mepolizumab ngokwakho okokuqala, funda imininingwane yomkhiqizi yesiguli esiza nomuthi. Cela udokotela wakho noma usokhemisi ukuthi akubonise noma umuntu ozokunikeza umuthi ukuthi ungawujova kanjani.

Sebenzisa i-syringe ngayinye noma i-autoinjector kanye kuphela bese ujova sonke isixazululo kusirinji noma ku-autoinjector. Lahla imijovo esetshenzisiwe noma ama-autoinjectors esitsheni esingamelana nokubhoboza. Khuluma nodokotela wakho noma usokhemisi mayelana nokuthi ungasilahla kanjani isitsha esingamelana nokubhoboza.

Susa isirinji noma i-autoinjector efakwe efrijini. Yibeke endaweni eyisicaba ngaphandle kokukhipha ikepisi lenaliti bese uyivumela ukuthi ifudumale ekamelweni lokushisa imizuzu engama-30 (engekho ngaphezu kwamahora ayisishiyagalombili) ngaphambi kokuba ulungele ukujova umuthi. Ungazami ukufudumeza umuthi ngokuwufudumeza ngemicrowave, uwufake emanzini ashisayo, uwushiye elangeni, noma nganoma iyiphi enye indlela.

Unganyakazisi isirinji equkethe i-mepolizumab.

Uma usebenzisa i-mepolizumab futhi une-asthma, qhubeka uphuze noma usebenzise yonke eminye imishanguzo oyinikezwe ngudokotela wakho ukuphatha i-asthma yakho. Unganciphisi umthamo wakho wanoma imuphi omunye umuthi wesifuba somoya noma uyeke ukuthatha noma imuphi omunye umuthi onikezwe ngudokotela wakho ngaphandle kokuthi udokotela wakho akutshele ukuthi wenze njalo. Udokotela wakho angafuna ukunciphisa imithamo yeminye imithi yakho kancane kancane.

Njalo bheka isixazululo se-mepolizumab ngaphambi kokusijova. Bheka ukuthi usuku lokuphelelwa yisikhathi aludlulanga yini nokuthi uketshezi lucacile futhi alunambala noma luphuzi kancane ukuze lube nsundu kancane. Uketshezi akufanele luqukethe izinhlayiya ezibonakalayo. Ungasebenzisi isirinji efriziwe noma uma uketshezi lunamafu noma luqukethe izinhlayiya ezincane.

Ungajova umjovo we-mepolizumab noma yikuphi ngaphambili kwamathanga akho (umlenze ongaphezulu) noma isisu (isisu) ngaphandle kwenkaba yakho nendawo engamasentimitha ama-5 ukuyizungeza. Uma umnakekeli ejova umuthi, ingemuva lengalo engaphezulu nayo ingasetshenziswa. Ukwehlisa amathuba okuba buhlungu noma okubomvu, sebenzisa isiza esihlukile ngomjovo ngamunye. Ungafaki endaweni lapho isikhumba sithambile, silimele, sibomvu, noma siqinile noma lapho unezibazi noma izimpawu zokwelula.

Umjovo weMepolizumab awusetshenziselwa ukwelapha ukuhlaselwa okungazelelwe kwezimpawu zesifuba somoya. Udokotela wakho uzokunikeza i-inhaler emfushane ezosebenza ngesikhathi sokuhlaselwa. Khuluma nodokotela wakho ngokuthi ungazelapha kanjani izimpawu zokuhlaselwa yisifuba somoya okungazelelwe.Uma izimpawu zakho ze-asthma ziba zimbi kakhulu noma uma uhlaselwa yi-asthma kaningi, qiniseka ukuthi ukhuluma nodokotela wakho.

Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi yesiguli.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthola umjovo we-mepolizumab,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane kumjovo we-mepolizumab, noma imiphi imithi, noma yiziphi izithako zomjovo we-mepolizumab. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma yikuphi okulandelayo: i-corticosteroids yomlomo efana ne-prednisone (i-Rayos) noma i-corticosteroid ehogelwayo. Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• Tshela udokotela wakho uma ungazange ube nenkukhu (varicella) noma uke waba nanoma yiluphi uhlobo lokutheleleka okubangelwa izibungu.
• utshele udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uncelisa. Uma ukhulelwa ngenkathi uthola umjovo we-mepolizumab, shayela udokotela wakho.
• uma unezinye izimo zezokwelapha, njenge-arthritis, noma i-eczema (isifo sesikhumba), zingase zibe zimbi kakhulu lapho umthamo wakho we-oral steroid wehla. Tshela udokotela wakho uma lokhu kwenzeka noma uma uhlangabezana nalezi zimpawu ezilandelayo ngalesi sikhathi: ukukhathala ngokweqile, ubuthakathaka bemisipha, noma ubuhlungu; ubuhlungu obungazelelwe esiswini, emzimbeni ophansi, noma emilenzeni; ukulahlekelwa ukudla; ukuncipha komzimba; isisu esibuhlungu; ukuhlanza; isifo sohudo; isiyezi; ukuquleka; ukucindezeleka; ukucasuka; nokumnyama kwesikhumba. Umzimba wakho kungenzeka ungakwazi ukubhekana nengcindezi njengokuhlinzwa, ukugula, ukuhlaselwa yisifuba somoya okunzima, noma ukulimala ngalesi sikhathi. Shayela udokotela wakho ngokushesha uma ugula futhi uqiniseke ukuthi bonke abahlinzeki bezokunakekelwa kwezempilo abakwelaphayo bayazi ukuthi usanda kwehlisa umthamo wakho we-steroid womlomo.
• Tshela udokotela wakho uma ungagonyelwanga ingxibongo. Ungadinga ukuthola umuthi wokugoma (wokudubula) ukuze uvikeleke kulesi sifo.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Sebenzisa umthamo ongabanjwanga ngokushesha nje lapho uwukhumbula bese uqhubeka nesimiso sakho sokulinganisa okuvamile. Ungasebenzisi umthamo ophindwe kabili ukwenza okulahlekile. Shayela udokotela wakho uma uphuthelwa umthamo futhi unemibuzo mayelana nokuthi wenzeni.

Umjovo weMepolizumab ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ubuhlungu, ububomvu, ukuvuvukala, imfudumalo, ukushisa, noma ukulunywa endaweni lapho i-mepolizumab yajova khona
• ikhanda
• isikhumba esomile futhi esilumayo esinemivimbo ebomvu noma engenakho okubomvu,
• ukuhlungu obusemhlane
• ukuphazamiseka kwemisipha

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nanoma yiziphi zalezi zimpawu noma lezo ezisohlwini lwe-SPECIAL PRECAUTIONS section, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• ukuphefumula noma ukuphefumula kanzima
• ukuphelelwa umoya
• ukukhwehlela
• ukuqina kwesifuba
• ukuqhuma
• isifuba
• ukuqubuka
• ukuvuvukala kobuso, umlomo nolimi
• ubunzima bokugwinya
• ukuquleka noma isiyezi

Umjovo weMepolizumab ungadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthola lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina umjovo we-mepolizumab esiqandisini noma kwikhathoni elingavulwa ekamelweni lokushisa kuze kube yizinsuku eziyi-7, kodwa ungayifaki iqhwa. Uma usususiwe ebhokisini, umjovo we-mepolizumab ungagcinwa ekamelweni lokushisa kuze kube amahora angama-8.

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho anga-oda izivivinyo ezithile zelebhu ukuze ahlole impendulo yomzimba wakho kumjovo we-mepolizumab.

Buza usokhemisi wakho noma imiphi imibuzo onayo ngomjovo we-mepolizumab.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

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